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Lista de obras de Shitij Kapur

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

artículo científico publicado en 2007

"Extended" Antipsychotic Dosing

scientific article published on 01 December 2005

"Extended" antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial

artículo científico publicado en 2010

'Jumping to conclusions' and delusions in psychosis: relationship and response to treatment.

artículo científico publicado en 2007

5-HT2 antagonism and EPS benefits: is there a causal connection?

artículo científico publicado en 1996

A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone

artículo científico publicado en 2006

A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone

artículo científico publicado en 2004

A comparison of two delivery modalities of a mobile phone-based assessment for serious mental illness: native smartphone application vs text-messaging only implementations.

artículo científico publicado en 2013

A computational model of the functional role of the ventral-striatal D2 receptor in the expression of previously acquired behaviors

artículo científico publicado en 2005

A model of anticholinergic activity of atypical antipsychotic medications

artículo científico publicado en 2006

A model of antipsychotic action in conditioned avoidance: a computational approach

artículo científico publicado en 2004

A neurobiological hypothesis for the classification of schizophrenia: type A (hyperdopaminergic) and type B (normodopaminergic).

artículo científico publicado en 2014

A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease

artículo científico publicado en 2007

A putative animal model of the "prodromal" state of schizophrenia

artículo científico publicado en 2005

A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex

artículo científico publicado en 2006

A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory

artículo científico publicado en 2008

A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects

artículo científico publicado en 2001

A systematic review of aripiprazole--dose, plasma concentration, receptor occupancy, and response: implications for therapeutic drug monitoring

artículo científico publicado en 2010

A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia

artículo científico publicado en 2000

Aberrant Effective Connectivity in Schizophrenia Patients during Appetitive Conditioning

artículo científico publicado en 2011

Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects.

artículo científico publicado en 2003

Activation of specific cortical regions by apomorphine: an [15O]H2O PET study in humans.

artículo científico publicado en 1994

Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain

artículo científico publicado en 2012

Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation

scientific article published on 06 September 2012

Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice.

artículo científico publicado en 2009

Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia

artículo científico publicado en 2007

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies

artículo científico publicado en 2014

Alterations of the brain reward system in antipsychotic naïve schizophrenia patients

artículo científico publicado en 2012

Amisulpride - dose, plasma concentration, occupancy and response: implications for therapeutic drug monitoring

artículo científico publicado en 2009

Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine

artículo científico publicado en 2008

Amoxapine as an antipsychotic: comparative study versus haloperidol

artículo científico publicado en 2007

Amoxapine as an atypical antipsychotic: a comparative study vs risperidone

artículo científico publicado en 2005

Amoxapine in schizophrenia: a negative double-blind controlled trial

artículo científico publicado en 2004

Amoxapine shows an antipsychotic effect but worsens motor function in patients with Parkinson's disease and psychosis.

artículo científico publicado en 2001

Amoxapine shows atypical antipsychotic effects in patients with schizophrenia: results from a prospective open-label study

artículo científico publicado en 2003

Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats.

artículo científico publicado en 2004

Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges

artículo científico publicado en 2002

Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia

artículo científico publicado en 2003

An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis

artículo científico publicado en 2011

An automated method for the extraction of regional data from PET images

artículo científico publicado en 2006

Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors

artículo científico publicado en 2003

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

artículo científico publicado en 2003

Antipsychotic dosing: how much but also how often?

artículo científico publicado en 2010

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.

artículo científico publicado en 2013

Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats

artículo científico publicado en 2000

Apathy in schizophrenia: clinical correlates and association with functional outcome.

artículo científico publicado en 2003

Attribution style as a factor in psychosis and symptom resolution.

artículo científico publicado en 2008

Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia

artículo científico publicado en 2001

BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humans

artículo científico publicado en 2009

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

artículo científico publicado en 2006

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank

artículo científico publicado en 2015

Biomarkers of treatment outcome in schizophrenia: Defining a benchmark for clinical significance

artículo científico

Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward

artículo científico publicado en 2006

Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.

artículo científico publicado en 2009

Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

artículo científico publicado en 2008

Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635.

artículo científico publicado en 2002

CNVs conferring risk of autism or schizophrenia affect cognition in controls

artículo científico publicado en 2013

Calculating occupancy when one does not have baseline: a comparison of different options

artículo científico publicado en 2011

Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia.

artículo científico publicado en 2009

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

artículo científico publicado en 2012

Cerebral gray matter volume deficits in first episode psychosis

artículo científico publicado en 1998

Challenging the assumption that improvement in functional outcomes is delayed relative to improvement in symptoms in the treatment of schizophrenia

artículo científico publicado en 2010

Changes in delusional dimensions and emotions over eight weeks of antipsychotic treatment in acute patients

artículo científico publicado en 2015

Changes in delusions in the early phase of antipsychotic treatment - an experience sampling study

artículo científico publicado en 2013

Clinical trials for negative symptoms--emerging directions and unresolved issues

artículo científico publicado en 2013

Clinically meaningful biomarkers for psychosis: a systematic and quantitative review

artículo científico publicado en 2014

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide

artículo científico publicado en 2008

Clozapine can induce high dopamine D(2) receptor occupancy in vivo

artículo científico publicado en 2001

Cognitive subtractions may not add up: the interaction between semantic processing and response mode

artículo científico

Combining efficacy and completion rates with no data imputation: a composite approach with greater sensitivity for the statistical evaluation of active comparisons in antipsychotic trials

artículo científico publicado en 2013

Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study.

artículo científico publicado en 2012

Connectomic correlates of response to treatment in first-episode psychosis.

artículo científico publicado en 2016

Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats

artículo científico publicado en 2005

Contrasting effects of haloperidol and lithium on rodent brain structure: a magnetic resonance imaging study with postmortem confirmation

artículo científico publicado en 2012

Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality

artículo científico publicado en 2005

Contributions of the mesial frontal cortex to the premovement potentials associated with intermittent hand movements in humans

artículo científico publicado en 1996

Copy number variants and therapeutic response to antidepressant medication in major depressive disorder

artículo científico publicado en 2014

Corrigendum to "Trajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trials" [Shizophr. Res. 130 (2011) 11–19]

scholarly article published in Schizophrenia Research

D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia

artículo científico publicado en 2009

D2 receptor occupancy of olanzapine pamoate depot using positron emission tomography: an open-label study in patients with schizophrenia.

artículo científico publicado en 2007

D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats

artículo científico publicado en 2008

Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease

artículo científico publicado en 2009

Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected

artículo científico publicado en 2003

Detecting improvements in acute psychotic symptoms using experience sampling methodology

artículo científico publicado en 2013

Determinants of antipsychotic response in schizophrenia: implications for practice and future clinical trials

artículo científico publicado en 2014

Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

artículo científico publicado en 2007

Differential effects of within-day continuous vs. transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats

artículo científico publicado en 2003

Direct activation of the ventral striatum in anticipation of aversive stimuli

artículo científico publicado en 2003

Disaster mental health in Asia and the Asian Journal of Psychiatry.

artículo científico publicado en 2008

Disruption of frontal θ coherence by Δ9-tetrahydrocannabinol is associated with positive psychotic symptoms

artículo científico publicado en 2010

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

artículo científico publicado en 2005

Do antipsychotics improve reasoning biases? A review

scientific article published on July 2010

Do loxapine plus cyproheptadine make an atypical antipsychotic? PET analysis of their dopamine D2 and serotonin2 receptor occupancy

artículo científico publicado en 1998

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

artículo científico publicado en 2001

Does intravenous Δ9-tetrahydrocannabinol increase dopamine release? A SPET study

artículo científico publicado en 2010

Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ.

