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Lista de obras de Manfred Schubert-Zsilavecz

2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo ⬇️

artículo científico publicado el 1 de septiembre de 2011

9-Hydroxyscilliphaeoside, a New Bufadienolide fromUrginea maritima1

scholarly article by Liselotte Krenn et al published January 1996 in Journal of Natural Products

A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm

artículo científico publicado en 2011

A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation

artículo científico publicado en 2016

A triterpene saponin from Herniaria glabra

scientific article published on 01 December 1993

Acidic elements in histamine H(3) receptor antagonists

artículo científico publicado en 2010

Advances in personalized medicine - medicinal chemistry and pharmacology of vemurafenib and ivacaftor

artículo científico

Allosteric modulation of the farnesoid X receptor by a small molecule

artículo científico publicado en 2018

Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma

artículo científico publicado en 2008

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

artículo científico publicado en 2013

An innovative method to study target protein-drug interactions by mass spectrometry

artículo científico publicado en 2009

Analysis of drugs of abuse in Cerumen - correlation of postmortem analysis results with those for blood, urine and hair

artículo científico publicado en 2017

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

artículo científico publicado en 2014

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.

artículo científico publicado en 2014

Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.).

scientific article published on 01 July 1997

Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription

artículo científico publicado en 2010

Antitussives and expectorants

artículo científico publicado en 2008

Bemerkung zum DPhG-Statement: Wissenschaftliche Pharmazie und Homöopathie

artículo científico publicado en 2006

Biorelevant dissolution testing of St John's wort products

artículo científico publicado en 2002

Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data

artículo científico publicado en 2011

Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice ⬇️

artículo científico publicado el 1 de enero de 2010

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

artículo científico publicado en 2008

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

artículo científico publicado en 2016

Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development

artículo científico publicado en 2013

Charge conformity and biopharmaceutic characterization. St. John's Wort extract preparations in comparison

artículo científico publicado en 2003

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

artículo científico publicado en 2004

Comparison of German St. John's wort products according to hyperforin and total hypericin content.

artículo científico publicado en 2001

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes

artículo científico publicado en 2003

Cutaneous administration rather than swallowing

artículo científico publicado en 2005

Degradation of ginsenosides in humans after oral administration

artículo científico publicado en 2003

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity

artículo científico publicado en 2010

Detection of oxidative hair treatment using fluorescence microscopy.

artículo científico publicado en 2015

Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas

artículo científico publicado en 2015

Determination of 11-keto-boswellic acid in human plasma

artículo científico publicado en 2002

Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection

artículo científico publicado en 2006

Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2005

Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2003

Determination of hypericin and pseudohypericin from Hypericum perforatum in rat brain after oral administration

Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry ⬇️

artículo científico publicado el 29 de julio de 2011

Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma

scientific article published on 01 September 2001

Development, structures, and new trends. H1-antihistamines

artículo científico publicado en 2004

Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells

artículo científico publicado en 2012

Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB ⬇️

artículo científico publicado el 3 de agosto de 2010

Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.

artículo científico publicado en 2009

Dose accuracy and injection force of different insulin glargine pens

artículo científico publicado en 2013

Dosing Accuracy of Two Disposable Insulin Pens According to New ISO 11608-1: 2012 Requirements

artículo científico publicado en 2015

Dosing accuracy of commonly used disposable insulin pens.

artículo científico publicado en 2010

Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present

artículo científico publicado en 2012

Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers

artículo científico publicado en 2009

Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract

artículo científico publicado en 2012

Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist

article

From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma

artículo científico publicado en 2010

Functionalization of Fatty Acid Mimetics for Solid‐Phase Coupling and Subsequent Target Identification ⬇️

artículo científico publicado el 1 de noviembre de 2010

Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients

artículo científico

Hemmstoffe von Beta-Adrenozeptoren: Gemeinsamkeiten und Unterschiede

scholarly article by Perry Paige Griffin et al published November 2004 in Pharmazie in unserer Zeit

High-throughput screening for inhibitors of bacterial transglycosylase

artículo científico publicado en 2008

Hyperforin modifies neuronal membrane properties in vivo

artículo científico publicado en 2004

Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients

artículo científico publicado en 2006

Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists

artículo científico publicado en 2015

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

artículo científico publicado en 2011

Identification of legal highs – Ergot alkaloid patterns in two Argyreia nervosa products

In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins

artículo científico publicado en 2012

Innovations in the Treatment of Cystic Fibrosis: Outriders for the Treatment of Diseases with Other Genetic Defects? ⬇️

artículo científico publicado el 1 de diciembre de 2011

Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways

artículo científico publicado en 2009

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

artículo científico publicado en 2012

Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin

artículo científico publicado en 2012

Isoscoparin-2″-O-glucoside from Passiflora incarnata

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist.

artículo científico publicado en 2010

Lack of correlation between surface and interfacial activities of saponins and their hemolytic properties.

