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Lista de obras de Michael J O Wakelam

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

artículo científico publicado en 2019

3T3-L1 adipocytes express two isoforms of phospholipase D in distinct subcellular compartments.

artículo científico publicado en 1999

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

artículo científico publicado en 2006

A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.

artículo científico publicado en 2011

A nutritional memory effect counteracts benefits of dietary restriction in old mice

artículo científico publicado en 2019

A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.

artículo científico publicado en 2000

A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer

artículo científico publicado en 2006

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

artículo científico publicado en 2015

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress.

artículo científico publicado en 2014

Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.

artículo científico publicado en 2004

Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho

artículo científico publicado en 1996

Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.

artículo científico publicado en 2003

Activation of two signal-transduction systems in hepatocytes by glucagon

artículo científico publicado en 1986

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion

artículo científico publicado en 2007

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

artículo científico publicado en 2012

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles

artículo científico publicado en 2008

Analysis of intact phosphoinositides in biological samples

artículo científico publicado en 2006

Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle

artículo científico publicado en 1994

Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells

scientific journal article

Antineutrophil Cytoplasm Antibody-Stimulated Neutrophil Adhesion Depends on Diacylglycerol Kinase-Catalyzed Phosphatidic Acid Formation

artículo científico publicado en 2007

Assays to study phospholipase D regulation by inositol phospholipids and ADP-ribosylation factor 6.

artículo científico publicado en 2005

Assessment of novel combinations of biomarkers for the detection of colorectal cancer

artículo científico publicado en 2010

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

artículo científico publicado en 2006

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

artículo científico publicado en 2017

Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway

artículo científico publicado en 2002

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

scientific article published on 01 October 2018

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

artículo científico publicado en 2018

C13orf31 (FAMIN) is a central regulator of immunometabolic function

artículo científico publicado en 2016

CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways

scientific article published on 29 October 2018

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.

artículo científico publicado en 2015

Chapter 15 Structure and function of the receptor for insulin

Confounding Effects of Benign Lung Diseases on Non-Small Cell Lung Cancer Serum Biomarker Discovery

Cross-talk between phospholipase D and MAP kinases activities

artículo científico publicado en 2009

De novo synthesis of glucokinase in hepatocytes isolated from neonatal rats

scientific article published on 01 February 1980

Deciphering lipid structures based on platform-independent decision rules.

artículo científico publicado en 2017

Determination of phospholipase D, lysophospholipase D and DG kinase signaling pathways in disease states by mass spectrometry

artículo científico publicado en 2008

Diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles.

artículo científico publicado en 2005

Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.

artículo científico publicado en 1999

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

artículo científico publicado en 2012

Diacylglycerol--when is it an intracellular messenger?

artículo científico publicado en 1998

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

artículo científico publicado en 1998

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

artículo científico publicado en 2017

Distinct phospholipase C-regulated signalling pathways in Swiss 3T3 fibroblasts induce the rapid generation of the same polyunsaturated diacylglycerols.

artículo científico publicado en 1998

Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.

artículo científico publicado en 2007

Establishing the added benefit of measuring MMP9 in FOB positive patients as a part of the Wolverhampton colorectal cancer screening programme.

artículo científico publicado en 2009

Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population.

artículo científico publicado en 2006

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

artículo científico publicado en 2005

Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells

artículo científico publicado en 2016

Extracellular vesicles: lipids as key components of their biogenesis and functions

scientific article published on 15 May 2018

Fast targeted multidimensional NMR metabolomics of colorectal cancer

artículo científico publicado en 2009

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

artículo científico publicado en 2014

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.

artículo científico publicado en 2018

G-proteins and second messengers in mitogenesis.

artículo científico

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.

artículo científico publicado en 2002

Growing pains

Heterologous desensitization of bombesin‐ and vasopressin‐stimulated phospholipase D activity in Swiss 3T3 fibroblasts ⬇️

artículo científico publicado el 20 de marzo de 1995

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets

artículo científico publicado en 2018

Identification of serum biomarkers for colon cancer by proteomic analysis

artículo científico publicado en 2006

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

artículo científico publicado en 2005

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

artículo científico publicado en 2016

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells

artículo científico publicado en 2003

Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin.

artículo científico publicado en 1997

Inhibition of the amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing

scientific article published on 01 February 1988

Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C.

artículo científico publicado en 1993

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations

artículo científico publicado en 2016

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.

artículo científico publicado en 2009

Introduction: Signal activated phospholipases

artículo científico publicado en 1997

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis

artículo científico publicado en 2013

L6 skeletal muscle cells have functional V1-vasopressin receptors coupled to stimulated inositol phospholipid metabolism

artículo científico publicado en 1987

LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training

artículo científico publicado en 2019

Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4.

