Lista de obras - John M. Sedivy - Dominio Público Uruguay

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

artículo científico publicado en 2014

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

scientific journal article

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

artículo científico publicado en 2010

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

artículo científico publicado en 2003

Accumulation of senescent cells in mitotic tissue of aging primates

artículo científico publicado en 2007

Active Degradation Explains the Distribution of Nuclear Proteins during Cellular Senescence

artículo científico publicado en 2015

Age-associated increase in heterochromatic marks in murine and primate tissues

artículo científico publicado en 2010

Cellular senescence and organismal aging

artículo científico publicado en 2008

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

artículo científico publicado en 2007

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

artículo científico publicado en 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

artículo científico publicado en 2018

Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position

artículo científico publicado en 2004

Epigenetic control of aging

artículo científico publicado en 2010

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

artículo científico publicado en 1999

Global regulation of nucleotide biosynthetic genes by c-Myc

artículo científico publicado en 2008

How to learn new and interesting things from model systems based on "exotic" biological species

artículo científico publicado en 2009

Human Genomics. Sleeping dogs of the genome

artículo científico publicado en 2014

Interventions to Slow Aging in Humans: Are We Ready?

artículo científico publicado en 2015

Involvement of the INK4a/Arf gene locus in senescence

artículo científico publicado en 2003

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

artículo científico publicado en 2011

Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point

artículo científico publicado en 2003

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts ⬇️

artículo científico publicado el 17 de octubre de 2003

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression

artículo científico publicado en 2007

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

artículo científico publicado en 2003

NFAT4 is required for JC virus infection of glial cells

artículo científico publicado en 2006

Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay ⬇️

artículo científico publicado el 1 de octubre de 2011

Phosphatidylenthanolamine Binding Protein aka Raf Kinase Inhibitor Protein: A Brief History of Its Discovery and the Remarkable Diversity of Biological Functions

artículo científico publicado el 1 de enero de 2011

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

artículo científico publicado en 2002

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

artículo científico publicado en 2012

Proteomic profiling of Myc-associated proteins

artículo científico publicado en 2010

Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit

artículo científico publicado en 2006

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

artículo científico publicado en 2003

Reconstructing networks of pathways via significance analysis of their intersections

artículo científico publicado en 2008

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

artículo científico publicado en 2006

Reduced expression of MYC increases longevity and enhances healthspan

artículo científico publicado en 2015

Regulation of RKIP function by Helicobacter pylori in gastric cancer

artículo científico publicado en 2012

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

artículo científico publicado en 2010

Regulation of growth arrest in senescence: telomere damage is not the end of the story

artículo científico publicado en 2005

Reorganization of chromosome architecture in replicative cellular senescence

artículo científico publicado en 2016

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

artículo científico publicado en 1998

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.

artículo científico publicado en 2019

Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction

artículo científico publicado en 2007

Somatic cell knockouts of tumor suppressor genes

artículo científico publicado en 2003

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

scientific journal article

Targeted inactivation of p53 in human cells does not result in aneuploidy

scientific article published on 01 February 2002

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

artículo científico publicado en 2004

The dark side of circulating nucleic acids

artículo científico publicado en 2016

The number of p16INK4a positive cells in human skin reflects biological age.

artículo científico publicado en 2012

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

scientific journal article

The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression

scientific journal article

Transcriptional landscape of repetitive elements in normal and cancer human cells

artículo científico publicado en 2014

Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse

artículo científico publicado en 2009

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

scientific journal article

p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress

artículo científico publicado en 2004

Lista de obras de John M. Sedivy

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

Accumulation of senescent cells in mitotic tissue of aging primates

Active Degradation Explains the Distribution of Nuclear Proteins during Cellular Senescence

Age-associated increase in heterochromatic marks in murine and primate tissues

Cellular senescence and organismal aging

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

Do senescence markers correlate in vitro and in situ within individual human donors?

Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position

Epigenetic control of aging

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

Global regulation of nucleotide biosynthetic genes by c-Myc

How to learn new and interesting things from model systems based on "exotic" biological species

Human Genomics. Sleeping dogs of the genome

Interventions to Slow Aging in Humans: Are We Ready?

Involvement of the INK4a/Arf gene locus in senescence

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts ⬇️

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

NFAT4 is required for JC virus infection of glial cells

Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay ⬇️

Phosphatidylenthanolamine Binding Protein aka Raf Kinase Inhibitor Protein: A Brief History of Its Discovery and the Remarkable Diversity of Biological Functions

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

Proteomic profiling of Myc-associated proteins

Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

Reconstructing networks of pathways via significance analysis of their intersections

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

Reduced expression of MYC increases longevity and enhances healthspan

Regulation of RKIP function by Helicobacter pylori in gastric cancer

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

Regulation of growth arrest in senescence: telomere damage is not the end of the story

Reorganization of chromosome architecture in replicative cellular senescence

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.

Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction

Somatic cell knockouts of tumor suppressor genes

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

Targeted inactivation of p53 in human cells does not result in aneuploidy

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

The dark side of circulating nucleic acids

The number of p16INK4a positive cells in human skin reflects biological age.

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression

Transcriptional landscape of repetitive elements in normal and cancer human cells

Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress