Filtros de búsqueda

Lista de obras de Carl H. June

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

artículo científico publicado en 2016

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

artículo científico publicado en 2010

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

scientific article published on 31 March 2020

4-1BB costimulation promotes human T cell adhesion to fibronectin

artículo científico publicado en 1999

4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy

artículo científico publicado en 2007

4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes

artículo científico publicado en 2010

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes

scientific article published on 01 May 1986

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

artículo científico publicado en 2016

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

artículo científico publicado en 2016

A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes

artículo científico publicado en 2002

A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells

artículo científico publicado en 2020

A human memory T cell subset with stem cell-like properties

artículo científico publicado en 2011

A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells

artículo científico publicado en 2004

A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.

artículo científico publicado en 2005

A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses

artículo científico publicado en 2007

A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions

artículo científico publicado en 2010

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

artículo científico publicado en 2002

A rational mouse model to detect on-target off-tumor CAR T cell toxicity

artículo científico publicado en 2020

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

artículo científico publicado en 2017

A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy

artículo científico publicado en 2003

A trial of intrapleural adenoviral-mediated Interferon-α2b gene transfer for malignant pleural mesothelioma

artículo científico publicado en 2011

A versatile system for rapid multiplex genome-edited CAR T cell generation

artículo científico publicado en 2017

AU RNA-binding factors differ in their binding specificities and affinities

artículo científico publicado en 1992

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

artículo científico publicado en 2017

Absorbable microparticulate cation exchanger for immunotherapeutic delivery

artículo científico publicado en 2004

Abstract B05: A biologic screen to evaluate potential toxicity of chimeric antigen receptor modified T cells against primary normal human tissues

artículo científico publicado en 2015

Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers

artículo científico publicado en 2015

Abstracts of the 29th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)

Activation of human B lymphocytes by nanogram concentrations of anti-IgM-dextran conjugates ⬇️

artículo científico publicado el 1 de agosto de 1990

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase

artículo científico publicado en 1990

Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.

artículo científico publicado en 2018

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules ⬇️

artículo científico publicado el 15 de agosto de 1995

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells

artículo científico publicado en 2007

Adoptive T cell therapy for cancer in the clinic

artículo científico publicado en 2007

Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology

scientific article published on July 2013

Adoptive cellular therapy

artículo científico publicado en 2011

Adoptive cellular therapy: a race to the finish line.

artículo científico

Adoptive immunotherapy for cancer or viruses

artículo científico

Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT.

artículo científico publicado en 2013

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

artículo científico publicado en 2008

Adoptive immunotherapy: new ways to skin the cat?

artículo científico publicado en 2005

Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.

artículo científico publicado en 2012

Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.

artículo científico publicado en 2002

Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation

artículo científico publicado en 2003

Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status

artículo científico publicado en 2002

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

artículo científico publicado en 2015

An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.

artículo científico publicado en 1991

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA

artículo científico publicado en 1991

Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome

artículo científico publicado en 1995

Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells

artículo científico publicado en 2009

Analysis of lymphocyte activation and metabolism by flow cytometry ⬇️

artículo científico publicado el 1 de abril de 1992

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma

artículo científico publicado en 2019

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

artículo científico publicado en 2018

Anti-CD3/anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma

scientific article published on 01 April 2000

Anti-CD3/anti-CD28 monoclonal antibody-coated suture enhances the immune response of patients with head and neck squamous cell carcinoma

scientific article published on 01 November 1999

Anti-Ig-mediated proliferation of human B cells in the absence of protein kinase C

artículo científico publicado en 1988

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells ⬇️

artículo científico publicado el 1 de abril de 1992

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression

artículo científico publicado en 1986

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

artículo científico publicado en 2014

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

artículo científico publicado en 2021

Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.

artículo científico publicado en 1988

Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation

artículo científico publicado en 1996

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

artículo científico publicado en 2012

Association between cyclosporin neurotoxicity and hypomagnesaemia ⬇️

artículo científico publicado el 17 de noviembre de 1984

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.

artículo científico publicado en 2017

Author Correction: Targeting cardiac fibrosis with engineered T cells

scientific article published on 01 December 2019

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals

artículo científico publicado en 2020

Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.

artículo científico publicado en 2013

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma

artículo científico publicado en 2019

B lymphocyte immunoglobulin receptor desensitization is downstream of tyrosine kinase activation.

artículo científico publicado en 1994

B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis

artículo científico publicado en 1995

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

artículo científico publicado en 2012

Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C

artículo científico publicado en 1991

Biochemical analysis of the immune B cell defect in xid mice ⬇️

artículo científico publicado el 1 de diciembre de 1991

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

artículo científico publicado en 2020

Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis

artículo científico publicado en 1999

Blocking HIV's attack

artículo científico publicado en 2012

Boosting engineered T cells

artículo científico publicado en 2019

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

artículo científico publicado en 1995

CAR T cell immunotherapy for human cancer.

artículo científico publicado en 2018

CAR T cell viability release testing and clinical outcomes: is there a lower limit?

scientific article published on 01 November 2019

CAR T-Cell Therapies in Glioblastoma: A First Look

artículo científico publicado en 2017

CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges

article

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

scientific article published on 01 November 2019

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

artículo científico publicado en 2018

CARTs on the road for myeloma

artículo científico publicado en 2014

CARs on track in the clinic

artículo científico publicado en 2011

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials

artículo científico publicado en 2021

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

artículo científico publicado en 2020

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

artículo científico publicado en 1989

CD28 activation promotes Th2 subset differentiation by human CD4+ cells

artículo científico publicado en 1995

CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes

artículo científico publicado en 2003

CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation

artículo científico publicado el 1 de noviembre de 1992

CD28 co-receptor signal transduction in T-cell activation

artículo científico publicado en 1997

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

artículo científico publicado en 1995

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98 ⬇️

artículo científico publicado el 1 de octubre de 2010

CD28 costimulation is essential for human T regulatory expansion and function

artículo científico publicado en 2008

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response

artículo científico publicado en 1997

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes

artículo científico publicado en 1990

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro ⬇️

artículo científico publicado el 1 de junio de 1995

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

artículo científico publicado en 1990

CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection

article

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

artículo científico publicado en 2015

CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis

artículo científico publicado en 2000

CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner

artículo científico publicado en 1998

CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling

artículo científico publicado en 1994

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

artículo científico publicado en 1987

CRISPR-engineered T cells in patients with refractory cancer

scientific article published on 07 February 2020

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis

article

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction

scientific article published on 01 January 1998

Calcium-independent calcineurin regulation.

artículo científico publicado en 2003

Can't Get Any Help? New Approaches for Adoptive Immunotherapy of Cancer

scientific article published on 01 September 2001

Can't get any help? New approaches for adoptive immunotherapy of cancer

artículo científico publicado en 2001

Cancer Killers.

artículo científico publicado en 2017

Cancer immunotherapy comes of age and looks for maturity

artículo científico publicado en 2020

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

scientific article published on 14 June 2013

Cellular and growth-factor requirements for the replication of human herpesvirus 6 in primary lymphocyte cultures

scientific article published on January 1990

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia

artículo científico publicado en 2017

Changing the mindset in life sciences toward translation: a consensus

artículo científico publicado en 2014

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

artículo científico publicado en 2018

Chemokine receptor 5 knockout strategies ⬇️

artículo científico publicado el 1 de enero de 2011

Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches

artículo científico publicado en 2020

Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

artículo científico publicado en 2015

Chimeric Antigen Receptor T Cells in Myeloma

artículo científico publicado en 2016

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

artículo científico publicado en 2017

Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You.

artículo científico publicado en 2016

Chimeric Antigen Receptor Therapy

artículo científico publicado en 2018

Chimeric Antigen Receptor Therapy for B-cell Malignancies

artículo científico publicado en 2011

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street

artículo científico publicado en 2015

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

article by Michael M Boyiadzis et al published 4 December 2018 in Journal for Immunotherapy of Cancer

Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo

artículo científico publicado en 2013

Chimeric antigen receptor T cells for sustained remissions in leukemia

artículo científico publicado en 2014

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

artículo científico publicado en 2015

Chimeric antigen receptor therapy for cancer

artículo científico publicado en 2014

Chimeric antigen receptor--modified T cells: clinical translation in stem cell transplantation and beyond

artículo científico publicado en 2012

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

artículo científico publicado en 2013

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

artículo científico publicado en 2011

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

artículo científico publicado en 2009

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

artículo científico publicado en 2019

Circulating and tissue-bound immune complex formation in murine malaria ⬇️

artículo científico publicado el 1 de junio de 1979

Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

artículo científico publicado en 2018

Clinical application of expanded CD4+25+ cells

artículo científico publicado en 2006

Clinical perspectives for regulatory T cells in transplantation tolerance

artículo científico

Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells

artículo científico publicado en 2014

Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.

artículo científico publicado en 2010

Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression ⬇️

artículo científico publicado el 5 de noviembre de 1993

Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010

artículo científico publicado en 2011

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

artículo científico publicado en 1999

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

artículo científico publicado en 2008

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

scholarly article

Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

artículo científico publicado en 2004

Correlation of hypomagnesemia with the onset of cyclosporine-associated hypertension in marrow transplant patients.

artículo científico publicado en 1986

Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy?

artículo científico publicado en 2017

Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation

artículo científico publicado en 2012

Costimulation light: activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile.

artículo científico publicado en 2000

Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increas ⬇️

artículo científico publicado el 15 de diciembre de 1992

Costimulatory approaches to adoptive immunotherapy.

artículo científico publicado en 1998

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

artículo científico publicado en 2001

Cross-linkage of Ly-6A/E induces Ca2+ translocation in the absence of phosphatidylinositol turnover and mediates proliferation of normal murine B lymphocytes

artículo científico publicado en 1991

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes

artículo científico publicado en 1987

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

artículo científico publicado en 2008

Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation

artículo científico publicado en 2002

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

artículo científico publicado en 2016

Cytokine Storm

scientific article published on 01 December 2020

Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights

artículo científico publicado en 2017

Cytokine release syndrome in severe COVID-19

artículo científico publicado en 2020

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

artículo científico publicado en 2012

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells

artículo científico publicado en 1998

Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes ⬇️

artículo científico publicado el 15 de septiembre de 1992

Defining the critical hurdles in cancer immunotherapy

artículo científico publicado en 2011

Delivery technologies for cancer immunotherapy

artículo científico publicado en 2019

Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.

artículo científico publicado en 2004

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

artículo científico publicado en 2009

Detection of antigen specific T lymphocytes by determination of intracellular calcium concentration using flow cytometry

scientific article published on 01 April 1992

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.

artículo científico publicado en 2018

Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells

artículo científico publicado en 1998

Development of novel substrates for tumor immunotherapy

artículo científico publicado en 2003

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children

artículo científico publicado en 2020

Different patterns of inositol polyphosphate production are seen in B lymphocytes after cross-linking of sIg by anti-Ig antibody or by a multivalent anti-Ig antibody dextran conjugate

artículo científico publicado en 1989

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

artículo científico publicado en 1997

Differential sensitivity of human leukocyte subpopulations to ultraviolet light

scientific article published on 01 February 1989

Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy

artículo científico publicado en 2011

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

artículo científico publicado en 2018

Disseminated Fusarium moniliforme infection after allogeneic marrow transplantation

artículo científico publicado en 1986

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

artículo científico publicado en 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

artículo científico publicado en 2016

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells

artículo científico publicado en 2008

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

artículo científico publicado en 1986

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis ⬇️

artículo científico publicado el 1 de noviembre de 1995

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

artículo científico publicado en 1995

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

artículo científico publicado en 2016

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

artículo científico publicado en 2018

Driving cars to the clinic for solid tumors

artículo científico publicado en 2018

Driving gene-engineered T cell immunotherapy of cancer

artículo científico publicado en 2016

Drugging the Undruggable Ras - Immunotherapy to the Rescue?

artículo científico publicado en 2016

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

artículo científico publicado en 2016

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

artículo científico publicado en 2020

Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor -T-cell therapy in B-cell non-Hodgkin lymphomas

artículo científico publicado en 2018

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.

artículo científico publicado en 1997

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

artículo científico publicado en 2013

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

artículo científico publicado en 2004

Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells

artículo científico publicado en 2000

Emerging Cellular Therapies for Cancer

scientific article published on 10 December 2018

Emerging Use of CRISPR Technology - Chasing the Elusive HIV Cure

artículo científico publicado en 2019

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

scientific article published on June 2016

Engineered T cells for cancer therapy.

artículo científico publicado en 2014

Engineered T cells: the promise and challenges of cancer immunotherapy.

artículo científico publicado en 2016

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

artículo científico publicado en 2011

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

artículo científico publicado en 2011

Engineering T cells for cancer: our synthetic future

artículo científico publicado en 2014

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

scientific article published on 20 March 2007

Engineering lymphocyte subsets: tools, trials and tribulations

artículo científico publicado en 2009

Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals

artículo científico publicado en 1998

Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: a proof-of-concept study

scientific article published on 24 May 2020

Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases

artículo científico publicado en 2013

Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation

artículo científico publicado en 2012

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation

artículo científico publicado en 1989

Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface

artículo científico publicado en 1989

Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

artículo científico publicado en 2018

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

scientific article published on 09 July 2020

Enhancing T cell persistence of CAR-redirected T cells in solid tumors

artículo científico publicado en 2014

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

artículo científico publicado en 2008

Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy

artículo científico publicado en 2016

Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model

artículo científico publicado en 1999

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

artículo científico publicado en 1989

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

artículo científico publicado en 2002

Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

artículo científico publicado en 2003

Ex vivo replicative potential of adult human peripheral blood CD4+ T cells

artículo científico publicado en 1997

Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens

artículo científico publicado en 1988

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

article by Keisuke Watanabe et al published 26 October 2018 in Frontiers in Immunology

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

artículo científico

Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts

artículo científico publicado en 2013

Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor ⬇️

artículo científico publicado el 5 de marzo de 1992

Extensive replicative capacity of human central memory T cells

artículo científico publicado en 2004

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer.

artículo científico publicado en 2013

Flow cytometric measurement of cellular ionized calcium concentration

artículo científico publicado en 1988

Flow cytometric measurement of intracellular ionized calcium in single cells with indo-1 and fluo-3.

artículo científico publicado en 1990

Flow cytometry in the evaluation of immune status in cancer and HIV infection

artículo científico publicado en 1999

GLYCAN-DIRECTED CAR-T CELLS.

artículo científico publicado en 2018

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

artículo científico publicado en 2014

Gene transfer in humans using a conditionally replicating lentiviral vector

artículo científico publicado en 2006

Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome

artículo científico publicado en 2006

Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia

artículo científico publicado en 2017

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

artículo científico publicado en 2011

Genetic engineering of T cells for adoptive immunotherapy

artículo científico publicado en 2008

Genetic therapies against HIV.

scientific article published on December 2007

Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer

artículo científico publicado en 2017

Glucocorticoids suppress calcium mobilization and phospholipid hydrolysis in anti-Ig antibody-stimulated B cells.

artículo científico publicado en 1987

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

artículo científico publicado en 2015

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division

artículo científico publicado en 1995

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

artículo científico publicado en 2022

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

artículo científico publicado en 2018

HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/antigen receptor

artículo científico publicado en 1988

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

article

Harnessing CAR T Cell Insights to Develop Treatments for Hyperinflammatory Responses in COVID-19 patients

scientific article published on 17 April 2020

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry

artículo científico publicado en 1986

High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses

artículo científico publicado en 2015

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence.

artículo científico publicado en 2017

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation

artículo científico publicado en 2002

Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment.

artículo científico publicado en 2017

Human T regulatory cell therapy: take a billion or so and call me in the morning

artículo científico publicado en 2009

Human chimeric antigen receptor macrophages for cancer immunotherapy

scientific article published on 23 March 2020

Human naive and memory T lymphocytes differ in telomeric length and replicative potential

artículo científico publicado en 1995

ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement

artículo científico publicado en 2001

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

artículo científico publicado en 2014

IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.

artículo científico publicado en 2013

IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate

scientific article published on 01 December 1990

IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA.

artículo científico publicado en 2015

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

artículo científico publicado en 2016

Ibrutinib treatment improves T cell number and function in CLL patients

artículo científico publicado en 2017

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

artículo científico publicado en 2016

Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

artículo científico publicado en 2013

Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

artículo científico publicado en 2015

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma

artículo científico publicado en 1989

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

artículo científico publicado en 2016

Immunopathological aspects of Plasmodium berghei infection in five strains of mice. I. Immune complexes and other serological features during the infection

artículo científico publicado en 1980

Immunopathological aspects of Plasmodium berghei infection in five strains of mice. II. Immunopathology of cerebral and other tissue lesions during the infection

artículo científico publicado en 1980

Immunotherapy for Brain Tumors.

artículo científico publicado en 2017

Immunotherapy for Breast Cancer: Current and Future Strategies.

artículo científico publicado en 2017

Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

artículo científico publicado en 2018

Immunotherapy opportunities in ovarian cancer.

artículo científico publicado en 2008

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

artículo científico publicado en 2020

Impaired induction of the apoptosis-protective protein Bcl-xL in activated PBMC from asymptomatic HIV-infected individuals

artículo científico publicado en 1997

Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice

artículo científico publicado en 2016

Improved detection of immune complexes in human and mouse serum using a microassay adaptation of the C1Q binding test ⬇️

artículo científico publicado el 1 de enero de 1979

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager

artículo científico publicado en 2018

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

artículo científico publicado en 2017

In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

artículo científico publicado en 2004

In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands

artículo científico publicado en 1992

In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

artículo científico publicado en 2011

Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18.

artículo científico publicado en 2009

Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells

artículo científico publicado en 1999

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation ⬇️

artículo científico publicado el 1 de marzo de 1990

Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16).

artículo científico publicado en 1987

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

artículo científico publicado en 2018

Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts

artículo científico publicado en 1997

Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment

artículo científico publicado en 2016

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics ⬇️

artículo científico publicado el 15 de octubre de 2010

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

artículo científico publicado en 1990

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

artículo científico publicado en 1990

Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection

artículo científico publicado en 1996

Interferon beta adenoviral gene therapy in a patient with ovarian cancer.

artículo científico publicado en 2006

Intracellular ionized calcium

artículo científico publicado en 1994

Intracellular survival pathways against glutamate receptor agonist excitotoxicity in cultured neurons. Intracellular calcium responses

scientific article published on 01 January 1999

Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation

artículo científico publicado en 1997

Introduction to functional cell assays.

artículo científico publicado en 1993

Introduction to the reports from the National Cancer Institute First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2010

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering ⬇️

artículo científico publicado en 2020

Is autoimmunity the Achilles' heel of cancer immunotherapy?

artículo científico publicado en 2017

Isolation of a new herpesvirus from human CD4+ T cells

artículo científico publicado en 1990

Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms.

artículo científico publicado en 2016

L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

artículo científico publicado en 2004

Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity

artículo científico publicado en 2001

Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation

artículo científico publicado en 1998

Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes ⬇️

artículo científico publicado el 15 de noviembre de 1991

Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14 ⬇️

artículo científico publicado el 1 de octubre de 1993

Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia

artículo científico publicado en 2020

Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

artículo científico publicado en 2016

Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

artículo científico publicado en 2011

Measurement of CD69 induction in the assessment of immune function in asymptomatic HIV-infected individuals

artículo científico publicado en 1997

Measurement of intracellular calcium ions by flow cytometry

artículo científico publicado en 2001

Measurement of intracellular ions by flow cytometry

scientific article published on December 2004

Measurement of intracellular ions by flow cytometry

artículo científico publicado en 2015

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

artículo científico publicado en 2016

Meeting report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, Columbus, Ohio; March 1-2, 2010.

artículo científico publicado en 2010

Mesothelin expression is associated with poor outcomes in breast cancer

artículo científico publicado en 2014

Mesothelin, a novel immunotherapy target for triple negative breast cancer

scientific article published on 15 March 2012

Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

artículo científico publicado en 2014

Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation

artículo científico publicado en 1989

Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation

artículo científico publicado en 1997

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

artículo científico publicado en 2002

Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.

artículo científico publicado en 2000

Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells ⬇️

artículo científico publicado el 1 de enero de 2004

Monoclonal TCR-redirected tumor cell killing.

artículo científico publicado en 2012

Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils

scientific article published on 01 April 1986

Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells.

artículo científico publicado en 2008

Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration

scientific article published on 01 March 1990

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

artículo científico publicado en 2014

Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma

scientific article published on 27 November 2018

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor ⬇️

artículo científico publicado el 5 de octubre de 2010

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

scientific article published on 01 November 2019

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

artículo científico publicado en 2019

Multiple mechanisms regulate c-myc gene expression during normal T cell activation.

artículo científico publicado en 1988

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

artículo científico publicado en 2016

NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic

artículo científico publicado en 2010

NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.

artículo científico publicado en 2015

National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee

artículo científico publicado en 2011

Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma

artículo científico publicado en 2014

Naïve and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.

artículo científico publicado en 1998

No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120 ⬇️

artículo científico publicado el 6 de diciembre de 1990

Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling.

artículo científico publicado en 2011

Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma

artículo científico publicado en 2018

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

artículo científico publicado en 2017

Novel cell and gene therapies for HIV.

artículo científico

Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation

artículo científico publicado en 2000

Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4

article

Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy

artículo científico publicado en 2017

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

scientific article published on 01 August 2019

Opposing effects of CTLA4-Ig and anti-CD80 (B7-1) plus anti-CD86 (B7-2) on experimental allergic encephalomyelitis

artículo científico publicado en 1996

Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials

artículo científico publicado en 2016

Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes

artículo científico publicado en 2009

Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

artículo científico publicado en 2017

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia

scientific article published on 09 December 2019

Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy

artículo científico publicado en 2015

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.

artículo científico publicado en 2017

PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

artículo científico publicado en 2016

PI 3-kinase: a pivotal pathway in T-cell activation?

artículo científico publicado en 1996

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

artículo científico publicado en 2018

Patient monitoring and follow-up in lentiviral clinical trials

artículo científico publicado en 2013

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

scientific article published on 10 May 2016

Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis

artículo científico publicado en 1993

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

artículo científico publicado en 2018

Perspective: assembly line immunotherapy

artículo científico publicado en 2013

Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

artículo científico publicado en 2013

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers

scientific article published on 30 July 2019

Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation

scientific article published on 01 November 2006

Phase I trial of adoptive cell transfer with mixed-profile type-I/type-II allogeneic T cells for metastatic breast cancer

artículo científico publicado en 2011

Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

artículo científico publicado en 2011

Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma

artículo científico publicado en 2007

Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling

scientific article published on 01 April 1998

Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections

artículo científico publicado en 2016

Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation

artículo científico publicado en 2013

Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells

artículo científico publicado en 2017

Post-transplant adoptive T-cell immunotherapy

scientific article published on September 2008

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

artículo científico publicado en 2016

Potential clinical applications of signal transduction measurements in marrow transplantation and HIV-1 infection

artículo científico publicado en 1993

Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion

artículo científico publicado en 1995

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells

artículo científico publicado en 2014

Predicting Dangerous Rides in CAR T Cells: Bridging the Gap between Mice and Humans

artículo científico publicado en 2018

Predicting cytokine storms: it's about density

scientific article published on 01 December 2011

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

artículo científico publicado en 2002

Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.

artículo científico publicado en 1999

Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation

artículo científico publicado en 1996

Principles of adoptive T cell cancer therapy

artículo científico publicado en 2007

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014.

artículo científico publicado en 2016

Productive infection of neonatal CD8+ T lymphocytes by HIV-1.

artículo científico publicado en 1998

Profound hypomagnesemia and renal magnesium wasting associated with the use of cyclosporine for marrow transplantation

artículo científico publicado en 1985

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

artículo científico publicado en 2010

Programming the next generation of dendritic cells

artículo científico publicado en 2007

Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects

artículo científico publicado en 2000

Protection against lethal toxic shock by targeted disruption of the CD28 gene

artículo científico publicado en 1996

Protein kinase C activation in B cells by indolactam inhibits anti-Ig-mediated phosphatidylinositol bisphosphate hydrolysis but not B cell proliferation

artículo científico publicado en 1990

Putting the brakes on BTLA in T cell-mediated cancer immunotherapy

artículo científico publicado en 2009

Radiation and immunotherapy: a synergistic combination.

artículo científico publicado en 2013

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

artículo científico publicado en 2010

Rapid activation of C-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells

artículo científico publicado en 1993

Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.

artículo científico publicado en 2009

Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma

artículo científico publicado en 2015

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1

artículo científico publicado en 1990

Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

scientific article published on 20 July 2018

Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

artículo científico publicado en 2013

Regulated expression of telomerase activity in human T lymphocyte development and activation

artículo científico publicado en 1996

Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms

artículo científico publicado en 1988

Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains

artículo científico publicado en 1993

Regulation of interleukin 3 gene induction in normal human T cells

artículo científico publicado en 1989

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

scientific article published on 01 April 1989

Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

artículo científico publicado en 1997

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

artículo científico publicado en 2001

Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma

scientific article published on 01 March 2005

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

artículo científico publicado en 2010

Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector

artículo científico publicado en 2005

Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy

artículo científico publicado en 2014

Remote Controlled CARs: Towards a Safer Therapy for Leukemia

artículo científico publicado en 2016

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

artículo científico publicado en 2012

Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging

artículo científico publicado en 2000

Responsiveness of fetal and adult CD4-, CD8- thymocytes to T cell activation

scientific article published on 01 April 1989

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

artículo científico publicado en 2005

Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials

artículo científico

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients

artículo científico publicado en 2017

Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis

artículo científico publicado en 1995

Role of CD2 cross-linking in cytoplasmic calcium responses and T cell activation

artículo científico publicado en 1988

Role of the CD28 receptor in T-cell activation

scientific article published on June 1990

SAP: natural inhibitor or grand SLAM of T cell activation?

artículo científico publicado en 2001

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

artículo científico publicado en 2004

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

artículo científico publicado en 2017

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

artículo científico publicado en 2017

Selective killing of malignant B cells using T cells redirected against malignancy variant receptor

artículo científico publicado en 2014

Serial Killers and Mass Murderers: Engineered T Cells Are up to the Task

artículo científico publicado en 2015

Signal transduction by B and T cells early after bone marrow transplantation: B cell calcium flux responses are intact whereas lack of CD4 cells accounts for impaired T cell responses

artículo científico publicado el 1 de julio de 1995

Signal transduction in T cells ⬇️

artículo científico publicado el 1 de junio de 1991

Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization

scientific article published on 01 October 1996

Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor

scientific article published on 01 April 1988

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

scientific article published on 25 October 2013

Single residue in CD28-costimulated CAR T cells limits long-term persistence and antitumor durability

scientific article published on 18 February 2020

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

scientific article published on 11 September 2020

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

artículo científico publicado en 2022

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

artículo científico publicado en 2008

Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

artículo científico publicado en 2005

Stimulation of CD5 enhances signal transduction by the T cell antigen receptor

artículo científico publicado en 1990

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway

artículo científico publicado en 1987

Stimulation of the antigen receptor complex leads to transcriptional activation of the c-myc gene in normal human T cells

artículo científico publicado en 1988

Studying Immunoreceptor Signaling in Human T Cells Using Electroporation of In Vitro Transcribed mRNA.

artículo científico publicado en 2017

Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor

artículo científico publicado en 2005

Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs

artículo científico publicado en 2006

Surface immunoglobulin-mediated B-cell activation in the absence of detectable elevations in intracellular ionized calcium: a model for T-cell-independent B-cell activation

artículo científico publicado en 1989

T cell engineering as therapy for cancer and HIV: our synthetic future

artículo científico publicado en 2015

T cells coactivated with immobilized anti-CD3 and anti-CD28 as potential immunotherapy for cancer

artículo científico publicado en 1999

T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

artículo científico publicado en 2013

T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma

artículo científico

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

artículo científico publicado en 2011

T-cell activation is required for efficient replication of human herpesvirus 6.

artículo científico publicado en 1990

T-cell immunotherapy: looking forward

artículo científico publicado en 2014

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

scientific article published on 01 October 2019

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

artículo científico publicado en 1987

T-cell reconstitution and expansion after hematopoietic stem cell transplantation: 'T' it up!

artículo científico publicado en 2005

T-cell therapy at the threshold

artículo científico publicado en 2012

T-cell-targeted immunotherapy

scientific article published on 01 March 1992

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.

artículo científico publicado en 2003

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

artículo científico publicado en 1997

Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.

artículo científico publicado en 2007

Targeting cardiac fibrosis with engineered T cells

artículo científico publicado en 2019

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

artículo científico publicado en 2013

Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling

artículo científico publicado en 2007

Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins

artículo científico publicado en 1997

The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells

artículo científico publicado en 1989

The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.

artículo científico publicado en 2016

The B7 and CD28 receptor families ⬇️

artículo científico publicado el 1 de julio de 1994

The CD28 and CTLA-4 receptor family

article

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

artículo científico publicado en 2004

The CD28 signaling pathway regulates glucose metabolism

artículo científico publicado en 2002

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations ⬇️

artículo científico publicado el 1 de septiembre de 1992

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.

artículo científico publicado en 2018

The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

artículo científico publicado en 1993

The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.

artículo científico publicado en 2015

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells

artículo científico publicado en 2011

The Principles of Engineering Immune Cells to Treat Cancer

artículo científico publicado en 2017

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma

artículo científico publicado en 2021

The cytological features of CAR(T) cells

artículo científico publicado en 2016

The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity

artículo científico publicado en 1990

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

artículo científico publicado en 2010

The promise of T-lymphocyte immunotherapy for the treatment of malignant disease

artículo científico publicado en 2001

The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor

artículo científico publicado en 1992

The road to recovery: translating PD-1 biology into clinical benefit

scientific article published on 22 December 2006

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

artículo científico publicado en 1998

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy.

artículo científico publicado en 2011

Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

artículo científico publicado en 2019

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

artículo científico publicado en 2018

Toward synthetic biology with engineered T cells: a long journey just begun

artículo científico publicado en 2014

Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig

article

Transcription of T cell antigen receptor genes is induced by protein kinase C activation

scientific article published on 01 September 1988

Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of epigenome

artículo científico publicado en 2020

Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.

artículo científico publicado en 2010

Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers

artículo científico publicado en 2008

Treatment of advanced leukemia in mice with mRNA engineered T cells

artículo científico publicado en 2011

Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells.

artículo científico publicado en 2015

Trispecific antibodies offer a third way forward for anticancer immunotherapy

artículo científico publicado en 2019

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells ⬇️

artículo científico publicado el 1 de septiembre de 2003

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.

artículo científico publicado en 2015

Tumor-associated macrophages as a source of functional dendritic cells in ovarian cancer patients

artículo científico publicado en 2002

Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes

artículo científico publicado en 1989

Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells ⬇️

artículo científico publicado el 5 de abril de 1992

UV irradiation of lymphocytes triggers an increase in intracellular Ca2+ and prevents lectin-stimulated Ca2+ mobilization: evidence for UV- and nifedipine-sensitive Ca2+ channels

artículo científico publicado el 1 de septiembre de 1991

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

artículo científico publicado en 2008

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation.

artículo científico publicado en 2007

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

artículo científico publicado en 2015

Use of cell-based therapies for modification of host immune responses.

artículo científico publicado en 2003

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation

scientific article published on 01 June 1986

Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance ⬇️

artículo científico publicado el 15 de julio de 1991

Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice

artículo científico publicado en 1995

Voices of biotech

artículo científico publicado en 2016

Zoom Zoom: racing CARs for multiple myeloma

artículo científico publicado en 2013

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

artículo científico publicado en 1992

iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

artículo científico publicado en 2016

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda