Lista de obras - Merlin Crossley - Dominio Público Uruguay

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden

artículo científico publicado en 2013

A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

artículo científico publicado en 2006

A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped.

artículo científico publicado en 2000

A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3

scientific journal article

A mechanism for Ikaros regulation of human globin gene switching.

artículo científico publicado en 2008

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site

artículo científico publicado en 2019

A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo

artículo científico publicado en 2008

A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution

artículo científico publicado en 2002

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.

artículo científico publicado en 2007

A rapid method for assessing the RNA-binding potential of a protein.

artículo científico publicado en 2012

Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages

artículo científico publicado en 2004

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

artículo científico publicado en 2021

Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad.

artículo científico publicado en 2007

Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting

artículo científico publicado en 2005

Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors

artículo científico publicado en 1999

C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis

artículo científico publicado en 2011

CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions

artículo científico publicado en 2003

Cellular Reprogramming toward the Erythroid Lineage

artículo científico publicado en 2011

Characterization of the conserved interaction between GATA and FOG family proteins

artículo científico publicado en 2002

Charting a noncoding gene for γ-globin activation

article

Chromatin modifiers in transcription and DNA repair.

artículo científico publicado en 2004

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators

artículo científico publicado en 1998

Comparative sequence analysis of mammalian factor IX promoters.

artículo científico publicado en 1990

Controlling the size of lipid droplets: lipid and protein factors

artículo científico publicado en 2012

Defining Eosinophil Function in Adiposity and Weight Loss

scientific article published on 22 August 2018

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells

artículo científico publicado en 2014

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch

artículo científico publicado en 2017

Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain

artículo científico publicado en 2015

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice

artículo científico publicado en 2013

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

artículo científico publicado en 2015

Engineering a protein scaffold from a PHD finger

artículo científico publicado en 2003

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

artículo científico publicado en 2000

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

artículo científico publicado en 2020

Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

artículo científico publicado en 2016

Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.

artículo científico publicado en 2007

Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins

artículo científico publicado en 2001

Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta

artículo científico publicado en 1998

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

artículo científico publicado en 1997

GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis

artículo científico publicado en 2010

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

artículo científico publicado en 2013

Genome Editing of Erythroid Cell Culture Model Systems

artículo científico publicado en 2018

Global citizen deliberation on genome editing

scientific article published on 01 September 2020

Hemophilia B Leyden and once mysterious cis-regulatory mutations

artículo científico publicado en 2013

Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act

scientific article published on 27 June 2019

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

artículo científico

Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans

artículo científico publicado en 2013

Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans

artículo científico publicado en 2016

Homo- and heterodimerization in transcriptional regulation.

artículo científico publicado en 2012

Human KLF17 is a new member of the Sp/KLF family of transcription factors

artículo científico publicado en 2006

Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.

artículo científico publicado en 2003

Impaired B cell development in the absence of Krüppel-like factor 3.

artículo científico publicado en 2011

Involvement of the N-finger in the self-association of GATA-1.

artículo científico publicado en 1998

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

artículo científico publicado en 2013

KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells

artículo científico publicado en 2005

KLF1 drives the expression of fetal hemoglobin in British HPFH.

artículo científico publicado en 2017

KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites

artículo científico publicado en 2010

Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic.

artículo científico publicado en 2017

Key residues characteristic of GATA N-fingers are recognized by FOG.

artículo científico publicado en 1998

Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).

artículo científico publicado en 2016

Krüppel-like factors compete for promoters and enhancers to fine-tune transcription

artículo científico publicado en 2017

Krüppel-like transcription factors: a functional family

artículo científico publicado en 2008

Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).

artículo científico publicado en 2013

Mammalian Krüppel-like transcription factors: more than just a pretty finger

artículo científico publicado en 1999

Mechanisms directing the nuclear localization of the CtBP family proteins.

artículo científico publicado en 2006

Methylation of a CGATA element inhibits binding and regulation by GATA-1 ⬇️

scientific article published on 22 May 2020

Modification with SUMO. A role in transcriptional regulation

artículo científico publicado en 2003

Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

artículo científico publicado en 2006

Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

artículo científico publicado en 2014

Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

artículo científico publicado en 2003

Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

article

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

artículo científico publicado en 2018

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

artículo científico publicado en 2013

PU.1 and Haematopoietic Cell Fate: Dosage Matters

artículo científico publicado en 2011

Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules

artículo científico publicado en 2018

Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

artículo científico publicado en 2015

Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3)

Protein interactions: is seeing believing?

artículo científico publicado en 2007

Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding.

artículo científico publicado en 2004

Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding

artículo científico publicado en 2003

Protein-protein interactions: Analysis of a false positive GST pulldown result

scientific article published on 02 June 2011

Recovery from Hemophilia B Leyden: An Androgen-Responsive Element in the Factor IX Promoter ⬇️

artículo científico publicado el 17 de julio de 1992

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

artículo científico publicado en 2013

Regulation of the beta-globin locus.

artículo científico publicado en 1993

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

artículo científico publicado en 2014

Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?

article

Role for SUMO modification in facilitating transcriptional repression by BKLF.

artículo científico publicado en 2005

Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression

artículo científico publicado en 2006

SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans

artículo científico

Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP)

artículo científico publicado en 2007

Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions

artículo científico publicado en 2000

Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins

artículo científico publicado en 2006

Sticky fingers: zinc-fingers as protein-recognition motifs

artículo científico publicado en 2007

Structural basis for human ZBTB7A action at the fetal globin promoter

artículo científico publicado en 2021

Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1

artículo científico publicado en 2011

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis

artículo científico publicado en 2008

The C-terminal Domain of Eos Forms a High Order Complex in Solution

scientific article published in Journal of Biological Chemistry

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo

artículo científico publicado en 2012

The Caenorhabditis elegans protein CTBP-1 defines a new group of THAP domain-containing CtBP corepressors.

artículo científico publicado en 2007

The CtBP family: enigmatic and enzymatic transcriptional co-repressors

artículo científico publicado en 2001

The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins

artículo científico publicado en 2014

The Ikaros family protein Eos associates with C-terminal-binding protein corepressors

scientific journal article

The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2

artículo científico publicado en 2003

The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA.

artículo científico publicado en 2001

The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).

artículo científico publicado en 2011

The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain

artículo científico publicado en 2011

The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y.

artículo científico publicado en 2016

The role of the coiled-coil motif in interactions mediated by TPD52

artículo científico publicado en 2001

The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG

artículo científico publicado en 1999

The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules

artículo científico publicado en 2000

The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan

artículo científico publicado en 2014

Transcription Factor Erythroid Krüppel-like Factor (ELKF) Is Essential for the Erythropoietin-induced Hemoglobin Production but Not for Proliferation, Viability, or Morphological Maturation ⬇️

artículo científico publicado el 11 de septiembre de 1998

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

artículo científico publicado en 2016

Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers

artículo científico publicado en 1999

Two-timing zinc finger transcription factors liaising with RNA.

artículo científico publicado en 2012

Unscrambling the genome ⬇️

artículo científico publicado el 30 de abril de 2003

X-linked thrombocytopenia caused by a novel mutation of GATA-1

artículo científico publicado en 2001

Zinc fingers are sticking together

artículo científico publicado en 1998

Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction

artículo científico publicado en 2005

hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation

artículo científico publicado en 1999

Lista de obras de Merlin Crossley

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden

A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped.

A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3

A mechanism for Ikaros regulation of human globin gene switching.

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site

A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo

A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.

A rapid method for assessing the RNA-binding potential of a protein.

Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad.

Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting

Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors

C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis

CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions

Cellular Reprogramming toward the Erythroid Lineage

Characterization of the conserved interaction between GATA and FOG family proteins

Charting a noncoding gene for γ-globin activation

Chromatin modifiers in transcription and DNA repair.

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators

Comparative sequence analysis of mammalian factor IX promoters.

Controlling the size of lipid droplets: lipid and protein factors

Defining Eosinophil Function in Adiposity and Weight Loss

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch

Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

Engineering a protein scaffold from a PHD finger

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.

Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins

Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

Genome Editing of Erythroid Cell Culture Model Systems

Global citizen deliberation on genome editing

Hemophilia B Leyden and once mysterious cis-regulatory mutations

Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans

Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans

Homo- and heterodimerization in transcriptional regulation.

Human KLF17 is a new member of the Sp/KLF family of transcription factors

Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.

Impaired B cell development in the absence of Krüppel-like factor 3.

Involvement of the N-finger in the self-association of GATA-1.

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells

KLF1 drives the expression of fetal hemoglobin in British HPFH.

KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites

Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic.

Key residues characteristic of GATA N-fingers are recognized by FOG.

Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).

Krüppel-like factors compete for promoters and enhancers to fine-tune transcription

Krüppel-like transcription factors: a functional family

Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).

Mammalian Krüppel-like transcription factors: more than just a pretty finger

Mechanisms directing the nuclear localization of the CtBP family proteins.

Methylation of a CGATA element inhibits binding and regulation by GATA-1 ⬇️

Modification with SUMO. A role in transcriptional regulation

Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

PU.1 and Haematopoietic Cell Fate: Dosage Matters

Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules

Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3)

Protein interactions: is seeing believing?

Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding.

Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding