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Lista de obras de Carlos Barbas

3-Pyrrolidinecarboxylic acid for direct catalytic asymmetric anti-Mannich-type reactions of unmodified ketones

artículo científico publicado en 2006

A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids

artículo científico publicado en 2002

A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives

artículo científico publicado en 2002

A modular assembly strategy for improving the substrate specificity of small catalytic peptides

artículo científico publicado en 2002

A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity.

artículo científico publicado en 2006

A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

artículo científico publicado en 2010

Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy

artículo científico publicado en 2004

Amine-catalyzed Michael reactions of an aminoaldehyde derivative to nitroolefins

Amine-catalyzed direct Diels–Alder reactions of α,β-unsaturated ketones with nitro olefins

An efficient chemical approach to bispecific antibodies and antibodies of high valency

artículo científico publicado en 2009

Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG

artículo científico publicado en 2013

Antibody-catalyzed Aldol Reactions

Antibody-catalyzed aminolysis of a chloropyrimidine derivative

artículo científico publicado en 2004

Antibody-catalyzed asymmetric intramolecular Michael addition of aldehydes and ketones to yield the disfavored cis-product

artículo científico publicado en 2005

Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic Michael-Henry cascade reactions

scientific article published on 22 March 2012

Assembly of spirooxindole derivatives via organocatalytic iminium-enamine cascade reactions

artículo científico publicado en 2012

Asymmetric construction of spirocyclopentenebenzofuranone core structures via highly selective phosphine-catalyzed [3 + 2] cycloaddition reactions.

artículo científico publicado en 2013

Asymmetric synthesis of quaternary alpha- and beta-amino acids and beta-lactams via proline-catalyzed mannich reactions with branched aldehyde donors

scientific article published on 01 July 2004

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

artículo científico publicado en 2004

Breaking the one antibody-one target axiom

artículo científico publicado en 2006

Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol

artículo científico publicado en 2007

Catalytic single-chain antibodies possessing β-lactamase activity selected from a phage displayed combinatorial library using a mechanism-based inhibitor

Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering

artículo científico publicado en 2014

Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.

artículo científico publicado en 2004

Chemically Programmed Antibodies AS HIV-1 Attachment Inhibitors

artículo científico publicado en 2013

Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.

artículo científico publicado en 2003

Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.

artículo científico publicado en 2011

Core structure-based design of organocatalytic [3+2]-cycloaddition reactions: highly efficient and stereocontrolled syntheses of 3,3'-pyrrolidonyl spirooxindoles

artículo científico publicado en 2011

Core-structure-motivated design of a phosphine-catalyzed [3+2] cycloaddition reaction: enantioselective syntheses of spirocyclopenteneoxindoles.

artículo científico publicado en 2011

Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.

artículo científico publicado en 2005

Custom zinc-finger nucleases for use in human cells

artículo científico publicado en 2005

De novo computational design of retro-aldol enzymes

artículo científico publicado en 2008

Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations

artículo científico publicado en 2004

Designing transcription factor architectures for drug discovery.

artículo científico publicado en 2004

Determination of cysteine concentration by fluorescence increase: reaction of cysteine with a fluorogenic aldehyde

artículo científico publicado en 2004

Development of a small peptide tag for covalent labeling of proteins

artículo científico publicado en 2007

Development of functional human monoclonal single-chain variable fragment antibody against HIV-1 from human cervical B cells

scientific article published on 01 April 2003

Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity

artículo científico publicado en 2005

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

artículo científico publicado en 2005

Dihydroxyacetone variants in the organocatalytic construction of carbohydrates: mimicking tagatose and fuculose aldolases

artículo científico publicado en 2006

Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: an organocatalytic approach to 3-hydroxyoxindole derivatives.

artículo científico publicado en 2010

Direct Asymmetric Organocatalytic Michael Reactions of α,α-Disubstituted Aldehydes with β-Nitrostyrenes for the Synthesis of Quaternary Carbon-Containing Products

scientific article published in 2004

Direct Observation of an Enamine Intermediate in Amine Catalysis

artículo científico publicado en 2009

Direct Organocatalytic Asymmetric Aldol Reactions of α-Amino Aldehydes:  Expedient Syntheses of Highly Enantiomerically Enrichedanti-β-Hydroxy-α-amino Acids

scientific article published in 2004

Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions

scientific article published on 01 April 2005

Direct asymmetric alpha-fluorination of aldehydes

artículo científico publicado en 2005

Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid

artículo científico publicado en 2006

Direct catalytic asymmetric synthesis of anti-1,2-amino alcohols and syn-1,2-diols through organocatalytic anti-Mannich and syn-aldol reactions

artículo científico publicado en 2007

Direct organocatalytic aldol reactions in buffered aqueous media

artículo científico publicado en 2002

Direct organocatalytic asymmetric heterodomino reactions: the Knoevenagel/Diels-Alder/epimerization sequence for the highly diastereoselective synthesis of symmetrical and nonsymmetrical synthons of benzoannelated centropolyquinanes

artículo científico publicado en 2004

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases

artículo científico publicado en 2010

Directed evolution of recombinase specificity by split gene reassembly

artículo científico publicado en 2010

Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells

artículo científico publicado en 2015

Enamine Catalysis: Aldol and Mannich-Type Reactions

Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions

artículo científico publicado en 2004

Engineering polydactyl zinc-finger transcription factors

artículo científico publicado en 2002

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

artículo científico publicado en 2003

Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection

artículo científico publicado en 2004

Evolution of programmable zinc finger-recombinases with activity in human cells.

artículo científico publicado en 2007

Expanding the scope of cinchona alkaloid-catalyzed enantioselective alpha-aminations of oxindoles: a versatile approach to optically active 3-amino-2-oxindole derivatives

artículo científico publicado en 2009

Expedient Synthesis of Chiral 1,2- and 1,4-Diamines:  Protecting Group Dependent Regioselectivity in Direct Organocatalytic Asymmetric Mannich Reactions

article published in 2006

Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease

artículo científico publicado en 2004

Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction

artículo científico publicado en 2013

Flow cytometric screening of aldolase catalytic antibodies

artículo científico publicado en 2004

Fluorescent detection of carbon-carbon bond formation

artículo científico publicado en 2003

Formylbenzene diazonium hexafluorophosphate reagent for tyrosine-selective modification of proteins and the introduction of a bioorthogonal aldehyde

artículo científico publicado en 2012

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

artículo científico publicado en 2002

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

artículo científico publicado en 2004

Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor

artículo científico publicado en 2003

Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

artículo científico publicado en 2011

Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

artículo científico publicado en 2011

Genetic reprogramming of tumor cells by zinc finger transcription factors

artículo científico publicado en 2005

Highly efficient hydrogen-bonding catalysis of the Diels-Alder reaction of 3-vinylindoles and methyleneindolinones provides carbazolespirooxindole skeletons.

artículo científico publicado en 2011

Highly enantio- and diastereoselective Mannich reactions of glycine Schiff bases with in situ generated N-Boc-imines catalyzed by a cinchona alkaloid thiourea

artículo científico publicado en 2010

Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts

artículo científico publicado en 2010

Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation.

artículo científico

Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells

artículo científico publicado en 2006

Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library.

artículo científico publicado en 2004

Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering

artículo científico publicado en 2015

Improving the serum stability of site-specific antibody conjugates with sulfone linkers

artículo científico publicado en 2014

In vivo programming of endogenous antibodies via oral administration of adaptor ligands

artículo científico publicado en 2017

In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation

artículo científico publicado en 2004

In water, on water, and by water: mimicking nature's aldolases with organocatalysis and water

artículo científico publicado en 2010

Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator

artículo científico publicado en 2012

Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site

artículo científico publicado en 2006

Instant immunity through chemically programmable vaccination and covalent self-assembly

scholarly article

Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody

artículo científico publicado en 2002

Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation

artículo científico publicado en 2003

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

artículo científico publicado en 2005

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

artículo científico publicado en 2003

Isolation of human prostate cancer cell reactive antibodies using phage display technology.

artículo científico publicado en 2004

Maspin alters the carcinoma proteome

artículo científico publicado en 2005

Mimicking Aldolases through Organocatalysis: syn-Selective Aldol Reactions with Protected Dihydroxyacetone

artículo científico publicado en 2007

Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars

artículo científico publicado en 2005

Mimicking fructose and rhamnulose aldolases: organocatalytic syn-aldol reactions with unprotected dihydroxyacetone

artículo científico publicado en 2007

Modular system for the construction of zinc-finger libraries and proteins

artículo científico publicado en 2010

Modulation of drug resistance by artificial transcription factors.

artículo científico publicado en 2008

Negative regulation of the RTBV promoter by designed zinc finger proteins

artículo científico publicado en 2010

Neutralization of Burkholderia pseudomallei protease by Fabs generated through phage display

artículo científico publicado en 2005

One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives:  Formation of Three Contiguous Stereogenic Centers

artículo científico publicado en 2002

One-Pot Enantioselective Syntheses of Iminosugar Derivatives Using Organocatalytic anti-Michael−anti-Aza-Henry Reactions ⬇️

artículo científico publicado el 29 de octubre de 2010

Organocatalysis as a safe practical method for the stereospecific dibromination of unsaturated compounds

artículo científico publicado en 2012

Organocatalytic Asymmetric Assembly Reactions: One-Pot Synthesis of Functionalized β-Amino Alcohols from Aldehydes, Ketones, and Azodicarboxylates ⬇️

artículo científico publicado el 15 de mayo de 2003

Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones ⬇️

artículo científico publicado el 15 de septiembre de 2003

Organocatalytic Direct Michael Reaction of Ketones and Aldehydes with β-Nitrostyrene in Brine [J. Am. Chem. Soc.2006,128, 4966−4967]

artículo científico publicado en 2006

Organocatalytic amidation and esterification of aldehydes with activating reagents by a cross-coupling strategy

scientific article published on 07 November 2012

Organocatalytic asymmetric assembly reactions for the syntheses of carbohydrate derivatives by intermolecular Michael-Henry reactions

artículo científico publicado en 2010

Organocatalytic direct asymmetric aldol reactions in water

artículo científico publicado en 2006

Organocatalytic direct michael reaction of ketones and aldehydes with beta-nitrostyrene in brine

artículo científico publicado en 2006

Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands

artículo científico publicado en 2005

Organocatalytic mannich-type reactions of trifluoroethyl thioesters

scientific article published on 16 July 2008

Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo

artículo científico publicado en 2005

Pipecolic acid-catalyzed direct asymmetric mannich reactions

artículo científico publicado en 2006

Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production

artículo científico publicado en 2009

Potent Inhibition of HIV‐1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis ⬇️

artículo científico publicado el 18 de octubre de 2010

Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc

artículo científico publicado en 2014

Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.

artículo científico publicado en 2007

Prodrug activation gated by a molecular "OR" logic trigger

artículo científico publicado en 2005

Proline-Catalyzed Direct Asymmetric Aldol Reactions

artículo científico publicado en 2000

Proline-catalyzed one-step asymmetric synthesis of 5-hydroxy-(2E)-hexenal from acetaldehyde.

artículo científico publicado en 2002

Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation.

artículo científico publicado en 2004

Protein delivery using Cys2-His2 zinc-finger domains

artículo científico publicado en 2014

Quantitation of DNA and RNA

artículo científico publicado en 2007

Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display

artículo científico publicado en 2003

Rapid Fluorescent Screening for Bifunctional Amine−Acid Catalysts:  Efficient Syntheses of Quaternary Carbon-Containing Aldols under Organocatalysis

article published in 2003

Rapid Monoclonal Antibody Generation Via Dendritic Cell TargetingIn Vivo ⬇️

artículo científico publicado el 1 de febrero de 2003

Rapid analysis of solvent effects on enamine formation by fluorescence: how might enzymes facilitate enamine chemistry with primary amines?

Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation

artículo científico publicado en 2013

Rationally designed amide donors for organocatalytic asymmetric Michael reactions

scientific article published on 13 April 2012

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

artículo científico publicado en 2016

Reactive Immunization: A Unique Approach to Aldolase Antibodies

Reactive immunization: a unique approach to catalytic antibodies

artículo científico publicado en 2002

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

artículo científico publicado en 2012

Reconstructing Aldolase Antibodies to Alter Their Substrate Specificity and Turnover

article published in 2000

Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome

artículo científico publicado en 2015

Scanning the human genome with combinatorial transcription factor libraries.

artículo científico publicado en 2003

Selection of phage-displayed peptides that bind to a particular ligand-bound antibody

artículo científico publicado en 2008

Single-triggered trimeric prodrugs.

artículo científico publicado en 2005

Site-selective labeling of a lysine residue in human serum albumin.

artículo científico publicado en 2014

Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector

scientific article published on 01 September 2006

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

artículo científico publicado en 2006

Synthesis of beta-hydroxyaldehydes with stereogenic quaternary carbon centers by direct organocatalytic asymmetric aldol reactions

artículo científico publicado en 2004

Synthesis of programmable integrases

scholarly article

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.

artículo científico publicado en 2007

Synthesis ofβ-Hydroxyaldehydes with Stereogenic Quaternary Carbon Centers by Direct Organocatalytic Asymmetric Aldol Reactions

article published in 2004

Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies

artículo científico publicado en 2014

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

artículo científico publicado en 2012

Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody

scientific article published on 01 February 2005

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

artículo científico publicado en 2003

The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles

artículo científico publicado en 2003

The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis

artículo científico publicado en 2004

Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine.

artículo científico publicado en 2009

Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter

artículo científico publicado en 2005

Towards organocatalytic polyketide synthases with diverse electrophile scope: trifluoroethyl thioesters as nucleophiles in organocatalytic Michael reactions and beyond

artículo científico publicado en 2008

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

artículo científico publicado en 2013

Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine

artículo científico publicado en 2010

Water-compatible organocatalysts for direct asymmetric syn-aldol reactions of dihydroxyacetone and aldehydes

artículo científico publicado en 2008

Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology

artículo científico publicado en 2005

anti-Selective asymmetric Michael reactions of aldehydes and nitroolefins catalyzed by a primary amine/thiourea

artículo científico publicado en 2009

{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice

artículo científico publicado en 2005

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