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Lista de obras de Patrik Rorsman

'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells

scientific article published on 27 July 2020

35th Annual Meeting of the European Association for the Study of Diabetes

artículo científico

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis.

artículo científico publicado en 2017

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

artículo científico publicado en 2007

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

artículo científico publicado en 2007

A pancreatic islet-specific microRNA regulates insulin secretion

artículo científico publicado en 2004

A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion

artículo científico publicado en 2017

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells

artículo científico publicado en 2002

AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

artículo científico publicado en 2018

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion

artículo científico publicado en 2014

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells

artículo científico publicado en 2004

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

artículo científico publicado en 1991

Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells

artículo científico publicado en 1999

Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

artículo científico publicado en 1994

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells

artículo científico publicado en 2018

Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels

artículo científico publicado en 1997

Alpha2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic ?-cells

artículo científico publicado en 1991

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

artículo científico publicado en 2013

Angular Approach Scanning Ion Conductance Microscopy.

artículo científico publicado en 2016

Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells

artículo científico publicado en 2017

Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells

artículo científico publicado en 2006

Autocrine regulation of insulin secretion

artículo científico

Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells

artículo científico publicado en 2018

CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells

artículo científico publicado en 2008

Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps

artículo científico publicado en 1996

Ca(2+)-induced Ca2+ release in insulin-secreting cells

artículo científico publicado en 1992

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

artículo científico publicado en 2017

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.

artículo científico publicado en 1980

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells

artículo científico publicado en 1999

CaV2.3 calcium channels control second-phase insulin release

scientific journal article

CaV2.3 calcium channels control second-phase insulin release

artículo científico publicado en 2005

Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions

artículo científico publicado en 1986

Calcium and pancreatic β-cell function XI. Modification of 45Ca fluxes by Na+ removal

artículo científico publicado en 1980

Calcium and potassium currents recorded from pancreatic beta-cells under voltage clamp control

artículo científico publicado en 1986

Calcium currents in insulin-secreting beta-cells

artículo científico publicado en 1989

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

artículo científico publicado en 2005

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

artículo científico publicado en 1993

Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans

artículo científico publicado en 2004

Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans

artículo científico publicado en 2008

Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets

artículo científico publicado en 2009

Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet

artículo científico publicado en 2002

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

artículo científico publicado en 1998

Characterisation of sulphonylurea and ATP-regulated K + channels in rat pancreatic A-cells

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

scientific article published on 01 September 1999

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules

artículo científico publicado en 2009

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

scholarly article by Lotte B Nielsen et al published June 2007 in European Journal of Endocrinology

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells

artículo científico publicado en 1995

Components of insulin secretion: lessons to be learnt from capacitance

artículo científico publicado en 1997

Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry

artículo científico publicado en 2000

Compound exocytosis in voltage-clamped mouse pancreatic β-cells revealed by carbon fibre amperometry

artículo científico publicado en 2000

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

artículo científico publicado en 2007

Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+.

artículo científico publicado en 1985

Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells

artículo científico publicado en 1992

Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism

artículo científico publicado en 1984

Defective secretion of islet hormones in chromogranin-B deficient mice

artículo científico publicado en 2010

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

artículo científico publicado en 2002

Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells

artículo científico publicado en 1990

Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice

artículo científico publicado en 2008

Demonstration of A-currents in pancreatic islet cells.

artículo científico publicado en 1989

Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells

artículo científico publicado en 1993

Demonstration of voltage-dependent and TTX-sensitive Na(+)-channels in human melanocytes

artículo científico publicado en 1994

Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose

artículo científico publicado en 1983

Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms

artículo científico publicado en 1996

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

scientific article published on 06 June 2019

Diabetes mellitus and the β cell: the last ten years

artículo científico publicado en 2012

Direct determination of manganese in microgram amounts of pancreatic tissue by electrothermal atomic absorption spectrometry

artículo científico publicado en 1982

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic ?-cells

artículo científico publicado en 1986

Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas

artículo científico publicado en 1985

Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell?

artículo científico publicado en 1989

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.

artículo científico publicado en 2016

Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.

artículo científico publicado en 1984

Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells

artículo científico publicado en 1996

Electrical bursting in islet ß cells

scientific article published in Nature

Electrophysiological properties of human β-cell lines EndoC-βH1 and -βH2 conform with human β-cells

Electrophysiological studies of insulin secretion, physiology and pathophysiology

artículo científico publicado el 1 de mayo de 1997

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

scientific article published on 06 July 2011

Electrophysiology of the pancreatic beta-cell

artículo científico publicado en 1989

Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity

artículo científico publicado en 1993

Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta

artículo científico publicado en 2009

Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content

artículo científico publicado en 2010

Exocytotic properties of human pancreatic beta-cells

artículo científico publicado en 2009

Expression of K channels in Xenopus laevis oocytes injected with poly(A+ ) mRNA from the insulin-secreting β-cell line, HIT T15

artículo científico publicado en 1988

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes

artículo científico publicado en 2008

Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction

artículo científico publicado en 1990

Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

artículo científico publicado en 1990

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels

artículo científico publicado en 1989

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate

artículo científico publicado en 2006

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

artículo científico publicado en 2001

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells

artículo científico publicado en 2002

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

artículo científico publicado en 2017

Functional identification of islet cell types by electrophysiological fingerprinting

scientific article published on March 2017

Fusion pore in exocytosis: More than an exit gate? A β-cell perspective

artículo científico publicado en 2017

G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells

artículo científico publicado en 1997

GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin

artículo científico publicado en 2004

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

artículo científico publicado en 2010

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

artículo científico publicado en 2015

GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion

artículo científico publicado en 2013

Galanin and the endocrine pancreas

artículo científico

Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells ⬇️

artículo científico publicado en 2010

Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels

artículo científico publicado en 2005

Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

artículo científico

Glucagon secretion from pancreatic α-cells

artículo científico publicado en 2016

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors

scientific journal article

Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic -Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

artículo científico publicado en 1998

Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca2+-Induced Secretion in Rat -Cells by a Protein Kinase A-Mediated Mechanism

artículo científico publicado en 1997

Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling

artículo científico publicado en 1998

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism

artículo científico publicado en 1997

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

artículo científico publicado en 1995

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

artículo científico publicado en 1995

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

artículo científico publicado en 2004

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.

artículo científico publicado en 1985

Glucose in glucagon release

artículo científico publicado en 1990

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells

artículo científico publicado en 2004

Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells

artículo científico publicado en 1982

Glucose stimulates the entry of Ca2+into the insulin-producingβcells but not into the glucagon-producingα2cells

artículo científico publicado en 1987

Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation

artículo científico publicado en 2002

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

artículo científico publicado en 1989

Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus

artículo científico publicado en 2010

Glucose-sensing mechanisms in pancreatic beta-cells.

artículo científico publicado en 2005

Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion

artículo científico publicado en 2014

Glutamate primes the pump

scientific article published in Nature

High-content screening identifies a role for Na(+) channels in insulin production

artículo científico publicado en 2015

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

artículo científico publicado en 2004

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

artículo científico publicado en 1999

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

artículo científico publicado en 2016

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells

artículo científico publicado en 2003

Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network

artículo científico publicado en 2009

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

scientific journal article

Improving the physiological realism of experimental models.

artículo científico publicado en 2016

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion

artículo científico publicado en 2016

Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes

artículo científico publicado en 1993

Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study

artículo científico publicado en 2020

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

artículo científico publicado en 1987

Inhibition of L-type calcium channels by internal GTP [?S] in mouse pancreatic ? cells

artículo científico publicado en 1992

Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration

artículo científico publicado en 1988

Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells

artículo científico publicado en 1991

Insulin granule dynamics in pancreatic beta cells

artículo científico publicado en 2003

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

artículo científico publicado en 2019

Insulin secretion: a high-affinity Ca2+ sensor after all?

artículo científico publicado en 2004

Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells

artículo científico publicado en 1991

Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells

artículo científico publicado en 1992

Intracellular pH, cytosolic calcium concentration and electrical activity in RINm5F insulinoma cells

artículo científico publicado en 1994

Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels

artículo científico publicado en 2004

Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+ channels

artículo científico publicado en 2004

K(ATP) channels and islet hormone secretion: new insights and controversies

artículo científico publicado en 2013

K(ATP)-channels and glucose-regulated glucagon secretion

artículo científico publicado en 2008

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

artículo científico publicado en 2016

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

artículo científico publicado en 2008

Large dense-core vesicle exocytosis in pancreatic $beta;-cells monitored by capacitance measurements

artículo científico publicado en 2004

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon

artículo científico publicado en 2008

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

artículo científico publicado en 2007

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

scientific article published on 01 November 2019

Manganese accumulation in pancreatic beta-cells and its stimulation by glucose

artículo científico publicado en 1982

Matthias Braun, 23 July 1966-16 November 2013.

artículo científico publicado en 2014

Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells

artículo científico publicado en 1991

Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture

artículo científico publicado en 1988

Mechanisms of action of entero-insular hormones and neural input on the insulin secretory process

artículo científico

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets

artículo científico publicado en 2010

MicroRNA-7a regulates pancreatic β cell function

artículo científico publicado en 2014

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

artículo científico publicado en 2010

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.

artículo científico publicado en 1989

Molecular defects in insulin secretion in type-2 diabetes

artículo científico publicado en 2004

Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells

artículo científico publicado en 1996

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors

artículo científico publicado en 1997

Multivesicular exocytosis in rat pancreatic beta cells.

artículo científico publicado en 2011

Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin

artículo científico publicado en 2010

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

artículo científico publicado en 2017

NALCN: a regulated leak channel

artículo científico publicado en 2009

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression

artículo científico publicado en 2014

Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis

artículo científico publicado en 2002

Neuropeptides in the regulation of islet hormone secretion--localization, effects and mode of action

artículo científico publicado en 1991

Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin

artículo científico publicado en 1996

New insights into the regulation of glucagon secretion by glucagon-like peptide-1.

artículo científico publicado en 2004

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

artículo científico publicado en 2015

Novel aspects of the molecular mechanisms controlling insulin secretion

artículo científico publicado en 2008

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells

artículo científico publicado en 1986

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

artículo científico publicado en 2006

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

artículo científico publicado en 2010

PKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic beta Cells

artículo científico publicado en 1996

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells

artículo científico publicado en 2008

PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery

artículo científico publicado en 2016

Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells

artículo científico publicado en 2004

Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium

artículo científico publicado en 2004

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

artículo científico publicado en 2018

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets

artículo científico publicado en 2000

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome

artículo científico publicado en 2008

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.

artículo científico publicado en 2011

Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials

artículo científico publicado en 2001

Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice

artículo científico publicado en 2020

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

artículo científico publicado en 2003

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

artículo científico publicado en 2001

Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles

artículo científico publicado en 2010

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells

artículo científico publicado en 1997

Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell

artículo científico publicado en 1992

Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs

artículo científico publicado en 2008

Quantification of mRNA in single cells and modelling of RT-qPCR induced noise

artículo científico publicado en 2008

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

scientific journal article

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells

artículo científico publicado en 2014

Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+-Induced Exocytosis in Mouse Pancreatic B-Cells

artículo científico publicado en 1997

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

artículo científico publicado en 2012

Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose

artículo científico publicado en 1983

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

artículo científico publicado en 2005

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

artículo científico publicado en 2004

Regulation of Insulin Granule Exocytosis

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

artículo científico publicado en 2009

Regulation of calcium in pancreatic α- and β-cells in health and disease

artículo científico publicado en 2011

Regulation of glucagon release from pancreatic A-cells

artículo científico publicado en 1991

Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels

artículo científico publicado en 2000

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

artículo científico

Regulation of insulin secretion in human pancreatic islets

artículo científico publicado en 2012

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

artículo científico publicado en 2006

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

artículo científico publicado en 2014

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes

scientific article published on December 2013

SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.

artículo científico publicado en 2010

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

artículo científico publicado en 2012

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

artículo científico publicado en 2003

Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: Evidence for the existence of insulinotropic agents in the stomach

artículo científico publicado en 2006

Selective nucleotide-release from dense-core granules in insulin-secreting cells

artículo científico publicado en 2005

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K + -channels in mouse pancreatic β-cells

artículo científico publicado en 1991

Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells

artículo científico publicado en 1999

Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells

artículo científico publicado en 1990

Single Ca channel currents in mouse pancreatic B-cells

artículo científico publicado en 1988

Single Calcium Channel Activity in Mouse Pancreatic ?-Cells

artículo científico publicado en 1989

Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules

artículo científico publicado en 2001

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

artículo científico publicado en 2009

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

artículo científico publicado en 2017

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

artículo científico publicado en 1995

Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes

artículo científico publicado en 1998

Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells

artículo científico publicado en 1993

Stimulus-secretion coupling in pancreatic beta cells.

artículo científico publicado en 1994

Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action

artículo científico publicado en 2002

Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.

artículo científico publicado en 1989

Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.

artículo científico publicado en 2009

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas

artículo científico publicado en 2009

Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells

artículo científico publicado en 2015

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

artículo científico publicado en 2013

The Cell Physiology of Biphasic Insulin Secretion.

artículo científico publicado en 2000

The Riddle of Formycin A Insulinotropic Action

artículo científico publicado en 1996

The dual action of glucose on the cytosolic Ca2+ activity in pancreatic beta-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man

artículo científico publicado en 1985

The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets

artículo científico publicado en 2011

The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus

artículo científico publicado en 2004

The glucagon-producing alpha cell: an electrophysiologically exceptional cell

artículo científico publicado en 2010

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

artículo científico publicado en 2007

The insulin receptor talks to glucagon?

artículo científico publicado en 2009

The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells

artículo científico publicado en 2012

The interaction between manganese and calcium fluxes in pancreatic beta-cells

artículo científico publicado en 1983

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

artículo científico publicado en 2007

The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint

artículo científico publicado en 1997

The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein

artículo científico publicado en 1999

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion

artículo científico publicado en 2015

The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery

artículo científico publicado en 1999

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells

artículo científico publicado en 2000

Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells

Two types of Ca2+ currents with different sensitivities to organic Ca2+ channel antagonists in guinea pig pancreatic alpha 2 cells

artículo científico publicado en 1988

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

Type 2 diabetes mellitus: not quite exciting enough?

artículo científico publicado en 2004

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function

artículo científico publicado en 2009

Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum

artículo científico publicado en 2009

Voltage-activated Na+ currents and their suppression by phorbol ester in clonal insulin-producing RINm5F cells

artículo científico publicado en 1986

Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials

artículo científico publicado en 1988

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets

artículo científico publicado en 1999

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion

artículo científico publicado en 2008

miR-375 maintains normal pancreatic alpha- and beta-cell mass

artículo científico publicado en 2009

α-cell glucokinase suppresses glucose-regulated glucagon secretion

artículo científico publicado en 2018

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.

artículo científico publicado en 2017

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