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Lista de obras de Herbert Waldmann

"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors

artículo científico publicado en 2008

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

artículo científico publicado en 2015

(S)-3-[(R)-2,4-Dimethylpent-4-enoyl]-4-isopropyl-5,5-diphenyl-1,3-oxazolidin-2-one

(S)-Proline benzyl ester as chiral auxiliary in Lewis acid catalyzed asymmetric Diels-Alder reactions

article

1,3-Dithian-2-yl Methyl Ester as Two-Step Protecting Group for the Carboxy Function in Peptide Synthesis

scholarly article by Horst Kunz & Herbert Waldmann published January 1983 in Angewandte Chemie International Edition

1,3-Dithian-2-ylmethyl esters as two-step carboxy-protecting groups in the synthesis of N-glycopeptides

article by Herbert Waldmann & Horst Kunz published September 1988 in Journal of Organic Chemistry

1H High-Resolution Magic Angle Spinning NMR Spectroscopy for the Investigation of a Ras Lipopeptide in a Lipid Membrane This work was supported by the Deutsche Forschungsgemeinschaft (SFB 197 and Innovationskolleg "Chemisches Signal und biologische A

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

artículo científico publicado en 2005

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics

artículo científico publicado en 2016

A Cyclization-Rearrangement Cascade for the Synthesis of Structurally Complex Chiral Gold(I)-Aminocarbene Complexes

scientific article published on 07 July 2014

A Highly Efficient Strategy for Modification of Proteins at the C Terminus

artículo científico publicado en 2010

A Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase

artículo científico publicado en 2007

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

artículo científico publicado en 2017

A Protein Fluorescence Amplifier: Continuous Fluorometric Assay for Rab Geranylgeranyltransferase

artículo científico publicado en 2006

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

artículo científico publicado en 2010

A crowdsourcing evaluation of the NIH chemical probes

artículo científico publicado en 2009

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

artículo científico publicado en 2012

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

artículo científico publicado en 2009

A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

A generic building block for C- and N-terminal protein-labeling and protein-immobilization

artículo científico publicado en 2006

A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins

scientific article published on 01 January 2005

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.

artículo científico publicado en 2017

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.

artículo científico publicado en 2012

A new access to chiral 2-furylcarbinols by enantioselective hydrolysis with penicillin acylase

article published in 1989

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

scientific article published on 27 October 2020

A small-molecule screening strategy to identify suppressors of statin myopathy

artículo científico publicado en 2011

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds

artículo científico publicado en 2008

Acid-labile protecting groups for the synthesis of lipidated peptides

artículo científico publicado en 2001

Activation of glycosyl phosphates by in situ conversion to glycosyl iodides under neutral conditions in concentrated solutions of lithium perchlorate in organic solvents

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

artículo científico publicado en 2010

Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity.

artículo científico publicado en 2016

Aldolase-catalyzed synthesis of complex C8 and C9 monosaccharides

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II

artículo científico publicado en 2001

Allyl esters as carboxy protecting groups in the synthesis of O-glycopeptides

article published in 1989

Amino Acid Esters as Chiral Auxiliary Groups in Lewis Acid Catalyzed Reactions of Electron-rich Siloxydienes with Imines

scholarly article by Herbert Waldmann et al published December 1990 in Angewandte Chemie International Edition

An Enzyme-Labile Linker Group for Organic Syntheses on Solid Supports.

artículo científico publicado en 1998

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

artículo científico publicado en 2005

An enantioselective inverse-electron-demand imino Diels-Alder reaction.

artículo científico publicado en 2014

An enzymatic protecting group strategy for the synthesis of nucleopeptides

An enzyme-initiated domino hydroxylation-oxidation-carbo-diels-alder reaction cascade

An optimised small-molecule stabiliser of the 14-3-3-PMA2 protein-protein interaction

artículo científico publicado en 2012

An oxidation-labile traceless linker for solid-phase synthesis

artículo científico publicado en 1999

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

artículo científico publicado en 2009

Anti-angiogenic properties of a sulindac analogue

artículo científico publicado en 2007

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

artículo científico publicado en 2005

Applications of protein biochips in biomedical and biotechnological research

artículo científico publicado en 2009

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

artículo científico publicado en 2011

Asymmetric Control in the Pictet–Spengler Reaction by Means ofN-Protected Amino Acids as Chiral Auxiliary Groups

Asymmetric Control of 1,3-Dipolar Cycloaddition Reactions with Azomethine Ylides by Means of Proline Esters as Chiral Auxiliary Groups

Asymmetric Hetero Diels-Alder Reactions

Asymmetric Pictet-Spengler reactions employing amino acid esters as mediators of selectivity

Asymmetric Pictet–Spengler Reactions EmployingN,N-Phthaloyl Amino Acids as Chiral Auxiliary Groups

Asymmetric Synthesis of Highly Substituted Pyrrolidines by 1,3-Dipolar Cycloadditions of Azomethine Ylides withN-Acryloylproline Benzyl Ester

scholarly article by Herbert Waldmann et al published 31 March 1994 in Angewandte Chemie International Edition

Asymmetric Synthesis of the Nakijiquinones-Selective Inhibitors of the Her-2/Neu Protooncogene

artículo científico publicado en 1999

Asymmetric aza Diels-Alder reactions of amino acid ester imines with Brassard's diene

Asymmetric solid-phase synthesis of 6,6-spiroketals

artículo científico publicado en 2004

Asymmetric steering of the Pictet-Spengler reaction by means of amino acid esters as chiral auxiliary groups

Asymmetric synthesis of highly functionalized tetracyclic indole bases embodying the basic skeleton of yohimbine- and reserpine type alkaloids

Asymmetric synthesis of indolo[2,3-a]quinolizidin-2-ones - congeners to yohimbine-type alkaloids

Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction

artículo científico publicado en 2008

Asymmetric tandem Mannich-Michael reactions of amino acid ester imines with Danishefsky's diene

article published in 1992

At the crossroads of chemistry and biology

scientific article published on 01 July 2003

BIOS: Similarity-based design of natural product derived compound collections

artículo científico publicado en 2008

Backbone conformational flexibility of the lipid modified membrane anchor of the human N-Ras protein investigated by solid-state NMR and molecular dynamics simulation

artículo científico publicado en 2009

Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

artículo científico publicado en 2008

Bioactivity-guided mapping and navigation of chemical space.

artículo científico publicado en 2009

Biocatalysis and biotransformation

artículo científico publicado en 1999

Biocatalysts as chemo- and regioselecting tools in organic synthesis

article

Biology-Oriented Synthesis of 3,3-Spiro(2-tetrahydrofuranyl)oxindoles

Biology-Oriented Synthesis of Stereochemically Diverse Natural-Product-Derived Compound Collections by Iterative Allylations on a Solid Support

artículo científico publicado en 2007

Biology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling

scientific article published on 03 March 2015

Biology-inspired synthesis of compound libraries

artículo científico publicado en 2008

Biology-oriented combined solid- and solution-phase synthesis of a macroline-like compound collection

artículo científico publicado en 2009

Biology-oriented synthesis

artículo científico publicado en 2011

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

artículo científico publicado en 2011

Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization

artículo científico publicado en 2013

Biology-oriented synthesis of benzopyrano[3,4- c ]pyrrolidines

artículo científico publicado en 2015

Biology-oriented synthesis: harnessing the power of evolution

artículo científico publicado en 2014

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction.

artículo científico publicado en 2000

Bioorthogonal chemistry for site-specific labeling and surface immobilization of proteins

artículo científico publicado en 2011

Biphenomycin B and derivatives: total synthesis and translation inhibition.

artículo científico publicado en 2011

Boron-based inhibitors of acyl protein thioesterases 1 and 2.

artículo científico publicado en 2012

Bridging the gap between cell biology and organic chemistry: chemical synthesis and biological application of lipidated peptides and proteins

article

Brunsvicamides A−C: Sponge-Related Cyanobacterial Peptides withMycobacteriumtuberculosisProtein Tyrosine Phosphatase Inhibitory Activity

Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes

C2-Symmetric Bicyclic Diols as Chiral Ligands in the titanate-catalyzed enantioselective addition of alkylzinc reagents to aldehydes

article

Cascade Syntheses Routes to the Centrocountins

Catalytic Aerobic Oxidation and Tandem Enantioselective Cycloaddition in Cascade Multicomponent Synthesis

artículo científico publicado en 2015

Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity

artículo científico publicado en 2018

Catalytic asymmetric exo-selective [6+3] cycloaddition of iminoesters with fulvenes.

artículo científico publicado en 2013

Catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis

artículo científico publicado en 2014

Catalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling.

artículo científico publicado en 2013

Charting Biological and Chemical Space: PSSC and SCONP as Guiding Principles for the Development of Compound Collections Based on Natural Product Scaffolds

article

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

artículo científico publicado en 2005

Charting, navigating, and populating natural product chemical space for drug discovery

artículo científico publicado en 2012

Chemical Biology Education at Dortmund: A Joint Endeavor with a Max Planck Institute

Chemical Genetics Reveals a Role of dCTP Pyrophosphatase 1 in Wnt Signaling

artículo científico publicado en 2019

Chemical biology of lipidated proteins

artículo científico publicado en 2012

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

artículo científico publicado en 2005

Chemical biology tools for regulating RAS signaling complexity in space and time

artículo científico publicado en 2014

Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis

artículo científico publicado en 2008

Chemical strategies for generating protein biochips

artículo científico publicado en 2008

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery

artículo científico publicado en 2012

Cheminformatic Analysis of Natural Products and their Chemical Space

article

Chemo-enzymatic synthesis of the C15 C23 unit of Leptomycin B

Chemoenzymatic Synthesis of Fluorescent N-Ras Lipopeptides and Their Use in Membrane Localization Studies in Vivo

Chemoenzymatic Synthesis of N-RasLipopeptides

scientific article published in 1998

Chemoenzymatic Synthesis of a Characteristic Phosphopeptide Fragment of the Raf-1 Kinase

Chemoenzymatic Synthesis of a Characteristic Phosphorylated and Glycosylated Peptide Fragment of the Large Subunit of Mammalian RNA Polymerase II

artículo científico publicado en 1997

Chemoenzymatic synthesis of O-glycopeptides carrying the tumor associated TN-antigen structure

artículo científico publicado en 1993

Chemoenzymatic synthesis of a biotin-labeled glycophosphononapeptide of the c-Myc oncoprotein

Chemoenzymatic synthesis of nucleopeptides

Chiral Titanium Alkoxides as Catalysts for the Enantioselective Reduction of Ketones with Boranes

scholarly article by Guido Giffels et al published 2 October 1995 in Angewandte Chemie International Edition

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

artículo científico publicado en 2012

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3 ⬇️

Combinatorial development of chiral phosphoramidite-ligands for enantioselective conjugate addition reactions

artículo científico publicado en 2002

Compound library development guided by protein structure similarity clustering and natural product structure

artículo científico publicado en 2004

Construction of DisaccharideN-Glycopeptides?Synthesis of the Linkage Region of the Transmembrance-Neuraminidase of an Influenza Virus

scholarly article by Horst Kunz & Herbert Waldmann published October 1985 in Angewandte Chemie International Edition

Construction of the tricyclic benzoquinolizine ring system by combination of a tandem Mannich-Michael reaction with a Heck reaction

Correction to "Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators"

artículo científico publicado en 2020

Corrigendum: Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides

scholarly article published in Angewandte Chemie International Edition

Covalent Protein Labeling at Glutamic Acids

artículo científico publicado en 2017

Cross-Linked Enzyme Crystals (CLECs) - powerful biocatalysts for synthetic chemistry

Cross-Linked Enzyme Crystals(CLECs): Efficient and Stable Biocatalysts for Preparative Organic Chemistry

article

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

artículo científico publicado en 2012

Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase

artículo científico publicado en 2001

C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors

C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors

scholarly article by Gang Shan et al published 11 October 2018 in Angewandte Chemie International Edition

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach

artículo científico publicado en 2011

Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).

artículo científico publicado en 2005

Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

scientific article published on 28 August 2019

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

artículo científico publicado en 2009

Development and Biological Evaluation of Acyl Protein Thioesterase 1 (APT1) Inhibitors

article

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

artículo científico publicado en 2016

Development of a PDEδ-Targeting PROTACs that Impair Lipid Metabolism

scientific article published on 22 January 2020

Development of a natural-product-derived chemical toolbox for modulation of protein function

artículo científico

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

artículo científico publicado en 2011

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

artículo científico publicado en 2003

Development of new acid-functionalized resins for combinatorial synthesis on solid supportsElectronic supplementary information (ESI) available: experimental section. See http://www.rsc.org/suppdata/cc/b2/b204423d/

article

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

artículo científico publicado en 2008

Development of selective, potent RabGGTase inhibitors

artículo científico publicado en 2012

Development of tau aggregation inhibitors for Alzheimer's disease

artículo científico publicado en 2009

Development of the traceless phenylhydrazide linker for solid-phase synthesis

artículo científico publicado en 2003

Diels-Alder ligation and surface immobilization of proteins.

artículo científico publicado en 2005

Diels–Alder Ligation of Peptides and Proteins

Direct Modulation of Small GTPase Activity and Function

artículo científico

Direct immobilization of oxyamine-modified proteins from cell lysates.

artículo científico publicado en 2012

Direct mass spectrometric monitoring of solid phase organic syntheses

artículo científico publicado en 2003

Direct targeting of Rab-GTPase-effector interactions

artículo científico publicado en 2014

Directed stereoselective synthesis of α- and β-N-acetyl neuraminic acid–galactose disaccharides using 2-choro and 2-fluoro derivatives of neuraminic acid allyl ester

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

artículo científico publicado en 2005

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.

artículo científico publicado en 2017

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction

artículo científico publicado en 2017

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis

artículo científico publicado en 2008

Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection

artículo científico publicado en 2013

Discovery of neuritogenic compound classes inspired by natural products

artículo científico publicado en 2013

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

artículo científico publicado en 2006

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

scientific article published on 31 August 2020

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

scientific article published on 04 October 2019

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

artículo científico publicado en 2018

Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator

artículo científico publicado en 2024

Dissociation of the K-Ras4B/PDEδ Complex upon Contact with Lipid Membranes: Membrane Delivery Instead of Extraction

article

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

artículo científico publicado en 2016

Divergent Gold(I)-Catalyzed Skeletal Rearrangements of 1,7-Enynes

article published in 2015

Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A.

artículo científico publicado en 2015

Editorial: Drug Discovery …︁ The Third in the Band!

scholarly article by Herbert Waldmann published 30 March 2012 in Angewandte Chemie International Edition

Efficient Solid-Phase Lipopeptide Synthesis Employing the Ellman Sulfonamide Linker

scholarly article by Jose M. Palomo et al published 9 January 2006 in Angewandte Chemie International Edition

Efficient enantioselective synthesis of a β-hydroxyepoxide building block for the construction of macrocyclic natural products

Efficient microwave-assisted synthesis of unsymmetrical disulfides

artículo científico publicado en 2010

Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition

artículo científico publicado en 2016

Enantioselective Catalysis on the Solid Phase: Synthesis of Natural Product-Derived Tetrahydropyrans Employing the Enantioselective Oxa-Diels–Alder Reaction

scholarly article by Miguel A. Sanz et al published August 2006 in Advanced Synthesis & Catalysis

Enantioselective Construction of Highly Functionalized Indoloquinolizines—congeners to Polycyclic Indole Alkaloids

Enantioselective Formal C(sp3 )−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives

artículo científico publicado en 2018

Enantioselective Formal C(sp3 )−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives

Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity

artículo científico publicado en 2017

Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex

artículo científico publicado en 2020

Enantioselective Synthesis of the C10–C20Fragment of Fusicoccin A

Enantioselective Synthesis of the Spiro-Tropanyl Oxindole Scaffold Through Bimetallic Relay Catalysis

artículo científico publicado en 2018

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis

Enantioselective synthesis of the spirotryprostatin A scaffold

Enantioselective synthesis on the solid phase

artículo científico publicado en 2006

Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A.

artículo científico publicado en 2001

Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity

artículo científico publicado en 2005

Enhancement of the enantioselectivity of penicillin G acylase from E. coli by “substrate tuning”

scholarly article by Torsten Pohl & Herbert Waldmann published April 1995 in Tetrahedron Letters

Enzymatic Protecting Group Techniques in bioorganic synthesis

Enzymatic Synthesis of Peptides andRas Lipopeptides Employing Choline Ester as a Solubilizing, Protecting, and Activating Group

scholarly article by Michael Schelhaas et al published 19 January 1996 in Angewandte Chemie International Edition

Enzymatic Synthesis of a Characteristic Phosphorylated and Glycosylated Peptide Fragment of the Large Subunit of Mammalian RNA Polymerase II

Enzymatic protecting group techniques

artículo científico publicado en 2001

Enzymatically cleavable linker groups in polymer-supported synthesis

artículo científico publicado en 2002

Enzymes and protecting group chemistry

artículo científico publicado en 1998

Enzymic Protecting Group Techniques

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1

artículo científico publicado en 2016

Erratum: A crowdsourcing evaluation of the NIH chemical probes

article

Erratum: Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

scholarly article published in Nature Chemical Biology

Exploiting the Substrate Tolerance of Farnesyltransferase for Site-Selective Protein Derivatization

scholarly article by Uyen T. T. Nguyen published in March 2007

Exploring Natural Product Fragments for Drug and Probe Discovery

artículo científico publicado en 2017

Exploring and exploiting biologically relevant chemical space

artículo científico publicado en 2011

Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma

artículo científico publicado en 1999

Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations

artículo científico publicado en 2007

Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro

artículo científico publicado en 2012

Flexible total synthesis of biphenomycin B.

artículo científico publicado en 2008

Fluorogenic probes for live-cell imaging of the cytoskeleton

artículo científico publicado en 2014

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

artículo científico publicado en 2002

Gamma-pyrone natural products--a privileged compound class provided by nature

artículo científico publicado en 2008

General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands

artículo científico publicado en 2017

General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands

Generation of live-cell microarrays by means of DNA-Directed immobilization of specific cell-surface ligands

artículo científico publicado en 2007

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins

artículo científico publicado en 2013

Gold(I)-Catalyzed Synthesis of Benzoxocines by an 8-endo-dig Cyclization

scholarly article by Kathrin Wittstein et al published 22 August 2011 in Angewandte Chemie International Edition

Gold(III)-Mediated Aldol Condensations Provide Efficient Access to Nitrogen Heterocycles

artículo científico publicado en 2008

Guided by Evolution: Biology-Oriented Synthesis of Bioactive Compound Classes

scholarly article by Herbert Waldmann & George Karageorgis published 11 October 2018 in Synthesis

Guided by evolution: from biology oriented synthesis to pseudo natural products

artículo científico publicado en 2020

Hide and seek: Identification and confirmation of small molecule protein targets

artículo científico publicado en 2015

Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

scientific article published on 01 April 2013

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors

artículo científico publicado en 2017

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors

Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides

artículo científico publicado en 2012

Highly Enantioselective Intramolecular 1,3-Dipolar Cycloaddition: A Route to Piperidino-Pyrrolizidines

artículo científico publicado en 2014

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

artículo científico publicado en 2010

Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

article

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

artículo científico publicado en 2006

Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions

artículo científico publicado en 2010

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

artículo científico publicado en 2011

Identification of Quinolinols as Activators of TEAD-Dependent Transcription

scientific article published on 02 December 2019

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

artículo científico publicado en 2017

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion

artículo científico publicado en 2017

Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line.

artículo científico publicado en 2004

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).

artículo científico publicado en 2007

Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library

artículo científico publicado en 2003

Identification of novel PDEδ interacting proteins

artículo científico publicado en 2017

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

artículo científico publicado en 2004

Identification of pyrazolopyridazinones as PDEδ inhibitors

artículo científico publicado en 2016

Identification of siRNA delivery enhancers by a chemical library screen

artículo científico publicado en 2015

Identification of the targets of biologically active small molecules using quantitative proteomics

artículo científico publicado en 2015

Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B.

artículo científico publicado en 2010

Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor

scientific article published on 24 January 2020

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

artículo científico publicado en 2012

Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell-Cycle Blockers

scholarly article by Frank Wehner published in February 2008

Influence of serine O-glycosylation or O-phosphorylation close to the vJun nuclear localisation sequence on nuclear import

artículo científico publicado en 2006

Influence of the lipid anchor motif of N-ras on the interaction with lipid membranes: a surface plasmon resonance study

artículo científico publicado en 2010

Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains

artículo científico publicado en 2009

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

artículo científico publicado en 2011

Inhibition of Rab Prenylation

article published in 2011

Inhibition of angiogenesis-relevant receptor tyrosine kinases by sulindac analogues

artículo científico publicado en 2005

Inhibitors of protein tyrosine phosphatases: next-generation drugs?

artículo científico publicado en 2005

Insertion of lipidated Ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS).

artículo científico publicado en 2006

Intein-mediated in vitro synthesis of lipidated Ras proteins

artículo científico publicado en 2005

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

artículo científico publicado en 2002

Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators

artículo científico publicado en 2007

Interaction of the human N-Ras protein with lipid raft model membranes of varying degrees of complexity

article

Interactive exploration of chemical space with Scaffold Hunter

artículo científico publicado en 2009

Invited Review Chemoenzymatic Synthesis of Lipidated Peptides

article

Killing 84 birds with one stone

Lateral Organization of Host Heterogeneous Raft-Like Membranes Altered by the Myristoyl Modification of Tyrosine Kinase c-Src

artículo científico publicado en 2017

Lewis Base Catalyzed [4+2] Annulation of Electron-Deficient Chromone-Derived Heterodienes and Acetylenes

LiClO4 and Organic Solvents - a powerful combination. 15

article

LiClO4 in Ether—an Unusual Solvent

scholarly article by Herbert Waldmann published October 1991 in Angewandte Chemie International Edition

Ligand-directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems

artículo científico publicado en 2017

Ligandengesteuerte divergente Synthese von carbo- und heterocyclischen Ringsystemen

article published in 2018

Linking chemistry and biology for the study of protein function

artículo científico publicado en 2007

Linking the fields--the interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation

artículo científico publicado en 2000

Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR.

artículo científico publicado en 2005

Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function

Lipidated peptide synthesis

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

artículo científico publicado en 2006

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Lipoprotein insertion into membranes of various complexity: lipid sorting, interfacial adsorption and protein clustering

artículo científico publicado en 2016

Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments

artículo científico publicado en 2020

Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase

scientific article published on 01 February 2001

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

artículo científico publicado en 2009

Membrane binding of a lipidated N-Ras protein studied in lipid monolayers

Membrane binding of lipidated Ras peptides and proteins--the structural point of view

artículo científico publicado en 2008

Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy

artículo científico publicado en 2003

Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes

artículo científico publicado en 2010

Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms

artículo científico publicado en 2010

Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

artículo científico publicado en 2014

Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues

artículo científico publicado en 2005

Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog.

artículo científico publicado en 2005

Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker

artículo científico publicado en 2003

N-Ras forms dimers at POPC membranes

artículo científico publicado en 2012

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells ⬇️

artículo científico publicado en 2017

Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

artículo científico publicado en 2002

Natural product fragment combination to performance-diverse pseudo-natural products

artículo científico publicado en 2021

Natural product guided compound library development

artículo científico publicado en 2002

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification

artículo científico publicado en 2017

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase

artículo científico publicado en 2007

Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

artículo científico publicado en 2002

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

Natural-product-derived fragments for fragment-based ligand discovery

artículo científico publicado en 2013

Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4

artículo científico publicado en 2015

Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.

artículo científico publicado en 2016

Novel approaches to map small molecule-target interactions.

artículo científico publicado en 2016

Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators

scientific article published on 26 August 2019

O-Glycoside Syntheses under Neutral Conditions in Concentrated Solutions of LiClO4 in Organic Solvents

scholarly article by Herbert Waldmann et al published 17 October 1994 in Angewandte Chemie International Edition

On the enhancement of stereoselection by cooperation between chiral auxiliaries. Asymmetric diels-alder reactions with fumaric acid bis ((S)-proline benzyl ester) amide

One-Pot Dual-Labeling of a Protein by Two Chemoselective Reactions

scientific article published on 14 July 2011

One-pot synthesis of a natural product inspired pyrrolocoumarine compound collection by means of an intramolecular 1,3-dipolar cycloaddition as key step

Optimization of three- and four-component reactions for polysubstituted piperidines: application to the synthesis and preliminary biological screening of a prototype library

artículo científico publicado en 2007

Organization and Function of the Rab Prenylation and Recycling Machinery

Oriented Immobilization of Farnesylated Proteins by the Thiol-Ene Reaction

artículo científico publicado en 2010

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

artículo científico publicado en 2016

Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation

artículo científico publicado en 2004

Peptide conjugates as tools for the study of biological signal transduction

artículo científico publicado en 1999

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

artículo científico publicado en 2017

Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization.

artículo científico publicado en 2015

Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis

artículo científico publicado en 2002

Phosphine-catalyzed dearomatizing [3+2] annulations of isoquinolinium methylides with allenes.

artículo científico publicado en 2015

Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II

artículo científico publicado en 2000

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions

artículo científico publicado en 2018

Photoactivatable synthetic Ras proteins: "baits" for the identification of plasma-membrane-bound binding partners of Ras.

artículo científico publicado en 2002

Photochemical surface patterning by the thiol-ene reaction

artículo científico publicado en 2008

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels ⬇️

artículo científico publicado en 2017

Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species

artículo científico publicado en 2014

Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.

artículo científico publicado en 2006

Polymer supported synthesis of a natural product-inspired oxepane library

artículo científico publicado en 2014

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

artículo científico publicado en 2015

Preface

Preface

scientific article published in 1997

Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization

artículo científico publicado en 2010

Pressure modulation of Ras-membrane interactions and intervesicle transfer

artículo científico publicado en 2013

Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.

artículo científico publicado en 2012

Principle and design of pseudo-natural products

artículo científico publicado en 2020

Principles, implementation, and application of biology-oriented synthesis (BIOS).

artículo científico publicado en 2010

Programmable enantioselective one-pot synthesis of molecules with eight stereocenters

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

artículo científico publicado en 2016

Protecting Group Strategies in Organic Synthesis

article

Protein Biochips: Oriented Surface Immobilization of Proteins

article by Po-Chiao Lin et al published 19 January 2010 in Macromolecular Chemistry and Physics

Protein structure similarity as guiding principle for combinatorial library design.

artículo científico publicado en 2003

Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.

artículo científico publicado en 2005

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

artículo científico publicado en 2005

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

artículo científico publicado en 2006

Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay

artículo científico publicado en 2012

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

artículo científico publicado en 2012

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI

artículo científico publicado en 2012

RAF kinase inhibitors in cancer treatment: like a bull in a China shop?

artículo científico publicado en 2010

Rab GTPase prenylation hierarchy and its potential role in choroideremia disease

artículo científico publicado en 2013

Rabbit muscle aldolase as a catalyst in organic synthesis

article

Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

artículo científico publicado en 2008

Raft protein clustering alters N-Ras membrane interactions and activation pattern.

artículo científico publicado en 2011

Reagent-controlled domino synthesis of skeletally-diverse compound collections

artículo científico publicado en 2008

Regioselectivity in the Formation of Small- and Medium-Sized Cyclic Ethers by Diene-Ene Ring-Closing Metathesis

Regulation of K-Ras4B Membrane Binding by Calmodulin

artículo científico publicado en 2016

Revealing conformational substates of lipidated N-Ras protein by pressure modulation

artículo científico publicado en 2011

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

artículo científico publicado en 2015

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

artículo científico publicado en 2007

Rhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids

artículo científico publicado en 2015

Rotational and Translational Dynamics of Ras Proteins upon Binding to Model Membrane Systems

article

S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts

artículo científico publicado en 1997

SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.

artículo científico publicado en 2004

Scaffold Hunter – Interactive Exploration of Chemical Space

Schutzgruppenstrategien in der organischen Synthese

article

Secondary structure of lipidated Ras bound to a lipid bilayer

artículo científico publicado en 2008

Selective Inhibition of Receptor Tyrosine Kinases by Synthetic Analogues of Aeroplysinin

Selective chemical imaging of static actin in live cells

artículo científico publicado en 2012

Selective enzymatic removal of protecting groups: The phenylacetamide as amino protecting group in phosphopeptide synthesis

article published in 1996

Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues

artículo científico publicado en 2010

Site-Selective Protein Immobilization by Staudinger Ligation

artículo científico publicado en 2006

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.

artículo científico publicado en 2017

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

artículo científico publicado en 2013

Small-Molecule Inhibition of Glucose Transporters GLUT-1-4

scientific article published on 08 November 2019

Small-Molecule Inhibition of the UNC119-Cargo Interaction

artículo científico publicado en 2017

Small-Molecule Target Engagement in Cells

artículo científico publicado en 2016

Small-molecule inhibition of APT1 affects Ras localization and signaling

artículo científico publicado en 2010

Small-molecule inhibitors of islet amyloid polypeptide fibril formation

artículo científico publicado en 2008

Small-molecule modulation of Ras signaling

artículo científico publicado en 2014

Small-molecule phenotypic screening with stem cells

artículo científico

Solid phase synthesis of a spiro[5.5]ketal library

artículo científico publicado en 2005

Solid phase synthesis of cyclic peptides by oxidative cyclative cleavage of an aryl hydrazide linker—synthesis of stylostatin 1

Solid phase synthesis of highly substituted tetrahydropyrans by tandem ene-reaction/intramolecular Sakurai cyclization

artículo científico publicado en 2007

Solid-Phase Synthesis of Decalin Scaffolds by Robinson Annulation with Immobilised Nazarov Reagents

Solid-Phase Synthesis of Lipidated Peptides

Solid-Phase Synthesis of Lipidated Peptides

scholarly article by Goran Kragol et al published 5 November 2004 in Angewandte Chemie International Edition

Solid-Phase Synthesis of Lipidated Ras Peptides Employing the Ellman Sulfonamide Linker

Solid-Phase Synthesis of Peptide Esters Employing the Hydrazide Linker

Solid-Phase Synthesis of [5.5]-Spiroketals

scholarly article by Stefan Sommer et al published 4 August 2008 in Advanced Synthesis & Catalysis

Solid-Support Based Total Synthesis and Stereochemical Correction of Brunsvicamide A

article by Thilo Walther et al published August 2008 in Organic Letters

Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions

artículo científico publicado en 2007

Solid-phase based total synthesis of Jasplakinolide by ring-closing metathesis.

artículo científico publicado en 2009

Solid-phase development of chiral phosphoramidite ligands for enantioselective conjugate addition reactions

artículo científico publicado en 2002

Solid-phase synthesis and biological evaluation of a pepticinnamin E library

artículo científico publicado en 2002

Solid-phase synthesis of a pepticinnamin E library

artículo científico publicado en 2003

Solid-phase synthesis of benzodiazepinediones mimicking the C-terminus of the H-Ras protein

Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors

artículo científico publicado en 2002

Solid-phase synthesis of lipidated peptides

artículo científico publicado en 2002

Solid-phase synthesis of palmitoylated and farnesylated lipopeptides employing the fluoride-labile PTMSEL linker

Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B.

artículo científico publicado en 2002

Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins

scholarly article by Tom Mejuch published in October 2015

Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays

artículo científico publicado en 2003

Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase

artículo científico publicado en 2006

Stereoselective allylation of aldehydes on solid support and its application in biology-oriented synthesis (BIOS)

article published in 2007

Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library

artículo científico publicado en 2015

Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide

Stereospecific CC-bond formation with rabbit muscle aldolase - A chemoenzymatic synthesis of (+)-exo-brevicomin

Structural Model of the Membrane-Bound C Terminus of Lipid-Modified Human N-Ras Protein

article

Structure assignment, total synthesis, and evaluation of the phosphatase modulating activity of glucolipsin A.

artículo científico publicado en 2004

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

artículo científico publicado en 2014

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

artículo científico publicado en 2003

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

artículo científico publicado en 2003

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

artículo científico publicado en 2006

Structure-based development of PDEδ inhibitors

artículo científico publicado en 2016

Structure-guided development of selective RabGGTase inhibitors

artículo científico publicado en 2011

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

artículo científico publicado en 2008

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

artículo científico publicado en 2004

Surface immobilization of biomolecules by click sulfonamide reaction

article by Thimmaiah Govindaraju et al published 2008 in Chemical Communications

Synthesis and Application of Fluorescence-Labeled Ras-Proteins for Live-Cell Imaging

artículo científico publicado en 2004

Synthesis and Membrane-Binding Properties of a Characteristic Lipopeptide from the Membrane-Anchoring Domain of Influenza Virus A Hemagglutinin This research was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie

artículo científico publicado en 2001

Synthesis and application of fluorescent ras proteins for live-cell imaging

artículo científico publicado en 2005

Synthesis and biological activity of photoactivatable N-ras peptides and proteins

artículo científico publicado en 2003

Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

artículo científico publicado en 1998

Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors

artículo científico publicado en 2004

Synthesis and biological evaluation of cytostatin analogues

artículo científico publicado en 2003

Synthesis and conformational analysis of stevastelin C3 analogues and their activity against the dual-specific vaccina H1-related phosphatase

artículo científico publicado en 2008

Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors

artículo científico publicado en 2006

Synthesis and evaluation of the antitumor agent TMC-69-6H and a focused library of analogs

Synthesis and membrane binding properties of a lipopeptide fragment from influenza virus a hemagglutinin

artículo científico publicado en 2002

Synthesis and structure-activity correlation of a brunsvicamide-inspired cyclopeptide collection

artículo científico publicado en 2009

Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin

artículo científico publicado en 2010

Synthesis of 2-acetamido-2-deoxyglucosylasparagine glyco-tripeptides and -pentapeptides by selective C- and N-terminal elongation of the peptide chain

scientific article published on 01 February 1990

Synthesis of 2-deoxy and 2,6-dideoxy glycosides under neutral conditions in LiClO4/Et2O mixtures

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of GTP-derived Ras ligands

artículo científico publicado en 2004

Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3

artículo científico publicado en 2019

Synthesis of Lipidated Proteins

artículo científico publicado en 2016

Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC)

Synthesis of a triply phosphorylated pentapeptide from human tau-protein

artículo científico publicado en 2000

Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors

scientific article published on 15 July 2016

Synthesis of analogs of 1,3-dihydroxyacetone phosphate and glyceraldehyde 3-phosphate for use in studies of fructose-1,6-diphosphate aldolase

Synthesis of characteristic H-Ras lipopeptides by employing noble-metal-, acid-, and reduction-labile blocking groups

artículo científico publicado en 2000

Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase

artículo científico publicado en 1997

Synthesis of characteristic palmitoylated lipopeptides from human Y1 receptor by a combination of enzyme-labile and Pd(0)-sensitive protecting groups

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

artículo científico publicado en 2004

Synthesis of functional Ras lipoproteins and fluorescent derivatives

artículo científico publicado en 2001

Synthesis of glycosides of fucose under neutral conditions in solutions of LiClO4 in organic solvents

article

Synthesis of lipidated peptides

artículo científico publicado en 2004

Synthesis of natural product inspired compound collections

artículo científico publicado en 2009

Synthesis of novel electron-deficient chromone-fused dienes via phosphine catalyzed [4+2] annulation

Synthesis of nucleopeptides by an enzyme labile urethane protecting group

Synthesis of palmitoylated Ras-peptides and -proteins

artículo científico publicado en 2006

Synthesis of the (9S,18R) Diastereomer of Cyclamenol A This research was supported by the Bayer AG and the Fonds der chemischen Industrie

artículo científico publicado en 2000

Synthesis of the (9S,18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A

Synthesis of the B-seco limonoid core scaffold

artículo científico publicado en 2014

Synthesis of the B-seco limonoid scaffold

scientific article published on 09 May 2011

Synthesis of the Glycopeptide Partial Sequence A80-A84 of Human Fibroblast Interferon

scholarly article by Horst Kunz & Herbert Waldmann published 15 May 1985 in Helvetica Chimica Acta

Synthesis of the Palmitoylated and Farnesylated C-Terminal Lipohexapeptide of the Human N-Ras Protein by Employing an Enzymatically Removable Urethane Protecting Group

scholarly article by Herbert Waldmann & Edgar Nägele published 3 November 1995 in Angewandte Chemie International Edition

Synthesis of the Rheb and K-Ras4B GTPases

Synthesis of the Rheb and K-Ras4B GTPases

Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-Ras proteins

artículo científico publicado en 1999

Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin

artículo científico publicado en 2002

Synthetic peptide conjugates—tailor-made probes for the biology of protein modification and protein processing

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A ⬇️

article by Sin Ying Cheung et al published 3 July 2018 in Oncotarget

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties

artículo científico publicado en 2017

Target identification for small bioactive molecules: finding the needle in the haystack

artículo científico publicado en 2013

Tetrahedron prize for creativity in organic chemistry

article

Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation

artículo científico publicado en 2017

The Allyl Ester as Carboxy-Protecting Group in the Stereoselective Construction of Neuraminic-Acid Glycosides

scholarly article by Horst Kunz et al published 14 December 1988 in Helvetica Chimica Acta

The Allyl Group as Mildly and Selectively Removable Carboxy-Protecting Group for the Synthesis of LabileO-Glycopeptides

scholarly article by Horst Kunz & Herbert Waldmann published January 1984 in Angewandte Chemie International Edition

The Lipid Modifications of Ras that Sense Membrane Environments and Induce Local Enrichment

article

The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway

scholarly article by Lisa Kötzner et al published 30 May 2016 in Angewandte Chemie International Edition

The Phenylacetyl Group—The First Amino Protecting Group That Can Be Removed Enzymatically from Oligonucleotides in Solution and on a Solid Support

scholarly article by Herbert Waldmann & Armin Reidel published 4 April 1997 in Angewandte Chemie International Edition

The Pictet-Spengler reaction in nature and in organic chemistry

artículo científico publicado en 2011

The Ras pathway modulator melophlin A targets dynamins.

artículo científico publicado en 2009

The Scaffold Tree — Visualization of the Scaffold Universe by Hierarchical Scaffold Classification

scholarly article by Ansgar Schuffenhauer et al published 10 April 2007 in ChemInform

The asymmetric hetero-Diels-Alder reaction in the syntheses of biologically relevant compounds

artículo científico

The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins

artículo científico publicado en 2014

The chemical biology of Ras lipidation

artículo científico publicado en 2001

The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins

artículo científico publicado en 2004

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

scientific article published on 20 June 2019

The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors

artículo científico publicado en 2004

The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and h

artículo científico publicado en 2010

The enzymic utilization of sucrose in the synthesis of amylose and derivatives of amylose, using phosphorylases

artículo científico publicado en 1986

The lipidated membrane anchor of full length N-Ras protein shows an extensive dynamics as revealed by solid-state NMR spectroscopy

artículo científico publicado en 2006

The mechanism of caseinolytic protease (ClpP) inhibition

artículo científico publicado en 2013

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

artículo científico publicado en 2010

The phenyl hydrazide as an enzyme-labile protecting group — Oxidative cleavage with mushroom tyrosinase

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

article

The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification

artículo científico publicado en 2007

The synthesis of acid- and base-labile lipopeptides on solid support

artículo científico publicado en 2003

The tetrabenzylglucosyloxycarbonyl(BGloc)-group-A carbohydrate-derived enzyme-labile urethane protecting group

The therapeutic potential of phosphatase inhibitors

scientific article published on 04 May 2009

The use of penicillin acylase for selective N-terminal deprotection in peptide synthesis

The ε-Isoform of PKC Mediates the Hypertonic Activation of Cation Channels in Confluent Monolayers of Rat Hepatocytes

Therapeutic intervention based on protein prenylation and associated modifications

artículo científico publicado en 2006

Three-Step Access to the Tricyclic Benzo[a]quinolizine Ring System

article by Stephan Kirschbaum & Herbert Waldmann published July 1998 in Journal of Organic Chemistry

Total Synthesis of (−)-Doliculide, Structure-Activity Relationship Studies and Its Binding to F-Actin

artículo científico publicado en 2012

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile

artículo científico publicado en 2011

Total synthesis and biological evaluation of the nakijiquinones

artículo científico publicado en 2001

Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues

artículo científico publicado en 2004

Total synthesis and reassessment of the phosphatase-inhibitory activity of the antitumor agent TMC-69-6H.

artículo científico publicado en 2003

Total synthesis of chondramide C and its binding mode to F-actin

artículo científico publicado en 2008

Toward the role of cholesterol and cholesterol transfer protein in autophagosome biogenesis

artículo científico publicado en 2019

Traceless Fischer indole synthesis on the solid phase

artículo científico publicado en 2003

Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalins

artículo científico publicado en 2009

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

artículo científico publicado en 2002

Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection

artículo científico publicado en 2015

Tumor-Associated MUC1 Tandem-Repeat Glycopeptide Microarrays to Evaluate Serum- and Monoclonal-Antibody Specificity

scientific article published on 01 January 2009

UNC119A decreases the membrane-binding of myristoylated c-Src.

artículo científico publicado en 2018

Using small molecules to target protein phosphatases

scientific article published in 2011

Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption

artículo científico publicado en 2006

Visualizing association of lipidated signaling proteins in heterogeneous membranes--partitioning into subdomains, lipid sorting, interfacial adsorption, and protein association

artículo científico publicado en 2009

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

artículo científico publicado en 2015

Navegación guiada por bioactividad del espacio químico.

artículo científico publicado en 2010

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