Lista de obras - Holger Stark - Dominio Público Uruguay

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

artículo científico publicado en 2010

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

artículo científico publicado en 2012

Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium

artículo científico publicado en 2005

An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy

artículo científico publicado en 2010

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

artículo científico publicado en 2008

Atomic-resolution protein structure determination by cryo-EM

artículo científico publicado en 2020

Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions

artículo científico publicado en 2012

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

artículo científico publicado en 2010

Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: influence of macromolecular structure on gene vector particle properties and tra

artículo científico publicado en 2010

Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.

artículo científico publicado en 2011

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

artículo científico publicado en 2007

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

artículo científico publicado en 2022

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

artículo científico publicado en 2021

Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

artículo científico publicado en 2016

Corrim-based alignment for improved speed in single-particle image processing

artículo científico publicado en 2003

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins

Cryo-EM in drug discovery: achievements, limitations and prospects

article

Cryo-electron microscopy of spliceosomal components

artículo científico publicado en 2006

Crystal structure of a core spliceosomal protein interface

artículo científico publicado en 2006

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase

artículo científico publicado en 2020

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

artículo científico publicado en 2016

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

artículo científico publicado en 2013

Electron radiation damage to protein crystals of bacteriorhodopsin at different temperatures

artículo científico publicado en 1996

Energy barriers and driving forces in tRNA translocation through the ribosome

artículo científico publicado en 2013

Exon, intron and splice site locations in the spliceosomal B complex

artículo científico publicado en 2009

GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM.

artículo científico publicado en 2015

GraFix: sample preparation for single-particle electron cryomicroscopy

artículo científico publicado en 2007

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

artículo científico publicado en 2008

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C

artículo científico publicado en 2005

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

artículo científico publicado en 2005

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

artículo científico publicado en 2016

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

artículo científico publicado en 2014

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

artículo científico publicado en 2020

Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion

artículo científico publicado en 2010

Molecular Architecture of the Multiprotein Splicing Factor SF3b ⬇️

artículo científico publicado el 9 de mayo de 2003

Molecular Basis of Transcription-Coupled Pre-mRNA Capping

artículo científico publicado en 2015

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

artículo científico publicado en 2016

Molecular architecture of the human 17S U2 snRNP

scientific article published on 03 June 2020

Molecular architecture of the human U4/U6.U5 tri-snRNP

artículo científico publicado en 2016

Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation.

artículo científico publicado en 2015

Novel insights into the architecture and protein interaction network of yeast eIF3

artículo científico publicado en 2012

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

artículo científico publicado en 2006

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

artículo científico publicado en 2018

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

artículo científico

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

artículo científico publicado en 2019

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

artículo científico publicado en 2015

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

artículo científico publicado en 2015

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

artículo científico publicado en 2009

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

artículo científico publicado en 2010

Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

artículo científico publicado en 2002

Self-assembly of a nanoscale DNA box with a controllable lid

artículo científico publicado en 2009

Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells

artículo científico publicado en 2009

Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo

artículo científico publicado en 2009

Spontaneous reverse movement of mRNA-bound tRNA through the ribosome

artículo científico publicado en 2007

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

scientific article published on 01 November 2019

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome

scientific article published on 01 October 2020

Structural basis for cooperativity of CRM1 export complex formation

artículo científico publicado en 2013

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

artículo científico publicado en 2005

Structural basis of assembly chaperone- mediated snRNP formation

artículo científico publicado en 2013

Structural determinants and mechanism of mammalian CRM1 allostery

artículo científico publicado en 2013

Structural insight into filament formation by mammalian septins

artículo científico publicado en 2007

Structural insights into how Prp5 proofreads the pre-mRNA branch site

artículo científico publicado en 2021

Structural insights into the cross-exon to cross-intron spliceosome switch

artículo científico publicado en 2024

Structural mapping of spliceosomes by electron microscopy

artículo científico publicado en 2009

Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

artículo científico publicado en 2015

Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy

artículo científico publicado en 2011

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

artículo científico publicado en 2009

Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

artículo científico publicado en 2005

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy

artículo científico publicado en 2008

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

artículo científico publicado en 2010

Systematic analysis of human protein complexes identifies chromosome segregation proteins

artículo científico publicado en 2010

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

artículo científico publicado en 2009

Three-Dimensional Reconstruction of Trypanosoma brucei Editosomes Using Single-Particle Electron Microscopy ⬇️

artículo científico publicado el 1 de enero de 2011

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

artículo científico publicado en 2004

Towards understanding selenocysteine incorporation into bacterial proteins

artículo científico publicado en 2007

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

artículo científico publicado en 2016

Lista de obras de Holger Stark

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium

An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

Atomic-resolution protein structure determination by cryo-EM

Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: influence of macromolecular structure on gene vector particle properties and tra

Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

Corrim-based alignment for improved speed in single-particle image processing

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins

Cryo-EM in drug discovery: achievements, limitations and prospects

Cryo-electron microscopy of spliceosomal components

Crystal structure of a core spliceosomal protein interface

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

Electron radiation damage to protein crystals of bacteriorhodopsin at different temperatures

Energy barriers and driving forces in tRNA translocation through the ribosome

Exon, intron and splice site locations in the spliceosomal B complex

GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM.

GraFix: sample preparation for single-particle electron cryomicroscopy

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion

Molecular Architecture of the Multiprotein Splicing Factor SF3b ⬇️

Molecular Basis of Transcription-Coupled Pre-mRNA Capping

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

Molecular architecture of the human 17S U2 snRNP

Molecular architecture of the human U4/U6.U5 tri-snRNP

Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation.

Novel insights into the architecture and protein interaction network of yeast eIF3

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

Self-assembly of a nanoscale DNA box with a controllable lid

Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells

Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo

Spontaneous reverse movement of mRNA-bound tRNA through the ribosome

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome

Structural basis for cooperativity of CRM1 export complex formation

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

Structural basis of assembly chaperone- mediated snRNP formation

Structural determinants and mechanism of mammalian CRM1 allostery

Structural insight into filament formation by mammalian septins

Structural insights into how Prp5 proofreads the pre-mRNA branch site

Structural insights into the cross-exon to cross-intron spliceosome switch

Structural mapping of spliceosomes by electron microscopy

Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

Systematic analysis of human protein complexes identifies chromosome segregation proteins

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

Three-Dimensional Reconstruction of Trypanosoma brucei Editosomes Using Single-Particle Electron Microscopy ⬇️

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

Towards understanding selenocysteine incorporation into bacterial proteins

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes