Lista de obras - Paul Knoepfler - Dominio Público Uruguay

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1

artículo científico publicado en 1999

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

scientific journal article

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

artículo científico publicado en 1999

Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19

publication published in 2021

Arrestin' the hedgehog: Shh limits its own signaling via β-Arrestin1.

artículo científico publicado en 2010

Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors.

artículo científico

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

artículo científico publicado en 1995

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells

artículo científico publicado en 2017

Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians.

artículo científico publicado en 2013

Chromatin immunoprecipitation assays for Myc and N-Myc.

artículo científico publicado en 2013

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

artículo científico publicado en 2012

Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function.

artículo científico publicado en 2000

Division and apoptosis of E2f-deficient retinal progenitors

artículo científico publicado en 2009

ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.

artículo científico publicado en 2018

Epigenetic mechanisms of tumorigenicity manifesting in stem cells.

artículo científico publicado en 2014

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

artículo científico publicado en 2014

Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.

artículo científico publicado en 1995

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

artículo científico publicado en 2005

Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer

scientific article published on 19 July 2018

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations

artículo científico publicado en 2004

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

artículo científico publicado en 2008

Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

artículo científico publicado en 2022

Histone H3.3 mutations: a variant path to cancer

artículo científico publicado en 2013

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

artículo científico publicado en 2014

Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.

artículo científico publicado en 2013

Induced Pluripotency and Oncogenic Transformation Are Related Processes ⬇️

artículo científico publicado el 26 de octubre de 2012

Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism

artículo científico publicado en 2012

Inducing iPSCs to escape the dish.

artículo científico publicado en 2011

Key action items for the stem cell field: looking ahead to 2014.

artículo científico publicado en 2013

Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells.

artículo científico publicado en 2012

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 ⬇️

artículo científico publicado el 23 de diciembre de 1997

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia ⬇️

artículo científico publicado el 30 de octubre de 2001

Miz-1 activates gene expression via a novel consensus DNA binding motif

artículo científico publicado en 2014

My year as a stem-cell blogger ⬇️

artículo científico publicado el 27 de julio de 2011

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.

artículo científico publicado en 2011

Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain

artículo científico publicado en 2013

Myc goes global: new tricks for an old oncogene.

artículo científico publicado en 2007

Myc influences global chromatin structure.

artículo científico publicado en 2006

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.

artículo científico publicado en 2012

N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor

artículo científico publicado en 2008

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

artículo científico publicado en 2009

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

artículo científico publicado en 2011

N-myc coordinates retinal growth with eye size during mouse development.

artículo científico publicado en 2008

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

artículo científico publicado en 2006

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

artículo científico publicado en 2002

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

scientific journal article

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

artículo científico publicado en 1996

Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years

artículo científico publicado en 2019

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling

artículo científico publicado en 2020

Reviewing post-publication peer review.

artículo científico publicado en 2015

Scientists: you really need to get out of the lab more

artículo científico publicado en 2013

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

artículo científico publicado en 2016

Sin meets NuRD and other tails of repression.

artículo científico publicado en 1999

Stem cells on the brain.

artículo científico publicado en 2008

The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis

artículo científico publicado en 2018

The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells.

artículo científico publicado en 1997

The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar

artículo científico publicado en 2016

The death of MyMouseHouse: lessons for systems for the efficient management of mouse colonies

scientific article published on 01 January 2010

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

scientific article published on 01 May 1997

To CRISPR and beyond: the evolution of genome editing in stem cells

artículo científico publicado en 2016

Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends

artículo científico publicado en 2018

Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety.

artículo científico publicado en 2011

Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion

artículo científico publicado en 1995

Utf1: Goldilocks for ESC bivalency.

artículo científico publicado en 2012

When patients reach out, scientists should reach back carefully

artículo científico publicado en 2016

myc maintains embryonic stem cell pluripotency and self-renewal

artículo científico publicado en 2010

Lista de obras de Paul Knoepfler

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19

Arrestin' the hedgehog: Shh limits its own signaling via β-Arrestin1.

Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors.

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells

Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians.

Chromatin immunoprecipitation assays for Myc and N-Myc.

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function.

Division and apoptosis of E2f-deficient retinal progenitors

ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.

Epigenetic mechanisms of tumorigenicity manifesting in stem cells.

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

Histone H3.3 mutations: a variant path to cancer

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.

Induced Pluripotency and Oncogenic Transformation Are Related Processes ⬇️

Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism

Inducing iPSCs to escape the dish.

Key action items for the stem cell field: looking ahead to 2014.

Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells.

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 ⬇️

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia ⬇️

Miz-1 activates gene expression via a novel consensus DNA binding motif

My year as a stem-cell blogger ⬇️

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.

Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain

Myc goes global: new tricks for an old oncogene.

Myc influences global chromatin structure.

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.

N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

N-myc coordinates retinal growth with eye size during mouse development.

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling

Reviewing post-publication peer review.

Scientists: you really need to get out of the lab more

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

Sin meets NuRD and other tails of repression.

Stem cells on the brain.

The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis

The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells.

The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar

The death of MyMouseHouse: lessons for systems for the efficient management of mouse colonies

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

To CRISPR and beyond: the evolution of genome editing in stem cells

Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends

Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety.

Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion

Utf1: Goldilocks for ESC bivalency.

When patients reach out, scientists should reach back carefully

myc maintains embryonic stem cell pluripotency and self-renewal