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Lista de obras de Frank Kirchhoff

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1.

artículo científico publicado en 2013

A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies

artículo científico publicado en 2015

A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells

artículo científico publicado en 2010

A molecular tweezer antagonizes seminal amyloids and HIV infection.

artículo científico publicado en 2015

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function

artículo científico publicado en 2004

A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

artículo científico publicado en 2013

A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo

artículo científico publicado en 2006

Alterations in HIV-1 LTR promoter activity during AIDS progression

artículo científico publicado en 2003

Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors

artículo científico publicado en 2004

Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).

artículo científico publicado en 2009

An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.

artículo científico publicado en 2011

Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses

artículo científico publicado en 2011

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

artículo científico publicado en 2007

Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques ⬇️

artículo científico publicado el 1 de agosto de 1997

BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

artículo científico publicado en 2017

CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells

artículo científico publicado en 2008

CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients

artículo científico publicado en 2015

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

artículo científico publicado en 2009

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry

artículo científico publicado en 2011

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux

artículo científico publicado en 2010

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques

artículo científico publicado en 2004

Conservation of Nef function across highly diverse lineages of SIVsmm

artículo científico publicado en 2009

Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry.

artículo científico publicado en 2007

Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection

artículo científico publicado en 2006

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

scientific article published on 10 July 2019

Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.

artículo científico publicado en 2010

Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains

artículo científico publicado en 2016

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins

artículo científico publicado en 2015

Differential regulation of human immunodeficiency virus type 2 and simian immunodeficiency virus promoter activity

artículo científico publicado en 2004

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.

artículo científico publicado en 2014

Discovery and characterization of an endogenous CXCR4 antagonist

artículo científico publicado en 2015

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

artículo científico publicado en 2007

Discovery of modulators of HIV-1 infection from the human peptidome

artículo científico publicado en 2014

Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins

artículo científico publicado en 2011

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

artículo científico publicado en 2003

EPI-X4, a novel endogenous antagonist of CXCR4

artículo científico publicado en 2015

Early Vertebrate Evolution of the Host Restriction Factor Tetherin

artículo científico publicado en 2015

Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo

artículo científico publicado en 2006

Effect of naturally-occurring gp41 HR1 variations on susceptibility of HIV-1 to fusion inhibitors

artículo científico publicado en 2005

Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus

artículo científico publicado en 2013

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

artículo científico publicado en 2012

Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation

artículo científico publicado en 2012

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

artículo científico publicado en 2017

Emerging Role of PYHIN Proteins as Antiviral Restriction Factors

scientific article published on 18 December 2020

Emerging role of the host restriction factor tetherin in viral immune sensing

artículo científico publicado en 2013

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

artículo científico publicado en 2017

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

artículo científico publicado en 2015

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication

artículo científico publicado en 2003

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

artículo científico publicado en 2012

Exploiting the human peptidome for novel antimicrobial and anticancer agents

artículo científico publicado en 2017

Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer

artículo científico publicado en 2009

First steps toward a globally effective HIV/AIDS vaccine.

artículo científico publicado en 2013

Frequencies of lymphoid T-follicular helper cells obtained longitudinally by lymph node fine-needle aspiration correlate significantly with viral load in SIV-infected rhesus monkeys

artículo científico publicado en 2015

Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels

artículo científico publicado en 2017

Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys

artículo científico publicado en 2010

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

artículo científico publicado en 2016

Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins

artículo científico publicado en 2016

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

artículo científico publicado en 2016

HIV infection in a patient with alpha-1 antitrypsin deficiency: a detrimental combination?

article

HIV replication: a game of hide and sense.

artículo científico publicado en 2015

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef.

artículo científico publicado en 2011

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

artículo científico publicado en 2013

HIV-1 Vpu does not degrade interferon regulatory factor 3.

artículo científico publicado en 2013

HIV-1 accessory proteins: Nef.

artículo científico publicado en 2014

HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells

artículo científico publicado en 2017

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

artículo científico publicado en 2002

Host proteins involved in HIV infection: new therapeutic targets.

artículo científico publicado en 2009

Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism

artículo científico publicado en 2005

Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain.

artículo científico publicado en 2008

Human immunodeficiency virus type 1 variants resistant to first- and second-version fusion inhibitors and cytopathic in ex vivo human lymphoid tissue

artículo científico publicado en 2007

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

artículo científico publicado en 2012

Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

artículo científico publicado en 2018

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

artículo científico publicado en 2021

IFITM proteins promote SARS-CoV-2 infection of human lung cells

IFITMs: Important Factors In Trans-Mission of HIV-1.

artículo científico publicado en 2016

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

artículo científico publicado en 2015

Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor

artículo científico publicado en 2002

Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection.

artículo científico publicado en 2015

Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses

artículo científico publicado en 2010

Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

artículo científico publicado en 2009

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques

artículo científico publicado en 2006

Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels

artículo científico publicado en 2015

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection

artículo científico publicado en 2008

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells

artículo científico publicado en 2012

Inhibition of HIV-1 group M and O isolates by fusion inhibitors

artículo científico publicado en 2005

Interferons and beyond: Induction of antiretroviral restriction factors

artículo científico publicado en 2017

Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation

artículo científico publicado en 2015

Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

artículo científico publicado en 2008

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

artículo científico publicado en 2009

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus

artículo científico publicado en 2005

Lentiviral Nef proteins manipulate T cells in a subset-specific manner

artículo científico publicado en 2014

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals

artículo científico publicado en 2014

Link between primate lentiviral coreceptor usage and Nef function

artículo científico publicado en 2013

Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection

artículo científico publicado en 2014

Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread

artículo científico publicado en 2020

Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression

artículo científico publicado en 2011

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

artículo científico publicado en 2015

Molecular Control of HIV and SIV Latency

artículo científico publicado en 2017

Monkeypox: A New Threat?

artículo científico publicado en 2022

Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins.

artículo científico publicado en 2018

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

artículo científico publicado en 2011

Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency

artículo científico publicado en 2003

Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection

artículo científico publicado en 2011

Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors.

artículo científico publicado en 2007

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

artículo científico publicado en 2004

Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism

artículo científico publicado en 2002

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells

artículo científico publicado en 2005

Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.

artículo científico publicado en 2005

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

artículo científico publicado en 2004

Nef proteins from simian immunodeficiency viruses are tetherin antagonists.

artículo científico publicado en 2009

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

artículo científico publicado en 2014

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

artículo científico publicado en 2006

Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

artículo científico publicado en 2007

Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection.

artículo científico publicado en 1994

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

scientific article published on 06 August 2020

Osteopontin regulates and attenuates aging-associated phenotypes of HSCS

scholarly article by Novella Guidi published in September 2016

Peptide nanofibrils as enhancers of retroviral gene transfer

artículo científico

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

artículo científico publicado en 2013

Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection

artículo científico publicado en 2011

Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2

scholarly article by Elena Heusinger published in September 2018

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

artículo científico publicado en 2014

Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice

artículo científico publicado en 2007

Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

artículo científico publicado en 2005

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

artículo científico publicado en 2017

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

artículo científico publicado en 2013

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

artículo científico publicado en 2017

Proceedings of the Frontiers of Retrovirology Conference 2016.

artículo científico publicado en 2016

Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo

artículo científico publicado en 2007

Properties of Human and Simian Immunodeficiency Viruses

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

artículo científico publicado en 2012

Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs

article

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

artículo científico publicado en 2017

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

artículo científico publicado en 2020

SEVI and Semen Impair the Anti-HIV-1 Activity of Drugs and Microbicides

article

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

scientific article published on 24 February 2021

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

article

Sandwich enzyme-linked immunosorbent assay for the quantification of human serum albumin fragment 408-423 in bodily fluids

artículo científico publicado en 2015

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

artículo científico publicado en 2007

Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2.

artículo científico publicado en 2008

Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides

artículo científico publicado en 2014

Semen-derived amyloid fibrils drastically enhance HIV infection

artículo científico publicado en 2007

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.

artículo científico publicado en 2010

Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide

artículo científico publicado en 2010

Silencing HIV-1 In Vivo

article

Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo

scientific article published on 02 August 2023

SnapShot: antiviral restriction factors

artículo científico publicado en 2015

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host

artículo científico publicado en 2018

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.

artículo científico publicado en 2018

Spike residue 403 affects binding of coronavirus spikes to human ACE2

artículo científico publicado en 2021

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

artículo científico publicado en 2020

Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration

article

T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques

artículo científico publicado en 2002

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

artículo científico publicado en 2014

Tetherin antagonism by HIV-1 and its SIV precursors.

artículo científico publicado en 2011

Tetherin antagonism by primate lentiviral nef proteins.

artículo científico publicado en 2011

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

artículo científico publicado en 2009

Tetherin: Holding On and Letting Go

artículo científico publicado en 2010

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific.

artículo científico publicado en 2018

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

artículo científico publicado en 2016

The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection

scientific article published on 22 October 2008

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

artículo científico publicado en 2013

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

artículo científico publicado en 2009

The most frequent naturally occurring length polymorphism in the HIV-1 LTR has little effect on proviral transcription and viral replication

artículo científico publicado en 2002

The negative (?) factor of HIV and SIV

artículo científico publicado el 1 de enero de 1992

The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses

artículo científico publicado en 2010

The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo

artículo científico publicado en 2005

The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function

artículo científico publicado en 2013

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

artículo científico publicado en 2009

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses.

artículo científico publicado en 2018

Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions

artículo científico publicado en 2014

Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo

artículo científico publicado en 2004

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

artículo científico publicado en 2020

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

artículo científico publicado en 2010

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

artículo científico publicado en 2016

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