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Lista de obras de Richard Lee

A Fluorescent Probe for Detecting Mycobacterium tuberculosis and Identifying Genes Critical for Cell Entry

artículo científico publicado en 2016

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

artículo científico publicado en 2008

A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin

artículo científico publicado en 2005

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

artículo científico publicado en 2004

A screen for and validation of prodrug antimicrobials

artículo científico publicado en 2013

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria

artículo científico publicado en 2009

A statistical framework to evaluate virtual screening

artículo científico publicado en 2009

A therapeutic approach to pantothenate kinase associated neurodegeneration

artículo científico publicado en 2018

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria

artículo científico publicado en 2015

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites

artículo científico publicado en 2004

Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

artículo científico publicado en 2006

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria

artículo científico publicado en 2012

Allosteric Regulation of Mammalian Pantothenate Kinase

artículo científico publicado en 2016

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections

artículo científico publicado en 2015

Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens

artículo científico publicado en 2019

Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone

artículo científico publicado en 2004

Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs ⬇️

artículo científico publicado el 5 de octubre de 2011

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties

artículo científico publicado en 2012

Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives

artículo científico publicado en 2013

Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs

artículo científico publicado en 2008

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

artículo científico publicado en 2012

Characterization of the in vitro synthesized arabinan of mycobacterial cell walls

scientific article published on 01 June 1997

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis

artículo científico publicado en 2007

Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri

artículo científico publicado en 2014

Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates

artículo científico publicado en 2003

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice

artículo científico publicado en 2018

Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone

artículo científico publicado en 2015

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

artículo científico publicado en 2010

Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase

artículo científico publicado en 2007

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

artículo científico publicado en 2013

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

artículo científico publicado en 2016

Design, synthesis, and evaluation of novel ethambutol analogues

artículo científico publicado en 2008

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue

artículo científico publicado en 2010

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay

artículo científico publicado en 2020

Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe

artículo científico publicado en 2014

Development of a pterin-based fluorescent probe for screening dihydropteroate synthase

artículo científico publicado en 2011

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy

artículo científico publicado en 2006

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

artículo científico publicado en 2020

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes

artículo científico publicado en 2005

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

artículo científico publicado en 2014

Discovery of novel isoxazolines as anti-tuberculosis agents

artículo científico publicado en 2007

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity

artículo científico publicado en 2004

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

artículo científico publicado en 2009

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead ⬇️

artículo científico publicado el 30 de julio de 2012

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections

artículo científico publicado en 2009

Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype

artículo científico publicado en 2018

First cultivation and characterization of mycobacterium ulcerans from the environment

artículo científico publicado en 2008

Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

artículo científico publicado en 2015

Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans

artículo científico publicado en 2005

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans ⬇️

artículo científico publicado en 2004

Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F

artículo científico publicado en 2006

Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence ⬇️

artículo científico publicado en 2003

Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase

artículo científico publicado en 2014

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis

scientific journal article

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

artículo científico publicado en 2015

In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori

artículo científico publicado en 2014

In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB

artículo científico publicado en 2010

Inhibition of UDP-Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose

article

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

scientific journal article

Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.

artículo científico publicado en 2000

LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators

artículo científico publicado en 2021

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium

artículo científico publicado en 1998

Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis

scientific article published on 11 December 2019

Metabolic activation of CaMKII by coenzyme A.

artículo científico publicado en 2013

Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria

artículo científico publicado en 2005

Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis

artículo científico publicado en 2021

Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay

article

Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence

artículo científico publicado en 1999

Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step

artículo científico publicado en 1997

Mycolic acids: structure, biosynthesis and physiological functions

artículo científico publicado en 1998

N-substituted 3-acetyltetramic acid derivatives as antibacterial agents

artículo científico publicado en 2008

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

artículo científico publicado en 2016

Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation

artículo científico publicado en 2007

Novel Polyoxyethylene-Containing Glycolipids Are Synthesized in Corynebacterium matruchotii and Mycobacterium smegmatis Cultured in the Presence of Tween 80.

artículo científico publicado en 2010

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria

artículo científico publicado en 2008

Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis

artículo científico publicado en 2003

Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

artículo científico publicado en 2014

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

artículo científico publicado en 2013

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

artículo científico publicado en 2015

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

artículo científico publicado en 2014

Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents

artículo científico publicado en 2008

Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation

artículo científico publicado en 2015

Potentiation of azole antifungals by 2-adamantanamine

artículo científico publicado en 2013

Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents

artículo científico publicado en 2016

Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents

scientific article published on 29 July 2008

Rapid structural characterization of the arabinogalactan and lipoarabinomannan in live mycobacterial cells using 2D and 3D HR-MAS NMR: structural changes in the arabinan due to ethambutol treatment and gene mutation are observed

article

RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host

scientific article published on 03 January 2017

Replacing sulfa drugs with novel DHPS inhibitors

artículo científico publicado en 2013

Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations

artículo científico publicado en 2011

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A

artículo científico publicado en 2016

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

artículo científico publicado en 2012

Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

artículo científico publicado en 2007

Solid-phase synthesis of a thymidinyl dipeptide urea library

artículo científico publicado en 2007

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

artículo científico publicado en 2016

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

scientific article published on 26 January 2014

Structural Characterization of the Mycobacterium tuberculosis Biotin Biosynthesis Enzymes 7,8-Diaminopelargonic Acid Synthase and Dethiobiotin Synthetase,

artículo científico publicado en 2010

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

artículo científico publicado en 2010

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

artículo científico publicado en 2017

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

scientific article published on 01 October 2020

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

artículo científico publicado en 2016

Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity

artículo científico publicado en 2012

Structure-Based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-deoxyadenosine and the 5′-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors

artículo científico publicado en 2009

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

artículo científico publicado en 2005

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents ⬇️

artículo científico publicado el 3 de abril de 2013

Synthesis and Evaluation of Thiazolidine Amide and N-Thiazolyl Amide Fluoroquinolone Derivatives.

artículo científico publicado en 2017

Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

artículo científico publicado en 2022

Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents

artículo científico publicado en 2005

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism

artículo científico publicado en 2003

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

artículo científico publicado en 2004

Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids

artículo científico publicado en 2015

Synthesis and structure of mycolactone E isolated from frog mycobacterium

artículo científico publicado en 2008

Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.

artículo científico publicado en 1998

Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes

artículo científico publicado en 2010

Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability

artículo científico publicado en 2006

Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents

artículo científico publicado en 2008

Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives

artículo científico publicado en 2014

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

artículo científico publicado en 2011

The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

artículo científico publicado en 2014

The membrane as a target for controlling hypervirulent Clostridium difficile infections

artículo científico publicado en 2012

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites

artículo científico publicado en 2004

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

artículo científico publicado en 2011

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

artículo científico publicado en 2016

Topology and Active Site of PlsY

artículo científico publicado en 2007

Ureadepsipeptides as ClpP Activators

scientific article published on 24 October 2019

Validation of molecular docking programs for virtual screening against dihydropteroate synthase

artículo científico publicado en 2009

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