Lista de obras -

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

artículo científico publicado en 2015

Agonist-bound structure of the human P2Y12 receptor

artículo científico publicado en 2014

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure

artículo científico publicado en 2016

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

artículo científico publicado en 2015

Design and Structure-Based Study of New Potential FKBP12 Inhibitors ⬇️

artículo científico publicado el 1 de noviembre de 2003

Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations

artículo científico publicado en 2007

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

artículo científico publicado en 2011

Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori

artículo científico publicado en 2008

Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4

artículo científico publicado en 2016

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

artículo científico publicado en 2013

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

artículo científico publicado en 2012

Hormone- and antibody-mediated activation of the thyrotropin receptor

artículo científico publicado en 2022

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

artículo científico publicado en 2021

Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

artículo científico publicado en 2013

Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

artículo científico publicado en 2009

Malonyl-CoA: acyl carrier protein transacylase fromHelicobacter pylori: Crystal structure and its interaction with acyl carrier protein

artículo científico publicado en 2007

Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ

artículo científico publicado en 2011

Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase fromE. coli: Enzymatic characterization with crystal structure analysis

artículo científico publicado en 2008

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

artículo científico publicado en 2010

Structural Basis for Molecular Recognition at Serotonin Receptors

artículo científico publicado en 2013

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

artículo científico publicado en 2011

Structural basis for activation of the growth hormone-releasing hormone receptor

artículo científico publicado en 2020

Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

artículo científico publicado en 2008

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

artículo científico publicado en 2020

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

artículo científico publicado en 2011

Structural basis of leukotriene B4 receptor 1 activation

artículo científico publicado en 2022

Structural insight into substrate preference for TET-mediated oxidation

artículo científico publicado en 2015

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

artículo científico publicado en 2013

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

artículo científico publicado en 2014

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

artículo científico publicado en 2020

Structures and mechanism for the design of highly potent glucocorticoids

artículo científico publicado en 2014

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

artículo científico publicado en 2010

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors

artículo científico publicado en 2014

Two disparate ligand-binding sites in the human P2Y1 receptor

artículo científico publicado en 2015

Lista de obras de

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

Agonist-bound structure of the human P2Y12 receptor

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Design and Structure-Based Study of New Potential FKBP12 Inhibitors ⬇️

Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori

Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Hormone- and antibody-mediated activation of the thyrotropin receptor

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

Malonyl-CoA: acyl carrier protein transacylase fromHelicobacter pylori: Crystal structure and its interaction with acyl carrier protein

Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ

Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase fromE. coli: Enzymatic characterization with crystal structure analysis

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Structural Basis for Molecular Recognition at Serotonin Receptors

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

Structural basis for activation of the growth hormone-releasing hormone receptor

Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

Structural basis of leukotriene B4 receptor 1 activation

Structural insight into substrate preference for TET-mediated oxidation

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Structures and mechanism for the design of highly potent glucocorticoids

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors

Two disparate ligand-binding sites in the human P2Y1 receptor