Lista de obras - Florian Greten - Dominio Público Uruguay

A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer

artículo científico publicado en 2020

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

artículo científico publicado en 2001

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer

artículo científico publicado en 2020

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

artículo científico publicado en 2014

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

artículo científico publicado en 2001

Bcl-2 is a critical mediator of intestinal transformation

artículo científico publicado en 2016

Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.

artículo científico publicado en 2018

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer

artículo científico publicado en 2017

Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors

artículo científico publicado en 2011

Cell plasticity in epithelial homeostasis and tumorigenesis.

artículo científico publicado en 2017

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells

scientific article published on 13 August 2018

Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis

Concurrent video-rate color and near-infrared fluorescence laparoscopy

artículo científico publicado en 2013

Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

artículo científico publicado en 2015

Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter

artículo científico publicado en 2002

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

artículo científico publicado en 2017

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

artículo científico publicado en 2007

Fructose stimulated de novo lipogenesis is promoted by inflammation

artículo científico publicado en 2020

Fungi Enter the Stage of Colon Carcinogenesis

artículo científico publicado en 2018

Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses

artículo científico publicado en 2006

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

artículo científico publicado en 2015

High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis

artículo científico publicado en 2016

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

artículo científico publicado en 2014

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

artículo científico publicado en 2009

IKK- and NF-κB-mediated functions in carcinogenesis

artículo científico publicado en 2011

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

artículo científico publicado en 2009

IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.

artículo científico publicado en 2006

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

scientific journal article

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

artículo científico publicado en 2017

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.

artículo científico publicado en 2014

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

artículo científico publicado en 2015

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

artículo científico publicado en 2014

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

artículo científico publicado en 2004

IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.

artículo científico publicado en 2010

Immunity, Inflammation, and Cancer

artículo científico publicado en 2010

In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model

artículo científico publicado en 2001

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

scientific article published on 01 July 2019

Inflammation and cancer: tissue regeneration gone awry

artículo científico publicado en 2016

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

artículo científico publicado en 2009

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

artículo científico publicado en 2011

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

artículo científico publicado en 2010

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

artículo científico publicado en 2013

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

artículo científico publicado en 2013

Lifting the Mist on Gastric Stem Cells

artículo científico publicado en 2016

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

artículo científico publicado en 2017

Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis

article

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

artículo científico publicado en 2012

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

artículo científico publicado en 2002

Mesenchymal Cells in Colon Cancer

artículo científico publicado en 2017

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

scientific article published on 14 June 2018

Modulating inflammation for cancer therapy

scientific article published on 25 April 2019

Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci

artículo científico publicado en 2003

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

artículo científico publicado en 2017

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

artículo científico publicado en 2007

NF-kappaB: linking inflammation and immunity to cancer development and progression

artículo científico publicado en 2005

Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression

artículo científico publicado en 2010

NoxO1 Controls Proliferation of Colon Epithelial Cells.

artículo científico publicado en 2018

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.

artículo científico publicado en 2018

Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

artículo científico publicado en 1997

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

artículo científico publicado en 2008

Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice

artículo científico publicado en 2003

Peering into the aftermath: JAKi rips STAT3 in cancer.

artículo científico publicado en 2010

Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

artículo científico publicado en 2018

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

artículo científico publicado en 2016

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

artículo científico publicado en 2013

Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells

artículo científico publicado en 2005

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion

scientific article published on 14 July 2020

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

artículo científico publicado en 2019

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe

artículo científico publicado en 2014

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

artículo científico publicado en 2005

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis

artículo científico publicado en 2002

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

artículo científico publicado en 2015

Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics

artículo científico publicado en 2015

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

artículo científico publicado en 2015

TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma.

artículo científico publicado en 2011

TGF alpha transgenic mice. A model of pancreatic cancer development.

artículo científico publicado en 2001

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

artículo científico publicado en 2017

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis

artículo científico publicado en 2011

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis

artículo científico publicado en 2019

The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

artículo científico publicado en 2004

The Iron y of Tumor-Induced Inflammation

artículo científico publicado en 2016

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine

artículo científico publicado en 2016

The architect who never sleeps: tumor-induced plasticity

artículo científico publicado en 2014

The gastrointestinal tumor microenvironment

artículo científico publicado en 2013

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

artículo científico publicado en 2003

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

artículo científico publicado en 2018

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

artículo científico publicado en 2019

Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells

artículo científico publicado en 2002

Trp53 deficiency protects against acute intestinal inflammation

artículo científico publicado en 2013

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

artículo científico publicado en 2013

Tumour stem-cell surprises

artículo científico publicado en 2017

Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.

artículo científico publicado en 2011

YAP1 takes over when oncogenic K-Ras slumbers.

artículo científico publicado en 2014

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

artículo científico publicado en 2009

Lista de obras de Florian Greten

A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer

A framework for advancing our understanding of cancer-associated fibroblasts

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

Bcl-2 is a critical mediator of intestinal transformation

Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer

Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors

Cell plasticity in epithelial homeostasis and tumorigenesis.

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells

Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis

Concurrent video-rate color and near-infrared fluorescence laparoscopy

Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Fructose stimulated de novo lipogenesis is promoted by inflammation

Fungi Enter the Stage of Colon Carcinogenesis

Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

IKK- and NF-κB-mediated functions in carcinogenesis

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.

Immunity, Inflammation, and Cancer

In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Inflammation and cancer: tissue regeneration gone awry

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

Lifting the Mist on Gastric Stem Cells

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

Mesenchymal Cells in Colon Cancer

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

Modulating inflammation for cancer therapy

Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

NF-kappaB: linking inflammation and immunity to cancer development and progression

Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression

NoxO1 Controls Proliferation of Colon Epithelial Cells.

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.

Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice

Peering into the aftermath: JAKi rips STAT3 in cancer.

Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma.

TGF alpha transgenic mice. A model of pancreatic cancer development.

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis