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Lista de obras de Hans Einar Krokan

22 DNA repair and cancer

A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

artículo científico publicado en 2012

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

artículo científico publicado en 2011

A filter binding assay for characterization of antibodies towards damaged DNA

artículo científico publicado en 1987

A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss

artículo científico publicado en 2004

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

artículo científico publicado en 2009

A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants

artículo científico publicado en 2011

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

artículo científico publicado en 2011

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

artículo científico publicado en 1996

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported

artículo científico publicado en 2013

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

artículo científico publicado en 1997

A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

artículo científico publicado en 1984

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

artículo científico publicado en 2008

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

artículo científico publicado en 2014

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

artículo científico publicado en 2013

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

artículo científico publicado en 2011

Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells

artículo científico publicado en 1999

Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors

artículo científico publicado en 2014

AlkB demethylases flip out in different ways

artículo científico publicado en 2008

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

artículo científico publicado en 2004

Analysis of uracil DNA glycosylase in human colorectal cancer.

artículo científico publicado en 2001

Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues

scientific journal article

Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway

artículo científico publicado en 2013

Autobiographical sketch: A life in DNA repair—and beyond

artículo científico publicado en 2012

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

artículo científico publicado en 2005

Base Excision Repair ⬇️

artículo científico publicado el 1 de abril de 2013

Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-implications for comparative studies

artículo científico publicado en 2011

Base excision repair in a network of defence and tolerance

artículo científico publicado en 2001

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

artículo científico publicado en 1998

Base excision repair of DNA in mammalian cells

artículo científico publicado en 2000

Bg/ll polymorphism in the UNG gene in 4 populations

article

Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase

artículo científico publicado en 1991

Cell cycle regulation and subcellular localization of the major human uracil-DNA glycosylase

artículo científico publicado en 1995

Cell cycle regulation of human DNA repair and chromatin remodeling genes

artículo científico publicado en 2015

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

artículo científico publicado en 2007

Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization

artículo científico publicado en 2005

Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid

artículo científico publicado en 2001

Characterization of antibodies specific for UV-damaged DNA by ELISA

scientific article published on 01 April 1987

Chromosomal assignment of human uracil-DNA glycosylase to chromosome 12.

artículo científico publicado en 1990

Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.

artículo científico publicado en 2006

Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase

artículo científico publicado en 1993

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

artículo científico publicado en 1995

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

artículo científico publicado en 1995

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

artículo científico publicado en 2008

DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells

artículo científico publicado en 2010

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis

artículo científico publicado en 2008

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates

artículo científico publicado en 2016

DNA glycosylases in the base excision repair of DNA

artículo científico publicado en 1997

DNA repair in mammalian tissues and cells

artículo científico

DNA replication in short-time organ cultures of human epidermis. Inhibition by aphidicolin, and detection of DNA polymerases alpha, beta, and gamma

artículo científico publicado en 1982

DNA-uracil and human pathology

artículo científico publicado en 2007

Damage Specific Mammalian Endonucleases ⬇️

artículo científico publicado el 1 de enero de 1990

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

artículo científico publicado en 2006

Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung

artículo científico publicado en 1985

Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes

artículo científico publicado en 2010

Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3

artículo científico publicado en 2010

Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells

artículo científico publicado en 2009

Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines

artículo científico publicado en 1995

Enzymatic repair of premutagenic DNA lesions in human epidermis. Quantitation of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activities

artículo científico publicado en 1984

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scholarly article published in Nature Genetics

Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article

Error-free versus mutagenic processing of genomic uracil--relevance to cancer

artículo científico publicado en 2014

Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids

artículo científico publicado en 1997

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

scientific article published on 19 October 2016

Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

artículo científico publicado en 1996

Excision of uracil from double-stranded DNA by uracil-DNA glycosylase is sequence specific

scientific article published on 01 July 1994

Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification

artículo científico publicado en 2014

Expression of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase in human placentae from smokers and non-smokers

artículo científico publicado en 1992

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

artículo científico publicado en 2009

Fading correction for fluorescence quantitation in confocal microscopy

artículo científico publicado en 1996

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

artículo científico publicado en 2003

Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing

artículo científico publicado en 2004

Genomic uracil and human disease

artículo científico publicado en 2006

Hexyl aminolevulinate and light induces posttranslational modifications of proteins in different cell pathways

High pressure liquid chromatographic separation of furocoumarins in Heracleum laciniatum

artículo científico publicado en 1984

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

artículo científico publicado en 2006

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

artículo científico publicado en 2008

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

artículo científico publicado en 2003

Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

artículo científico publicado en 1998

Human uracil-DNA glycosylase complements E. coli ung mutants

artículo científico publicado en 1991

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

artículo científico publicado en 2003

Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1

artículo científico publicado en 1996

Identification of a novel, widespread, and functionally important PCNA-binding motif

artículo científico publicado en 2009

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

artículo científico publicado en 2015

In vivoandin vitrophototoxicity of different parts ofHeracleum Laciniatum ⬇️

artículo científico publicado el 1 de julio de 1983

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

artículo científico publicado en 2004

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

artículo científico publicado en 2012

Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs

artículo científico publicado en 1983

Investigation of the fine structure of European populations with applications to disease association studies

artículo científico publicado en 2008

LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA

scholarly article published 6 May 1999

Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines

artículo científico publicado en 2005

Low Incorporation of dUMP by Some Thermostable DNA Polymerases May Limit Their Use in PCR Amplifications

scientific article published in 1993

Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner

artículo científico publicado en 2005

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium

artículo científico publicado en 2012

Lung cancer susceptibility locus at 5p15.33

artículo científico publicado en 2008

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding

artículo científico publicado en 2010

Metabolism of dITP in HeLa cell extracts, incorporation into DNA by isolated nuclei and release of hypoxanthine from DNA by a hypoxanthine-DNA glycosylase activity.

artículo científico publicado en 1982

Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.

artículo científico publicado en 2012

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

artículo científico publicado en 2008

Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme

artículo científico publicado en 1989

Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy

artículo científico publicado en 2008

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice

artículo científico publicado en 2005

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

artículo científico publicado en 2002

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

artículo científico publicado en 2012

Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

scientific journal article

Novel aspects of macromolecular repair and relationship to human disease

artículo científico publicado en 2004

Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene

artículo científico publicado en 1993

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

artículo científico publicado en 1998

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

artículo científico publicado en 1997

Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.

artículo científico publicado en 2008

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression

artículo científico publicado en 2009

Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells

article

Photochemical reactions of Heracleum laciniatum. Influence of dimethyl sulphoxide and corticosteroids

scientific article published on 01 July 1983

Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways

artículo científico publicado en 2011

Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins

artículo científico publicado en 2016

Phototoxic and contact toxic reactions of the exocarp of sweet oranges: a common cause of cheilitis?

artículo científico publicado en 1983

Post-replicative base excision repair in replication foci

artículo científico publicado en 1999

Preface

Properties and functions of human uracil-DNA glycosylase from the UNG gene

artículo científico publicado en 2001

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

article

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities

artículo científico publicado en 2014

Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.

artículo científico publicado en 1996

Purification and determination of the NH2-terminal amino acid sequence of uracil-DNA glycosylase from human placenta

scientific article published on 01 January 1989

RNA base damage and repair

artículo científico publicado en 2007

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro

artículo científico publicado en 2014

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

artículo científico publicado en 1998

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

artículo científico publicado en 2006

Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver

artículo científico publicado en 1982

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

scientific article published on 12 October 2004

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

artículo científico publicado en 2000

Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus

artículo científico publicado en 1998

Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues

artículo científico publicado en 1983

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.

artículo científico publicado en 2011

Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots

scientific article published on 01 April 1995

Sequence variation in the human uracil-DNA glycosylase (UNG) gene

artículo científico publicado en 2001

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article by Holthe M et al published 1 January 2003 in The Pharmacogenomics Journal

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

artículo científico publicado en 2018

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

artículo científico publicado en 2012

Structural basis for the removal and exclusion of uracil from DNA

article published in 1996

Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function

artículo científico publicado en 1994

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

artículo científico publicado en 2004

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage

artículo científico publicado en 2012

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

artículo científico publicado en 2012

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

artículo científico publicado en 2005

The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis

artículo científico publicado en 2008

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

artículo científico publicado en 2012

The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation

artículo científico publicado el 1 de julio de 1995

The interacting pathways for prevention and repair of oxidative DNA damage

artículo científico publicado en 2003

The methylation status of the gene for O6-methylguanine-DNA methyltransferase in human Mer+ and Mer- cells

artículo científico publicado en 1995

The rate of base excision repair of uracil is controlled by the initiating glycosylase

artículo científico publicado en 2008

Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action

artículo científico publicado en 2011

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication

artículo científico publicado en 2013

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

artículo científico publicado en 2004

U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods

artículo científico publicado en 1983

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

artículo científico publicado en 2011

UV-Irradiated SV40 minichromosomes as substrates for DNA repair endonucleases ⬇️

artículo científico publicado el 31 de mayo de 1983

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

artículo científico publicado en 2017

Uracil in DNA and its processing by different DNA glycosylases

artículo científico publicado en 2009

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

artículo científico publicado en 2006

Uracil in DNA--occurrence, consequences and repair

artículo científico publicado en 2002

Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation

artículo científico publicado en 2015

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

artículo científico publicado en 2000

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

artículo científico publicado en 2011

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

artículo científico publicado en 2000

Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

artículo científico publicado en 2007

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil

artículo científico publicado en 2019

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

artículo científico publicado en 2011

[DNA repair enzymes and their genes]

artículo científico publicado en 1998

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

artículo científico publicado en 2002

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