Lista de obras - Heyo Klaus Kroemer - Dominio Público Uruguay

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3

artículo científico publicado en 2011

A genome-wide association study of metabolic traits in human urine

artículo científico publicado en 2011

A network-based approach to visualize prevalence and progression of metabolic syndrome components

artículo científico publicado en 2012

Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression

scientific journal article

Advances in coronary stent technology--active drug-loaded stent surfaces for prevention of restenosis and improvement of biocompatibility.

artículo científico publicado en 2013

Antibodies Against Potassium Channel Interacting Protein 2 Induce Necrosis in Isolated Rat Cardiomyocytes

scientific article published on 01 April 2014

Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.

artículo científico publicado en 2012

Beta‐Amyloid Downregulates MDR1‐P‐Glycoprotein (Abcb1) Expression at the Blood‐Brain Barrier in Mice ⬇️

artículo científico publicado el 29 de mayo de 2011

Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application

artículo científico publicado en 2010

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

artículo científico publicado en 2003

CUBN is a gene locus for albuminuria

artículo científico publicado en 2011

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

artículo científico publicado en 2004

Calcium antagonists and deep gingival pockets in the population-based SHIP study

artículo científico publicado en 2005

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

artículo científico publicado en 2004

Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.

artículo científico publicado en 2014

Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5).

artículo científico publicado en 2005

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

artículo científico publicado en 2011

Cohort Profile: The Study of Health in Pomerania

article

Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

artículo científico publicado en 2014

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

artículo científico publicado en 2010

Common variants in Mendelian kidney disease genes and their association with renal function

artículo científico publicado en 2013

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population

artículo científico publicado en 2009

Comparing different scientific approaches to personalized medicine: research ethics and privacy protection.

artículo científico publicado en 2011

Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals

artículo científico publicado en 2009

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report

artículo científico publicado en 2014

Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

artículo científico publicado en 2011

Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents

artículo científico publicado en 2008

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

artículo científico publicado en 2005

Dose optimization of a doxorubicin prodrug (HMR 1826) in isolated perfused human lungs: low tumor pH promotes prodrug activation by beta-glucuronidase

artículo científico publicado en 2002

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

artículo científico

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil

artículo científico publicado en 2010

Drug-drug interactions of beta-adrenoceptor blockers

artículo científico publicado en 2003

Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.

artículo científico publicado en 2002

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

artículo científico publicado en 2011

Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

artículo científico publicado en 2006

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.

artículo científico publicado en 2013

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell

artículo científico publicado en 2010

Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart

artículo científico publicado en 2003

Expression of ABC-type transport proteins in human platelets

artículo científico publicado en 2010

Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival

artículo científico publicado en 2009

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy

artículo científico publicado en 2016

Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus

artículo científico publicado en 2002

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

artículo científico publicado en 2007

Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation

artículo científico publicado en 2005

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

artículo científico publicado en 2004

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

artículo científico publicado en 2016

Genetic evidence of assortative mating in humans

article

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

artículo científico publicado en 2009

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

artículo científico publicado en 2011

Genome-wide association analysis identifies multiple loci related to resting heart rate

artículo científico publicado en 2010

Genome-wide association and functional follow-up reveals new loci for kidney function

artículo científico publicado en 2012

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

artículo científico publicado en 2011

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

artículo científico publicado en 2002

Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters.

artículo científico publicado en 2010

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

artículo científico publicado en 2008

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

artículo científico publicado en 2010

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

artículo científico publicado en 2009

Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications

artículo científico publicado en 2013

In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2) ⬇️

artículo científico publicado el 1 de enero de 2011

In vitro dissolution testing of drug-eluting stents.

artículo científico publicado en 2013

In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release.

artículo científico publicado en 2013

Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania

artículo científico publicado en 2014

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation ⬇️

artículo científico publicado el 6 de enero de 2011

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

artículo científico publicado en 2012

Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

artículo científico publicado en 2006

Involvement of AP-2 binding sites in regulation of human beta-glucuronidase

artículo científico publicado en 2004

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

artículo científico publicado en 2010

MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists

artículo científico publicado en 2006

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier

artículo científico publicado en 2007

Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro

artículo científico publicado en 2011

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Modification of OATP2B1-mediated transport by steroid hormones

artículo científico publicado en 2006

Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy

artículo científico publicado en 2012

New loci associated with kidney function and chronic kidney disease

artículo científico publicado en 2010

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

artículo científico publicado en 2009

Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells

artículo científico publicado en 2004

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide

artículo científico publicado en 2013

Open letter on access to the BIA 10-2474 clinical trial data

artículo científico publicado en 2016

Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta.

artículo científico publicado en 2006

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

artículo científico publicado en 2006

Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression

artículo científico publicado en 2002

Personalized cardiovascular medicine: concepts and methodological considerations.

artículo científico

Pharmacogenomics of heart failure -- focus on drug disposition and action

artículo científico publicado en 2004

Pharmacogenomics: the genetics of variable drug responses

artículo científico publicado en 2011

Pharmacogenomics: will the promise be fulfilled?

artículo científico publicado en 2010

Pharmacokinetics of intravenous etoposide in patients with breast cancer: influence of dose escalation and cyclophosphamide and doxorubicin coadministration

artículo científico publicado en 2002

Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia.

artículo científico publicado en 2011

Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis

artículo científico publicado en 2013

Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches.

artículo científico publicado en 2010

Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation

artículo científico publicado en 2010

Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.

artículo científico publicado en 2010

Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells.

artículo científico publicado en 2007

Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies

artículo científico publicado en 2010

Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy

artículo científico publicado en 2011

Stereoselective disposition of talinolol in man.

artículo científico publicado en 2002

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

artículo científico publicado en 2012

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition

artículo científico publicado en 2006

Tailored surface design of biodegradable endovascular implants by functionalization of poly (L-lactide) with elastin-like proteins

artículo científico publicado en 2015

The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance

artículo científico publicado en 2004

The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart.

artículo científico publicado en 2005

The adhesion and spreading of thrombocyte vesicles on electrode surfaces

artículo científico publicado en 2008

The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy

artículo científico publicado en 2007

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

artículo científico publicado en 2004

The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

artículo científico publicado en 2004

Tooth loss, periodontitis, and statins in a population-based follow-up study

artículo científico publicado en 2013

Transporters in human platelets: physiologic function and impact for pharmacotherapy

artículo científico publicado en 2012

Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

artículo científico publicado en 2006

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

artículo científico publicado en 2005

Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy.

artículo científico publicado en 2012

Verapamil decreases glucuronidase activity in the gut.

artículo científico publicado en 2002

Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes

artículo científico publicado en 2011

β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant

artículo científico publicado en 2010

Lista de obras de Heyo Klaus Kroemer

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3

A genome-wide association study of metabolic traits in human urine

A network-based approach to visualize prevalence and progression of metabolic syndrome components

Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression

Advances in coronary stent technology--active drug-loaded stent surfaces for prevention of restenosis and improvement of biocompatibility.

Antibodies Against Potassium Channel Interacting Protein 2 Induce Necrosis in Isolated Rat Cardiomyocytes

Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.

Beta‐Amyloid Downregulates MDR1‐P‐Glycoprotein (Abcb1) Expression at the Blood‐Brain Barrier in Mice ⬇️

Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

CUBN is a gene locus for albuminuria

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

Calcium antagonists and deep gingival pockets in the population-based SHIP study

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.

Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5).

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

Cohort Profile: The Study of Health in Pomerania

Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Common variants in Mendelian kidney disease genes and their association with renal function

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population

Comparing different scientific approaches to personalized medicine: research ethics and privacy protection.

Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report

Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

Dose optimization of a doxorubicin prodrug (HMR 1826) in isolated perfused human lungs: low tumor pH promotes prodrug activation by beta-glucuronidase

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil

Drug-drug interactions of beta-adrenoceptor blockers

Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell

Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart

Expression of ABC-type transport proteins in human platelets

Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy

Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Genetic evidence of assortative mating in humans

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Genome-wide association analysis identifies multiple loci related to resting heart rate

Genome-wide association and functional follow-up reveals new loci for kidney function

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters.

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications

In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2) ⬇️

In vitro dissolution testing of drug-eluting stents.

In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release.

Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation ⬇️

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

Involvement of AP-2 binding sites in regulation of human beta-glucuronidase

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier

Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Modification of OATP2B1-mediated transport by steroid hormones

Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy

New loci associated with kidney function and chronic kidney disease

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide

Open letter on access to the BIA 10-2474 clinical trial data