Lista de obras - Óscar Fernández-Capetillo

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

artículo científico publicado en 2013

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

scientific article published on 01 July 2019

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats

scientific article published on 06 December 2018

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

artículo científico publicado en 2016

A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules ⬇️

artículo científico publicado el 28 de marzo de 2013

A SUMO and ubiquitin code coordinates protein traffic at replication factories.

artículo científico publicado en 2016

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

artículo científico publicado en 2015

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

artículo científico publicado en 2011

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

artículo científico publicado en 2009

A p53-dependent response limits the viability of mammalian haploid cells.

artículo científico publicado en 2017

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

artículo científico publicado en 2009

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens

artículo científico publicado en 2014

ATM breaks into heterochromatin.

artículo científico publicado en 2008

ATR is required to complete meiotic recombination in mice.

artículo científico publicado en 2018

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

artículo científico publicado en 2010

Aging counts on chromosomes

artículo científico publicado en 2004

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation ⬇️

artículo científico publicado el 27 de febrero de 2012

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair ⬇️

artículo científico publicado el 22 de marzo de 2012

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

artículo científico publicado en 2011

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

artículo científico publicado en 2009

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

artículo científico publicado en 2006

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

artículo científico publicado en 2010

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression

artículo científico publicado en 2012

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

artículo científico publicado en 2002

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

artículo científico publicado en 2018

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

scientific article published on 26 August 2016

Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses

artículo científico

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

artículo científico publicado en 2016

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

artículo científico publicado en 2011

Fos-dependent induction of Chk1 protects osteoblasts from replication stress

artículo científico publicado en 2014

Genomic instability in iPS: time for a break ⬇️

artículo científico publicado el 16 de marzo de 2011

Genomic instability in mice lacking histone H2AX

scientific journal article

Genomic instability: on the birth and death of cancer.

artículo científico publicado en 2007

Global chromatin compaction limits the strength of the DNA damage response

artículo científico publicado en 2007

H2AX regulates meiotic telomere clustering ⬇️

artículo científico publicado el 6 de octubre de 2003

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding

artículo científico publicado en 2010

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

artículo científico publicado en 2003

INK4a/ARF limits the expansion of cells suffering from replication stress

artículo científico publicado en 2013

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability ⬇️

artículo científico publicado el 24 de enero de 2013

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

artículo científico publicado en 2015

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

artículo científico publicado en 2009

Lac operator repeats generate a traceable fragile site in mammalian cells

artículo científico publicado en 2011

Late-replicating CNVs as a source of new genes.

artículo científico publicado en 2014

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

artículo científico publicado en 2009

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

artículo científico publicado en 2015

Modeling the study of DNA damage responses in mice

artículo científico publicado en 2015

Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity

article

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

artículo científico publicado en 2015

Naked replication forks break apRPArt

artículo científico publicado en 2013

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

scientific article published on 02 November 2004

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

artículo científico publicado en 2011

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

artículo científico publicado en 2014

POLD3 Is Haploinsufficient for DNA Replication in Mice.

artículo científico publicado en 2016

Phosphorylation of histone H2B at DNA double-strand breaks.

artículo científico publicado en 2004

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

artículo científico publicado en 2013

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

artículo científico publicado en 2021

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

scientific journal article

Reducing genomic instability in iPSCs

artículo científico publicado en 2015

Replication fork stability confers chemoresistance in BRCA-deficient cells

artículo científico publicado en 2016

Replication stress and cancer: it takes two to tango.

artículo científico publicado en 2014

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

artículo científico publicado en 2015

Silencing of unsynapsed meiotic chromosomes in the mouse

artículo científico publicado en 2004

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

artículo científico publicado en 2010

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress

artículo científico publicado en 2018

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs

artículo científico publicado en 2011

Targeting ATR in cancer

artículo científico publicado en 2018

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

artículo científico publicado en 2016

The (elusive) role of the SMC5/6 complex

artículo científico publicado en 2016

The ATR barrier to replication-born DNA damage.

artículo científico publicado en 2010

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

artículo científico publicado en 2018

The maternal side of Fanconi Anemia

artículo científico publicado en 2014

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

artículo científico publicado en 2014

TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.

artículo científico publicado en 2017

USP7 is a SUMO deubiquitinase essential for DNA replication

artículo científico publicado en 2016

USP7 limits CDK1 activity throughout the cell cycle

artículo científico publicado en 2021

When the going gets tough: scientists' personal challenges

artículo científico publicado en 2014

Why cells respond differently to DNA damage: a chromatin perspective

scientific article published on 18 January 2008

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

artículo científico publicado en 2013

p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.

artículo científico publicado en 2009

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint

artículo científico publicado en 2009

Lista de obras de Óscar Fernández-Capetillo

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules ⬇️

A SUMO and ubiquitin code coordinates protein traffic at replication factories.

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

A p53-dependent response limits the viability of mammalian haploid cells.

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens

ATM breaks into heterochromatin.

ATR is required to complete meiotic recombination in mice.

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

Aging counts on chromosomes

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation ⬇️

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair ⬇️

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Fos-dependent induction of Chk1 protects osteoblasts from replication stress

Genomic instability in iPS: time for a break ⬇️

Genomic instability in mice lacking histone H2AX

Genomic instability: on the birth and death of cancer.

Global chromatin compaction limits the strength of the DNA damage response

H2AX regulates meiotic telomere clustering ⬇️

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

INK4a/ARF limits the expansion of cells suffering from replication stress

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability ⬇️

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Lac operator repeats generate a traceable fragile site in mammalian cells

Late-replicating CNVs as a source of new genes.

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

Modeling the study of DNA damage responses in mice

Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

Naked replication forks break apRPArt

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

POLD3 Is Haploinsufficient for DNA Replication in Mice.

Phosphorylation of histone H2B at DNA double-strand breaks.

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

Reducing genomic instability in iPSCs

Replication fork stability confers chemoresistance in BRCA-deficient cells

Replication stress and cancer: it takes two to tango.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

Silencing of unsynapsed meiotic chromosomes in the mouse

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs

Targeting ATR in cancer

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

The (elusive) role of the SMC5/6 complex

The ATR barrier to replication-born DNA damage.

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

The maternal side of Fanconi Anemia

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.

USP7 is a SUMO deubiquitinase essential for DNA replication

USP7 limits CDK1 activity throughout the cell cycle

When the going gets tough: scientists' personal challenges

Why cells respond differently to DNA damage: a chromatin perspective

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.