artículo científico publicado en 2014

Lipid systems and techniques. Introduction

artículo científico publicado en 2009

LipidHome: a database of theoretical lipids optimized for high throughput mass spectrometry lipidomics

artículo científico publicado en 2013

Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms

artículo científico publicado en 2013

Lipidomic analysis of signaling pathways.

artículo científico publicado en 2007

Lipidomics in the analysis of malignancy

artículo científico publicado en 2013

Lipidomics: Current state of the art in a fast moving field

artículo científico publicado en 2019

MS-based lipidomics of human blood plasma - a community-initiated position paper to develop accepted guidelines

article

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

artículo científico publicado en 2020

Mammalian phospholipase D: Function, and therapeutics

artículo científico publicado en 2019

Mass measurement of inositol phosphates.

artículo científico publicado en 1989

Mechanical and biochemical responses to endothelin-1 and endothelin-3 in human bronchi

artículo científico publicado en 1994

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

artículo científico publicado en 2014

Methods for analyzing phosphoinositides using mass spectrometry

artículo científico

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism ⬇️

article

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.

artículo científico publicado en 2014

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

artículo científico publicado en 2012

MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability

artículo científico publicado en 2007

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans

artículo científico publicado en 2021

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

publication published on 27 April 2021

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

artículo científico publicado en 2014

PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly

artículo científico publicado en 2006

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils

artículo científico publicado en 2011

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

artículo científico publicado en 2012

Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells ⬇️

artículo científico publicado el 12 de septiembre de 1997

Phosphatidylinositolphosphate phosphatase activities and cancer

artículo científico

Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options

artículo científico publicado en 2015

Phospholipase D

artículo científico publicado en 2004

Phospholipase D

artículo científico publicado en 1997

Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.

artículo científico publicado en 2016

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

artículo científico publicado en 2005

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells ⬇️

artículo científico publicado el 15 de diciembre de 2001

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

scientific journal article

Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection

artículo científico publicado en 2020

Prostaglandins and cyclic AMP stimulate creatine kinase synthesis but not fusion in cultured embryonic chick muscle cells

scientific article published on 01 October 1984

Protein kinase C: Current concepts and future perspectives

Proteomic profiling of urine for the detection of colon cancer.

artículo científico publicado en 2008

Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans

artículo científico publicado en 2015

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

artículo científico publicado en 2011

Reply: Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients

artículo científico publicado en 2008

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

scientific article published on April 2009

Role and regulation of phospholipase D activity in normal and cancer cells

artículo científico

Runx regulation of sphingolipid metabolism and survival signaling.

artículo científico publicado en 2010

Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.

artículo científico publicado en 2016

Second messengers. Sphingolipid signalling.

artículo científico publicado en 1994

Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines

artículo científico publicado en 1992

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.

artículo científico publicado en 2006

Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test.

artículo científico publicado en 2012

Shorthand notation for lipid structures derived from mass spectrometry.

artículo científico publicado en 2013

SnapShot: Lipid kinase and phosphatase reaction pathways

artículo científico publicado en 2014

SnapShot: lipid kinases and phosphatases.

artículo científico publicado en 2013

Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids

artículo científico publicado en 2015

Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18

scientific article published on 07 March 2007

Steps Towards Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications

artículo científico publicado en 2020

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

artículo científico publicado en 2013

Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis.

artículo científico publicado en 1991

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

artículo científico publicado en 2002

THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation

scientific article published on 21 May 2020

The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear

artículo científico publicado en 2022

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.

artículo científico publicado en 2016

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

artículo científico publicado en 2019

The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex ⬇️

artículo científico publicado el 1 de diciembre de 2001

The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.

artículo científico publicado en 2014

The regulation by phosphorylation of ‘priming’ of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells ⬇️

artículo científico publicado el 1 de septiembre de 1997

The regulation of phospholipase D by inositol phospholipids and small GTPases

artículo científico publicado en 2002

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages.

artículo científico publicado en 1992

The search for new targets for cancer chemotherapeutics

scientific article published on 01 August 2005

The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies.

artículo científico

Thyroid hormones and the precocious induction of hepatic glucokinase in the neonatal rat

scientific article published on 01 October 1979

Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes

scientific article published in Nature

Update of the LIPID MAPS comprehensive classification system for lipids

artículo científico publicado en 2009

Update on LIPID MAPS Classification, Nomenclature and Shorthand Notation for MS-derived Lipid Structures

scientific article published on 09 October 2020

Using lipidomics analysis to determine signalling and metabolic changes in cells.

artículo científico publicado en 2016

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

artículo científico publicado en 1995

lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

artículo científico publicado en 2006

v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis

artículo científico publicado el 1 de mayo de 1992

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