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Lista de obras de Varda Rotter

'Cancer associated fibroblasts'--more than meets the eye.

artículo científico publicado en 2013

A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells

article

A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype

artículo científico publicado en 2010

Abelson murine leukemia virus-transformed cells that lack p53 protein synthesis express aberrant p53 mRNA species

artículo científico publicado en 1984

Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

artículo científico publicado en 1999

Activated p53 suppresses the histone methyltransferase EZH2 gene

artículo científico publicado en 2004

Activation of p53 protein by telomeric (TTAGGG)n repeats

artículo científico publicado en 2001

Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer ⬇️

artículo científico publicado el 31 de enero de 2011

Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.

artículo científico publicado en 2007

An insight into the life of p53: a protein coping with many functions! Review of the 9th p53 Workshop, Crete, May 9-13, 1998

scientific article published on 01 November 1998

Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies

artículo científico publicado en 2001

Beyond tumor suppression: p53 controls blastocyst implantation.

artículo científico publicado en 2011

COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.

artículo científico publicado en 1999

Can an iPS cell secure its genomic fidelity?

artículo científico publicado en 2011

Cancer research, a field on the verge of a paradigm shift?

artículo científico publicado en 2012

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.

artículo científico publicado en 2016

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

artículo científico publicado en 2016

Cellular events and the pattern of p53 protein expression following cyclophosphamide-initiated cell death in various organs of developing embryo

artículo científico publicado en 1999

Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits

artículo científico publicado en 2016

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

artículo científico publicado en 2011

Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

artículo científico publicado en 2001

Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.

artículo científico publicado en 2012

Chromosomal Assignment of the Murine Gene Encoding the Transformation-Related Protein p53 ⬇️

artículo científico publicado el 1 de febrero de 1984

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.

artículo científico publicado en 2008

Convergence of logic of cellular regulation in different premalignant cells by an information theoretic approach

artículo científico publicado en 2011

Correction: Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

artículo científico publicado en 2019

Corrigendum to 'p53 balances between tissue hierarchy and anarchy'

artículo científico publicado en 2019

Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate.

artículo científico publicado en 2009

DNA binding and 3′–5′ exonuclease activity in the murine alternatively-spliced p53 protein

scientific article published on 01 August 2002

DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response

artículo científico publicado en 2004

Deconstruction of p53 functions and regulation

artículo científico publicado en 2002

Did experimental biology die? Lessons from 30 years of p53 research.

artículo científico publicado en 2009

Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation ⬇️

artículo científico publicado el 1 de agosto de 1997

Differential influence of normal and cancer-associated fibroblasts on the growth of human epithelial cells in an in vitro cocultivation model of prostate cancer

artículo científico publicado en 2009

Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

artículo científico publicado en 2016

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

scientific article published on 01 May 1999

Discovery of novel proteasome inhibitors using a high-content cell-based screening system

artículo científico publicado en 2009

Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells

artículo científico publicado en 2012

Diverse p53/DNA binding modes expand the repertoire of p53 response elements

artículo científico publicado en 2017

Does wild-type p53 play a role in normal cell differentiation?

artículo científico publicado en 1994

Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy

artículo científico publicado en 2017

Endothelial matrix assembly during capillary morphogenesis: insights from chimeric TagRFP-fibronectin matrix.

artículo científico publicado en 2014

Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension.

artículo científico publicado en 2007

Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

artículo científico publicado en 2012

Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation

artículo científico publicado en 2008

Expression of p53 in human leukemia and lymphoma

scientific article published on 01 July 1986

Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes

artículo científico publicado en 1993

Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.

artículo científico publicado en 2003

Falkor, a novel cell growth regulator isolated by a functional genetic screen

artículo científico publicado en 2002

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis ⬇️

artículo científico

Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis ⬇️

artículo científico publicado en 2009

Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells ⬇️

artículo científico publicado el 25 de noviembre de 2010

High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry

artículo científico publicado en 2017

Human p53 gene localized to short arm of chromosome 17

artículo científico publicado en 1986

Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter

artículo científico publicado en 2004

Identification of gene networks associated with erythroid differentiation

artículo científico publicado en 2009

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

artículo científico publicado en 1998

Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

artículo científico publicado en 2016

Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis.

artículo científico publicado en 1998

In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene

artículo científico publicado en 1985

Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.

artículo científico publicado en 2007

Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences ⬇️

artículo científico publicado el 1 de julio de 1984

Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis.

artículo científico publicado en 2010

Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels.

artículo científico publicado en 1996

Induction of apoptosis and p53 expression in immature thymocytes by direct interaction with thymic epithelial cells

artículo científico publicado en 1996

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense

artículo científico publicado en 1987

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

artículo científico publicado en 2001

Involvement of p53 in cell differentiation and development ⬇️

artículo científico publicado el 8 de agosto de 1997

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein

artículo científico publicado en 1993

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule

artículo científico publicado en 1985

Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?

artículo científico publicado en 2019

Meth A fibrosarcoma cells express two transforming mutant p53 species

artículo científico publicado en 1988

Modulated expression of WFDC1 during carcinogenesis and cellular senescence

artículo científico publicado en 2008

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.

artículo científico publicado en 2014

Modulation of the vitamin D3 response by cancer-associated mutant p53

artículo científico publicado en 2010

Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA.

artículo científico publicado en 2004

Mutant p53 Prolongs NF-kB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II

artículo científico publicado en 2007

Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta

artículo científico publicado en 2013

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

scientific article published on 01 March 2007

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

artículo científico publicado en 2010

Mutant p53 gain of function is interwoven into the hallmarks of cancer

artículo científico publicado en 2011

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

artículo científico publicado en 2018

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

scientific article published on 01 August 2003

Mutant p53 gain-of-function in cancer

artículo científico publicado en 2010

Mutant p53 oncogenicity - dominant-negative or gain-of-function?

artículo científico publicado en 2020

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

artículo científico publicado en 2013

Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction

artículo científico publicado en 2006

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

artículo científico publicado en 1998

Mutant p53 proteins bind DNA abnormally in vitro

artículo científico publicado el 1 de enero de 1991

Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells.

artículo científico publicado en 2010

Mutant p53-a potential player in shaping the tumor-stroma crosstalk

scientific article published on 01 July 2019

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

artículo científico publicado en 2018

Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

artículo científico publicado en 2012

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

artículo científico publicado en 2011

Mutations in the tetramerization domain of p53: more than just keeping monomers apart.

artículo científico publicado en 2009

Myocardin in tumor suppression and myofibroblast differentiation.

artículo científico publicado en 2007

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

artículo científico publicado en 2002

Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.

artículo científico publicado en 2015

Nuclear localization is essential for the activity of p53 protein

artículo científico publicado el 1 de noviembre de 1991

On a fundamental structure of gene networks in living cells

artículo científico publicado en 2012

Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation

artículo científico publicado en 2016

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.

artículo científico publicado en 2014

Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.

artículo científico publicado en 2017

Prevalence of autoantibodies to the p53 protein in autoimmune hepatitis

scientific article published on 01 December 2002

Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.

artículo científico publicado en 2003

Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.

artículo científico publicado en 2009

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

artículo científico publicado en 1984

Regulation of AIF expression by p53.

artículo científico publicado en 2006

Regulation of lipid metabolism by p53 - fighting two villains with one sword.

artículo científico

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

artículo científico publicado en 2006

Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

artículo científico publicado en 2010

Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.

artículo científico publicado en 2014

Retraction: Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function

scientific article published on 01 April 2019

Role of wild type p53 in the G2 phase: regulation of the gamma-irradiation-induced delay and DNA repair

artículo científico publicado en 1997

SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

scientific journal article

Same stem cells but different: Isogenic embryonic stem cells harboring different p53 mutants.

artículo científico publicado en 2011

Single chain antibody against the common epitope of mutant p53 restores wild-type activity to mutant p53 protein

artículo científico publicado en 2005

Spot-1, a novel NLS-binding protein that interacts with p53 through a domain encoded by p(CA)n repeats

artículo científico publicado el 7 de septiembre de 1995

Structural and functional involvement of p53 in BER in vitro and in vivo

artículo científico publicado en 2001

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

artículo científico publicado en 2009

Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminal domain of p53 that recognizes damaged DNA

artículo científico publicado en 2000

TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.

artículo científico publicado en 2016

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model

artículo científico publicado en 2011

TP53 in hematological cancer: low incidence of mutations with significant clinical relevance

artículo científico publicado en 2003

Targeting mutant p53 for cancer therapy

artículo científico publicado en 2016

Testicular Tissue-Specific Expression of the p53 Suppressor Gene ⬇️

artículo científico publicado el 1 de marzo de 1993

The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity

artículo científico publicado en 2009

The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis

artículo científico publicado en 2001

The DNA binding activity of wild type p53 is modulated by blocking its various antigenic epitopes

artículo científico publicado en 1995

The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif

scientific article published on 15 January 2019

The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.

artículo científico publicado en 2018

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

artículo científico publicado en 2003

The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene.

artículo científico publicado en 2009

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

artículo científico publicado en 2014

The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells

artículo científico publicado en 1997

The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein.

artículo científico publicado en 2003

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

artículo científico publicado en 2014

The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.

artículo científico publicado en 2002

The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts

artículo científico publicado en 2003

The paradigm of mutant p53-expressing cancer stem cells and drug resistance

artículo científico

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

artículo científico publicado en 2005

The role of p53 in base excision repair following genotoxic stress

artículo científico publicado en 2003

The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells.

artículo científico publicado en 1996

The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop.

artículo científico publicado en 2001

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

artículo científico publicado en 2004

Transcription regulation by mutant p53.

artículo científico publicado en 2007

Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression.

artículo científico publicado en 2011

Transcriptional control of the proliferation cluster by the tumor suppressor p53.

artículo científico publicado en 2009

Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation

artículo científico publicado en 2005

Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations

artículo científico publicado en 2012

Two promoters that map to 5'-sequences of the human p53 gene are differentially regulated during terminal differentiation of human myeloid leukemic cells

artículo científico publicado en 1989

Unleash the wild type: Restoration of p53 suppressive activity in skin cancer

artículo científico publicado en 2011

Unleash the wild type: restoration of p53 suppressive activity in skin cancer

artículo científico publicado el 1 de marzo de 2011

Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

artículo científico publicado en 2009

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

artículo científico publicado en 2012

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner.

artículo científico publicado en 2018

Visual barcodes for clonal-multiplexing of live microscopy-based assays

artículo científico publicado en 2022

When mutants gain new powers: news from the mutant p53 field.

artículo científico publicado en 2009

Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site

artículo científico publicado en 2007

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

artículo científico publicado en 1993

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif

artículo científico publicado en 1993

c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif

artículo científico publicado en 1993

hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis

artículo científico publicado en 2006

p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.

artículo científico publicado en 2010

p53 and its mutants on the slippery road from stemness to carcinogenesis

artículo científico publicado en 2017

p53 and the Viral Connection: Back into the Future ‡.

artículo científico publicado en 2018

p53 balances between tissue hierarchy and anarchy

scientific article published on 01 July 2019

p53 controls low DNA damage-dependent premeiotic checkpoint and facilitates DNA repair during spermatogenesis

scientific article published on 01 October 1999

p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.

artículo científico publicado en 2011

p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

artículo científico publicado en 2012

p53 in liver pathologies-taking the good with the bad.

artículo científico publicado en 2014

p53 increases experimental metastatic capacity of murine carcinoma cells

artículo científico publicado en 1988

p53 is a regulator of macrophage differentiation.

artículo científico publicado en 2004

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention.

artículo científico publicado en 2010

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

artículo científico publicado en 2013

p53 mediates density-dependent growth arrest.

artículo científico publicado en 2004

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

artículo científico publicado en 2001

p53 on the crossroad between regeneration and cancer

artículo científico publicado en 2016

p53 orchestrates between normal differentiation and cancer.

artículo científico

p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells

artículo científico publicado en 1996

p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

artículo científico publicado en 2008

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

artículo científico publicado en 2013

p53 tumor suppressor gene expression in the mouse ovary during an artificially induced ovulatory cycle

scientific article published on 01 February 1999

p53, a novel regulator of lipid metabolism pathways

p53, a novel regulator of lipid metabolism pathways.

artículo científico publicado en 2011

p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

artículo científico publicado en 2008

p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53

artículo científico publicado en 2000

p53-dependent down-regulation of telomerase is mediated by p21waf1.

artículo científico publicado en 2004

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

scientific journal article

p53: balancing tumour suppression and implications for the clinic

artículo científico publicado en 2009

p53: the barrier to cancer stem cell formation.

artículo científico publicado en 2014

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model

artículo científico publicado en 2013

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