Lista de obras - Roman Lesyk - Dominio Público Uruguay

2-[7-(3,5-Dibromo-2-hydroxyphenyl)-6-ethoxycarbonyl-2-oxo-5H-2,3,6,7-tetrahydrothiopyrano[2,3-d][1,3]thiazol-6-yl]acetic acid ethanol monosolvate ⬇️

artículo científico publicado el 15 de agosto de 2012

2-[N-(2,4-Dimeth-oxy-phen-yl)acetamido]-1,3-thia-zol-4-yl acetate.

artículo científico publicado en 2013

2-{5-[(,2)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule

artículo científico publicado en 2022

3D-MoRSE descriptors explained

artículo científico publicado en 2014

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.

artículo científico publicado en 2017

5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines

artículo científico publicado en 2020

5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry

artículo científico publicado en 2017

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

artículo científico publicado en 2016

5-Year Trends in QSAR and its Machine Learning Methods.

artículo científico publicado en 2016

A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates

artículo científico publicado en 2011

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).

artículo científico publicado en 2017

Anticancer properties of 5Z-(4-fluorobenzylidene)-2-(4-hydroxyphenylamino)-thiazol-4-one

scientific article published on 23 July 2019

Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.

artículo científico publicado en 2006

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

artículo científico publicado en 2016

Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier

artículo científico publicado en 2016

Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds.

artículo científico publicado en 2014

Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization

artículo científico publicado en 2014

Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one

artículo científico publicado en 2014

Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.

artículo científico publicado en 2017

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.

artículo científico publicado en 2017

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

artículo científico publicado en 2019

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.

artículo científico publicado en 2012

Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives

artículo científico publicado en 2014

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

artículo científico publicado en 2017

Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro

artículo científico publicado en 2020

Isothiocoumarin-3-carboxylic acid derivatives: synthesis, anticancer and antitrypanosomal activity evaluation.

artículo científico publicado en 2014

New 5-substituted thiazolo[3,2-b][1,2,4]triazol-6-ones: synthesis and anticancer evaluation

artículo científico publicado en 2007

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats

artículo científico publicado en 2016

Recent developments with rhodanine as a scaffold for drug discovery

artículo científico publicado en 2017

Study of novel anticancer 4-thiazolidinone derivatives.

artículo científico publicado en 2016

Synthesis and Anticancer Activity of Isatin‐Based Pyrazolines and Thiazolidines Conjugates ⬇️

artículo científico publicado el 16 de junio de 2011

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

artículo científico publicado en 2014

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety

artículo científico publicado en 2013

Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety.

artículo científico publicado en 2010

Synthesis and anticancer activity of 6-heteroarylcoumarins.

artículo científico publicado en 2015

Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles

artículo científico publicado en 2012

Synthesis and evaluation of anticancer activity of 5-ylidene-4- aminothiazol-2(5H)-one derivatives.

artículo científico publicado en 2015

Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives

artículo científico publicado en 2016

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

artículo científico publicado en 2009

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity.

artículo científico publicado en 2010

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity

artículo científico publicado en 2019

Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity

artículo científico publicado en 2012

Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

artículo científico publicado en 2008

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity.

artículo científico publicado en 2014

Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.

artículo científico publicado en 2008

Synthesis, Antibacterial and Antifungal Activity of New 3-Aryl-5-pyrrolo[1,2-]imidazole and 5-Imidazo[1,2-]azepine Quaternary Salts

artículo científico publicado en 2021

Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides

artículo científico publicado en 2020

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

artículo científico publicado en 2017

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids.

artículo científico publicado en 2016

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents

artículo científico publicado en 2019

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

artículo científico publicado en 2018

Trends in research of antitrypanosomal agents among synthetic heterocycles.

artículo científico publicado en 2014

rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid

artículo científico publicado en 2022

Lista de obras de Roman Lesyk

2-[7-(3,5-Dibromo-2-hydroxyphenyl)-6-ethoxycarbonyl-2-oxo-5H-2,3,6,7-tetrahydrothiopyrano[2,3-d][1,3]thiazol-6-yl]acetic acid ethanol monosolvate ⬇️

2-[N-(2,4-Dimeth-oxy-phen-yl)acetamido]-1,3-thia-zol-4-yl acetate.

2-{5-[(,2)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule

3D-MoRSE descriptors explained

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.

5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines

5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

5-Year Trends in QSAR and its Machine Learning Methods.

A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).

Anticancer properties of 5Z-(4-fluorobenzylidene)-2-(4-hydroxyphenylamino)-thiazol-4-one

Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier

Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds.

Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization

Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one

Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.

Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro

Isothiocoumarin-3-carboxylic acid derivatives: synthesis, anticancer and antitrypanosomal activity evaluation.

New 5-substituted thiazolo[3,2-b][1,2,4]triazol-6-ones: synthesis and anticancer evaluation

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats

Recent developments with rhodanine as a scaffold for drug discovery

Study of novel anticancer 4-thiazolidinone derivatives.

Synthesis and Anticancer Activity of Isatin‐Based Pyrazolines and Thiazolidines Conjugates ⬇️

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety

Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety.

Synthesis and anticancer activity of 6-heteroarylcoumarins.

Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles

Synthesis and evaluation of anticancer activity of 5-ylidene-4- aminothiazol-2(5H)-one derivatives.

Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity.

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity

Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity

Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity.

Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.

Synthesis, Antibacterial and Antifungal Activity of New 3-Aryl-5-pyrrolo[1,2-]imidazole and 5-Imidazo[1,2-]azepine Quaternary Salts

Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids.

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

Trends in research of antitrypanosomal agents among synthetic heterocycles.

rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid