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Lista de obras de William Douglas Figg

2-Methoxyestradiol, a promising anticancer agent

scientific journal article

A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug–Drug Interaction Liabilities

artículo científico publicado en 2022

A Phase II Study of Pembrolizumab in Combination with Capecitabine and Oxaliplatin with Molecular Profiling in Patients with Advanced Biliary Tract Carcinoma

artículo científico publicado en 2022

A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma.

artículo científico publicado en 2017

A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma

artículo científico publicado en 2019

A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer ⬇️

artículo científico publicado el 19 de noviembre de 2010

A double-blind randomized crossover study of oral thalidomide versus placebo for androgen dependent prostate cancer treated with intermittent androgen ablation.

artículo científico publicado en 2009

A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma

artículo científico publicado en 2002

A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms.

artículo científico publicado en 2014

A phase I clinical study of high dose ketoconazole plus weekly docetaxel for metastatic castration resistant prostate cancer

artículo científico publicado en 2010

A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors.

artículo científico publicado en 2012

A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas

artículo científico publicado en 2011

A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

artículo científico publicado en 2002

A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.

artículo científico publicado en 2014

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.

artículo científico publicado en 2008

A prospective analysis of the time to normalization of serum androgens following 6 months of androgen deprivation therapy in patients on a randomized phase III clinical trial using limited hormonal therapy

artículo científico publicado en 2005

A very long-acting Poly(ADP-ribose) polymerase inhibitor suppresses cancer cell growth in DNA repair-deficient tumor models

artículo científico publicado en 2020

ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel

artículo científico publicado en 2008

Aflibercept in Pediatric Solid Tumors: Moving Beyond the Trap ⬇️

artículo científico publicado el 6 de agosto de 2012

Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32

artículo científico publicado en 2018

Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

artículo científico publicado en 2021

Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: results From the Prostate Cancer Prevention Trial.

artículo científico publicado en 2014

Androgen receptor CAG repeat length and association with prostate cancer risk: results from the prostate cancer prevention trial

artículo científico publicado en 2010

Androgen receptor sequence and variations in several common prostate cancer cell lines

artículo científico publicado en 2010

Androgen receptor splice variant 7 (AR-V7) and AR full-length (AR-FL) as predictive biomarkers of therapeutic resistance: partners in crime?

scientific article published on 20 September 2019

Androgen receptor variation affects prostate cancer progression and drug resistance

artículo científico publicado en 2016

Angiogenesis in spontaneous tumors and implications for comparative tumor biology

artículo científico publicado en 2014

Angiogenesis inhibitors in the treatment of prostate cancer

artículo científico publicado en 2010

Angiogenesis inhibitors increase tumor stem cells ⬇️

artículo científico publicado el 1 de junio de 2012

Antiangiogenesis therapeutic strategies in prostate cancer

artículo científico publicado en 2002

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

scientific article published on 02 December 2020

Antibody-drug conjugates for cancer

scientific article published on 01 August 2019

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues.

artículo científico publicado en 2015

Are race-specific ERCC1 haplotypes in melanoma cases versus controls related to the predictive and prognostic value of ERCC1 N118N? ⬇️

artículo científico publicado el 3 de enero de 2013

Are sex discordant outcomes in COVID-19 related to sex hormones?

scientific article published on 17 June 2020

Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia

artículo científico publicado en 2006

Association of a CYP17 polymorphism with overall survival in Caucasian patients with androgen-independent prostate cancer

artículo científico publicado en 2007

Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the Prostate Cancer Prevention Trial

artículo científico publicado en 2016

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival.

artículo científico publicado en 2008

BET bromodomain inhibitors--a novel epigenetic approach in castration-resistant prostate cancer

artículo científico publicado en 2014

BETting on next-generation bromodomain inhibitors

scientific article published on 15 August 2020

CECs and IL-8 Have Prognostic and Predictive Utility in Patients with Recurrent Platinum-Sensitive Ovarian Cancer: Biomarker Correlates from the Randomized Phase-2 Trial of Olaparib and Cediranib Compared with Olaparib in Recurrent Platinum-Sensitiv

artículo científico publicado en 2015

CHIP and gp78-mediated ubiquitination of CYP3A4: Implications for the pharmacology of anticancer agents

artículo científico publicado en 2011

COVID-19 Clinical Diagnostics and Testing Technology

artículo científico publicado en 2020

CYP2D6 polymorphisms and the impact on tamoxifen therapy

artículo científico publicado en 2007

Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations

artículo científico publicado en 2006

Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms.

artículo científico publicado en 2017

Case report: severe toxicity in an African-American patient receiving FOLFOX carrying uncommon allelic variants in <i>DPYD</i>

artículo científico publicado en 2020

Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide

scientific article published on 16 October 2019

Challenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures ⬇️

artículo científico publicado el 2 de julio de 2012

Clinical and molecular responses in lung cancer patients receiving Romidepsin

artículo científico publicado en 2008

Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform.

artículo científico publicado en 2010

Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis

artículo científico publicado en 2008

Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity

artículo científico publicado en 2008

Combining mTOR inhibition with metronomic chemotherapy in targeting angiogenesis

artículo científico publicado en 2008

Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

artículo científico publicado en 2019

Current status of thalidomide and CC-5013 in the treatment of metastatic prostate cancer.

artículo científico publicado en 2009

Current status of thalidomide and its role in the treatment of metastatic prostate cancer

artículo científico publicado en 2003

Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients.

artículo científico publicado en 2010

Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease

artículo científico publicado en 2016

Determination of 2-methoxyestradiol in human plasma, using liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2005

Determination of midazolam in human plasma by liquid chromatography with mass-spectrometric detection

artículo científico publicado en 2004

Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.

artículo científico publicado en 2017

Disclosing a diagnosis of cancer: where and how does it occur?

artículo científico publicado en 2010

Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

artículo científico publicado en 2022

Dual targeting of the androgen receptor and hypoxia-inducible factor 1α pathways synergistically inhibits castration-resistant prostate cancer cells

artículo científico publicado en 2015

Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer

artículo científico publicado en 2008

Effect of finasteride on serum androstenedione and risk of prostate cancer within the prostate cancer prevention trial: differential effect on high- and low-grade disease

artículo científico publicado en 2015

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers

artículo científico publicado en 2014

Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.

artículo científico publicado en 2015

Efficacy, tolerability and pharmacokinetics of combined targeted MEK and dual mTORC1/2 inhibition in a preclinical model of mucosal melanoma

scientific article published on 17 September 2020

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

artículo científico publicado en 2014

Estrogen Receptor α and Aromatase Polymorphisms Affect Risk, Prognosis, and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy.

artículo científico publicado en 2011

Estrogen receptor α and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy

artículo científico publicado en 2010

Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1

artículo científico publicado en 2008

Evaluation of entinostat alone and in combination with standard-of-care cytotoxic agents against rhabdomyosarcoma xenograft models

artículo científico publicado en 2019

Exploiting defects in homologous recombination repair for metastatic, castration-resistant prostate cancer

scientific article published on 26 August 2020

Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression ⬇️

artículo científico publicado el 19 de mayo de 2011

Final analysis of a phase II trial using sorafenib for metastatic castration-resistant prostate cancer.

artículo científico publicado en 2009

Finasteride concentrations and prostate cancer risk: results from the Prostate Cancer Prevention Trial

artículo científico publicado en 2015

Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer

artículo científico publicado en 2010

Genetic variation: effect on prostate cancer.

artículo científico publicado en 2014

Genetic variations in the vitamin D receptor, androgen receptor and enzymes that regulate androgen metabolism

artículo científico publicado en 2004

Heterogeneity in drug disposition determines interindividual variability of docetaxel pharmacokinetics

scientific article published on 12 July 2006

Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib

artículo científico publicado en 2010

IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

artículo científico publicado en 2019

Impact of ABCB1 allelic variants on QTc interval prolongation

artículo científico publicado en 2010

Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance

artículo científico publicado en 2014

In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

artículo científico publicado en 2016

Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2 ⬇️

artículo científico publicado el 19 de octubre de 2010

Inhibition of angiogenesis: treatment options for patients with metastatic prostate cancer

artículo científico publicado en 2002

Integrating pharmacogenetic information and clinical decision support into the electronic health record

artículo científico publicado en 2013

Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier

artículo científico publicado en 2017

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

artículo científico publicado en 2009

Loss of OATP1B3 function causes Rotor syndrome: implications for potential use of inhibitors in cancer

artículo científico publicado en 2012

Mechanisms of disease: Polymorphisms of androgen regulatory genes in the development of prostate cancer

artículo científico publicado en 2005

Metastasis-specific gene expression in autochthonous and allograft mouse mammary tumor models: stratification and identification of targetable signatures

artículo científico publicado en 2020

Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells

artículo científico publicado en 2016

Molecular alterations in primary prostate cancer after androgen ablation therapy

artículo científico publicado en 2005

Molecular and phenotypic heterogeneity of metastatic prostate cancer

artículo científico publicado en 2005

More than an accessory: implications of type III transforming growth factor-beta receptor loss in prostate cancer

artículo científico publicado en 2010

Multi-institutional Study of Outcomes After Pediatric Heart Transplantation: Candidate Gene Polymorphism Analysis of ABCC2.

artículo científico publicado en 2014

Mutations in the EGFR: the importance of genotyping

artículo científico publicado en 2004

New tricks from an old drug: a role for quinacrine in anti-cancer therapy?

artículo científico publicado en 2009

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

artículo científico publicado en 2018

On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs

artículo científico publicado en 2020

PARP Inhibitors & Prostate Cancer: To Infinity and Beyond BRCA

artículo científico publicado en 2020

Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research

scientific article published on 01 July 2008

Pharmacogenetics and regulation of human cytochrome P450 1B1: implications in hormone-mediated tumor metabolism and a novel target for therapeutic intervention

artículo científico publicado en 2006

Pharmacogenetics of membrane transporters: a review of current approaches

artículo científico publicado en 2008

Pharmacogenetics of membrane transporters: an update on current approaches

artículo científico publicado en 2010

Pharmacologic biomarkers in the development of stratified cancer medicine

artículo científico publicado en 2014

Phase 1 trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors

artículo científico publicado en 2015

Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment

scientific article published on 29 March 2020

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma

artículo científico publicado en 2011

Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura

artículo científico publicado en 2006

Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies

artículo científico publicado en 2005

Phase I study of oral lenalidomide in patients with refractory metastatic cancer

artículo científico publicado en 2009

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

artículo científico publicado en 2010

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (bolus) infusion schedule of alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

artículo científico publicado en 2014

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms.

artículo científico publicado en 2011

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

artículo científico publicado en 2002

Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analyses

artículo científico publicado en 2014

Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.

artículo científico publicado en 2017

Phase II clinical trial of cediranib in patients with metastatic castration‐resistant prostate cancer ⬇️

artículo científico publicado el 18 de febrero de 2013

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

artículo científico publicado en 2009

Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: a pharmacogenetic assessment of outcome and toxicity

artículo científico publicado en 2013

Phase II trial of bevacizumab and satraplatin in docetaxel-pretreated metastatic castrate-resistant prostate cancer

artículo científico publicado en 2013

Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer

artículo científico publicado en 2010

Phase II trial of docetaxel, bevacizumab, lenalidomide and prednisone in patients with metastatic castration-resistant prostate cancer.

artículo científico publicado en 2016

Piecing the puzzle together: Docetaxel cycles and current considerations in the treatment of metastatic castration-resistant prostate cancer

artículo científico publicado en 2017

Piecing together the HIF-1 puzzle: the role of the CTGF as a molecular mechanism of HIF-1 regulation

artículo científico publicado en 2006

Pilot Study Comparing Systemic and Tissue Pharmacokinetics of Irinotecan and Metabolites after Hepatic Drug-Eluting Chemoembolization

artículo científico publicado en 2018

Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer

artículo científico publicado en 2005

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

artículo científico publicado en 2013

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

artículo científico publicado en 2020

Population pharmacokinetic analysis of sorafenib in patients with solid tumours.

artículo científico publicado en 2011

Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma

artículo científico publicado en 2009

Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment

artículo científico publicado en 2016

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

scientific article published on 19 July 2018

Prostate cancer genomic signature offers prognostic value ⬇️

artículo científico publicado el 1 de diciembre de 2010

Prostate tumor development and androgen receptor function alterations in a new mouse model with ERG overexpression and PTEN inactivation

artículo científico publicado en 2014

Racial Disparities in the Association Between Variants on 8q24 and Prostate Cancer: A Systematic Review and Meta-Analysis ⬇️

artículo científico publicado el 1 de enero de 2012

Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases

artículo científico publicado en 2018

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

artículo científico publicado en 2014

Revisiting 5α-reductase inhibitors and the risk of prostate cancer

artículo científico publicado en 2018

Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

artículo científico publicado en 2020

Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.

artículo científico publicado en 2010

SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer

artículo científico publicado en 2011

Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers

artículo científico publicado en 2011

Sarcosine as a potential prostate cancer biomarker and therapeutic target

artículo científico publicado en 2010

Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.

artículo científico publicado en 2016

Selective leukemic-cell killing by a novel functional class of thalidomide analogs

artículo científico publicado en 2006

Selumetinib in Children with Inoperable Plexiform Neurofibromas

artículo científico publicado en 2020

Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer.

artículo científico publicado en 2016

Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control study

artículo científico publicado en 2011

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model.

artículo científico publicado en 2016

Significant addition to treatment options for bone metastasis in prostate cancer ⬇️

artículo científico publicado el 15 de enero de 2012

Slow tight binding inhibition of CYP17A1 by abiraterone redefines its kinetic selectivity and dosing regimen

scientific article published on 17 June 2020

Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

artículo científico publicado en 2015

Suramin's development: what did we learn?

artículo científico publicado en 2002

TMPRSS2: Potential Biomarker for COVID-19 Outcomes

scientific article published on 21 May 2020

Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro

scientific article published on 13 February 2020

Targeting the metastatic niche: Single-cell lineage tracing in prime time

artículo científico publicado en 2023

Thalidomide analogues as anticancer drugs

artículo científico publicado en 2007

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

artículo científico publicado en 2009

The ERCC1 N118N polymorphism does not change cellular ERCC1 protein expression or platinum sensitivity ⬇️

artículo científico publicado el 16 de febrero de 2011

The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor ⬇️

artículo científico publicado el 1 de enero de 2011

The canSAR data hub for drug discovery.

artículo científico publicado en 2016

The combination of antiangiogenic and cytotoxic agents in the treatment of prostate cancer

artículo científico publicado en 2003

The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors

artículo científico publicado en 2009

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy ⬇️

artículo científico publicado el 1 de enero de 2012

Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic Efficacy ⬇️

artículo científico publicado el 24 de noviembre de 2010

U.S. Public Health Service Commissioned Corps pharmacists: making a difference in advancing the nation's health

artículo científico publicado en 2009

UGT genotyping in belinostat dosing

artículo científico publicado en 2016

VEGF inhibition and metastasis: possible implications for antiangiogenic therapy

artículo científico publicado en 2009

Validation of analytic methods for biomarkers used in drug development

artículo científico publicado en 2008

hTert-immortalized endothelial cells: an important new research tool.

artículo científico publicado en 2004

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