artículo científico publicado en 1999

Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes

artículo científico publicado en 2008

MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease

artículo científico publicado en 2018

MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease

artículo científico publicado en 2015

Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors

scientific article published on February 2010

Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

artículo científico publicado en 2012

Modulation of Pgp function by boswellic acids

artículo científico publicado en 2006

Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor

artículo científico publicado en 2012

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats

artículo científico publicado en 2012

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

artículo científico publicado en 2015

NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor

artículo científico publicado en 2015

Natural compound renews hope for diabetes and obesity therapeutic target

artículo científico publicado en 2015

New classes of drugs in the pipeline. New in the treatment of diabetes mellitus

artículo científico publicado en 2010

New drugs for GERD treatment

artículo científico publicado en 2005

New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?

artículo científico publicado en 2012

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol

artículo científico publicado en 2010

Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity

scientific article published on January 2009

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

artículo científico publicado en 2008

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

artículo científico publicado en 2013

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

artículo científico publicado en 2012

Novel strategies to control lipid metabolism: can the antisense drug mipomersen fulfill the unmet need?

artículo científico publicado en 2012

Nuclear receptors as pharmaceutical targets: rise of FXR and rebirth of PPAR?

artículo científico publicado en 2012

PTCA (1H-pyrrole-2,3,5-tricarboxylic acid) as a marker for oxidative hair treatment

artículo científico publicado en 2017

Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

artículo científico publicado en 2008

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity

artículo científico publicado en 2014

Phospholipid bound to the flavohemoprotein from Alcaligenes eutrophus

artículo científico publicado en 1999

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

artículo científico publicado en 2008

Pirinixic acids: flexible fatty acid mimetics with various biological activities

artículo científico

Plant derived omega-3-fatty acids protect mitochondrial function in the brain

artículo científico publicado en 2010

Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®.

artículo científico publicado en 2010

Polarographic assay of chimaphilin in Chimaphila umbellata primary tincture

scholarly article

Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice.

artículo científico publicado en 2016

Quantification of active ingredients in semi-solid pharmaceutical formulations by near infrared spectroscopy

artículo científico publicado en 2017

Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator

artículo científico publicado en 2010

Rationales Design von Hemmern: Vom Teprotid zum Captopril

scholarly article by Karin Nemec & Manfred Schubert-Zsilavecz published January 2003 in Pharmazie in unserer Zeit

Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: galactosylation and glucosylation of protopanaxatriol ginsenosides

artículo científico publicado en 2001

Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator

artículo científico publicado en 2013

Resumption-inhibition in presynaptic action: the medicinal

artículo científico publicado en 2004

Revealing the macromolecular targets of complex natural products

artículo científico publicado en 2014

SAR studies of acidic dual γ-secretase/PPARγ modulators ⬇️

artículo científico publicado el 6 de agosto de 2011

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease

artículo científico publicado en 2014

SQUIRRELnovo: de novo design of a PPARα agonist by bioisosteric replacement

Schilddrüsentherapeutika

scholarly article by Daniel Merk & Manfred Schubert-Zsilavecz published September 2012 in Pharmazie in unserer Zeit

Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.

artículo científico publicado en 2006

Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma

artículo científico publicado en 2005

Small molecules with anti-inflammatory properties in clinical development

artículo científico publicado en 2015

St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.

artículo científico publicado en 2008

Structural properties of so-called NSAID–phospholipid-complexes

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

artículo científico publicado en 2013

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

artículo científico publicado en 2012

Study of microbial contamination and dosing accuracy of oral dispensers ⬇️

artículo científico publicado el 1 de junio de 2010

Study on the dosing accuracy of commonly used disposable insulin pens

artículo científico publicado en 2012

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

artículo científico publicado en 2016

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

artículo científico publicado en 2016

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

artículo científico publicado en 2013

Synthesis of imidazo[1,2-a]pyridines in a sequential one-pot Groebke-Blackburn modification using 2-aminopyridines, aldehydes and amines.

artículo científico publicado en 2015

The medicinal chemistry of tricyclic antidepressives. Targets and stereochemistry

artículo científico publicado en 2008

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

artículo científico publicado en 2009

The treatment of dyslipidemia--what's left in the pipeline?

artículo científico publicado en 2008

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).

artículo científico publicado en 2012

Transepithelial Transport of Curcumin in Caco-2 Cells Is significantly Enhanced by Micellar Solubilisation

artículo científico publicado en 2016

Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators

artículo científico publicado en 2010

Vanillin-derived antiproliferative compounds influence Plk1 activity

artículo científico publicado en 2014

Virtual screening for PPAR modulators using a probabilistic neural network

artículo científico publicado en 2006

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

[Clinically relevant interaction between clopidogrel and proton pump inhibitors].

artículo científico publicado en 2009

[Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?].

artículo científico publicado en 2012

[Regarding public health there is no doubt that in Germany and Europe that it is driven by economic considerations].

artículo científico publicado en 2003

[Various therapy options. Medical Chemistry of platelet aggregation inhibitors].

artículo científico publicado en 2009

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