Lista de obras - Heinrich Betz - Dominio Público Uruguay

A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit

artículo científico publicado en 2003

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

artículo científico publicado en 2009

Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator

artículo científico publicado en 2008

Building Bridges through Science.

artículo científico publicado en 2017

Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2

Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2.

artículo científico publicado en 2004

Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors.

artículo científico publicado en 2016

Cellular localization and subcellular distribution of Unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2.

artículo científico publicado en 2005

Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins

scientific journal article

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

artículo científico publicado en 2013

Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus

artículo científico publicado en 2008

Crystal structure of the GABAA-receptor-associated protein, GABARAP

artículo científico publicado en 2002

Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality

artículo científico publicado en 2003

Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors

artículo científico publicado en 2009

Distribution of the glycine receptor β-subunit in the mouse CNS as revealed by a novel monoclonal antibody.

artículo científico publicado en 2012

Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit

artículo científico publicado en 2003

Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes.

artículo científico publicado en 2003

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

artículo científico publicado en 2016

Expression of a soluble glycine binding domain of the NMDA receptor in Escherichia coli

artículo científico publicado en 2003

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

artículo científico publicado en 2010

Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.

artículo científico publicado en 2016

G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes

artículo científico publicado en 2002

GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes

artículo científico publicado en 2009

GABARAP is not essential for GABA receptor targeting to the synapse

artículo científico publicado en 2005

Generation of a mouse line expressing Cre recombinase in glycinergic interneurons.

artículo científico publicado en 2010

Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes

artículo científico publicado en 2002

Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering.

artículo científico publicado en 2007

Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice.

artículo científico publicado en 2010

Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2.

artículo científico publicado en 2011

GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization

artículo científico publicado en 2004

Glycine Receptors

article from 2001

Glycine as a Neurotransmitter

scholarly article published 19 April 2001

Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain

artículo científico publicado en 2017

Glycine receptors: recent insights into their structural organization and functional diversity

artículo científico publicado en 2006

Glycine transporter dimers: evidence for occurrence in the plasma membrane

artículo científico publicado en 2008

Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises

artículo científico publicado el 1 de septiembre de 2003

Glycine transporters: essential regulators of neurotransmission.

artículo científico publicado en 2005

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation.

artículo científico publicado en 2005

Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses

artículo científico publicado en 2012

Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

scientific journal article

Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta

artículo científico publicado en 2003

Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice

artículo científico publicado en 2007

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

artículo científico publicado en 2003

Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo

artículo científico publicado en 2010

Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo.

artículo científico publicado en 2009

Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7

artículo científico publicado en 2008

Inhibitory glycine receptors: an update

artículo científico publicado en 2012

Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice

artículo científico publicado en 2009

Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin

artículo científico publicado en 2002

Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C.

artículo científico publicado en 2002

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.

artículo científico publicado en 2008

Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function

artículo científico publicado en 2016

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

artículo científico publicado en 2006

Mass spectrometric analysis of glycine receptor-associated gephyrin splice variants

artículo científico publicado en 2006

Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B.

artículo científico publicado en 2009

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

artículo científico publicado en 2002

Molecular basis of gephyrin clustering at inhibitory synapses: role of G- and E-domain interactions.

artículo científico publicado en 2006

Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor

artículo científico publicado en 2004

Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo ⬇️

artículo científico publicado el 10 de diciembre de 2012

Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel

artículo científico publicado en 2008

Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia.

artículo científico publicado en 2006

Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin

artículo científico publicado en 2009

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.

artículo científico publicado en 2010

PICK1 uncoupling from mGluR7a causes absence-like seizures

artículo científico publicado en 2008

Pias1 interaction and sumoylation of metabotropic glutamate receptor 8

scientific journal article

Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.

artículo científico publicado en 2010

Presynaptic glycine receptors on hippocampal mossy fibers

artículo científico publicado en 2010

Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function

artículo científico publicado en 2006

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site

artículo científico publicado en 2012

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2

artículo científico publicado el 8 de septiembre de 2011

Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.

artículo científico publicado en 2004

Protein interactions in the sumoylation cascade: lessons from X-ray structures

artículo científico publicado en 2008

Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.

artículo científico publicado en 2014

Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.

artículo científico publicado en 2010

Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene

artículo científico publicado en 2003

Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.

artículo científico publicado en 2012

Structural Model of the N-Methyl-D-aspartate Receptor Glycine Site Probed by Site-directed Chemical Coupling ⬇️

artículo científico publicado el 15 de abril de 2003

Structural basis of dynamic glycine receptor clustering by gephyrin

artículo científico publicado en 2004

Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A.

artículo científico publicado en 2007

Sumoylation in neurons: nuclear and synaptic roles?

artículo científico publicado en 2007

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.

artículo científico publicado en 2008

Synaptophysins: vesicular cation channels?

artículo científico publicado en 2002

The C-terminal PDZ-ligand motif of the neuronal glycine transporter GlyT2 is required for efficient synaptic localization

artículo científico publicado en 2007

The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors

artículo científico publicado en 2016

The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors

artículo científico publicado en 2007

The beta subunit determines the ligand binding properties of synaptic glycine receptors

artículo científico publicado en 2005

The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors

artículo científico publicado en 2005

The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1.

artículo científico publicado en 2004

The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members

artículo científico publicado en 2006

The trafficking proteins Vacuolar Protein Sorting 35 and Neurobeachin interact with the glycine receptor β-subunit ⬇️

artículo científico publicado el 29 de julio de 2011

Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord

artículo científico publicado en 2012

X-ray structure of a neuronal complexin-SNARE complex from squid

artículo científico publicado en 2002

Lista de obras de Heinrich Betz

A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator

Building Bridges through Science.

Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2

Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2.

Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors.

Cellular localization and subcellular distribution of Unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2.

Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus

Crystal structure of the GABAA-receptor-associated protein, GABARAP

Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality

Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors

Distribution of the glycine receptor β-subunit in the mouse CNS as revealed by a novel monoclonal antibody.

Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit

Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes.

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

Expression of a soluble glycine binding domain of the NMDA receptor in Escherichia coli

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.

G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes

GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes

GABARAP is not essential for GABA receptor targeting to the synapse

Generation of a mouse line expressing Cre recombinase in glycinergic interneurons.

Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes

Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering.

Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice.

Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2.

GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization

Glycine Receptors

Glycine as a Neurotransmitter

Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain

Glycine receptors: recent insights into their structural organization and functional diversity

Glycine transporter dimers: evidence for occurrence in the plasma membrane

Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises

Glycine transporters: essential regulators of neurotransmission.

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation.

Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses

Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta

Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo

Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo.

Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7

Inhibitory glycine receptors: an update

Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice

Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin

Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C.

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.

Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

Mass spectrometric analysis of glycine receptor-associated gephyrin splice variants

Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B.

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

Molecular basis of gephyrin clustering at inhibitory synapses: role of G- and E-domain interactions.

Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor

Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo ⬇️

Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel

Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia.

Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.

PICK1 uncoupling from mGluR7a causes absence-like seizures

Pias1 interaction and sumoylation of metabotropic glutamate receptor 8

Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.

Presynaptic glycine receptors on hippocampal mossy fibers

Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2

Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.

Protein interactions in the sumoylation cascade: lessons from X-ray structures

Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.

Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.

Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene

Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.

Structural Model of the N-Methyl-D-aspartate Receptor Glycine Site Probed by Site-directed Chemical Coupling ⬇️

Structural basis of dynamic glycine receptor clustering by gephyrin

Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A.