Lista de obras - Annette Dolphin - Dominio Público Uruguay

3D structure of the skeletal muscle dihydropyridine receptor

artículo científico publicado en 2002

A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant

artículo científico publicado en 2016

A new look at calcium channel α2δ subunits

artículo científico publicado en 2010

A short history of voltage-gated calcium channels

artículo científico publicado en 2006

Ablation of αδ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo

article published in the Proceedings of the National Academy of Sciences of the United States of America

Age of quantitative proteomics hits voltage-gated calcium channels

artículo científico publicado en 2010

Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain

artículo científico publicado en 2014

Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs

artículo científico publicado en 2015

Amino acid sensor conserved from bacteria to humans

artículo científico publicado en 2022

Beta subunits of voltage-gated calcium channels

artículo científico publicado en 2003

Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation

artículo científico publicado en 2011

Ca2+ channel beta-subunits: structural insights AID our understanding

artículo científico publicado en 2004

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond ⬇️

artículo científico publicado el 18 de julio de 2012

Calcium channel diversity: multiple roles of calcium channel subunits

scientific article published on 24 June 2009

Calcium channel α(2)δ subunits in epilepsy and as targets for antiepileptic drugs ⬇️

artículo científico publicado el 13 de julio de 2012

Calcium channel α2δ subunits in epilepsy and as targets for antiepileptic drugs

Calcium currents are enhanced by α2δ-1 lacking its membrane anchor

artículo científico publicado en 2012

Calmodulin regulates Cav3 T-type channels at their gating brake.

artículo científico publicado en 2017

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture

artículo científico publicado en 2012

Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain

artículo científico publicado en 2009

Determinants of the voltage dependence of G protein modulation within calcium channel beta subunits.

artículo científico publicado en 2008

Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

artículo científico publicado en 2013

Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

scientific article published on 01 October 2019

Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.

artículo científico publicado en 2004

Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons

artículo científico publicado en 2016

Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

article

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels

scientific article published on 25 January 2020

Fight or flight: The culprit is lurking in the neighbourhood

artículo científico publicado en 2020

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

scientific journal article

Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels

artículo científico publicado en 2007

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits

artículo científico publicado en 2014

Functions of Presynaptic Voltage-gated Calcium Channels

artículo científico publicado en 2020

G protein modulation of voltage-gated calcium channels

artículo científico publicado en 2003

Gender: missing the prizes that can inspire a career

artículo científico publicado en 2006

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

artículo científico publicado en 2015

Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes

artículo científico publicado en 2003

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

artículo científico publicado en 2006

IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survival

scientific article published on 11 December 2019

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties

scientific journal article

Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future"

scientific article published on 01 January 2020

Kinetics and Gbetagamma modulation of Ca(v)2.2 channels with different auxiliary beta subunits

artículo científico publicado en 2002

L-Type Calcium Channels: On the Fast Track to Nuclear Signaling

artículo científico publicado en 2012

L-type voltage-gated calcium channels: understanding function through structure

artículo científico publicado en 2004

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit

artículo científico publicado en 2017

Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel

scientific article published on 01 November 2009

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

artículo científico publicado en 2018

Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandems

artículo científico publicado en 2003

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

scientific journal article

N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.

artículo científico publicado en 2009

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane

artículo científico publicado en 2004

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

artículo científico publicado en 2008

Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology

artículo científico publicado en 2011

Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses

artículo científico publicado en 2011

Presynaptic calcium channels: specialized control of synaptic neurotransmitter release

scientific article published on 11 March 2020

Proteolytic maturation of α2δ controls the probability of synaptic vesicular release.

artículo científico publicado en 2018

Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels ⬇️

artículo científico publicado en 2016

Regulation of Voltage-Gated Calcium Channel Trafficking and Function by Auxiliary Subunits

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

artículo científico publicado en 2013

Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth

artículo científico publicado en 2011

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling

artículo científico publicado en 2017

The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination

artículo científico publicado en 2016

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

artículo científico publicado en 2007

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

artículo científico publicado en 2015

The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.

artículo científico publicado en 2010

The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

artículo científico publicado en 2010

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo

artículo científico publicado en 2010

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

artículo científico publicado en 2006

The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function

artículo científico publicado en 2001

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

artículo científico publicado en 2006

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function

artículo científico publicado en 2006

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

artículo científico publicado en 2009

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways

scientific article published on March 2014

The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression

artículo científico publicado en 2002

The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.

artículo científico publicado en 2008

The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif

artículo científico publicado en 2003

The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons

artículo científico publicado en 2015

The α2δ subunits of voltage-gated calcium channels

artículo científico publicado en 2012

The αδ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with αδ-1

artículo científico publicado en 2018

Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture

artículo científico publicado en 2009

Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed

artículo científico publicado en 2016

Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin

artículo científico publicado en 2008

Using Exofacially Tagged Functional Cav2.2 to Investigate the Modulation of Pore Subunit Trafficking by Auxiliary Calcium Channel Subunits

Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation.

artículo científico publicado en 2008

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

scientific article published on 24 June 2019

Voltage-gated calcium channel α δ subunits: an assessment of proposed novel roles

Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

artículo científico publicado en 2016

Voltage-gated calcium channels: their discovery, function and importance as drug targets

α2δ expression sets presynaptic calcium channel abundance and release probability

artículo científico publicado en 2012

α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage

artículo científico publicado en 2013

Lista de obras de Annette Dolphin

3D structure of the skeletal muscle dihydropyridine receptor

A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant

A new look at calcium channel α2δ subunits

A short history of voltage-gated calcium channels

Ablation of αδ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo

Age of quantitative proteomics hits voltage-gated calcium channels

Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain

Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs

Amino acid sensor conserved from bacteria to humans

Beta subunits of voltage-gated calcium channels

Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation

Ca2+ channel beta-subunits: structural insights AID our understanding

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond ⬇️

Calcium channel diversity: multiple roles of calcium channel subunits

Calcium channel α(2)δ subunits in epilepsy and as targets for antiepileptic drugs ⬇️

Calcium channel α2δ subunits in epilepsy and as targets for antiepileptic drugs

Calcium currents are enhanced by α2δ-1 lacking its membrane anchor

Calmodulin regulates Cav3 T-type channels at their gating brake.

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture

Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain

Determinants of the voltage dependence of G protein modulation within calcium channel beta subunits.

Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.

Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons

Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels

Fight or flight: The culprit is lurking in the neighbourhood

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits

Functions of Presynaptic Voltage-gated Calcium Channels

G protein modulation of voltage-gated calcium channels

Gender: missing the prizes that can inspire a career

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survival

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties

Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future"

Kinetics and Gbetagamma modulation of Ca(v)2.2 channels with different auxiliary beta subunits

L-Type Calcium Channels: On the Fast Track to Nuclear Signaling

L-type voltage-gated calcium channels: understanding function through structure

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit

Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandems

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology

Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses

Presynaptic calcium channels: specialized control of synaptic neurotransmitter release

Proteolytic maturation of α2δ controls the probability of synaptic vesicular release.

Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels ⬇️

Regulation of Voltage-Gated Calcium Channel Trafficking and Function by Auxiliary Subunits

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling

The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.

The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways

The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression

The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.

The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif

The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons

The α2δ subunits of voltage-gated calcium channels

The αδ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with αδ-1

Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture