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A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies

artículo científico publicado en 2016

A phase I study of two dosing schedules of oral BI 847325 in patients with advanced solid tumors.

artículo científico publicado en 2015

A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours ⬇️

artículo científico publicado el 24 de noviembre de 2011

A phase II study of gefitinib for patients with advanced HER-1 expressing synovial sarcoma refractory to doxorubicin-containing regimens

artículo científico publicado en 2008

A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma ⬇️

artículo científico publicado el 13 de diciembre de 2010

A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer

A possible role for microRNA-141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance

artículo científico publicado en 2012

A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal

artículo científico publicado en 2013

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

artículo científico publicado en 2012

Absence of progression as assessed by response evaluation criteria in solid tumors predicts survival in advanced GI stromal tumors treated with imatinib mesylate: the intergroup EORTC-ISG-AGITG phase III trial

artículo científico publicado en 2009

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenibvsplacebo in TKI-refractory metastatic GIST

article

Acral necrosis after inadequate excessive administration of bleomycin in a testicular cancer patient

artículo científico publicado en 2005

Adaptation and performance of an immuno-PCR assay for the quantification of Aviscumine in patient plasma samples

artículo científico publicado en 2005

An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and neck cancer in Belgium, France, Italy, Switzerland, and the United Kingdom

artículo científico publicado en 2008

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).

artículo científico publicado en 2010

Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial

artículo científico publicado en 2017

Biological ageing and frailty markers in breast cancer patients

artículo científico publicado en 2015

Biology and management of clear cell sarcoma: state of the art and future perspectives

artículo científico publicado en 2016

Bisphosphonates in patients with renal cell carcinoma and bone metastases: a sunitinib global expanded-access trial subanalysis

artículo científico publicado en 2015

Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations

artículo científico publicado en 2016

Cabozantinib for metastatic breast carcinoma: results of a phase II placebo-controlled randomized discontinuation study

artículo científico publicado en 2016

Cabozantinib in Patients With Advanced Prostate Cancer: Results of a Phase II Randomized Discontinuation Trial ⬇️

artículo científico publicado el 19 de noviembre de 2012

Cabozantinib in progressive medullary thyroid cancer

artículo científico publicado en 2013

Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II study

artículo científico publicado en 2005

Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines

artículo científico publicado en 2006

Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors

artículo científico publicado en 2014

Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas

artículo científico publicado en 2013

Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: correlation with chronological age but not with fitness/frailty status

artículo científico publicado en 2014

Circulating levels of soluble KIT serve as a biomarker for clinical outcome in gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure

artículo científico publicado en 2009

Clinical presentation, pathological features and natural course of metastatic uveal melanoma, an orphan and commonly fatal disease

artículo científico publicado en 2014

Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma

artículo científico publicado en 2010

Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure

artículo científico publicado en 2012

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

artículo científico publicado en 2016

Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer

artículo científico publicado en 2016

Corrigendum to “Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?” [Eur. J. Cancer 42 (2006) 42–49]

article

Crizotinib achieves long-lasting disease control in advanced papillary renal-cell carcinoma type 1 patients with MET mutations or amplification. EORTC 90101 CREATE trial

artículo científico publicado en 2017

Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug,

artículo científico publicado en 2018

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection

artículo científico publicado en 2002

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

artículo científico publicado en 2002

Documentation of thyroid function in clinical studies with sunitinib: why does it matter?

artículo científico publicado en 2008

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?

artículo científico publicado en 2005

Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors

scholarly article by Ben Tran et al published 25 September 2018 in Journal for Immunotherapy of Cancer

Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial

artículo científico publicado en 2017

Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer

artículo científico publicado en 2008

Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors

artículo científico publicado en 2010

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

artículo científico publicado en 2012

Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate

artículo científico publicado en 2006

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib

artículo científico publicado en 2014

Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography

artículo científico publicado en 2006

First-in-man phase I study assessing the safety and pharmacokinetics of a 1-hour intravenous infusion of the doxorubicin prodrug DTS-201 every 3 weeks in patients with advanced or metastatic solid tumours

artículo científico publicado en 2017

Flare-up: an often unreported phenomenon nevertheless familiar to oncologists prescribing tyrosine kinase inhibitors

artículo científico publicado en 2009

Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors

artículo científico publicado en 2014

Gastrointestinal stromal tumors I: pathology, pathobiology, primary therapy, and surgical issues

scientific article published on August 2009

Gastrointestinal stromal tumors II: medical oncology and tumor response assessment

artículo científico publicado en 2009

Ghrelin in chronic liver disease

artículo científico publicado en 2003

High efficacy of panobinostat towards human gastrointestinal stromal tumors in a xenograft mouse model

artículo científico publicado en 2009

Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial

artículo científico

Impact of tumor chronology and tumor biology on lymph node metastasis in breast cancer

artículo científico publicado en 2013

Implications of mutational analysis for the management of patients with gastrointestinal stromal tumors and the application of targeted therapies

artículo científico publicado en 2010

In Vivo Antitumoral Efficacy of PhAc-ALGP-Doxorubicin, an Enzyme-Activated Doxorubicin Prodrug, in Patient-Derived Soft Tissue Sarcoma Xenograft Models

artículo científico publicado en 2017

Inter-telomeric recombination is present in telomerase-positive human cells

artículo científico publicado en 2013

International expert opinion on patient-tailored management of soft tissue sarcomas

artículo científico publicado en 2013

Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA.

artículo científico publicado en 2006

Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs

artículo científico publicado en 2011

Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion

artículo científico publicado en 2015

Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial

artículo científico publicado en 2008

MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema

artículo científico publicado en 2009

Metastatic HER-2-positive salivary gland carcinoma treated with trastuzumab and a taxane: a series of six patients

artículo científico publicado en 2016

Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features

artículo científico publicado en 2014

Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors

artículo científico publicado en 2011

Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors.

artículo científico publicado en 2010

Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Res

artículo científico publicado en 2010

Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors (GIST): the EORTC STBSG experience

artículo científico publicado en 2013

New targets and therapies for gastrointestinal stromal tumors

artículo científico publicado en 2017

Outcome of patients with platelet-derived growth factor receptor alpha-mutated gastrointestinal stromal tumors in the tyrosine kinase inhibitor era.

artículo científico publicado en 2012

Overcoming Cost Implications of Mutational Analysis in Patients with Gastrointestinal Stromal Tumors: A Pragmatic Approach

artículo científico publicado en 2016

Patient preference for oral chemotherapy

artículo científico publicado en 2002

Patient selection for oncology phase I trials: a multi-institutional study of prognostic factors

artículo científico publicado en 2012

Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib

artículo científico publicado en 2011

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

artículo científico publicado en 2012

Pazopanib in the treatment of soft tissue sarcoma ⬇️

artículo científico publicado el 1 de junio de 2012

Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models

artículo científico publicado en 2014

Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC stu

artículo científico publicado en 2009

Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma

artículo científico publicado en 2016

Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors

artículo científico publicado en 2005

Phase I trial of volasertib, a Polo-like kinase inhibitor, plus platinum agents in solid tumors: safety, pharmacokinetics and activity

artículo científico publicado en 2015

Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours ⬇️

artículo científico publicado el 16 de agosto de 2011

Phase II randomised discontinuation trial of cabozantinib in patients with advanced solid tumours

artículo científico publicado en 2017

Phase II randomized study of Plitidepsin (Aplidin), alone or in association with L-carnitine, in patients with unresectable advanced renal cell carcinoma

artículo científico publicado en 2009

Phase II study of biweekly plitidepsin as second-line therapy for advanced or metastatic transitional cell carcinoma of the urothelium

artículo científico publicado en 2009

Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: rationale and efficacy

artículo científico publicado en 2014

Plasma P-selectin levels are elevated in patients with chronic liver disease

artículo científico publicado en 2003

Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology

scientific article published on 27 May 2009

Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma

artículo científico publicado en 2017

Prognostic factors in adolescents and young adults (AYA) with high risk soft tissue sarcoma (STS) treated by adjuvant chemotherapy: A study based on pooled European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62771 and 6

Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumour pathogenesis.

artículo científico publicado en 2012

Proteolytic Processing of ErbB4 in Breast Cancer

artículo científico publicado en 2012

Recurrent low- to intermediate-grade chondrosarcoma of the thumb with lung metastases: an objective response to trofosfamide

artículo científico publicado en 2007

Retrospective Analysis of Outcome of Patients with Metastatic Leiomyosarcoma in a Tertiary Referral Center

artículo científico publicado en 2018

Retrospective quality control review of FDG scans in the imaging sub-study of PALETTE EORTC 62072/VEG110727: a randomized, double-blind, placebo-controlled phase III trial

artículo científico publicado en 2015

Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial

artículo científico publicado en 2009

Sarcomatoid dedifferentiation in metastatic clear cell renal cell carcinoma and outcome on treatment with anti-vascular endothelial growth factor receptor tyrosine kinase inhibitors: a retrospective analysis.

artículo científico publicado en 2014

Shrinkage of thyroid volume in sunitinib-treated patients with renal-cell carcinoma: a potential marker of irreversible thyroid dysfunction?

artículo científico publicado en 2010

Single-Center Experience with Intimal Sarcoma, an Ultra-Orphan, Commonly Fatal Mesenchymal Malignancy

artículo científico publicado en 2017

Soft tissue sarcoma: an update on systemic treatment options for patients with advanced disease

artículo científico publicado en 2014

Sphincter sparing resection of a large obstructive distal rectal gastrointestinal stromal tumour after neoadjuvant therapy with imatinib (Glivec).

artículo científico publicado en 2015

Targeted therapies in the treatment of GIST: Adverse events and maximising the benefits of sunitinib through proactive therapy management

artículo científico publicado en 2010

The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models

artículo científico publicado en 2012

The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations

artículo científico publicado en 2011

The effect of baseline morphology and its change during treatment on the accuracy of Response Evaluation Criteria in Solid Tumours in assessment of liver metastases

artículo científico publicado en 2014

The footprint of the ageing stroma in older patients with breast cancer

artículo científico publicado en 2017

The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors

artículo científico publicado en 2011

The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters

artículo científico publicado en 2016

The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors

artículo científico publicado en 2004

The more you look, the more you find: challenging results on FDG-PET CT in a patient with neurofibromatosis type I.

artículo científico publicado en 2014

The preclinical and clinical activity of aviscumine: A potential anticancer drug ⬇️

artículo científico publicado el 12 de abril de 2011

The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2

artículo científico publicado en 2018

Therapeutic Efficacy Assessment of CK6, a Monoclonal KIT Antibody, in a Panel of Gastrointestinal Stromal Tumor Xenograft Models

artículo científico publicado en 2015

Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease

artículo científico publicado en 2002

Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma

artículo científico publicado en 2007

Tumor cell-based vaccination in renal cell carcinoma: rationale. approaches, and recent clinical development

artículo científico publicado en 2002

Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: a european multicenter analysis based on ConticaGIST.

artículo científico publicado en 2014

Tumor volume as an alternative response measurement for imatinib treated GIST patients

artículo científico publicado en 2012

Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors

artículo científico publicado en 2014

Using pharmacokinetic and pharmacodynamic data in early decision making regarding drug development: a phase I clinical trial evaluating tyrosine kinase inhibitor, AEE788.

artículo científico publicado en 2012

VEGFR1 single nucleotide polymorphisms associated with outcome in patients with metastatic renal cell carcinoma treated with sunitinib - a multicentric retrospective analysis.

artículo científico publicado en 2013

Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib

artículo científico publicado en 2016

XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer

artículo científico publicado en 2004

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