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Lista de obras de Joan Brugge

<em>In vitro</em> Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis

artículo científico publicado el 17 de febrero de 2012

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

artículo científico publicado en 2020

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

artículo científico publicado en 2004

A new mutational AKTivation in the PI3K pathway

artículo científico publicado en 2007

A non-genetic route to aneuploidy in human cancers

artículo científico publicado en 2011

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

artículo científico publicado en 2007

A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

artículo científico publicado en 2016

A stiff blow from the stroma: collagen crosslinking drives tumor progression.

artículo científico publicado en 2009

A structure-guided approach to creating covalent FGFR inhibitors

artículo científico publicado en 2010

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

artículo científico publicado en 2004

Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells

artículo científico publicado en 2005

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

artículo científico publicado en 2020

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

artículo científico publicado en 2003

Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57 Kip2

artículo científico publicado el 6 de marzo de 2012

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

artículo científico publicado en 2017

Altered metabolic requirements in cancer cell migration and metastasis.

artículo científico publicado en 2012

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

artículo científico publicado en 2012

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

artículo científico publicado en 2006

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

artículo científico publicado en 2009

At the leading edge of cancer research: an interview with Joan Brugge. Interview by Sarah Allan

artículo científico publicado en 2011

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

artículo científico publicado en 2004

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

scientific journal article

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

artículo científico publicado en 2005

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

artículo científico publicado en 2005

CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin

artículo científico publicado en 2018

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

artículo científico publicado en 2018

Cancer: The enemy of my enemy is my friend.

artículo científico publicado en 2015

Chaperone-mediated autophagy degrades mutant p53.

artículo científico publicado en 2013

Chaperone-mediated autophagy degrades mutant p53.

artículo científico publicado en 2013

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

artículo científico publicado en 2015

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness

artículo científico publicado en 2019

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells

artículo científico publicado en 2004

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

artículo científico publicado en 2002

Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters

artículo científico publicado en 2015

Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

artículo científico publicado en 2016

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

artículo científico publicado en 2016

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

scientific article published on 21 February 2019

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

artículo científico publicado en 2016

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

artículo científico publicado en 2012

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

artículo científico publicado en 2005

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

artículo científico publicado en 2010

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

artículo científico publicado en 2016

Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells

artículo científico publicado en 2004

ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells

artículo científico publicado el 18 de octubre de 2010

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

artículo científico publicado en 2011

Erratum

scholarly article published in Cell

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

artículo científico publicado en 2017

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

artículo científico publicado en 2016

Evidence for a multipotent mammary progenitor with pregnancy-specific activity

artículo científico publicado el 1 de enero de 2013

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival

artículo científico publicado en 2009

Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

scientific article published on 29 June 2020

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

artículo científico publicado el 6 de diciembre de 2012

Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer

artículo científico publicado en 2006

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

artículo científico publicado en 2007

G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression

artículo científico publicado en 2005

IL-6 involvement in epithelial cancers

artículo científico publicado en 2007

Identification of cancer genes that are independent of dominant proliferation and lineage programs

artículo científico publicado en 2017

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

artículo científico publicado en 2008

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

artículo científico publicado en 2012

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

artículo científico publicado en 2003

Joan Brugge: running rings around cancer. Interview by Caitlin Sedwick

artículo científico publicado en 2010

Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

artículo científico publicado en 2020

Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis

article by Lisa L Gallegos et al published 1 July 2014 in Developmental Cell

Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids

scientific article published on 10 March 2021

Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models

scientific article published on 09 October 2007

MYC regulation of a "poor-prognosis" metastatic cancer cell state

artículo científico publicado en 2010

Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

artículo científico publicado en 2014

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

artículo científico publicado en 2014

Metabolic changes promote rejection of oncogenic cells

artículo científico publicado en 2017

Modelling glandular epithelial cancers in three-dimensional cultures

artículo científico publicado en 2005

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

artículo científico publicado en 2003

Moving Closer To Victory

artículo científico publicado en 2017

Mutant p53 drives invasion by promoting integrin recycling

artículo científico publicado en 2009

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.

artículo científico publicado en 2016

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

scientific article published on 30 November 2020

Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo

scientific article published on 08 April 2019

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

artículo científico publicado en 2017

Not just Salk

artículo científico publicado en 2017

Novel role for PDEF in epithelial cell migration and invasion

artículo científico publicado en 2005

Oncogene-like induction of cellular invasion from centrosome amplification

artículo científico publicado en 2014

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

scientific article published on 06 April 2020

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

artículo científico publicado en 2012

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium

artículo científico publicado en 2011

Overview of the Alliance for Cellular Signaling

artículo científico publicado en 2002

PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells

artículo científico publicado en 2013

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

artículo científico publicado el 23 de julio de 2010

Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07)

artículo científico publicado en 2020

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

artículo científico publicado el 1 de agosto de 1997

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

scientific article published on 01 May 2000

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

artículo científico publicado en 2011

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells

artículo científico publicado en 2010

Psidin, a conserved protein that regulates protrusion dynamics and cell migration

artículo científico publicado en 2011

Q&A: Joan Brugge on empowering post-docs

artículo científico publicado en 2012

Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues

artículo científico publicado en 2017

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.

artículo científico publicado en 2017

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1

artículo científico publicado en 2008

Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis

artículo científico publicado en 2006

Role for polo-like kinase 4 in mediation of cytokinesis

scientific article published on 16 May 2019

SePARating polarity and proliferation in ErbB2 oncogenesis

artículo científico publicado en 2006

Sensing the environment: a historical perspective on integrin signal transduction

artículo científico publicado en 2002

Starved epithelial cells uptake extracellular matrix for survival

artículo científico publicado en 2017

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.

artículo científico publicado en 2012

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

artículo científico publicado en 2020

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

artículo científico

Tensins: a new switch in cell migration

artículo científico publicado en 2007

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

artículo científico publicado en 2003

The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

artículo científico publicado en 2016

The cell biology of cell-in-cell structures

scientific article published on 11 September 2008

The myosin-II-responsive focal adhesion proteome: a tour de force?

artículo científico publicado en 2011

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini

artículo científico publicado en 2002

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

artículo científico publicado en 2006

Transient commensal clonal interactions can drive tumor metastasis

artículo científico publicado en 2020

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

scholarly article

Tumor self-seeding: bidirectional flow of tumor cells

artículo científico publicado en 2009

Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers

artículo científico publicado el 4 de marzo de 2011

United They Stand, Divided They Fall

scientific article published on 01 October 2019

Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis

artículo científico publicado en 2004

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

artículo científico publicado en 2004

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

artículo científico publicado el 17 de noviembre de 2003

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

artículo científico publicado en 2009

YB-1 translational control of epithelial-mesenchyme transition

artículo científico publicado en 2009

[Entosis, a cell death process related to cell cannibalism between tumor cells]

scientific article published on 01 March 2008

p63 regulates an adhesion programme and cell survival in epithelial cells

artículo científico publicado en 2006