artículo científico publicado en 2000

Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects

artículo científico publicado en 2001

Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient

artículo científico publicado en 2001

Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus

artículo científico publicado en 2006

Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats

artículo científico publicado en 2000

Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

artículo científico publicado en 2007

Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.

artículo científico publicado en 2005

Dopamine synthesis capacity in patients with treatment-resistant schizophrenia

artículo científico publicado en 2012

Dopamine, prediction error and associative learning: a model-based account

artículo científico publicado en 2006

Dopamine-induced changes in neural network patterns supporting aversive conditioning

artículo científico publicado en 2009

Dopaminergic activity in depressed smokers: a positron emission tomography study.

scientific article published on August 2009

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

artículo científico publicado en 2013

Drug-induced receptor occupancy: substantial differences in measurements made in vivo vs ex vivo

artículo científico publicado en 2001

Dynamic regulation of dopamine and serotonin responses to salient stimuli during chronic haloperidol treatment

artículo científico publicado en 2011

EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study

artículo científico publicado en 2004

Early improvement on antipsychotic treatment as a predictor of subsequent response in schizophrenia: analyses from ziprasidone clinical studies

artículo científico publicado en 2011

Early onset of antipsychotic action in schizophrenia: evaluating the possibility of shorter acute efficacy trials

artículo científico publicado en 2010

Early onset of antipsychotic response in the treatment of acutely agitated patients with psychotic disorders

artículo científico publicado en 2008

Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia

artículo científico publicado en 2010

Early use of clozapine for poorly responding first-episode psychosis.

artículo científico publicado en 2007

Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine.

artículo científico publicado en 2004

Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation

artículo científico publicado en 2003

Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation.

artículo científico publicado en 2010

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.

artículo científico publicado en 2014

Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections.

artículo científico publicado en 2011

Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO.

artículo científico publicado en 2011

Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study

artículo científico publicado en 2003

Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in rats

artículo científico publicado en 2005

Effects of novel antipsychotics, amisulpiride and aripiprazole, on maternal behavior in rats

artículo científico publicado en 2005

Effects of self-generated sad mood on regional cerebral activity: a PET study in normal subjects

artículo científico publicado en 1996

Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion

artículo científico publicado en 2009

Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats

artículo científico publicado en 2004

Electroconvulsive shock increases tyrosine hydroxylase and neuropeptide Y gene expression in the locus coeruleus

artículo científico publicado en 1993

Elevation of prolactin levels by atypical antipsychotics

artículo científico publicado en 2002

Emerging drugs for schizophrenia

artículo científico publicado en 2008

Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics

artículo científico publicado en 2004

Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people

artículo científico publicado en 2013

Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies

artículo científico publicado en 2006

Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases

artículo científico publicado en 2004

Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation

artículo científico publicado en 2002

Evidence for onset of antipsychotic effects within the first 24 hours of treatment

artículo científico publicado en 2005

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro

artículo científico publicado en 2009

Exploring the neural correlates of delusions of reference

artículo científico publicado en 2011

First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study

artículo científico publicado en 2007

From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

artículo científico publicado en 2005

Functional brain maps of retrieval mode and recovery of episodic information.

artículo científico publicado en 1995

Functional role of the prefrontal cortex in retrieval of memories: a PET study

artículo científico publicado en 1995

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

artículo científico publicado en 2012

Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia

artículo científico publicado en 2006

Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine.

artículo científico publicado en 2009

Going beyond "trial-and-error" in psychiatric treatments: OPTiMiSE-ing the treatment of first episode of schizophrenia

artículo científico publicado en 2015

Grand challenges in global mental health

artículo científico publicado en 2011

Half a century of antipsychotics and still a central role for dopamine D2 receptors

artículo científico publicado en 2003

Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways.

artículo científico publicado en 2013

Haloperidol modulates noradrenergic responses to aversive stimulation depending on treatment duration

artículo científico publicado en 2011

High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO.

artículo científico publicado en 2005

How Antipsychotics Work: Linking Receptors to Response

How antipsychotics become anti-"psychotic"--from dopamine to salience to psychosis

artículo científico publicado en 2004

How antipsychotics impact the different dimensions of Schizophrenia: a test of competing hypotheses

artículo científico publicado en 2014

How antipsychotics work-from receptors to reality

artículo científico publicado en 2006

How antipsychotics work: the patients' perspective.

artículo científico publicado en 2005

How change comes: translating biological research into care

How psychotropic polypharmacy in schizophrenia begins: a longitudinal perspective

artículo científico

Imaging of brain structure and function: relevance to psychiatric disorders

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing.

artículo científico publicado en 2014

Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia

artículo científico

In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system

artículo científico publicado en 2006

In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H]raclopride versus [3H]spiperone

artículo científico publicado en 2003

Increased Antipsychotic Sensitivity in Elderly Patients

Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms

artículo científico publicado en 2008

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

artículo científico publicado en 2000

Increased dopamine D2(High) receptors in amphetamine-sensitized rats, measured by the agonist [(3)H](+)PHNO.

artículo científico publicado en 2007

Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine

artículo científico publicado en 2001

Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action

artículo científico publicado en 2002

Increasing Versus Maintaining the Dose of Olanzapine or Risperidone in Schizophrenia Patients Who Did Not Respond to a Modest Dosage: A Double-Blind Randomized Controlled Trial

artículo científico publicado en 2016

Individualized prediction of illness course at the first psychotic episode: a support vector machine MRI study

artículo científico publicado en 2011

Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials

artículo científico publicado en 2016

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

artículo científico publicado en 2000

Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study.

artículo científico publicado en 2013

Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers

artículo científico publicado en 2001

Investigating schizophrenia in a "dish": possibilities, potential and limitations

artículo científico publicado en 2012

Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy

artículo científico publicado en 1999

Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study

artículo científico publicado en 2010

Issues and perspectives in designing clinical trials for negative symptoms in schizophrenia

artículo científico publicado en 2013

Jumping to conclusions, a lack of belief flexibility and delusional conviction in psychosis: a longitudinal investigation of the structure, frequency, and relatedness of reasoning biases

artículo científico publicado en 2011

Ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor

artículo científico publicado en 2001

Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery

artículo científico publicado en 2008

Linking animal models of psychosis to computational models of dopamine function

artículo científico publicado en 2006

Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero.

artículo científico publicado en 2015

Looking for a "biological test" to diagnose"schizophrenia": are we chasing red herrings?

artículo científico publicado en 2011

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers

artículo científico publicado en 2016

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease

artículo científico publicado en 2015

Mapping neural interactivity onto regional activity: an analysis of semantic processing and response mode interactions

artículo científico

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.

artículo científico publicado en 2009

Meta-regression analysis of placebo response in antipsychotic trials, 1970-2010.

artículo científico publicado en 2013

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

artículo científico publicado en 2015

Microvascular abnormality in schizophrenia as shown by retinal imaging

artículo científico publicado en 2013

Mobile early detection and connected intervention to coproduce better care in severe mental illness.

artículo científico publicado en 2015

Modafinil combined with cognitive training is associated with improved learning in healthy volunteers--a randomised controlled trial

artículo científico publicado en 2014

Modafinil combined with cognitive training: pharmacological augmentation of cognitive training in schizophrenia.

artículo científico publicado en 2015

Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans

artículo científico publicado en 1994

Molecular imaging as a guide for the treatment of central nervous system disorders

artículo científico publicado en 2013

Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophrenia.

artículo científico

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia

artículo científico publicado en 2002

Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data

artículo científico publicado en 2012

Negative symptoms in schizophrenia – the remarkable impact of inclusion definitions in clinical trials and their consequences

artículo científico publicado en 2013

Neuroanatomical Correlates of Human Reasoning

artículo científico

Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine: an [15O]H2O PET study in humans

artículo científico publicado en 1996

New and old antipsychotics: what ‘effectiveness’ trials tell us

New insights into schizophrenia from neuroimaging

Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response

artículo científico

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

artículo científico publicado en 2009

Oral D-amphetamine causes prolonged displacement of [11C]raclopride as measured by PET.

artículo científico publicado en 2004

Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models

artículo científico publicado en 2010

Pharmacogenetics in psychiatry: are we ready for widespread clinical use?

artículo científico publicado en 2008

Pharmacogenetics of antidepressant response: A polygenic approach

artículo científico publicado en 2017

Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human

article

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

artículo científico publicado en 2016

Polypharmacy: the good, the bad and the ugly

artículo científico publicado en 2013

Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain.

artículo científico publicado en 2006

Predicting a 'combined treatment outcome' in chronic schizophrenia: the role of demographics, symptomatology, functioning and subjective well-being

artículo científico publicado en 2013

Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship

artículo científico publicado en 2011

Predicting clinical response in people at ultra-high risk of psychosis: a systematic and quantitative review

artículo científico

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

artículo científico publicado en 2003

Psychosis: from diagnosis to syndrome

artículo científico publicado en 2010

Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection

artículo científico publicado en 2006

Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats

artículo científico publicado en 2004

Quetiapine extended-release versus immediate-release formulation: a positron emission tomography study.

artículo científico publicado en 2008

Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade.

artículo científico publicado en 2002

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

artículo científico publicado en 2005

Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission

artículo científico publicado en 2009

Re-examining the role of benzodiazepines in the treatment of schizophrenia: a systematic review

artículo científico publicado en 2014

Reduced cortical volume and elevated astrocyte density in rats chronically treated with antipsychotic drugs-linking magnetic resonance imaging findings to cellular pathology

artículo científico publicado en 2013

Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate

artículo científico publicado en 2004

Relationship between central and peripheral serotonin 5-HT2A receptors: a positron emission tomography study in healthy individuals

artículo científico publicado en 1999

Relationship between daily dose, plasma concentrations, dopamine receptor occupancy, and clinical response to quetiapine: a review

artículo científico publicado en 2011

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

artículo científico publicado en 2000

Reply to: Lithium and the Expanding Brain

Response

Review: amisulpride is effective and safe for schizophrenia

artículo científico publicado en 2002

Role of dopamine D(2) receptors for antipsychotic activity

artículo científico publicado en 2012

Role of the dopaminergic system in depression

artículo científico publicado en 1992

Salience and psychosis: moving from theory to practise

artículo científico publicado en 2008

Schizophrenia

scholarly article about schizophrenia

Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

scientific journal article

Schizophrenia: more dopamine, more D2 receptors

artículo científico publicado en 2000

Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms

artículo científico publicado en 2009

Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex

artículo científico publicado en 2005

Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition

artículo científico publicado en 2005

Separate brain regions code for salience vs. valence during reward prediction in humans

artículo científico publicado en 2007

Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET.

artículo científico publicado en 2001

Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations

artículo científico publicado en 2009

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release

artículo científico publicado en 2003

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia

artículo científico publicado en 2006

Task-independent effect of time on rCBF.

artículo científico publicado en 1998

Temporal difference modeling of the blood-oxygen level dependent response during aversive conditioning in humans: effects of dopaminergic modulation

artículo científico publicado en 2007

Tetrabenazine augmentation in treatment-resistant schizophrenia: a 12-week, double-blind, placebo-controlled trial

artículo científico publicado en 2012

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.

artículo científico publicado en 2006

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

artículo científico publicado en 1995

The D2 receptor occupancy profile of loxapine determined using PET.

artículo científico publicado en 1996

The Enduring Centrality of Dopamine in the Pathophysiology of Schizophrenia

scholarly article published 2014

The Pharmacology of Typical and Atypical Antipsychotics

scholarly article

The Relationship Between Risperidone Plasma Levels and Dopamine D (2) Occupancy

artículo científico publicado en 1998

The Role of Neuroimaging in Development of and Treatment With Antipsychotics

article

The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning

artículo científico publicado en 2009

The amphetamine-induced sensitized state as a model of schizophrenia

artículo científico publicado en 2007

The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist

artículo científico publicado en 2008

The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro

artículo científico publicado en 2010

The different trajectories of antipsychotic response: antipsychotics versus placebo

artículo científico publicado en 2010

The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats

artículo científico publicado en 2002

The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study

artículo científico publicado en 2008

The dopamine hypothesis of schizophrenia: version III--the final common pathway

artículo científico publicado en 2009

The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for mot

artículo científico publicado en 2006

The effect of antipsychotic treatment on Theory of Mind

artículo científico publicado en 2006

The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.

artículo científico publicado en 2009

The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study

artículo científico publicado en 2001

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

artículo científico publicado en 2017

The effects of a single dose of oxytocin on working memory in schizophrenia.

scientific article published on 08 January 2015

The effects of reality distortion syndrome on salient stimuli processing in patients with schizophrenia: an fMRI study

artículo científico publicado en 2010

The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET.

artículo científico publicado en 1999

The evolution of antipsychotic switch and polypharmacy in natural practice--a longitudinal perspective

artículo científico publicado en 2011

The feasibility and validity of ambulatory self-report of psychotic symptoms using a smartphone software application.

artículo científico publicado en 2012

The formation of abnormal associations in schizophrenia: neural and behavioral evidence

artículo científico publicado en 2007

The heterogeneity of antipsychotic response in the treatment of schizophrenia

artículo científico publicado en 2010

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study.

artículo científico publicado en 2014

The nature of dopamine dysfunction in schizophrenia and what this means for treatment

artículo científico publicado en 2012

The neural correlates of intentional learning of verbal materials: a PET study in humans.

artículo científico publicado en 1996

The neurobiology of schizophrenia: new leads and avenues for treatment.

artículo científico publicado en 2010

The newer antipsychotics: underlying mechanisms and the new clinical realities

The optimization of treatment and management of schizophrenia in Europe (OPTiMiSE) trial: rationale for its methodology and a review of the effectiveness of switching antipsychotics

artículo científico publicado en 2015

The promise of biological markers for treatment response in first-episode psychosis: a systematic review

artículo científico publicado en 2015

The relationship between D 2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study

artículo científico publicado en 1997

The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole

artículo científico publicado en 2012

The relationship between dopamine D2 receptor occupancy and the vacuous chewing movement syndrome in rats

artículo científico publicado en 2002

The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics

artículo científico publicado en 2009

The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders

artículo científico publicado en 2006

The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study

artículo científico publicado en 2011

Time course of the antipsychotic effect and the underlying behavioral mechanisms

artículo científico publicado en 2006

Trajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trials

artículo científico publicado en 2011

Translating genome-wide association findings into new therapeutics for psychiatry

artículo científico publicado en 2016

Treating impaired cognition in schizophrenia: the case for combining cognitive-enhancing drugs with cognitive remediation

artículo científico publicado en 2013

UK Doubles Its "World-Leading" Research in Life Sciences and Medicine in Six Years: Testing the Claim?

artículo científico publicado en 2015

Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics

artículo científico publicado en 2008

Use of random-sequence riboflavin as a marker of medication compliance in chronic schizophrenics

artículo científico publicado en 1991

Variations of rest – activity rhythm and sleep – wake in schizophrenic patients versus healthy subjects: An actigraphic comparative study

Ventajas y desventajas del tratamiento de combinación con antipsicóticos. Reunión ECNP Consensus, marzo de 2008, Niza

What Kraepelin might say about schizophrenia: Just the facts

scientific article published on 01 May 2011

White matter integrity as a predictor of response to treatment in first episode psychosis

artículo científico publicado en 2013

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

artículo científico publicado en 2012

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