Lista de obras - Michael Sternberg - Dominio Público Uruguay

3D-Garden: a system for modelling protein-protein complexes based on conformational refinement of ensembles generated with the marching cubes algorithm.

artículo científico publicado en 2008

3DLigandSite: predicting ligand-binding sites using similar structures

artículo científico publicado en 2010

A combinational approach to the prediction of the tertiary fold of globular proteins ⬇️

artículo científico publicado el 1 de octubre de 1982

A common TMPRSS2 variant has a protective effect against severe COVID-19

artículo científico publicado en 2022

A continuum model for protein-protein interactions: application to the docking problem.

artículo científico publicado en 1995

A general approach for developing system-specific functions to score protein-ligand docked complexes using support vector inductive logic programming.

artículo científico publicado en 2007

A highly conserved program of neuronal microexons is misregulated in autistic brains

artículo científico publicado en 2014

A large-scale evaluation of computational protein function prediction

artículo científico publicado en 2013

A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.

artículo científico publicado en 1990

A new structural model of the acid-labile subunit: pathogenetic mechanisms of short stature-causing mutations ⬇️

artículo científico publicado el 12 de octubre de 2012

A novel binding site in catalase is suggested by structural similarity to the calycin superfamily.

artículo científico publicado en 1996

A novel logic-based approach for quantitative toxicology prediction.

artículo científico publicado en 2007

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

scientific article published on 19 April 2020

A predicted three-dimensional structure for the carcinoembryonic antigen (CEA)

scientific article published on 01 April 1992

A predicted three-dimensional structure of human cytochrome P450: implications for substrate specificity

scientific article published on 01 February 1991

A simple method to generate non-trivial alternate alignments of protein sequences.

artículo científico publicado en 1991

A structural census of metabolic networks for E. coli

artículo científico publicado en 2001

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation ⬇️

artículo científico publicado el 1 de diciembre de 1991

AMBIENT: Active Modules for Bipartite Networks--using high-throughput transcriptomic data to dissect metabolic response

artículo científico publicado en 2013

AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis

artículo científico publicado en 2015

An analysis of conformational changes on protein-protein association: implications for predictive docking.

artículo científico publicado en 1999

An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase ⬇️

artículo científico publicado el 25 de febrero de 1978

An analysis of the three-dimensional structure of chicken triose phosphate isomerase

artículo científico publicado el 1 de enero de 1977

An approach to improving multiple alignments of protein sequences using predicted secondary structure

artículo científico publicado en 2001

An expanded evaluation of protein function prediction methods shows an improvement in accuracy ⬇️

artículo científico publicado en 2016

Analysis and classification of disulphide connectivity in proteins. The entropic effect of cross-linkage

artículo científico publicado en 1994

Analysis and prediction of protein beta-sheet structures by a combinatorial approach

artículo científico publicado en 1980

Analysis and prediction of structural motifs in the glycolytic enzymes ⬇️

artículo científico publicado el 26 de junio de 1981

Analysis and prediction of the packing of alpha-helices against a beta-sheet in the tertiary structure of globular proteins

artículo científico publicado en 1982

Analysis of Phenetic Trees Based on Metabolic Capabilites Across the Three Domains of Life

article

Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance ⬇️

artículo científico publicado el 1 de abril de 1981

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

scientific article published on 01 November 1987

Analysis of the tertiary structure of protein beta-sheet sandwiches

scientific article published on 01 May 1981

Application of scaled particle theory to model the hydrophobic effect: implications for molecular association and protein stability

artículo científico publicado en 1994

ArchDB: automated protein loop classification as a tool for structural genomics.

artículo científico publicado en 2004

Assessing protein co-evolution in the context of the tree of life assists in the prediction of the interactome.

artículo científico publicado en 2005

Automated classification of antibody complementarity determining region 3 of the heavy chain (H3) loops into canonical forms and its application to protein structure prediction.

artículo científico publicado en 1998

Automated discovery of structural signatures of protein fold and function.

artículo científico publicado en 2001

Automated structure-based prediction of functional sites in proteins: applications to assessing the validity of inheriting protein function from homology in genome annotation and to protein docking.

artículo científico publicado en 2001

Benchmarking PSI-BLAST in genome annotation.

artículo científico publicado en 1999

Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated?

artículo científico publicado en 2019

Capturing expert knowledge with argumentation: a case study in bioinformatics.

artículo científico publicado en 2006

Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto.

artículo científico publicado en 1997

Computation Resources for Molecular Biology: A Special Issue.

artículo científico publicado en 2016

Computation Resources for Molecular Biology: Special Issue 2017.

artículo científico publicado en 2016

Computation Resources for Molecular Biology: Special Issue 2018

artículo científico publicado en 2018

Computation Resources for Molecular Biology: Special Issue 2019

artículo científico publicado en 2019

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

artículo científico publicado en 1998

Crystallographic studies of the dynamic properties of lysozyme

artículo científico publicado el 16 de agosto de 1979

Discovering rules for protein-ligand specificity using support vector inductive logic programming.

artículo científico publicado en 2009

Drug design by machine learning: the use of inductive logic programming to model the structure-activity relationships of trimethoprim analogues binding to dihydrofolate reductase ⬇️

artículo científico publicado el 1 de diciembre de 1992

Dynamic information from protein crystallography. An analysis of temperature factors from refinement of the hen egg-white lysozyme structure

artículo científico publicado el 25 de mayo de 1979

Electrostatic interactions in globular proteins. Different dielectric models applied to the packing of alpha-helices

article

Evaluation of the 3D-Dock protein docking suite in rounds 1 and 2 of the CAPRI blind trial.

artículo científico publicado en 2003

Evaluation of the sequence template method for protein structure prediction. Discrimination of the (beta/alpha)8-barrel fold.

artículo científico publicado en 1992

Evolution of enzymes in metabolism: a network perspective.

artículo científico publicado en 2002

Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types

artículo científico publicado en 2015

Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre

artículo científico publicado en 2008

EzMol: A Web Server Wizard for the Rapid Visualization and Image Production of Protein and Nucleic Acid Structures.

artículo científico publicado en 2018

Flexible protein sequence patterns

artículo científico publicado en 1990

Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition

artículo científico publicado en 2013

GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes

artículo científico publicado en 2022

Genetic loci influencing kidney function and chronic kidney disease

artículo científico publicado en 2010

Genetic variation in SCN10A influences cardiac conduction

artículo científico publicado en 2010

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

artículo científico publicado en 2011

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

artículo científico publicado en 2013

Genome3D: exploiting structure to help users understand their sequences

artículo científico publicado en 2015

Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation

artículo científico publicado en 2020

IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty

artículo científico publicado en 2016

Identification and analysis of domains in proteins

artículo científico publicado en 1995

Identification of disease-associated loci using machine learning for genotype and network data integration

artículo científico publicado en 2019

Identification of sequence motifs from a set of proteins with related function.

artículo científico publicado en 1994

In Silico Analysis of the Small Molecule Content of Outer Membrane Vesicles Produced by Bacteroides thetaiotaomicron Indicates an Extensive Metabolic Link between Microbe and Host.

artículo científico publicado en 2017

Incorporating Virtual Reactions into a Logic-based Ligand-based Virtual Screening Method to Discover New Leads

artículo científico publicado en 2015

Inductive logic programming used to discover topological constraints in protein structures

artículo científico publicado el 1 de enero de 1994

Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking

artículo científico publicado en 2008

Inter-species sequence conservation of single-spanning transmembrane regions

artículo científico publicado en 1990

Interferon: a tertiary structure predicted from amino acid sequences

scientific article published on 01 September 1982

Introduction. Bioinformatics: from molecules to systems.

artículo científico publicado en 2006

Isolation of a small molecule inhibitor of DNA base excision repair.

artículo científico publicado en 2005

Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights

artículo científico publicado en 2016

Machine learning approach for the prediction of protein secondary structure.

artículo científico publicado en 1990

Misleading local sequence alignments: implications for comparative protein modelling ⬇️

artículo científico publicado el 1 de agosto de 1998

Missense3D-DB web catalogue: an atom-based analysis and repository of 4M human protein-coding genetic variants

artículo científico publicado en 2021

Modeling of protein interactions in genomes

artículo científico publicado en 2002

Modelling protein docking using shape complementarity, electrostatics and biochemical information

artículo científico publicado en 1997

Modelling the ATP-binding site of oncogene products, the epidermal growth factor receptor and related proteins ⬇️

artículo científico publicado el 1 de octubre de 1984

Modelling the structure and function of enzymes by machine learning

artículo científico publicado el 1 de enero de 1992

Molecular mimicry in liver disease

artículo científico publicado en 1992

Neu receptor dimerization

scientific article published in Nature

New algorithm to model protein-protein recognition based on surface complementarity. Applications to antibody-antigen docking

artículo científico publicado el 5 de noviembre de 1992

PINALOG: a novel approach to align protein interaction networks--implications for complex detection and function prediction.

artículo científico publicado en 2012

Partial protein domains: evolutionary insights and bioinformatics challenges.

artículo científico publicado en 2015

PhenoRank: reducing study bias in gene prioritisation through simulation.

artículo científico publicado en 2018

PhyreRisk: A Dynamic Web Application to Bridge Genomics, Proteomics and 3D Structural Data to Guide Interpretation of Human Genetic Variants

scientific article published on 07 May 2019

PhyreStorm: A Web Server for Fast Structural Searches Against the PDB.

artículo científico publicado en 2015

Predicting Protein Dynamics and Allostery Using Multi-Protein Atomic Distance Constraints.

artículo científico publicado en 2017

Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins.

artículo científico publicado en 1987

Prediction of protein structure from amino acid sequence

artículo científico publicado en 1978

Prediction of protein-protein interactions by docking methods.

artículo científico publicado en 2002

Prediction of the conformation and geometry of loops in globular proteins: testing ArchDB, a structural classification of loops.

artículo científico publicado en 2005

Predictive docking of protein-protein and protein-DNA complexes.

artículo científico publicado en 1998

Properties of human genes guided by their enrichment in rare and common variants.

artículo científico publicado en 2017

Protein folding requires crowd control in a simulated cell.

artículo científico publicado en 2010

Protein sequences--homologies and motifs

scientific article published on 01 September 1991

Protein-protein interaction sites are hot spots for disease-associated nonsynonymous SNPs.

artículo científico publicado en 2011

Proteins and domains vary in their tolerance of non-synonymous single nucleotide polymorphisms (nsSNPs).

artículo científico publicado en 2013

Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls.

artículo científico publicado en 2012

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

artículo científico publicado en 2014

Quantitative structure-activity relationships by neural networks and inductive logic programming. I. The inhibition of dihydrofolate reductase by pyrimidines.

artículo científico publicado en 1994

Rapid refinement of protein interfaces incorporating solvation: application to the docking problem ⬇️

artículo científico publicado el 13 de febrero de 1998

Recognition of analogous and homologous protein folds: analysis of sequence and structure conservation 1 1Edited by F. E. Cohen

article

Scaffold hopping in drug discovery using inductive logic programming.

artículo científico publicado en 2008

Search for rare protein altering variants influencing susceptibility to multiple myeloma

artículo científico publicado en 2017

Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe.

artículo científico publicado en 2010

Similarity in membrane proteins

artículo científico publicado en 1989

Structural and evolutionary analysis of HLA-D-region products

artículo científico publicado en 1984

Structural characterization of the human proteome.

artículo científico publicado en 2002

Structure prediction. How good are we?

artículo científico publicado en 1995

Structure-activity relationships derived by machine learning: the use of atoms and their bond connectivities to predict mutagenicity by inductive logic programming

artículo científico publicado en 1996

Structure-based prediction of protein allostery

artículo científico publicado en 2017

SuSPect: enhanced prediction of single amino acid variant (SAV) phenotype using network features

artículo científico publicado en 2014

Support vector inductive logic programming outperforms the naive Bayes classifier and inductive logic programming for the classification of bioactive chemical compounds.

artículo científico publicado en 2007

Systems analysis of bacterial glycomes

artículo científico publicado en 2010

The BRCA1 C-terminal domain: structure and function.

artículo científico publicado en 2000

The C1q receptor site on immunoglobulin G

artículo científico publicado en 1980

The Contribution of Missense Mutations in Core and Rim Residues of Protein-Protein Interfaces to Human Disease

artículo científico publicado en 2015

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

artículo científico publicado en 2012

The Phyre2 web portal for protein modeling, prediction and analysis

artículo científico publicado en 2015

The automatic discovery of structural principles describing protein fold space.

artículo científico publicado en 2003

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

artículo científico publicado en 2014

The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.

artículo científico publicado en 2013

The fine details of evolution

artículo científico publicado en 2009

The flagellum in malarial parasites.

artículo científico publicado en 2010

The relationship between the flexibility of proteins and their conformational states on forming protein-protein complexes with an application to protein-protein docking

scientific article published on 01 April 2005

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

artículo científico publicado en 2017

Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein ⬇️

artículo científico publicado el 1 de enero de 1992

Three-Dimensional Model of Human Nicotinamide Nucleotide Transhydrogenase (NNT) and Sequence-Structure Analysis of its Disease-Causing Variations

artículo científico publicado en 2016

Towards an automatic method of predicting protein structure by homology: an evaluation of suboptimal sequence alignments

artículo científico publicado el 1 de junio de 1992

Understanding molecular effects of naturally occurring genetic differences.

artículo científico publicado en 2013

ePlant: Visualizing and Exploring Multiple Levels of Data for Hypothesis Generation in Plant Biology.

artículo científico

k-SLAM: accurate and ultra-fast taxonomic classification and gene identification for large metagenomic data sets

artículo científico publicado en 2016

Lista de obras de Michael Sternberg

3D-Garden: a system for modelling protein-protein complexes based on conformational refinement of ensembles generated with the marching cubes algorithm.

3DLigandSite: predicting ligand-binding sites using similar structures

A combinational approach to the prediction of the tertiary fold of globular proteins ⬇️

A common TMPRSS2 variant has a protective effect against severe COVID-19

A continuum model for protein-protein interactions: application to the docking problem.

A general approach for developing system-specific functions to score protein-ligand docked complexes using support vector inductive logic programming.

A highly conserved program of neuronal microexons is misregulated in autistic brains

A large-scale evaluation of computational protein function prediction

A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.

A new structural model of the acid-labile subunit: pathogenetic mechanisms of short stature-causing mutations ⬇️

A novel binding site in catalase is suggested by structural similarity to the calycin superfamily.

A novel logic-based approach for quantitative toxicology prediction.

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

A predicted three-dimensional structure for the carcinoembryonic antigen (CEA)

A predicted three-dimensional structure of human cytochrome P450: implications for substrate specificity

A simple method to generate non-trivial alternate alignments of protein sequences.

A structural census of metabolic networks for E. coli

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation ⬇️

AMBIENT: Active Modules for Bipartite Networks--using high-throughput transcriptomic data to dissect metabolic response

AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis

An analysis of conformational changes on protein-protein association: implications for predictive docking.

An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase ⬇️

An analysis of the three-dimensional structure of chicken triose phosphate isomerase

An approach to improving multiple alignments of protein sequences using predicted secondary structure

An expanded evaluation of protein function prediction methods shows an improvement in accuracy ⬇️

Analysis and classification of disulphide connectivity in proteins. The entropic effect of cross-linkage

Analysis and prediction of protein beta-sheet structures by a combinatorial approach

Analysis and prediction of structural motifs in the glycolytic enzymes ⬇️

Analysis and prediction of the packing of alpha-helices against a beta-sheet in the tertiary structure of globular proteins

Analysis of Phenetic Trees Based on Metabolic Capabilites Across the Three Domains of Life

Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance ⬇️

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

Analysis of the tertiary structure of protein beta-sheet sandwiches

Application of scaled particle theory to model the hydrophobic effect: implications for molecular association and protein stability

ArchDB: automated protein loop classification as a tool for structural genomics.

Assessing protein co-evolution in the context of the tree of life assists in the prediction of the interactome.

Automated classification of antibody complementarity determining region 3 of the heavy chain (H3) loops into canonical forms and its application to protein structure prediction.

Automated discovery of structural signatures of protein fold and function.

Automated structure-based prediction of functional sites in proteins: applications to assessing the validity of inheriting protein function from homology in genome annotation and to protein docking.

Benchmarking PSI-BLAST in genome annotation.

Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated?

Capturing expert knowledge with argumentation: a case study in bioinformatics.

Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto.

Computation Resources for Molecular Biology: A Special Issue.

Computation Resources for Molecular Biology: Special Issue 2017.

Computation Resources for Molecular Biology: Special Issue 2018

Computation Resources for Molecular Biology: Special Issue 2019

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

Crystallographic studies of the dynamic properties of lysozyme

Discovering rules for protein-ligand specificity using support vector inductive logic programming.

Drug design by machine learning: the use of inductive logic programming to model the structure-activity relationships of trimethoprim analogues binding to dihydrofolate reductase ⬇️

Dynamic information from protein crystallography. An analysis of temperature factors from refinement of the hen egg-white lysozyme structure

Electrostatic interactions in globular proteins. Different dielectric models applied to the packing of alpha-helices

Evaluation of the 3D-Dock protein docking suite in rounds 1 and 2 of the CAPRI blind trial.

Evaluation of the sequence template method for protein structure prediction. Discrimination of the (beta/alpha)8-barrel fold.

Evolution of enzymes in metabolism: a network perspective.

Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types

Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre

EzMol: A Web Server Wizard for the Rapid Visualization and Image Production of Protein and Nucleic Acid Structures.

Flexible protein sequence patterns

Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition

GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes

Genetic loci influencing kidney function and chronic kidney disease

Genetic variation in SCN10A influences cardiac conduction

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

Genome3D: exploiting structure to help users understand their sequences

Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation

IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty

Identification and analysis of domains in proteins

Identification of disease-associated loci using machine learning for genotype and network data integration

Identification of sequence motifs from a set of proteins with related function.

In Silico Analysis of the Small Molecule Content of Outer Membrane Vesicles Produced by Bacteroides thetaiotaomicron Indicates an Extensive Metabolic Link between Microbe and Host.

Incorporating Virtual Reactions into a Logic-based Ligand-based Virtual Screening Method to Discover New Leads

Inductive logic programming used to discover topological constraints in protein structures

Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking

Inter-species sequence conservation of single-spanning transmembrane regions

Interferon: a tertiary structure predicted from amino acid sequences

Introduction. Bioinformatics: from molecules to systems.