Lista de obras - Gunther Hartmann - Dominio Público Uruguay

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice

artículo científico publicado en 2011

5'-Triphosphate RNA is the ligand for RIG-I

artículo científico publicado en 2006

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

artículo científico publicado en 2008

A Message from the Oligonucleotide Therapeutics Society

artículo científico publicado en 2012

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

artículo científico publicado en 2013

A mammalian microRNA expression atlas based on small RNA library sequencing

artículo científico publicado en 2007

AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.

artículo científico publicado en 2013

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

artículo científico publicado en 2018

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

artículo científico publicado en 2015

Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models

Accessing the therapeutic potential of immunostimulatory nucleic acids

scientific article published on 30 July 2008

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

artículo científico publicado en 2003

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

artículo científico publicado en 2017

Analysis of integrated clinical trial protocols in early phases of medicinal product development

artículo científico publicado en 2017

Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium

artículo científico publicado en 2006

Antisense therapy in oncology: new hope for an old idea?

artículo científico publicado en 2001

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

artículo científico publicado en 2014

Approaching the RNA ligand for RIG-I?

artículo científico publicado en 2009

Basic principles, planning and implementation of non-commercial clinical trials

artículo científico

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

artículo científico publicado en 2014

Calponin-h2: a potential serum marker for the early detection of human breast cancer?

artículo científico publicado en 2014

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

artículo científico publicado en 2014

Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays

artículo científico publicado en 2017

Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers

artículo científico publicado en 2017

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells.

artículo científico publicado en 2005

CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model

artículo científico publicado en 2004

CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo

article

CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells

artículo científico publicado en 2003

Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination.

artículo científico publicado en 2016

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

artículo científico publicado en 2013

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

artículo científico publicado en 2011

Deficiency in coatomer complex I causes aberrant activation of STING signalling

artículo científico publicado en 2022

Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides

article

Delivery with polycations extends the immunostimulant Ribomunyl® into a potent antiviral Toll-like receptor 7/8 agonist

article published in 2011

Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters

artículo científico publicado en 2010

Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer

artículo científico publicado en 2017

Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer

artículo científico publicado en 2017

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells

artículo científico publicado en 2019

Discriminating self from non-self in nucleic acid sensing

artículo científico publicado en 2016

Effects of an active immunization on the immune response of laying Japanese quail (Coturnix coturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize

artículo científico publicado en 2010

Efficient solid-phase synthesis of pppRNA by using product-specific labeling

artículo científico publicado en 2014

Endothelial RIG-I activation impairs endothelial function

artículo científico publicado en 2012

Enhanced Dendritic Cell Maturation by TNF- or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

article

Enzymatic synthesis and purification of a defined RIG-I ligand

artículo científico publicado en 2014

Exosomes as nucleic acid nanocarriers

artículo científico

Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study

artículo científico publicado en 2017

Funktion von extrazellulären Vesikeln und Bedeutung für die labormedizinische Diagnostik

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes

artículo científico publicado en 2016

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

artículo científico publicado en 2009

Human TLR8 Senses RNA From -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

artículo científico publicado en 2009

IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.

artículo científico

Identification of specific nuclear structural protein alterations in human breast cancer

artículo científico publicado en 2011

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

artículo científico publicado en 2011

Immunohistological analysis of in-transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta-interferon: A case report

artículo científico publicado en 2012

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

artículo científico publicado en 2009

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

artículo científico publicado en 2009

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.

artículo científico publicado en 2007

Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer

artículo científico publicado en 2006

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.

artículo científico publicado en 2018

In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination.

artículo científico publicado en 1998

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

artículo científico publicado en 2020

Inflammasome-Dependent Induction of Adaptive NK Cell Memory

artículo científico publicado en 2016

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

artículo científico publicado en 2005

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

artículo científico publicado en 2021

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

artículo científico publicado en 2010

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis

artículo científico publicado en 2016

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

artículo científico publicado en 2021

Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice

artículo científico publicado en 2010

Monocyte-Mediated Inhibition of TLR9-Dependent IFN- Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

artículo científico publicado en 2010

No indication for a defect in toll-like receptor signaling in patients with hyper-IgE syndrome

artículo científico publicado en 2005

Nucleic Acid Immunity

artículo científico publicado en 2016

Nucleic acid adjuvants: toward an educated vaccine

artículo científico

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

artículo científico publicado en 2013

Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model.

artículo científico publicado en 2002

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

artículo científico publicado en 2005

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

artículo científico publicado en 2003

Preferential expression and function of Toll-like receptor 3 in human astrocytes

artículo científico publicado en 2004

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

artículo científico publicado en 2009

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

artículo científico publicado en 2002

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection

artículo científico publicado en 2017

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

artículo científico publicado en 2017

RIG-I activation induces the release of extracellular vesicles with antitumor activity

artículo científico publicado en 2016

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

artículo científico publicado en 2012

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

artículo científico publicado en 2013

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

artículo científico publicado en 2009

RNA recognition via TLR7 and TLR8.

artículo científico publicado en 2008

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

artículo científico publicado en 2003

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

artículo científico publicado en 2009

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

artículo científico publicado en 2009

Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.

artículo científico publicado en 2009

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

artículo científico publicado en 2004

Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells

artículo científico publicado en 2003

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

artículo científico publicado en 2009

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

artículo científico publicado en 2009

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

artículo científico publicado en 2014

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

artículo científico publicado en 2015

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

artículo científico publicado en 2005

Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides.

artículo científico publicado en 2001

SiRNA delivery with exosome nanoparticles.

artículo científico publicado en 2011

Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer.

artículo científico publicado en 2010

Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients

artículo científico publicado en 2013

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

artículo científico publicado en 2004

Staphylococcus aureus Protein A Triggers T Cell-Independent B Cell Proliferation by Sensitizing B Cells for TLR2 Ligands

artículo científico publicado en 2007

Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice

artículo científico publicado en 2010

Structural alterations of MET trigger response to MET kinase inhibition in lung adenocarcinoma patients

artículo científico publicado en 2017

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

artículo científico publicado en 2010

Structural studies of oligonucleotides containing G-quadruplex motifs using AFM.

artículo científico

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

artículo científico publicado en 2013

Suppression of tumor necrosis factor-α production by interleukin-10 is enhanced by cAMP-elevating agents

scientific article published on 01 February 1997

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

artículo científico publicado en 2009

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

artículo científico publicado en 2006

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

artículo científico publicado en 2009

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells

artículo científico publicado en 2010

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

artículo científico publicado en 2013

The chase for the RIG-I ligand--recent advances

artículo científico publicado en 2010

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer

artículo científico publicado en 2013

Therapeutic tissue regeneration by a macrophage colony-stimulating factor Fc conjugate

artículo científico publicado en 2014

Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha

artículo científico publicado en 2009

Turning tumors into vaccines: co-opting the innate immune system

artículo científico

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation

artículo científico publicado en 2012

Virally Infected Mouse Liver Endothelial Cells Trigger CD8+ T-Cell Immunity

Where Failure Is Not an Option -Personalized Medicine in Astronauts

artículo científico publicado en 2015

Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.

artículo científico publicado en 2014

siRNA and isRNA: two edges of one sword

artículo científico publicado en 2006

Lista de obras de Gunther Hartmann

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice

5'-Triphosphate RNA is the ligand for RIG-I

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

A Message from the Oligonucleotide Therapeutics Society

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

A mammalian microRNA expression atlas based on small RNA library sequencing

AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models

Accessing the therapeutic potential of immunostimulatory nucleic acids

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Analysis of integrated clinical trial protocols in early phases of medicinal product development

Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium

Antisense therapy in oncology: new hope for an old idea?

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

Approaching the RNA ligand for RIG-I?

Basic principles, planning and implementation of non-commercial clinical trials

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Calponin-h2: a potential serum marker for the early detection of human breast cancer?

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays

Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells.

CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model

CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo

CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells

Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination.

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides

Delivery with polycations extends the immunostimulant Ribomunyl® into a potent antiviral Toll-like receptor 7/8 agonist

Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters

Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer

Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells

Discriminating self from non-self in nucleic acid sensing

Effects of an active immunization on the immune response of laying Japanese quail (Coturnix coturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize

Efficient solid-phase synthesis of pppRNA by using product-specific labeling

Endothelial RIG-I activation impairs endothelial function

Enhanced Dendritic Cell Maturation by TNF- or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

Enzymatic synthesis and purification of a defined RIG-I ligand

Exosomes as nucleic acid nanocarriers

Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study

Funktion von extrazellulären Vesikeln und Bedeutung für die labormedizinische Diagnostik

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

Human TLR8 Senses RNA From -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.

Identification of specific nuclear structural protein alterations in human breast cancer

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

Immunohistological analysis of in-transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta-interferon: A case report

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.

Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.

In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination.

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

Inflammasome-Dependent Induction of Adaptive NK Cell Memory

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice

Monocyte-Mediated Inhibition of TLR9-Dependent IFN- Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

No indication for a defect in toll-like receptor signaling in patients with hyper-IgE syndrome

Nucleic Acid Immunity

Nucleic acid adjuvants: toward an educated vaccine

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model.

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

Preferential expression and function of Toll-like receptor 3 in human astrocytes