Filtros de búsqueda

Lista de obras de Daniel J. Drucker

A Comprehensive Pythagorean Theorem for All Dimensions

A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity

artículo científico publicado en 2012

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

artículo científico publicado en 2009

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

artículo científico publicado en 2014

A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.

artículo científico publicado en 2004

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice

artículo científico publicado en 2007

Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line

artículo científico publicado en 2003

Absence of the Glucagon-Like Peptide-1 Receptor Does Not Affect the Metabolic Phenotype of Mice with Liver-Specific Gsα Deficiency ⬇️

artículo científico publicado el 19 de julio de 2011

Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice

artículo científico publicado en 2012

Activation of glucagon-like peptide-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells

artículo científico publicado en 2006

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

artículo científico publicado en 2008

Advances in oral peptide therapeutics

scientific article published on 17 December 2019

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis

artículo científico publicado en 2008

Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice ⬇️

artículo científico publicado el 1 de agosto de 2011

Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes

artículo científico publicado en 2008

Beta-cell replication by loosening the brakes of glucagon-like peptide-1 receptor signaling

artículo científico publicado en 2008

Biologic actions and therapeutic potential of the proglucagon-derived peptides

artículo científico publicado en 2005

Biological actions and therapeutic potential of the glucagon-like peptides

artículo científico publicado en 2002

Body weight homeostat that regulates fat mass independently of leptin in rats and mice

artículo científico publicado en 2017

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ ⬇️

artículo científico publicado el 1 de agosto de 2011

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

artículo científico publicado en 2005

Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity

artículo científico publicado en 2008

Cardiac function in mice lacking the glucagon-like peptide-1 receptor

scientific journal article

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

artículo científico publicado en 2014

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways

artículo científico publicado en 2008

Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors

artículo científico publicado en 2017

Cardiovascular actions of incretin-based therapies

artículo científico

Cardiovascular biology of the incretin system

artículo científico publicado en 2012

Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies

artículo científico publicado en 2009

Cardiovascular safety and diabetes drug development

artículo científico publicado en 2011

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis

artículo científico publicado en 2016

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose ⬇️

artículo científico publicado el 22 de enero de 2013

Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo

artículo científico publicado en 2004

Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons

artículo científico publicado en 2009

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition

Clinical decisions. Management of type 2 diabetes

artículo científico publicado en 2008

Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.

artículo científico publicado en 2004

Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications

scientific article published on 15 April 2020

Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation

scientific journal article

DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks

artículo científico publicado en 2010

Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting Lecture

artículo científico publicado en 2015

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo

artículo científico publicado en 2003

Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats

artículo científico publicado en 2009

Differential Effects of PPAR-γ Activation versus Chemical or Genetic Reduction of DPP-4 Activity on Bone Quality in Mice ⬇️

artículo científico publicado el 22 de diciembre de 2010

Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice

artículo científico publicado en 2007

Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice

artículo científico publicado en 2009

Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes.

artículo científico publicado en 2017

Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action

artículo científico publicado en 2007

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

artículo científico publicado en 2012

Discovery, characterization, and clinical development of the glucagon-like peptides

artículo científico publicado en 2017

Disruption of the Murine Glp2r Impairs Paneth Cell Function and Increases Susceptibility to Small Bowel Enteritis ⬇️

artículo científico publicado el 17 de enero de 2012

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action

artículo científico publicado en 2019

Does exenatide provide a meaningful new treatment option for patients with type 2 diabetes?

scientific article published on 01 December 2005

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis ⬇️

artículo científico publicado el 11 de abril de 2011

Dual regulation of cell proliferation and survival via activation of glucagon-like peptide-2 receptor signaling.

artículo científico publicado en 2003

Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides.

artículo científico publicado en 2012

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

artículo científico publicado en 2013

Emerging combinatorial hormone therapies for the treatment of obesity and T2DM ⬇️

artículo científico publicado el 12 de marzo de 2013

Emerging therapies mimicking the effects of amylin and glucagon-like peptide 1.

artículo científico publicado en 2006

Endocrine Society 2014 Laureate Awards

artículo científico publicado en 2014

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

scientific article published on 21 November 2019

Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.

artículo científico publicado en 2005

Enhancing Incretin Action for the Treatment of Type 2 Diabetes ⬇️

artículo científico publicado el 1 de octubre de 2003

Enhancing the action of incretin hormones: a new whey forward?

scientific article published on 01 July 2006

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

artículo científico publicado en 2017

Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport

artículo científico publicado en 2017

ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel

artículo científico publicado en 2010

ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut.

artículo científico publicado en 2009

Erratum. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes. Diabetes Care 2017;40:1073-1081

artículo científico publicado en 2017

Essay for the 2011 CIHR/CMAJ award: glucagon-like peptides for metabolic and gastrointestinal disorders ⬇️

artículo científico publicado el 23 de enero de 2012

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

artículo científico publicado en 2015

Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study

artículo científico publicado en 2008

Exendin-4 modulates diabetes onset in nonobese diabetic mice

artículo científico publicado en 2007

Expression of peptide hormone genes in human islet cell tumors

artículo científico publicado en 1988

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

artículo científico publicado en 2006

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

artículo científico publicado en 2015

Fibroblast activation protein (FAP) as a novel metabolic target

artículo científico publicado en 2016

Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice

scientific article published on 05 November 2018

Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression

scientific journal article

GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

artículo científico publicado en 2005

GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9

artículo científico publicado en 2018

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure ⬇️

artículo científico publicado el 31 de marzo de 2013

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

scientific article published on 01 November 2006

GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice

artículo científico publicado en 2012

GLP-1 receptor expression within the human heart

artículo científico publicado en 2018

GLP-1 receptor signaling differentially modifies the outcomes of sterile vs. viral pulmonary inflammation in male mice

artículo científico publicado en 2020

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents

scientific article published on 15 January 2014

GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

artículo científico publicado en 2018

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R.

artículo científico publicado en 2015

GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice

artículo científico publicado en 2009

GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

artículo científico publicado en 2015

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy

scholarly article by Anita Patel published in October 2018

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion

artículo científico publicado en 2007

GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms

artículo científico publicado en 2010

Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice

artículo científico publicado en 2010

Genetic variation in Glp1r expression influences the rate of gastric emptying in mice

artículo científico publicado en 2007

Ghrelin Is a Novel Regulator of GLP-1 Secretion

artículo científico publicado en 2014

Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice

artículo científico publicado en 2011

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

scientific article published on 20 June 2018

Glucagon receptor signaling is essential for control of murine hepatocyte survival

artículo científico publicado en 2008

Glucagon-Like Peptide-1 Receptor Activation Inhibits Growth and Augments Apoptosis in Murine CT26 Colon Cancer Cells ⬇️

artículo científico publicado el 19 de julio de 2011

Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation

scientific article published on 22 November 2019

Glucagon-like Peptide-1 Receptor co-agonists for the treatment of metabolic disease

artículo científico publicado en 2020

Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.

artículo científico publicado en 2010

Glucagon-like Peptide-2.

artículo científico publicado en 2006

Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor.

artículo científico publicado en 2010

Glucagon-like peptide 1 and type 1 diabetes: NOD ready for prime time?

artículo científico publicado en 2007

Glucagon-like peptide 2: an update

Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis

artículo científico publicado en 2003

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

artículo científico publicado en 2015

Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice

artículo científico publicado en 2009

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

artículo científico publicado en 2014

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

artículo científico publicado en 2003

Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance

artículo científico publicado en 2010

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

scientific journal article

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

scientific journal article

Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight

artículo científico publicado en 2014

Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.

artículo científico publicado en 2003

Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells

artículo científico publicado en 2008

Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36.

artículo científico publicado en 2009

Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway

artículo científico publicado en 2017

Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase.

artículo científico publicado en 2002

Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa

scientific journal article

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse

artículo científico

Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse

artículo científico publicado en 2008

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

artículo científico publicado en 2003

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

artículo científico publicado en 2004

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

artículo científico publicado en 2007

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

artículo científico publicado en 2019

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

scientific article published on 05 September 2019

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice

artículo científico publicado en 2019

Harnessing the therapeutic potential of glucagon-like peptide-1: a critical review

artículo científico publicado en 2002

Hematopoietic vs. enterocyte-derived dipeptidyl peptidase-4 differentially regulates triglyceride excursion in mice

artículo científico publicado en 2020

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

scientific article published on 27 August 2018

Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression ⬇️

artículo científico publicado el 1 de enero de 2002

Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene

artículo científico publicado en 2003

Implications of the New Food and Drug Administration Draft Guidance on Human Factors Engineering for Diabetes Device Manufacturers ⬇️

artículo científico publicado el 1 de marzo de 2012

Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor

artículo científico publicado en 2006

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction

artículo científico publicado en 2017

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection

artículo científico publicado en 2014

Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

scientific article published on July 2013

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy

artículo científico publicado en 2014

Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.

artículo científico publicado en 2007

Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits

artículo científico publicado en 2010

Incretin-based therapies for type 2 diabetes mellitus

artículo científico publicado en 2009

Incretin-based therapies: a clinical need filled by unique metabolic effects

artículo científico publicado en 2006

Incretin-based therapy and the quest for sustained improvements in β-cell health ⬇️

artículo científico publicado el 1 de septiembre de 2011

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice

artículo científico publicado en 2015

Insulin Secretion Depends on Intra-islet Glucagon Signaling

artículo científico publicado en 2018

Insulin action in the double incretin receptor knockout mouse

artículo científico publicado en 2007

Integrating global proteomic and genomic expression profiles generated from islet alpha cells: opportunities and challenges to deriving reliable biological inferences.

artículo científico publicado en 2005

Intensive insulin therapy in newly diagnosed type 2 diabetes.

artículo científico publicado en 2008

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

artículo científico publicado en 2011

International Union of Pharmacology. XXXV. The glucagon receptor family

artículo científico publicado en 2003

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

artículo científico publicado en 2020

Intestinotrophic Glucagon-Like Peptide-2 (GLP-2) Activates Intestinal Gene Expression and Growth Factor-Dependent Pathways Independent of the Vasoactive Intestinal Peptide Gene in Mice ⬇️

artículo científico publicado el 24 de abril de 2012

Islet α cells and glucagon--critical regulators of energy homeostasis

artículo científico

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

artículo científico publicado en 2020

Lipid raft-dependent glucagon-like peptide-2 receptor trafficking occurs independently of agonist-induced desensitization.

artículo científico publicado en 2004

Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity ⬇️

artículo científico publicado el 19 de agosto de 2012

Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway.

artículo científico publicado en 2013

Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic peptide in hypertensive subjects with type 2 diabetes

artículo científico publicado en 2014

Liraglutide.

artículo científico publicado en 2010

Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.

artículo científico publicado en 2012

Localization of Glucagon-Like Peptide-2 Receptor Expression in the Mouse

scientific article published on 01 August 2019

Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice

artículo científico publicado en 2020

Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice

artículo científico publicado en 2006

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

artículo científico publicado en 2018

Metabolic disease puts up a fight: are diet and exercise helpful for the heart?

artículo científico publicado en 2013

Microbial modulation of energy availability in the colon regulates intestinal transit

artículo científico publicado en 2013

Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

artículo científico publicado en 2016

Modulation of taste sensitivity by GLP-1 signaling

artículo científico publicado en 2008

Modulation of taste sensitivity by GLP-1 signaling in taste buds

artículo científico publicado en 2009

Mucosal adaptation to enteral nutrients is dependent on the physiologic actions of glucagon-like peptide-2 in mice

artículo científico publicado en 2005

N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway

artículo científico publicado en 2014

Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice

artículo científico publicado en 2012

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research

artículo científico publicado en 2016

Normalization of obesity-associated insulin resistance through immunotherapy

artículo científico publicado en 2009

Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure

artículo científico publicado en 2004

Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor

artículo científico publicado en 2006

Oxyntomodulin increases intrinsic heart rate through the glucagon receptor

artículo científico publicado en 2013

Oxyntomodulin regulates resetting of the liver circadian clock by food.

artículo científico publicado en 2015

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

artículo científico publicado en 2011

Parathyroid hormone-like peptide

artículo científico publicado en 1991

Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine

artículo científico publicado en 2002

Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium

artículo científico publicado en 2003

Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells

artículo científico publicado en 2004

Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice

artículo científico publicado en 2005

Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors

artículo científico

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

artículo científico publicado en 2015

Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice

artículo científico publicado en 2011

Physiological roles of the GIP receptor in murine brown adipose tissue

scientific article published on 10 August 2019

Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2.

artículo científico publicado en 2013

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

artículo científico publicado en 2020

Precision medicine in the management of type 2 diabetes

artículo científico publicado en 2018

Proglucagon-Derived Peptides, Glucose-Dependent Insulinotropic Polypeptide, and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue

artículo científico publicado en 2020

Proglucagon-derived peptides: mechanisms of action and therapeutic potential

artículo científico publicado en 2005

Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor

scientific article published on 01 July 2002

Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis

artículo científico publicado en 2008

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

artículo científico publicado en 2019

Regulation of Peptide-YY Synthesis and Secretion in Fetal Rat Intestinal Cultures* ⬇️

artículo científico publicado el 1 de diciembre de 1991

Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control

artículo científico publicado en 2011

Revisiting the complexity of GLP-1 action-from sites of synthesis to receptor activation

artículo científico publicado en 2020

Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing

artículo científico publicado en 2008

Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy

artículo científico publicado en 2003

Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior

artículo científico publicado en 2015

Sitagliptin

scientific article published on 01 February 2007

Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling

artículo científico publicado en 2018

Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy

artículo científico publicado en 2016

TCF1 links GIPR signaling to the control of beta cell function and survival

artículo científico publicado en 2015

Tales beyond the crypt: glucagon-like peptide-2 and cytoprotection in the intestinal mucosa

artículo científico publicado en 2005

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications

scientific article published on 01 September 2018

The Cardiovascular Biology of Glucagon-like Peptide-1.

artículo científico publicado en 2016

The Discovery of GLP-2 and Development of Teduglutide for Short Bowel Syndrome

scientific article published on 01 March 2019

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice

artículo científico publicado en 2016

The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice

artículo científico publicado en 2017

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

artículo científico publicado en 2017

The biology of incretin hormones

artículo científico publicado en 2006

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

artículo científico publicado en 2017

The evidence for achieving glycemic control with incretin mimetics

artículo científico publicado en 2006

The glucagon receptor is required for the adaptive metabolic response to fasting

scientific journal article

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice

artículo científico publicado en 2008

The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action

artículo científico publicado en 2008

The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.

artículo científico publicado en 2005

The gut hormone receptor GIPR links energy availability to control of hematopoiesis

scientific article published on 07 May 2020

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

artículo científico publicado en 2006

The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.

artículo científico publicado en 2007

The past 10 years-new hormones, new functions, new endocrine organs

artículo científico

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential

artículo científico publicado en 2013

The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice

artículo científico publicado en 2004

The role of gut hormones in glucose homeostasis

artículo científico publicado en 2007

The safety of incretin-based therapies--review of the scientific evidence

artículo científico publicado en 2011

Therapeutic approaches to preserve islet mass in type 2 diabetes

artículo científico publicado en 2006

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

artículo científico publicado en 2003

Three Matrix Factorizations from the Steps of Elimination

artículo científico publicado en 2022

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action

artículo científico publicado en 2008

Transgenic mice in the study of endocrine systems

artículo científico publicado en 1992

Treatment of type 2 diabetes with the designer cytokine IC7Fc

artículo científico publicado en 2019

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

artículo científico publicado en 2013

Unraveling the complexities of gut endocrinology

artículo científico publicado en 2007

Vascular Biology of Glucagon Receptor Superfamily Peptides: Mechanistic and Clinical Relevance

artículo científico publicado en 2016

Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency

artículo científico publicado en 2013

WDC15 Basic and Clinical Stream to offer extensive coverage on treatment advances

scientific article published on 01 October 2015

When Does Water Find the Shortest Path Downhill? The Geometry of Steepest Descent Curves

beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

artículo científico publicado en 2005

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

artículo científico publicado en 2016

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation

artículo científico publicado en 2017

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda