"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.
artículo científico publicado en 2001
"Viologen" dendrimers as antiviral agents: the effect of charge number and distance
artículo científico publicado en 2010
(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties
artículo científico publicado en 1992
(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity
artículo científico publicado en 2001
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent
artículo científico publicado en 1979
(E)-5-(2-Bromovinyl)-2?-deoxyuridine (BVDU)
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis
artículo científico publicado en 1980
(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
artículo científico publicado en 2005
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity
artículo científico publicado en 1989
(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.
artículo científico publicado en 1995
(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis
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artículo científico publicado el 1 de mayo de 1991
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication
artículo científico publicado en 1988
(S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity
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artículo científico publicado el 5 de mayo de 1978
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity
artículo científico publicado en 1998
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation
artículo científico publicado en 2009
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2008
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors
artículo científico publicado en 2010
1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro
article
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells
artículo científico publicado en 2008
1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries
artículo científico publicado en 2017
18 Synthesis and metabolic study of 1H,3H-oxazolo[3,4-a]benzimidazoles, a new class of non-nucleoside HIV-1 RT inhibitors
article
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri
artículo científico publicado en 1992
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
artículo científico publicado en 1990
2-(2,6-Dihalo-phenyl)-3-heteroaryl-2-ylmethyl-1, 3-thiazolidin-4-ones: anti-HIV agents.
artículo científico publicado en 2008
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance
artículo científico publicado en 2009
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action
artículo científico publicado en 2014
2-5A synthetase activity induced by interferon α, β, and γ in human cell lines differing in their sensitivity to the anticellular and antiviral activities of these interferons
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artículo científico publicado el 1 de marzo de 1982
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections
artículo científico publicado en 2002
2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives
2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine
artículo científico publicado en 1992
3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues
artículo científico publicado en 1999
3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties
artículo científico publicado en 1992
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins
artículo científico publicado en 2016
3,5-Bis(Phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A Novel Group of Cytotoxic Agents
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artículo científico publicado el 1 de agosto de 2003
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins
artículo científico publicado en 2011
3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties
artículo científico publicado en 2009
32 Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates
artículo científico publicado el 1 de enero de 1981
4 Viral entry as the primary target of anti-HIV activity of chicoric acid and its tetra-acetyl esters
article
4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.
artículo científico publicado en 2001
4-(β-Arylvinyl)-3-(β-arylvinylketo)-1-ethyl-4-piperidinols and Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents
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artículo científico publicado el 8 de octubre de 1998
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation
artículo científico publicado en 2010
40 Interferon inducers: General survey and classification
artículo científico publicado el 1 de enero de 1981
5'-Nor carbocyclic 5'-deoxy-5'-(isobutylthio)adenosine and a 2',3'-dideoxy-2',3'-didehydro derivative
artículo científico publicado en 2001
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity
artículo científico publicado en 1990
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication
artículo científico publicado en 1991
5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series
artículo científico publicado en 2004
5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
article
5-Nitro-2′-deoxyuridine 5′-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase
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artículo científico publicado el 30 de octubre de 1978
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives
scientific article published on 01 May 1991
5-Propyl-2'-deoxyuridine: a specific anti-herpes agent
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artículo científico publicado el 1 de marzo de 1978
5-Substituted 2'-deoxyuridines which selectively inhibit herpes simplex virus replication
artículo científico publicado el 1 de enero de 1979
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase
artículo científico publicado en 1982
5-Substituted uracil arabinonucleosides as potential antiviral agents
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artículo científico publicado el 1 de marzo de 1979
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity
artículo científico publicado en 2003
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells
artículo científico publicado en 2007
6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins
artículo científico publicado en 2017
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity
artículo científico publicado en 2002
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity
artículo científico publicado en 2004
6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains
artículo científico publicado en 2004
7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase
artículo científico publicado en 1998
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
artículo científico publicado en 1994
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
artículo científico publicado en 1989
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys
artículo científico publicado en 1991
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
artículo científico publicado en 1989
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
artículo científico publicado en 1999
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo
artículo científico publicado en 1991
A 40-Year Journey in Search of Selective Antiviral Chemotherapy*
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artículo científico publicado el 1 de enero de 2011
A New Topical Treatment for Resistant Herpes Simplex Infections
A case of human orf in an immunocompromised patient treated successfully with cidofovir cream
artículo científico publicado en 2001
A combination of poor adherence and a low baseline susceptibility score is highly predictive for HAART failure.
artículo científico publicado en 2002
A continuous high molecular weight base-paired structure is not an absolute requirement for a potential polynucleotide inducer of interferon
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artículo científico publicado el 15 de abril de 1977
A cutting-edge view on the current state of antiviral drug development
artículo científico publicado en 2013
A guided tour through the antiviral drug field
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells
artículo científico publicado en 1988
A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.
artículo científico publicado en 2002
A mercapto analogue of 5'-noraristeromycin
artículo científico publicado en 2002
A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate
artículo científico publicado en 2009
A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors
artículo científico publicado en 2005
A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470.
artículo científico publicado en 1999
A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities
artículo científico publicado en 2015
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine
artículo científico publicado en 1989
A novel selective broad-spectrum anti-DNA virus agent
artículo científico publicado en 1986
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase
artículo científico publicado en 2006
A potent interferon inducer derived from poly (7-deazainosinic acid)
artículo científico publicado en 1974
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
artículo científico publicado en 2009
A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses
artículo científico publicado en 2003
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export
artículo científico publicado en 2002
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
artículo científico publicado en 2002
A time-of-drug addition approach to target identification of antiviral compounds
artículo científico publicado en 2011
AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.
artículo científico publicado en 2001
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
artículo científico publicado en 1998
AMD3100/CXCR4 Inhibitor
artículo científico publicado en 2015
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
artículo científico publicado en 2005
ANN-QSAR model for selection of anticancer leads from structurally heterogeneous series of compounds.
artículo científico publicado en 2006
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.
artículo científico publicado en 1998
Abatement of Cutaneous Kaposi's Sarcoma Associated with Cidofovir Treatment
article
Absence of infectious retinitis after injection of human cytomegalovirus into rabbit eyes
artículo científico publicado en 1995
Ac2IDU, BVDU, and Thymine Arabinoside Therapy in Experimental Herpes Keratitis
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artículo científico publicado el 1 de septiembre de 1981
Activation of herpes simplex virus (HSV) type 1 genome by temperature-sensitive mutants of HSV type 2
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artículo científico publicado el 30 de enero de 1982
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures
artículo científico publicado en 2005
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures
artículo científico publicado en 2006
Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages
artículo científico publicado en 2000
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models
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artículo científico publicado en 2007
Activities of various compounds against murine and primate polyomaviruses
artículo científico publicado en 1997
Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses
article by M. Witvrouw et al published October 1994 in Antiviral Chemistry & Chemotherapy
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes
artículo científico publicado en 1991
Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.
artículo científico publicado en 1992
Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor
artículo científico publicado en 1999
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV
artículo científico publicado en 1999
Activity of recombinant HIV-1 integrase on mini-HIV DNA.
artículo científico publicado en 1999
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
artículo científico publicado en 1996
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo
article
Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures
artículo científico publicado en 2007
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.
artículo científico publicado en 1995
Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections
artículo científico publicado en 2006
Acyclic Nucleoside Phosphonates in the Chemotherapy of DNA Virus and Retrovirus Infections
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artículo científico publicado el 1 de enero de 1997
Acyclic Nucleoside Phosphonates: A New Dimension To The Chemotherapy Of Dna Virus And Retrovirus Infections
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artículo científico publicado el 1 de enero de 1998
Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection
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artículo científico publicado el 1 de abril de 1992
Acyclic nucleoside phosphonates: An unfinished story
Acyclic nucleoside phosphonates: a key class of antiviral drugs
artículo científico publicado en 2005
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
artículo científico publicado en 1996
Acyclic nucleotide analogues based on phosphonic acids
artículo científico publicado el 1 de enero de 1998
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
artículo científico publicado en 2001
Additions and Corrections - Resolution of Aristeromycin Enantiomers
article
Adefovir dipivoxil
Adverse Events and Autopsy Findings after Intravitreous Cidofovir (HPMPC) Therapy in Patients with Acquired Immune Deficiency Syndrome (AIDS)
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artículo científico publicado el 1 de noviembre de 1997
Ajoene [(e,z)-4,5,9-trithiadodeca-1, 6, 11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations
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artículo científico publicado el 1 de enero de 1998
Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility
artículo científico publicado en 2002
Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds
artículo científico publicado en 1992
Alopecia in laboratory animals induced by a polyampholyte, polyethylene alanine.
artículo científico publicado en 1980
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
artículo científico publicado en 1991
Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation
artículo científico publicado el 1 de junio de 1992
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
artículo científico publicado en 1998
An Animal Model for Cidofovir (HPMPC) Toxicity: Intraocular Pressure and Histopathologic Effects
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artículo científico publicado el 1 de mayo de 1997
An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice
artículo científico publicado en 2019
An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014
artículo científico publicado en 2015
An active interferon inducer obtained from Hemophilus influenzae type B
artículo científico publicado en 1969
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives
artículo científico publicado en 1991
An epimer of 5'-noraristeromycin and its antiviral properties.
artículo científico publicado en 1994
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs
artículo científico publicado en 1999
Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.
artículo científico publicado en 2004
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives
artículo científico publicado en 2009
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes
artículo científico publicado en 2000
Anti-DNA Virus Agents
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends
artículo científico publicado en 2015
Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.
artículo científico publicado en 2006
Anti-HIV activity of dextran sulphate as determined under different experimental conditions
artículo científico publicado en 1989
Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone
artículo científico publicado en 2002
Anti-HIV agents to be used in drug combination regimens
article
Anti-HIV agents: design and discovery of new potent RT inhibitors
artículo científico publicado en 2003
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.
artículo científico publicado en 1996
Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action
artículo científico publicado en 2015
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.
artículo científico publicado en 2008
Anti-HIV-1 activity of benzothiadiazine dioxide
artículo científico publicado en 2001
Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship
article
Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase
artículo científico publicado en 2002
Anti-complement activity of polynucleotides
artículo científico publicado el 3 de noviembre de 1975
Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles
scientific article published in 2007
Anti-herpes activity of deoxythymidine analogues: specific dependence on virus-induced deoxythymidine kinase
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artículo científico publicado el 1 de septiembre de 1977
Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.
artículo científico publicado en 2001
Anti-herpesvirus chemotherapy: experimental and clinical aspects. Concluding remarks
artículo científico publicado el 1 de enero de 1979
Anti-human immunodeficiency virus drug combination strategies
artículo científico publicado en 1998
Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives
artículo científico publicado en 1990
Anti-influenza virus agents: synthesis and mode of action
artículo científico publicado en 2008
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered
artículo científico publicado en 1990
Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency
artículo científico publicado en 2000
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues
artículo científico publicado en 2005
Anticonvulsant phenytoinergic pharmacophores and anti-HIV activity — Preliminary evidence for the dual requirement of the 4-aminophthalimide platform and the N-(1-adamantyl) substitution for antiviral properties
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artículo científico publicado el 1 de enero de 1998
Antiherpes drugs: Promises and pitfalls
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artículo científico publicado el 1 de abril de 1984
Antihistaminic and antiviral activities of steroids of Turbinaria conoides
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artículo científico publicado el 1 de abril de 2011
Antimalarial chloroquine metamorphosed into antiviral agent against HIV with four modes of actions
artículo científico publicado en 2012
Antimetabolic activities of 2-fluoro-L-histidine
artículo científico publicado en 1978
Antimicrobial and cytotoxic activities of turbinariaconoides (j.agardh) kuetz
artículo científico publicado en 2010
Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles
artículo científico publicado en 2012
Antiproliferative and antiviral activity of three libraries of adamantane derivatives
artículo científico publicado en 2014
Antiproliferative and apoptotic effects of iron chelators on human cervical carcinoma cells
artículo científico publicado en 2002
Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines.
artículo científico publicado en 1998
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected [...]
artículo científico publicado en 1997
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine
artículo científico publicado en 1996
Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics
artículo científico publicado en 2003
Antiretroviral drugs
artículo científico publicado en 2010
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice
artículo científico publicado en 1998
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
artículo científico publicado en 2002
Antitumor Potential of Acyclic Nucleoside Phosphonates
artículo científico publicado en 1999
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures
artículo científico publicado en 2002
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity
artículo científico publicado en 2006
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity
artículo científico publicado en 2007
Antiviral Activity Spectrum of Nucleoside and Nucleotide Analogues
Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses
artículo científico publicado en 2008
Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): retroviruses and hepadnaviruses
artículo científico publicado en 2008
Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2006 (1st edition).
artículo científico publicado en 2006
Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2008 (2nd edition): RNA viruses
artículo científico publicado en 2008
Antiviral Drug Development – Success and Failure: A Personal Perspective with a Japanese Connection
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artículo científico publicado el 16 de mayo de 2013
Antiviral Research, at its 30th anniversary, remembrances from its Editor-in-Chief
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artículo científico publicado el 14 de julio de 2011
Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds
artículo científico publicado en 1991
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
artículo científico publicado en 2007
Antiviral activity of 5-ethyl pyrimidine deoxynucleosides
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artículo científico publicado el 15 de mayo de 1975
Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines
artículo científico publicado en 1979
Antiviral activity of 5-thiocyanatopyrimidine nucleosides
artículo científico publicado en 1975
Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1).
artículo científico publicado en 1996
Antiviral activity of O'-alkylated derivatives of cytosine arabinoside
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artículo científico publicado el 15 de febrero de 1975
Antiviral activity of O′-methylated derivatives of adenine arabinoside
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artículo científico publicado el 15 de abril de 1977
Antiviral activity of a novel compound P-4018 against different strains of herpes simplex virus in vitro and in vivo
artículo científico publicado en 1997
Antiviral activity of aliphatic nucleoside analogues: structure-function relationship
artículo científico publicado en 1979
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique
artículo científico publicado en 1991
Antiviral activity of carbopol, a cross-linked polycarboxylate
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artículo científico publicado el 1 de enero de 1976
Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir
artículo científico publicado en 2001
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts
artículo científico publicado en 2006
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses
artículo científico publicado en 2000
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines
artículo científico publicado en 1987
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro
scientific article published on September 1968
Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo
artículo científico publicado en 1968
Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic or 2-methylthioinosinic acid
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artículo científico publicado el 1 de enero de 1975
Antiviral activity of polynucleotides: poly 2′-o-ethyladenylic acid and poly 2′-o-ethyluridylic acid
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artículo científico publicado el 15 de junio de 1974
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
artículo científico publicado en 1995
Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 1983
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses
artículo científico publicado en 2017
Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.
artículo científico publicado en 1996
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds
artículo científico publicado en 2007
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.
artículo científico publicado en 2001
Antiviral agents active against influenza A viruses.
artículo científico publicado en 2006
Antiviral agents and immunity
Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact.
artículo científico publicado en 1993
Antiviral and antimetabolic activities of formycin and its N1-, N2-, 2'-O- and 3'-O-methylated derivatives
artículo científico publicado en 1975
Antiviral and antimetabolic activities of poly (7-deazaadenylic acid) and poly(7-deazainosinic acid)
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artículo científico publicado el 15 de diciembre de 1975
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines
artículo científico publicado en 1992
Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives
artículo científico publicado en 2005
Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo
artículo científico publicado en 2002
Antiviral drug discovery and development: where chemistry meets with biomedicine
artículo científico publicado en 2005
Antiviral drug discovery: ten more compounds, and ten more stories (part B).
artículo científico publicado en 2009
Antiviral drug susceptibility of human herpesvirus 8
artículo científico publicado en 1997
Antiviral drugs in current clinical use.
artículo científico publicado en 2004
Antiviral enantiomeric preference for 5'-noraristeromycin.
artículo científico publicado en 1994
Antiviral metal complexes.
artículo científico
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines
artículo científico publicado en 2005
Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy
artículo científico publicado en 2006
Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir
artículo científico publicado en 2004
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses
artículo científico publicado en 2006
Antiviral research at the Rega Institute (KU leuven), now 50 years old.
artículo científico publicado en 2004
Antiviral therapy: quo vadis?
artículo científico publicado en 2010
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection
artículo científico publicado en 2005
Antiviral treatment of chronic hepatitis B virus (HBV) infections
artículo científico publicado en 2010
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future
artículo científico publicado en 2008
Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2′-deoxyuridine and their 5′-phosphates
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artículo científico publicado el 1 de marzo de 1981
Antivirals and antiviral strategies
artículo científico publicado en 2004
Antivirals: Past, present and future
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artículo científico publicado el 24 de diciembre de 2012
Antivirals: current state of the art
Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure
artículo científico publicado en 2004
Application of a gastric cancer cell line (MKN-28) for anti-adenovirus screening using the MTT method
artículo científico publicado en 1996
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency
artículo científico publicado en 2005
Approved Antiviral Drugs over the Past 50 Years
artículo científico publicado en 2016
Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
artículo científico publicado en 2003
Are Cytotoxicity and Interferon Inducing Activity of Poly(I).Poly(C) Invariably Linked in Interferon-treated L cells?
artículo científico publicado el 1 de abril de 1975
Are the 2-isomers of the drug rimantadine active anti-influenza A agents?
artículo científico publicado en 2003
Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity
artículo científico publicado en 2002
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents
artículo científico publicado en 2012
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
artículo científico publicado en 2012
Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors
artículo científico publicado en 2014
Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach
artículo científico publicado en 2016
Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach
article
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors
artículo científico publicado en 2011
Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytes
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artículo científico publicado el 1 de noviembre de 1992
Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations
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artículo científico publicado el 1 de agosto de 1998
Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention.
artículo científico publicado en 2007
BVDU ((E)-5-(2-Bromovinyl)-2’-Deoxyuridine)
article
Baculovirus Replication: Inhibition of Trichoplusia ni Multiple Nuclear Polyhedrosis Virus by [E]-5-(2-Bromovinyl)-2'-deoxyuridine
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artículo científico publicado el 1 de junio de 1983
Baseline HIV Type 1 Genotypic Resistance to a Newly Added Nucleoside Analog Is Predictive of Virologic Failure of the New Therapy
article
Basic approaches to anti-retroviral treatment
artículo científico publicado el 1 de enero de 1991
Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations
artículo científico publicado en 2011
Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
artículo científico publicado en 2010
Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4
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artículo científico publicado el 1 de agosto de 1997
Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication.
artículo científico publicado en 1999
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity
artículo científico publicado en 2004
Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
artículo científico publicado en 2000
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain
artículo científico publicado en 2005
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of varicella-zoster virus modified on the sugar moiety: 3' and 5' derivatives.
artículo científico publicado en 2004
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives
artículo científico publicado en 2003
Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain
artículo científico publicado en 2002
Bicyclic nucleoside inhibitors of varicella-zoster virus: synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro and 2'-deoxy-xylo derivatives
artículo científico publicado en 2003
Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.
artículo científico publicado en 2009
Biological evaluation of proanthocyanidin dimers and related polyphenols
artículo científico publicado en 1999
Biological, biochemical and physicochemical evidence for the existence of the polyadenylate · polyuridylate · poly 2'-fluoro-2'-deoxyuridylate triple-stranded complex
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artículo científico publicado el 1 de julio de 1976
Biological, biochemical, and physicochemical evidence for the existence of the polyadenylic-polyuridylic-polyinosinic acid triplex
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artículo científico publicado el 10 de abril de 1975
Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum.
artículo científico publicado en 2005
Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins
artículo científico publicado en 2011
Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm
artículo científico publicado en 2010
Bone marrow transplantation in a child with Wiskott-Aldrich syndrome latently infected with acyclovir-resistant (ACV(r)) herpes simplex virus type 1: emergence of foscarnet-resistant virus originating from the ACV(r) virus
artículo científico publicado en 2002
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
artículo científico publicado en 1987
Brief Communication : Regression of Autochthonous Moloney Sarcoma Virus-Induced Tumors in Mice Treated With Polyriboinosinic Acid-Polyribocytidylic Acid 2
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artículo científico publicado el 1 de febrero de 1974
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives
artículo científico publicado en 1989
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
artículo científico publicado en 1998
Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
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artículo científico publicado el 15 de enero de 1990
Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine
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artículo científico publicado el 1 de marzo de 1983
C-Nucleosides To Be Revisited
artículo científico publicado en 2015
CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor
artículo científico publicado en 2002
CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro
artículo científico publicado en 2004
CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.
artículo científico publicado en 1998
CXCR4 as a functional coreceptor for human immunodeficiency virus type 1 infection of primary macrophages
artículo científico publicado en 1998
CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles
artículo científico publicado en 2012
CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes
artículo científico publicado en 2001
CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity
artículo científico publicado en 2001
Capsid (CA) protein as a novel drug target: recent progress in the research of HIV-1 CA inhibitors
artículo científico publicado en 2009
Carbocyclic Adenosine Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Antiviral Agents: Recent Advances
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artículo científico publicado el 1 de enero de 1998
Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues
artículo científico publicado en 2003
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers
artículo científico publicado en 1998
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335
artículo científico publicado en 1992
Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation
artículo científico publicado en 2005
Cellular uptake of phosphonylmethoxyalkylpurine derivatives
artículo científico publicado en 1991
Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport
artículo científico publicado en 2009
Characterization of Cowpox Virus (CPV) Mutants Arising under Pressure with Different Acyclic Nucleoside Phosphonates
scientific article published in 2009
Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors
artículo científico publicado en 2007
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin
artículo científico publicado en 2005
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine
artículo científico publicado en 1999
Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay
artículo científico publicado en 2003
Charge modification of plasma and milk proteins results in antiviral active compounds
artículo científico publicado en 1999
ChemInform Abstract: Antiinfluenza Virus Agents: Synthesis and Mode of Action
ChemInform Abstract: Antiviral Drug Discovery: Ten More Compounds, and Ten More Stories. Part B
ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors
ChemInform Abstract: Difluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity
ChemInform Abstract: Selective Inhibitors of Picornavirus Replication
ChemInform Abstract: Yet Another Ten Stories on Antiviral Drug Discovery. Part D. Paradigms, Paradoxes, and Paraductions
Chemical crosslinking of the subunits of HIV-1 reverse transcriptase.
artículo científico publicado en 1996
Chemical studies of essential oils of Juniperus oxycedrus ssp. badia
artículo científico publicado en 2002
Chemo-enzymatic synthesis of 3-deoxy-beta-D-ribofuranosyl purines and study of their biological properties
artículo científico publicado en 2003
Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity
artículo científico publicado en 2004
Chemoenzymatic synthesis and antiviral evaluation of conformationally constrained and 3'-methyl-branched carbanucleosides using both enantiomers of the same building block
artículo científico publicado en 2007
Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.
artículo científico publicado en 2002
Chemotherapy of respiratory syncytial virus infections: the final breakthrough
artículo científico publicado en 2015
Chemotherapy of the acquired immune deficiency syndrome (AIDS): Non-nucleoside inhibitors of the human immunodeficiency virus type 1 reverse transcriptase
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artículo científico publicado el 1 de enero de 1991
Chemotherapy of varicella zoster virus infections.
artículo científico publicado en 1994
Chicoric acid analogues as HIV-1 integrase inhibitors
artículo científico publicado en 1999
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2002
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2012
Chromosome 21 does not code for an interferon receptor
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artículo científico publicado el 18 de noviembre de 1976
Cidofovir in the therapy and short-term prophylaxis of poxvirus infections
artículo científico publicado en 2002
Cidofovir in the treatment of HPV-associated lesions.
artículo científico publicado en 2001
Cidofovir in the treatment of poxvirus infections
artículo científico publicado en 2002
Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice
artículo científico publicado en 2006
Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III)
artículo científico publicado en 2000
Cidofovir: Induction of apoptosis in human papilloma virus (HPV)-containing cell lines
scientific article published in 1997
Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa
artículo científico publicado en 2007
Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections
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artículo científico publicado el 1 de octubre de 2003
Clinical features and treatment of adenovirus infections
artículo científico publicado en 2008
Combination of Azidothymidine (AZT) and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) Inhibits the Replication of Herpes Simplex Virus Type 1 (HSV-1) and Type 2 (HSV-2) and Varicella Zoster Virus (VZV) Strains That Are Deficient in the Expression of th
article published in 1995
Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice
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artículo científico publicado el 1 de marzo de 1988
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase
artículo científico publicado en 1992
Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus
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artículo científico publicado el 1 de mayo de 1980
Comparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against rat cytomegalovirus infection in vitro and in vivo
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artículo científico publicado el 1 de noviembre de 1991
Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus
artículo científico publicado en 1991
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus
artículo científico publicado en 1995
Comparative activity of various compounds against clinical strains of herpes simplex virus
artículo científico publicado en 1992
Comparative efficacy of antiherpes drugs in different cell lines
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artículo científico publicado el 1 de abril de 1982
Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits
artículo científico publicado el 1 de enero de 1979
Comparative inhibition of DNA polymerases from varicella zoster virus (TK+ and TK-) strains by (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate
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artículo científico publicado el 1 de septiembre de 1984
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro
artículo científico publicado en 1991
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV)
scientific article (publication date: 15 March 1986)
Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity
artículo científico publicado en 2002
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues
artículo científico publicado en 2008
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector
artículo científico publicado en 2002
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector
artículo científico publicado en 2002
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
artículo científico publicado en 2005
Concentration of interferon by nucleic acid precipitation
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artículo científico
Concert chromatography purification of mouse interferon [proceedings]
artículo científico publicado el 1 de febrero de 1979
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.
artículo científico publicado en 2006
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
artículo científico publicado en 1997
Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.
artículo científico publicado en 1991
Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence
artículo científico publicado en 2002
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.
artículo científico publicado en 2001
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.
artículo científico publicado en 2002
Corrigendum to “Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents” [Tetrahedron 54 (1998) 2209]
scholarly article published in Tetrahedron
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus
artículo científico publicado en 2011
Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus
artículo científico publicado en 2013
Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase
artículo científico publicado en 2009
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential
artículo científico
Curious discoveries in antiviral drug development: the role of serendipity
artículo científico
Current Concepts of Interferon and Interferon Induction
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artículo científico publicado en 1970
Current acquisitions in antiviral drugs (anti-HIV)
artículo científico publicado el 1 de julio de 1992
Current race in the development of DAAs (direct-acting antivirals) against HCV.
artículo científico publicado en 2014
Current therapy for chronic hepatitis C: The role of direct-acting antivirals
artículo científico publicado en 2017
Current treatment of hepatitis B virus infections
artículo científico
CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA
artículo científico publicado en 1999
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP
artículo científico publicado en 2000
Cytostatic activity of novel 4′-aminochalcone-based imides
scientific article published in 2007
Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs
artículo científico publicado en 2009
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds
scientific article published on 01 October 2002
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds
artículo científico publicado en 2002
Cytotoxic 4'-aminochalcones and related compounds
artículo científico publicado el 1 de abril de 2003
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
artículo científico publicado en 2006
Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds
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artículo científico publicado el 26 de marzo de 1998
Cytotoxic Mannich Bases of 1-Arylidene-2-tetralones
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artículo científico publicado el 1 de agosto de 2003
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds
artículo científico publicado en 2002
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones
artículo científico publicado en 2003
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds
artículo científico publicado en 2004
Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii
artículo científico publicado en 2009
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
artículo científico publicado en 2007
DNA-Dependent protein kinase is not required for efficient lentivirus integration
artículo científico publicado en 2000
DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy
artículo científico publicado en 2002
Dancing with chemical formulae of antivirals: A panoramic view (Part 2).
artículo científico publicado en 2013
Dancing with chemical formulae of antivirals: a personal account
artículo científico publicado en 2013
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy
artículo científico publicado en 2020
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
artículo científico publicado en 2002
Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle
artículo científico publicado en 2009
Degradation of Poly(inosinic acid) . poly(cytidylic acid) [(I)n . (Cn)] by Human Plasma
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artículo científico publicado el 2 de enero de 1979
Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine
scientific article published on 01 May 1986
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents
artículo científico publicado en 2005
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore
artículo científico publicado en 2010
Desferrioxamine enhances AIDS-associated Kaposi's sarcoma tumor development in a xenograft model
artículo científico publicado en 2002
Design and development of curcumin bioconjugates as antiviral agents
artículo científico publicado en 2008
Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity
artículo científico publicado en 2009
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
artículo científico publicado en 2007
Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine
artículo científico publicado en 2018
Design and synthesis of bioactive 1,2-annulated adamantane derivatives.
artículo científico publicado en 2008
Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines
artículo científico publicado en 2010
Design and synthesis of bioactive adamantane spiro heterocycles
artículo científico publicado en 2007
Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.
artículo científico publicado en 2006
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR
artículo científico publicado en 1999
Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity
artículo científico publicado en 2003
Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy
scientific article published on 26 February 2020
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
artículo científico publicado en 2011
Design of nucleoside, oligonucleotide and polynucleotide analogues as antiviral agents
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artículo científico publicado el 1 de enero de 1982
Design strategies of novel NNRTIs to overcome drug resistance
scientific article published on January 2009
Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket
artículo científico publicado en 2014
Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents
artículo científico publicado en 2015
Design, Synthesis, and Biological Evaluation of Novel 4-Aminopiperidinyl-linked 3,5-Disubstituted-1,2,6-thiadiazine-1,1-dione Derivatives as HIV-1 NNRTIs
artículo científico publicado en 2014
Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents
artículo científico publicado en 2014
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
artículo científico publicado en 2016
Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents
artículo científico publicado en 2016
Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization
artículo científico publicado en 2014
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs
artículo científico publicado en 2017
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket
artículo científico publicado en 2015
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells
artículo científico publicado en 2007
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents
artículo científico publicado en 2009
Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase
scientific article published on 06 July 2019
Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs
artículo científico publicado en 2011
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs
scientific article published on 30 December 2018
Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction
artículo científico publicado en 2014
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds
artículo científico publicado en 2006
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
artículo científico publicado en 2001
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket
artículo científico publicado en 2016
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
artículo científico publicado en 2009
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors
artículo científico publicado en 2018
Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors
scientific article published on 24 January 2019
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders
artículo científico publicado en 2004
Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors
artículo científico publicado en 2016
Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues
artículo científico publicado en 2007
Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase
artículo científico publicado en 2000
Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
artículo científico publicado en 2006
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents
artículo científico publicado en 2009
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2004
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2012
Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline-triazine derivatives.
artículo científico publicado en 2013
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents
artículo científico publicado en 2002
Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100
artículo científico publicado en 1998
Development of a Model for the Study of Antivirals Against Molluscum Contagiosum Virus (MCV)
artículo científico publicado en 2008
Development of a cell-based enzyme-linked immunosorbent assay for high-throughput screening of HIV type 1 entry inhibitors targeting the coreceptor CXCR4.
artículo científico publicado en 2003
Development of antiviral drugs for the treatment of hepatitis C at an accelerating pace
artículo científico
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations
artículo científico publicado en 2003
Development of resistance of human immunodeficiency virus (HIV) to anti-HIV agents: how to prevent the problem?
artículo científico publicado en 1997
Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.
artículo científico publicado en 1997
Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.
artículo científico publicado en 1990
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages
artículo científico publicado el 1 de abril de 1992
Differential Susceptibility of Several Drug-Resistant Strains of Herpes Simplex Virus Type 2 to Various Antiviral Compounds
article
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains
artículo científico publicado en 1995
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins
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artículo científico publicado el 1 de julio de 1981
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
artículo científico publicado en 1993
Differential antiviral activity of several IMP dehydrogenase inhibitors
scientific article published in 1997
Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2′-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases
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artículo científico publicado el 1 de junio de 1984
Differential effects of various double-stranded RNAs on protein synthesis in rabbit reticulocyte lysates
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artículo científico publicado el 10 de enero de 1978
Differential inhibition of herpes simplex viruses, type 1 (HSV-1) an type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2'-deoxyuridines
artículo científico publicado el 1 de enero de 1981
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue
artículo científico publicado en 1991
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid
artículo científico publicado en 1988
Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus
artículo científico publicado en 1992
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases
artículo científico publicado en 1989
Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins
artículo científico publicado en 1991
Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK.
artículo científico publicado en 1998
Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir
artículo científico publicado en 2003
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
artículo científico publicado en 1989
Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011).
artículo científico
Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases
artículo científico publicado en 2009
Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine
artículo científico publicado en 2003
Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity
artículo científico publicado en 2008
Dipyridamole Potentiates the Activity of Various Acyclic Nucleoside Phosphonates against Varicella-Zoster Virus, Herpes Simplex Virus and Human Cytomegalovirus
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
scientific article published on 24 January 2020
Discovery and Development of Tenofovir Disoproxil Fumarate
article
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster
artículo científico publicado en 2004
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
artículo científico publicado en 2001
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays
artículo científico publicado en 2014
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site
artículo científico publicado en 2018
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile
artículo científico publicado en 2006
Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.
artículo científico publicado en 2017
Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.
artículo científico publicado en 2004
Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.
artículo científico publicado en 2018
Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents
artículo científico publicado en 2011
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach
artículo científico publicado en 2014
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
artículo científico publicado en 2012
Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays
artículo científico publicado en 2017
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains
artículo científico publicado en 2007
Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach
artículo científico publicado en 2014
Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".
artículo científico publicado en 2018
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement
artículo científico publicado en 2016
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
artículo científico publicado en 2010
Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2015
Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2013
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I
article
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif
artículo científico
Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.
artículo científico publicado en 2014
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization
artículo científico publicado en 2017
Disulfide-containing macrolides that inhibit a late stage of the replicative cycle of human immunodeficiency virus
scientific article published in 1997
Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils
artículo científico publicado en 2001
Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects
scientific article published on 01 March 2000
Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine
artículo científico publicado en 1990
Drug targets in cytomegalovirus infection
artículo científico publicado en 2009
Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient
artículo científico publicado en 2007
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins
artículo científico publicado en 2007
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties
artículo científico publicado en 2008
E-5-(2-Bromovinyl)-2'-Deoxyuridine vs. Interferon in the Systemic Treatment of Infection with Herpes Simplex Virus of Athymic Nude Mice
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artículo científico publicado el 1 de junio de 1981
Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides
artículo científico publicado en 2009
Ebola virus (EBOV) infection: Therapeutic strategies
artículo científico publicado en 2014
Editorial
Editorial overview: Antiviral strategies
scholarly article by Erik De Clercq published in June 2016
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides
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artículo científico publicado el 1 de mayo de 1984
Effect of 5-iodo-2'-deoxyuridine on vaccinia virus (orthopoxvirus) infections in mice
artículo científico publicado en 2002
Effect of Interferon, Polyacrylic Acid, and Polymethacrylic Acid on Tail Lesions in Mice Infected with Vaccinia Virus
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artículo científico publicado en 1968
Effect of cidofovir on the tumor growth of SiHa (human cervical carcinoma) cells in nude mice
scientific article published in 1997
Effect of cytosine, arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus
artículo científico publicado en 1976
Effect of human and mouse interferon and of polyriboinosinic acid.polyribocytidylic acid on the growth of human fibrosarcoma and melanoma tumors in nude mice
artículo científico publicado el 1 de noviembre de 1978
Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity
artículo científico publicado el 1 de septiembre de 1995
Effects of (E)-5-(2-bromovinyl)-2′-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells
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artículo científico publicado el 1 de septiembre de 1983
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits
artículo científico publicado en 1991
Effects of topical and subconjunctival cidofovir (HPMPC) in an animal model
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artículo científico publicado el 1 de junio de 1998
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis
scientific article published on 01 January 1981
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine in the treatment of intracerebral murine cytomegalovirus infections in immunocompetent and immunodeficient mice
artículo científico publicado en 1993
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice
scientific article published on 01 May 1992
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice
artículo científico publicado en 1993
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice
artículo científico publicado en 1991
Efficacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for treatment of vaccinia virus (orthopoxvirus) infections in mice
artículo científico publicado en 2001
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections
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artículo científico publicado el 1 de octubre de 1984
Efficacy of cidofovir in a murine model of disseminated progressive vaccinia
artículo científico publicado en 2004
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice
scientific article published on 01 February 1993
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo
artículo científico publicado en 1989
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus
artículo científico publicado en 1998
Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV+3TC) combination therapy in patients previously treated with ZDV+ddC
artículo científico publicado en 1996
Efficient 3D database screening for novel HIV-1 IN inhibitors
artículo científico publicado en 2004
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis
artículo científico publicado en 1993
Emerging anti-HIV drugs
artículo científico publicado en 2005
Emerging antiviral drugs
article
Emtricitabine
Enfuvirtide
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
artículo científico publicado en 1998
Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor
artículo científico publicado en 1998
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.
artículo científico publicado en 1994
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs
scientific article published on 01 February 2000
Enzymatic activities induced by interferon in human fibroblast cell lines differing in their sensitivity to the anticellular activity of interferon
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artículo científico publicado el 1 de mayo de 1981
Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness
artículo científico publicado en 2017
Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus
artículo científico publicado en 1990
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists
artículo científico publicado en 2004
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof
artículo científico publicado en 2003
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity
artículo científico publicado en 2007
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.
artículo científico publicado en 2000
Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections.
artículo científico publicado en 2007
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry
artículo científico publicado en 2003
Evaluation of antiherpetic compounds using a gastric cancer cell line: pronounced activity of BVDU against herpes simplex virus replication
artículo científico publicado en 1996
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay
artículo científico publicado en 2004
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections
artículo científico publicado en 2007
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA
artículo científico publicado en 1999
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
artículo científico publicado en 1996
Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance
article
Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice
artículo científico publicado en 2004
Existing Influenza Antivirals: Their Mechanisms of Action and Potential in the Face of Avian Influenza
Experimental herpetic keratitis in rabbit corneal organ cultures
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artículo científico publicado el 1 de febrero de 1984
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine
artículo científico publicado en 1982
Experimental thymidine kinase-deficient HSV-1 keratitis: therapeutic attempts
scientific article published on 01 April 1987
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.
artículo científico publicado en 2001
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubili
artículo científico publicado en 2019
Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication
artículo científico publicado en 2004
Expression of human fibroblast interferon gene in Escherichia coli
artículo científico publicado en 1980
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency
artículo científico publicado en 1999
Failure of duplexes based on polylaurusin (poly(L), "Polyformycin B") to induce interferon
artículo científico publicado el 3 de febrero de 1975
Fidelity analysis of HIV-1 reverse transcriptase mutants with an altered amino-acid sequence at residues Leu74, Glu89, Tyr115, Tyr183 and Met184.
artículo científico publicado en 2000
Fifty Years in Search of Selective Antiviral Drugs
scientific article published on 12 April 2019
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain
artículo científico publicado en 2018
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication
artículo científico publicado en 2005
Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents
artículo científico publicado en 1992
Flow cytometric method to demonstrate whether anti-HIV-1 agents inhibit virion binding to T4+ cells.
artículo científico publicado en 1989
Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells
artículo científico publicado en 1990
Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus
artículo científico publicado en 2008
Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies
artículo científico publicado en 2004
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
artículo científico publicado en 2005
Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains
artículo científico publicado en 2019
Fomivirsen
From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
artículo científico publicado en 2005
From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor
From adefovir to Atripla™ via tenofovir, Viread™ and Truvada™
Functional roles of azoles motif in anti-HIV agents
artículo científico publicado en 2011
Furano pyrimidines as novel potent and selective anti-VZV agents
artículo científico publicado en 2001
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery
artículo científico publicado en 2018
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach
artículo científico publicado en 2014
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches
artículo científico publicado en 2015
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines
artículo científico publicado en 2015
Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives
artículo científico publicado en 2014
Gammaherpesviruses encode functional dihydrofolate reductase activity
artículo científico publicado en 2002
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates
artículo científico publicado en 1991
Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain
scientific article published on 01 May 1992
Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain
artículo científico publicado en 2002
Genotypic characterization of various herpes simplex virus type 1 (HSV-1) clones resistant to acyclic nucleoside phosphonates
scientific article published in 1997
Gliotoxin analogs as inhibitors of reverse transcriptase. 1. Effect of lipophilicity
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artículo científico publicado el 1 de agosto de 1978
Gliotoxin analogs as inhibitors of reverse transcriptase. 2. Resolution and x-ray crystal structure determination
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artículo científico publicado el 1 de agosto de 1978
Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins
artículo científico publicado en 1986
HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
artículo científico publicado en 2016
HIV Reverse Transcriptase Inhibitors
article
HIV inhibitors targeted at the reverse transcriptase
artículo científico publicado el 1 de febrero de 1992
HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design
artículo científico publicado en 2011
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
artículo científico publicado en 2000
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
artículo científico publicado en 2003
HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches
artículo científico publicado en 2004
HIV‐1‐specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase
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artículo científico publicado el 1 de mayo de 1993
Halophenyl furanopyrimidines as potent and selective anti-VZV agents
artículo científico publicado en 2003
Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats.
artículo científico publicado en 2005
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin
artículo científico publicado en 2006
Heparin-mimicking sulfonic acid polymers as multitarget inhibitors of human immunodeficiency virus type 1 Tat and gp120 proteins
artículo científico publicado en 2007
Herpes Simplex Acyclovir-Resistant Mutant in Experimental Keratouveitis
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artículo científico publicado el 1 de noviembre de 1983
Herpesvirus infections in immunocompromised patients
artículo científico publicado en 1995
Heterocyclic rimantadine analogues with antiviral activity
artículo científico publicado en 2003
Heterocyclic rimantadine analogues with antiviral activity
artículo científico publicado en 2006
High Efficiency Latency and Activation of Herpes Simplex Virus in Human Cells
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artículo científico publicado el 17 de septiembre de 1982
Highlights in antiviral drug research: antivirals at the horizon
artículo científico
Highlights in the discovery of antiviral drugs: a personal retrospective
scientific article published on February 2010
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives
artículo científico publicado el 1 de abril de 1992
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
artículo científico publicado en 1994
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives
artículo científico publicado en 1991
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain
artículo científico publicado en 2000
Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues
artículo científico publicado en 2003
Highly specific inhibitors of human immunodeficiency virus type I that are particularly targeted at the reverse transcriptase
artículo científico publicado el 1 de marzo de 1993
Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring
artículo científico publicado en 2000
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
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artículo científico publicado el 14 de junio de 2010
Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity
artículo científico publicado en 1996
Host Defense Mechanisms Against Murine Cytomegalovirus Infection Induced by Poly l:C in Severe Combined Immune Deficient (SCID) Mice
artículo científico publicado el 1 de noviembre de 1994
How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications
artículo científico publicado en 2004
How to overcome resistance of HIV-1 to HIV-1-specific reverse transcriptase inhibitors
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artículo científico publicado el 1 de julio de 1994
Human Brain Tumour Cell Lines as Cell Substrate to Demonstrate Sensitivity/Resistance of Herpes Simplex Virus Types 1 and 2 to Nucleoside Analogues
Human Cytomegalovirus Stimulates Thymidylate Synthase in Human Embryonic Lung Cells: A Possible Target for Anti-HCMV Therapy?
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures.
artículo científico publicado en 1995
Human fibroblast interferon for clinical trials: pharmacokinetics and tolerability in experimental animals and humans.
artículo científico publicado en 1979
Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance
artículo científico publicado en 2004
Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle
artículo científico publicado en 2004
Human herpesvirus 8 gene encodes a functional thymidylate synthase
artículo científico publicado en 2002
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants
artículo científico publicado en 1994
Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy.
artículo científico publicado en 1999
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
artículo científico publicado en 1998
Human immunodeficiency virus gp120 as the primary target of action of AR177 (Zintevir)
scientific article published in 1997
Human viral diseases: what is next for antiviral drug discovery?
artículo científico publicado el 28 de julio de 2012
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2015
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy
artículo científico publicado en 2010
Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond
artículo científico publicado en 2004
Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity
artículo científico publicado en 2006
Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: impact on the search for vaginal microbicides.
artículo científico publicado en 2000
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs
artículo científico publicado en 1999
Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
artículo científico publicado en 2019
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
artículo científico publicado en 2001
Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells
artículo científico publicado en 2003
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus
artículo científico publicado en 1996
Identification of the Type of Cells Responsible for Transfer of Herpes Simplex Virus (HSV) and Vaccinia Virus (VACV) Infection to Epithelial Cells Grown in 3D
scientific article published in 2009
Imidazothiadiazine dioxides: synthesis and antiviral activity
artículo científico publicado en 1999
Immunochemical Measurement of Conformational Heterogeneity of Poly(Inosinic Acid)
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artículo científico publicado el 16 de enero de 1978
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models
artículo científico publicado en 1991
Impact of 9-(2-phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells
artículo científico publicado en 1999
Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model
scholarly article by Pieter Leyssen et al published January 2003 in Journal of NeuroVirology
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model
artículo científico publicado en 2003
Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction
artículo científico publicado en 2003
Improving AZT efficacy
artículo científico publicado en 1998
Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position
artículo científico publicado en 2005
In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
artículo científico publicado en 2008
In Vivo Release of Previously Cleared Interferon by Cycloheximide
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artículo científico publicado el 1 de marzo de 1972
In search of a selective antiviral chemotherapy
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artículo científico publicado el 1 de octubre de 1997
In search of a selective therapy of viral infections
scientific article published on 21 October 2009
In search of authentic inhibitors of HIV-1 integration
artículo científico publicado en 2002
In search of effective anti-HHV-6 agents
artículo científico publicado en 2006
In search of specific inhibitors of retrovirus replication.
artículo científico publicado en 1985
In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against newly isolated clinical varicella-zoster virus strains
artículo científico publicado en 1987
In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses
artículo científico publicado en 1989
In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.
artículo científico publicado en 2001
In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents.
artículo científico publicado en 1998
In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion
artículo científico publicado en 1994
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma
scientific article published on 01 January 1998
In vitro andin vivo inhibition of virus multiplication by microwave hyperthermia
artículo científico publicado el 1 de enero de 1977
In vitro effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5′-amino-5-iodo-2′,5′-dideoxyuridine and 2-deoxy-d-glucose on latent ganglionic herpes simplex virus infection
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artículo científico publicado el 1 de abril de 1984
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
artículo científico publicado en 2006
In vitro evaluation of the effect of temporary removal of HIV drug pressure.
artículo científico publicado en 2000
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
artículo científico publicado en 2004
In vitro sensitivity of Kaposi's sarcoma cells to various chemotherapeutic agents including acyclic nucleoside phosphonates.
artículo científico publicado en 1999
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds
artículo científico publicado en 1982
In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)
In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine
artículo científico publicado en 1995
In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells
artículo científico publicado en 2003
Inactivation of S-Adenosyl-l-Homocysteine hydrolase with novel 5′-thioadenosine derivatives. Antiviral effects
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artículo científico publicado el 19 de mayo de 2003
Inactivation of S-Adenosyl-l-homocysteine Hydrolase and Antiviral Activity with 5‘,5‘,6‘,6‘-Tetradehydro-6‘-deoxy-6‘-halohomoadenosine Analogues (4‘-Haloacetylene Analogues Derived from Adenosine)
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artículo científico publicado el 24 de septiembre de 1998
Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects
artículo científico publicado en 2006
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase
artículo científico publicado en 2004
Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells
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artículo científico publicado el 25 de enero de 1982
Increased Susceptibility of Cells Treated with Interferon to the Toxicity of Polyriboinosinic·Polyribocytidylic Acid
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artículo científico publicado el 1 de julio de 1972
Increased resistance of trisomic-21 cells to virus replication: Role of interferon
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artículo científico publicado el 1 de mayo de 1978
Increased toxicity of double-stranded ribonucleic acid in virus-infected animals.
artículo científico publicado en 1973
Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells.
artículo científico publicado en 2000
Induction of interferon by nonviral agents
artículo científico publicado el 1 de julio de 1970
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis
artículo científico publicado en 2002
Influence of (E)-5-(2-bromovinyl)-2'-deoxyuridine on corneal epithelium healing
scientific article published on 01 January 1982
Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus
artículo científico publicado en 2002
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
artículo científico publicado en 2007
Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
artículo científico publicado en 2008
Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2',3'-Dideoxynucleosides
article
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A.
artículo científico publicado en 2006
Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A-, B- and C-type oncornaviruses
artículo científico publicado en 1975
Influence of intravitreal injections of HPMPC and related nucleoside analogues on intraocular pressure in guinea pig eyes
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artículo científico publicado el 1 de junio de 1998
Influence of various 2- and 2′-substituted polyadenylic acids on murine leukemia virus reverse transcriptase
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artículo científico publicado el 1 de junio de 1979
Inhibiting effects of cidofovir (HPMPC) on the growth of the human cervical carcinoma (SiHa) xenografts in athymic nude mice
scientific article published on 01 January 1998
Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
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artículo científico publicado el 15 de julio de 1988
Inhibition of Oncornavirus Activities by Polynucleotide Analogues
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
artículo científico publicado en 1997
Inhibition of antibody production in rats and mice by intravenous injection of interferon-inducing amounts of Sindbis virus or E. coli
artículo científico publicado en 1967
Inhibition of coxsackie B3 virus induced myocarditis in mice by 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile
artículo científico publicado en 2004
Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
artículo científico publicado en 2006
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir.
artículo científico publicado en 2001
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives
artículo científico publicado en 2003
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
artículo científico publicado en 2004
Inhibition of human immunodeficiency virus type (HIV-1) replication by some diversely functionalized spirocyclopropyl derivatives
artículo científico publicado en 1999
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives
artículo científico publicado en 2002
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent
artículo científico publicado en 2008
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives
artículo científico publicado en 2007
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study
scientific article published on 01 July 1999
Inhibition of murine leukaemia virus reverse transcriptase by 2-halogenated polyadenylic acids
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artículo científico publicado el 1 de junio de 1982
Inhibition of oncornavirus functions by 2'-azido polynucleotides
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artículo científico publicado el 1 de enero de 1975
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid)
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artículo científico publicado el 1 de diciembre de 1975
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir
artículo científico publicado en 2000
Inhibition of tubulin polymerization by select alkenyldiarylmethanes
artículo científico publicado en 2007
Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.
artículo científico publicado en 1995
Inhibitory Activity of (E)-5-(2-Bromovinyl)-2′-Deoxyuridine on the Salmonid Herpesviruses,Oncorhynchus masouVirus (OMV) andHerpesvirus salmonis
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artículo científico publicado el 1 de enero de 1988
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains
artículo científico publicado en 2007
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection
artículo científico publicado en 1993
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs
artículo científico publicado en 1995
Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis
artículo científico publicado en 1982
Inhibitory effect of a broad-spectrum antiviral egent, (S)-9-(2,3-dihydroxypropyl)adenine, on spermatogenesis in mice
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artículo científico publicado el 1 de julio de 1981
Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro
artículo científico publicado en 1987
Inhibitory effect of interferon on the growth of spontaneous mammary tumors in mice
artículo científico publicado el 1 de septiembre de 1982
Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro
artículo científico publicado en 1990
Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro
artículo científico publicado en 1989
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus
artículo científico publicado en 1990
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication
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artículo científico publicado el 1 de noviembre de 1991
Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro
artículo científico publicado en 1987
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication
artículo científico publicado en 1998
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro
artículo científico publicado en 1990
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis
artículo científico publicado en 1991
Interactions of the dimeric triad of HIV-1 aspartyl protease with inhibitors
artículo científico publicado en 2003
Interferon Inducing Activity of Polyinosinic Acid
artículo científico publicado el 1 de julio de 1978
Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide
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artículo científico publicado en 1969
Interferon Induction by Two 2'-Modified Double-Helical RNAs, Poly(2'-nuoro-2'-deoxymosimc acid) . poly(cytidylic acid) and Poly(2'-chloro-2'-deoxyinosinic acid) . poly(cytidylic acid)
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artículo científico publicado el 1 de enero de 1980
Interferon Induction by a 2'-Modified Double-Helical RNA, Poly(2'-azido-2'-deoxyinosinic acid) . polycytidylic acid
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artículo científico publicado el 1 de agosto de 1978
Interferon Induction: Tool for Establishing Interactions among Homopolyribonucleotides
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artículo científico publicado el 29 de noviembre de 1974
Interferon Production Linked to Toxicity of Polyriboinosinic Acid-Polyribocytidylic Acid
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artículo científico publicado el 1 de septiembre de 1972
Interferon Production in Rabbit Kidney Cell Cultures Exposed to Poly (I).Poly (C) Adsorbed to Rabbit Red Blood Cells
artículo científico publicado el 1 de febrero de 1974
Interferon and its inducers--a never-ending story: "old" and "new" data in a new perspective
artículo científico publicado en 2006
Interferon inducers
artículo científico publicado en 1980
Interferon inducing activity of (A)n.(U)n complexes of varying chain length
artículo científico publicado el 26 de enero de 1978
Interferon induction by mismatched analogues of polyinosinic add . polycytidylic acid [(Ix.U)n.(C)nJ
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artículo científico publicado el 11 de diciembre de 1979
Interferon induction by poly(inosinic acid).cntdot.poly(cytidylic acid) segmented by spin-labels
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artículo científico publicado el 4 de agosto de 1981
Interferon induction by polynucleotides: structure-function relationship
artículo científico publicado el 1 de enero de 1977
Interferon induction by synthetic polynucleotides: importance of purine N-7 and strandwise rearrangement.
artículo científico publicado en 1974
Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice
artículo científico publicado en 2003
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
artículo científico publicado en 2002
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound
artículo científico publicado en 1991
Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication.
artículo científico publicado en 1998
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
artículo científico publicado en 2008
Intranasal Challenge of Mice with Herpes Simplex Vims: An Experimental Model for Evaluation of the Efficacy of Antiviral Drugs
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artículo científico publicado el 1 de junio de 1976
Intraocular Pressure and Aqueous Humor Dynamics in Patients With AIDS Treated With Intravitreal Cidofovir (HPMPC) for Cytomegalovirus Retinitis
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artículo científico publicado el 1 de agosto de 1997
Intrathecal administration of interferon in neonatal herpes
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artículo científico publicado el 1 de mayo de 1975
Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient
artículo científico publicado en 2004
Investigation of anti-HIV activity, cytotoxicity and HIV integrase inhibitory activity of polyherbal formulation BH extracts
article
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors
artículo científico publicado en 2007
Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice
artículo científico publicado en 2003
Isolation and Characterization of a Human Fibroblast Interferon Gene and Its Expression in Escherichia coli
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artículo científico publicado el 1 de noviembre de 1981
Isothiazole derivatives as antiviral agents.
artículo científico publicado en 2007
Isothiazole derivatives as novel HIV replication inhibitors.
artículo científico publicado en 2004
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity
artículo científico publicado en 2005
Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.
artículo científico publicado en 2000
Kinetics and distribution of interferon mRNA in interferon-primed and unprimed mouse L-929 cells
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artículo científico publicado el 16 de septiembre de 1980
Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors
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artículo científico publicado el 1 de abril de 1993
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-di
artículo científico publicado en 1992
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.
artículo científico publicado en 1993
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
artículo científico publicado en 2003
Lack of retinal toxicity of the anticytomegalovirus drug (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine
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artículo científico publicado el 1 de abril de 1992
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase
artículo científico publicado en 2002
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture
artículo científico publicado en 2000
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
artículo científico publicado en 2010
Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles
artículo científico publicado en 2019
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase
artículo científico publicado en 1988
Local treatment of HPV-induced skin lesions by Cidofovir
artículo científico publicado en 2002
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors
artículo científico publicado en 2000
Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood.
artículo científico publicado en 1999
Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective
artículo científico publicado en 2009
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity
artículo científico publicado en 2001
Managing resistance to anti-HIV drugs: an important consideration for effective disease management.
artículo científico publicado en 1999
Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection
artículo científico publicado en 2004
Marked Inhibitory Activity of Masked Aryloxy Aminoacyl Phosphoramidate Derivatives of Dideoxynucleoside Analogues Against Visna Virus Infection
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artículo científico publicado el 1 de abril de 1998
Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.
artículo científico publicado en 2005
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent
artículo científico publicado en 1989
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.
artículo científico publicado en 1994
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives
artículo científico publicado en 1996
Mechanism of anti-human immunodeficiency virus (HIV) action of selected ATA-polymer analogues
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artículo científico publicado en 1995
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents
artículo científico publicado en 1992
Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs
artículo científico publicado en 2008
Mechanism of binding of mouse interferon to controlled pore glass
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artículo científico publicado el 29 de septiembre de 1979
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro
artículo científico publicado en 1988
Mechanism of interaction of sodium dodecyl sulfate with mouse interferon
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artículo científico publicado el 25 de agosto de 1979
Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues
article published in 1996
Mechanism of the antiviral activity resulting from sequential administration of complementary homopolyribonucleotides to cell cultures
artículo científico publicado en 1972
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus
artículo científico publicado en 1991
Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS.
artículo científico publicado en 1993
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
artículo científico publicado en 2003
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells
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artículo científico publicado el 1 de noviembre de 1984
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety
artículo científico publicado en 1998
Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase
scientific article published on 01 January 1998
Metabolism of eicar (5-ethynyl-1-B-dribofurano-sylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase
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scholarly article
Methods in Anti-HCMV Research
artículo científico publicado en 2000
Mode of Interaction of G-Quartets with the Integrase of Human Immunodeficiency Virus Type 1
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artículo científico publicado el 1 de noviembre de 1997
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives.
artículo científico publicado en 1997
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor
artículo científico publicado en 2007
Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds
artículo científico publicado en 1999
Molecular Targets for Selective Antiviral Chemotherapy
Molecular approaches for the treatment of hemorrhagic fever virus infections.
artículo científico publicado en 1993
Molecular design opportunities presented by solvent-exposed regions of target proteins
scientific article published on 19 April 2019
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2013
Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies
artículo científico publicado en 2007
Molecular strategies to inhibit the replication of RNA viruses
artículo científico publicado en 2008
Monitoring drug resistance for herpesviruses.
artículo científico publicado en 2000
Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration
artículo científico publicado en 2019
Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites
artículo científico publicado en 2005
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
artículo científico publicado en 2000
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.
artículo científico publicado en 2004
Multivalent agents: a novel concept and preliminary practice in Anti-HIV drug discovery
artículo científico publicado en 2013
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
artículo científico publicado en 2001
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors
artículo científico publicado en 2000
Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT.
artículo científico publicado en 2001
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry
artículo científico publicado en 2003
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology
artículo científico publicado en 2005
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
artículo científico publicado en 2009
Mycophenolate Mofetil markedly enhances the antiviral activity of acyclovir, ganciclovir and penciclovir against herpes simplex virus (wild type and TK− strains) and human cytomegalovirus
scientific article published in 1997
Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice
artículo científico publicado en 2003
Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir.
artículo científico publicado en 1998
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase
artículo científico publicado en 2003
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action
artículo científico publicado en 2003
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties
artículo científico publicado en 1999
NF-kappaB: the inducible factors of HIV-1 transcription and their inhibitors
artículo científico publicado en 2009
Neutralization of Interferon Activity in Homologous and Heterologous Cells with Homologous and Heterologous Antibody
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artículo científico publicado el 1 de octubre de 1980
New 1,1,3-trioxo-2H,4H-thieno[3,4-e]thiadiazine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase
article
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation
artículo científico publicado en 2002
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.
artículo científico publicado en 2001
New AZT Analogues Having 5′-Alkylsulfonyl Groups: Synthesis and Anti-HIV Activity
article
New Approaches Toward anti-HIV Chemotherapy
article
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections
scientific article published on 07 August 2019
New Perspectives for the Treatment of HIV Infections
artículo científico publicado el 1 de enero de 1998
New Polyacetal Polysulphate Active against Human Immunodeficiency Virus and other Enveloped Viruses
New analogs of acyclovir substituted at the side chain
artículo científico publicado en 2007
New anti-HIV Agents and Targets
article
New anti-HIV agents and targets
artículo científico publicado en 2002
New approaches toward anti-HIV chemotherapy
artículo científico publicado en 2005
New class of HIV integrase inhibitors that block viral replication in cell culture
artículo científico publicado en 2002
New developments in anti-HIV chemotherapy
article
New developments in anti-HIV chemotherapy.
artículo científico publicado en 2001
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity
scientific article published on 01 January 1994
New inhibitors of human cytomegalovirus (HCMV) on the horizon
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artículo científico publicado el 14 de abril de 2003
New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents
artículo científico publicado en 1992
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.
artículo científico publicado en 1996
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
artículo científico publicado en 1996
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs
artículo científico publicado en 1994
New therapeutic approaches targeted at the late stages of the HIV-1 replication cycle
artículo científico publicado en 2011
New treatments for genital herpes
artículo científico publicado en 2002
New treatments for genital herpes
article
New trends in antiviral chemotherapy
artículo científico publicado el 1 de mayo de 1979
Niacin esters of chalcones with tumor-selective properties
artículo científico publicado en 2016
Nitroimidazoles Part 6. Synthesis, structure and in vitro anti-HIV activity of new 5-substituted piperazinyl-4-nitroimidazole derivatives
artículo científico publicado en 2007
Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles
artículo científico publicado en 2006
Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives.
artículo científico publicado en 2007
Non-Nucleoside HIV-1 Reverse-Transcriptase Inhibitors. Part 10
article
Non-antiviral activities of interferon are not controlled by chromosome 21
artículo científico publicado el 10 de julio de 1975
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues
artículo científico publicado en 2005
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues
artículo científico publicado en 2006
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity
artículo científico publicado en 2007
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain
artículo científico publicado en 2009
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future
artículo científico publicado en 2004
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.
artículo científico publicado en 2009
Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
artículo científico publicado en 2004
Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT
article
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues
artículo científico publicado en 2003
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones
artículo científico publicado en 2004
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues
artículo científico publicado en 2005
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors
artículo científico publicado el 1 de julio de 1995
Novel 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine Derivatives as Non-Nucleoside Reverse Transcriptase Inhibitors That Inhibit Human Immunodeficiency Virus Type 1 Replication
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artículo científico publicado el 8 de octubre de 1998
Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies
artículo científico publicado en 2009
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2010
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity
artículo científico publicado en 2014
Novel 6-azapyrimidine-2'-deoxy-4'-thionucleosides: synthesis, biological evaluation and conformational analysis
artículo científico publicado en 1999
Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety
article
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations
artículo científico publicado en 2007
Novel Carbocyclic Nucleosides Containing A Cyclobutyl Ring. Guanosine and Adenosine Analogues
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artículo científico publicado el 1 de julio de 1998
Novel DNA groove binding alkylators: design, synthesis, and biological evaluation
artículo científico publicado en 1988
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity.
artículo científico publicado en 1996
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2008
Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.
artículo científico publicado en 2005
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities
artículo científico publicado en 2005
Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents
artículo científico publicado en 2001
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity
artículo científico publicado en 2003
Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation
artículo científico publicado en 2004
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action
artículo científico publicado en 2003
Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation
artículo científico publicado en 2004
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives
artículo científico publicado en 2007
Novel inhibitors of HIV-1 integration.
artículo científico publicado en 2004
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation
artículo científico publicado en 1989
Novel lipophilic hydroxyurea derivatives: synthesis, cytostatic and antiviral activity evaluations
artículo científico publicado en 2008
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2013
Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides
artículo científico publicado en 1999
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2
artículo científico publicado en 2000
Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.
artículo científico publicado en 1994
Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region
artículo científico publicado en 1999
Novel sulfated polysaccharides: dissociation of anti-human immunodeficiency virus activity from antithrombin activity.
artículo científico publicado en 1990
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.
artículo científico publicado en 1999
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides
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artículo científico publicado el 1 de mayo de 1983
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogs
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artículo científico publicado el 1 de noviembre de 1984
Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogs that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase
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artículo científico publicado el 12 de junio de 1992
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition
scientific article published on 01 October 1994
Nucleoside Analogues Exerting Antiviral Activity Through a Non-Nucleoside Mechanism
Nucleoside Analogues in the Chemotherapy of Viral Infections
Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.
artículo científico publicado en 2018
Nucleoside analogues as antiviral agents
artículo científico publicado el 1 de enero de 1981
Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism
artículo científico publicado en 2004
Nucleoside inhibitors of Zika virus
artículo científico publicado en 2016
Nucleoside inhibitors of tick-borne encephalitis virus
artículo científico publicado en 2015
Nucleoside-catabolizing enzyme activities in primary rabbit kidney cells and human skin fibroblasts
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artículo científico publicado el 15 de mayo de 1978
Nucleoside/Nucleotide Inhibitors of HIV Reverse Transcriptase
article
Nucleotides. Part. XXXII. Synthesis of 2?-5? Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides
scholarly article by Piet Herdewijn et al published 13 December 1989 in Helvetica Chimica Acta
Oligo(2'-5')adenylate synthetase in human lymphoblastoid cells.
artículo científico publicado en 1980
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine
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artículo científico publicado el 1 de mayo de 1981
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
artículo científico publicado en 1990
Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine
artículo científico publicado en 1982
Oral antiviral drugs in experimental herpes simplex keratitis
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artículo científico publicado el 1 de diciembre de 1983
Organic Chemist Whose Inventions Reshaped the Antiviral Drug World
article
Organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses
artículo científico publicado en 2005
Outlook of the Antiviral Drug Era, Now More Than 50 Years after Description of the First Antiviral Drug
Overview of Recent Strategic Advances in Medicinal Chemistry
scientific article published on 28 May 2019
Ovine skin organotypic cultures applied to the ex vivo study of orf virus infection
artículo científico publicado en 2005
Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antivirial effects and thymidylate synthetase inhibition
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artículo científico publicado el 1 de junio de 1980
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists
artículo científico publicado en 2010
Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides
artículo científico publicado en 2010
Palladium-catalyzed synthesis of (E)-5-(2-acylvinyl)-2′-deoxyuridines and their antiviral and cytotoxic activities
artículo científico publicado en 1995
Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils--their antiviral and cytotoxic activities
artículo científico publicado en 1997
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro
artículo científico publicado en 1991
Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir
article
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro
artículo científico publicado en 1996
Pd-catalyzed C-C bond-forming reactions of thymidine mesitylene sulfonate
artículo científico publicado en 2007
Perspectives for the treatment of infections with Flaviviridae
artículo científico publicado en 2000
Pharmacokinetics in mice of bis(POM)-PMEA, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine
scholarly article
Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine
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artículo científico publicado el 1 de septiembre de 1992
Pharmacokinetics of E -5-(2-Bromovinyl)-2′-Deoxyuridine in Mice
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artículo científico publicado en 1979
Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients
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artículo científico publicado el 1 de diciembre de 1991
Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection
artículo científico publicado en 2001
Phenotypic Assays and Sequencing Are Less Sensitive Than Point Mutation Assays for Detection of Resistance in Mixed HIV-1 Genotypic Populations
article
Phosphonates Derivatives of 2',3'-Dideoxy-2',3'-didehydro-pentopyranosyl Nucleosides
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
artículo científico publicado en 1990
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents
artículo científico publicado en 1988
Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity
article
Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.
artículo científico publicado en 1997
Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
article
Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine
artículo científico publicado en 2000
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets
artículo científico publicado en 1983
Phosphorylation of aciclovir, ganciclovir, penciclovir and S2242 by the cytomegalovirus UL97 protein: a quantitative analysis using recombinant vaccinia viruses
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artículo científico publicado el 1 de septiembre de 1997
Poly(Hydroxy)Carboxylates as Selective Inhibitors of Cytomegalovirus and Herpes Simplex Virus Replication
Poly(rI) more important than poly(rC) in the interferon induction process by poly(rI)·poly(rC)
article
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.
artículo científico publicado en 1998
Polynucleotide displacement reactions: detection by interferon induction
artículo científico publicado el 24 de febrero de 1976
Polysulfonates derived from metal thiolate complexes as inhibitors of HIV-1 and various other enveloped viruses in vitro.
artículo científico publicado en 2002
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.
artículo científico publicado en 1986
Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry
artículo científico publicado en 2003
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event
artículo científico publicado en 1992
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase
artículo científico publicado en 1991
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
artículo científico publicado en 1999
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action
artículo científico publicado en 2000
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats
artículo científico publicado en 1998
Potent antitumor activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in choriocarcinoma-bearing rats
scholarly article
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model
scientific article published on 01 October 1998
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir.
artículo científico publicado en 1998
Potent inhibition of hemangiosarcoma development in mice by cidofovir
artículo científico publicado en 2001
Potent inhibitory effects of the 5'-triphosphates of (E)-5-(2-bromovinyl)-2'-deoxyuridine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on DNA polymerase gamma
artículo científico publicado en 1990
Potent nonclassical nucleoside antiviral drugs based on the N,N-diarylformamidine concept
artículo científico publicado en 2004
Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.
artículo científico publicado en 2004
Potential antivirals and antiviral strategies against SARS coronavirus infections
artículo científico publicado en 2006
Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100.
artículo científico publicado en 2005
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region
artículo científico publicado en 1999
Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities
artículo científico publicado en 1992
Potential use of antiviral agents in polio eradication
artículo científico publicado en 2008
Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo
artículo científico publicado en 1989
Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside
artículo científico publicado en 1990
Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents
artículo científico publicado en 2010
Pre-exposure chemoprophylaxis of HIV infection: Quo vadis?
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artículo científico publicado el 29 de octubre de 2011
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro
artículo científico publicado en 1994
Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.
artículo científico publicado en 1998
Preface
Preface
Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.
artículo científico publicado en 1999
Preliminary results on the activity of cidofovir for the treatment of cervical intraepithelial neoplasia (CIN) grade III
scientific article published in 1997
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight
artículo científico publicado en 1991
Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect
article
Preparation and biological properties of a highly active poly(G) · poly(C) inducer of interferon
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artículo científico publicado el 1 de diciembre de 1984
Pretreatment with topical 0.1% (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine inhibits adenovirus type 5 replication in the New Zealand rabbit ocular model
artículo científico publicado el 1 de noviembre de 1992
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues
artículo científico publicado en 2000
Prevalence and origin of HIV-1 group M subtypes among patients attending a Belgian hospital in 1999.
artículo científico publicado en 2002
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine
artículo científico publicado en 1998
Pridine Oxide Derivatives: Structure‐Activity Relationship for Inhibition of Human Immunodeficiency Virus and Cytomegalovirus Replication in Cell Culture
artículo científico publicado en 2002
Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists
artículo científico publicado en 2007
Productive infection of primary macrophages with human herpesvirus 7.
artículo científico publicado en 2001
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins
article
Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins
artículo científico publicado en 2004
Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of Hiv Infection
article
Prolonged Antiviral Protection by Interferon Inducers
artículo científico publicado en 1969
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines
artículo científico publicado en 2006
Protective activity of lipid A analogue GLA-60 against murine cytomegalovirus infection in mice
scientific article published on 01 July 1993
Purification of interferon by adsorption chromatography on controlled pore glass
artículo científico publicado el 1 de diciembre de 1976
Purification of mouse interferon by sequential chromatography
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artículo científico publicado el 21 de abril de 1979
Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture
artículo científico publicado en 2005
Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding
artículo científico publicado en 2006
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action
artículo científico publicado en 2005
Pyrimidine Nucleoside Analogues as Antiviral Agents
article
Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue
artículo científico publicado en 2015
QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices.
artículo científico publicado en 2005
Quantification of HIV-1 RNA in Plasma: Comparable Results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV Monitor Test
article
Quantitative analysis of human herpesvirus 6 cell tropism
artículo científico publicado en 2005
RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE)
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artículo científico publicado el 1 de octubre de 1997
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
artículo científico publicado en 1988
Recent Advances in the Search for Selective Antiviral Agents
Recent advances in DAPYs and related analogues as HIV-1 NNRTIs
artículo científico publicado en 2011
Recent advances in antiviral activity of benzo/heterothiadiazine dioxide derivatives
scientific article published on January 2008
Recent advances in the research of 2,3-diaryl-1,3-thiazolidin-4-one derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico
Recent advances in the research of HIV-1 RNase H inhibitors
artículo científico publicado en 2008
Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers
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artículo científico publicado el 15 de septiembre de 2010
Recent highlights in the development of new antiviral drugs
artículo científico publicado en 2005
Recent progress in small molecule CCR5 antagonists as potential HIV-1 entry inhibitors
artículo científico publicado en 2012
Recent progress in the research of small molecule HIV-1 RNase H inhibitors
artículo científico publicado en 2014
Recent trends and development in antiviral chemotherapy
article
Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection
artículo científico publicado en 2008
Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analogues
artículo científico publicado en 1998
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice
artículo científico publicado en 1979
Renaturation of inactivated interferons by "defensive reversible denaturation".
artículo científico publicado en 1974
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents
artículo científico publicado en 2006
Replication of not-known-vector flaviviruses in mosquito cells is restricted by intracellular host factors rather than by the viral envelope proteins
artículo científico publicado en 2010
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.
artículo científico publicado en 2005
Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4
artículo científico publicado en 1999
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720
artículo científico publicado en 1994
Retroviral restriction factors TRIM5α: therapeutic strategy to inhibit HIV-1 replication
artículo científico publicado en 2011
Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine
artículo científico publicado en 2006
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir
artículo científico publicado en 2006
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.
artículo científico publicado en 2000
Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro
artículo científico publicado en 1987
Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation
artículo científico publicado en 2003
Ribavirin for HIV
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artículo científico publicado el 17 de agosto de 1991
Ribosylation of Pyrimidine 2′-Deoxynucleosides
Rodent models for the study of therapy against flavivirus infections
artículo científico publicado en 2004
Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.
artículo científico publicado en 1999
Role of deoxycytidine kinase in the inhibitory activity of 5-substituted 2'-deoxycytidines and cytosine arabinosides on tumor cell growth
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artículo científico publicado el 1 de enero de 1983
Role of interferon in the protective effect of the double-stranded polyribonucleotide against murine tumors induced by Moloney sarcoma virus
artículo científico publicado el 1 de diciembre de 1971
Role of purine N-3 in the biologic activities of poly(A) and poly(I)
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artículo científico publicado el 1 de junio de 1976
Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections
artículo científico publicado en 2017
Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof
scientific article published on March 2009
Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir
artículo científico publicado en 2002
Rubella virus interference and interferon production
artículo científico publicado en 1967
S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin
article
S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.
artículo científico publicado en 1997
SIV/HIV-1 Hybrid Virus Expressing the Reverse Transcriptase Gene of HIV-1 Remains Sensitive to HIV-1-Specific Reverse Transcriptase Inhibitors After Passage in Rhesus Macaques
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artículo científico publicado el 1 de mayo de 1997
SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME 2-{4-[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL] PHENOXY}-N-PHENYLACETAMIDE
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES
scholarly article by Arpit Katiyar et al published September 2016 in Acta Poloniae Pharmaceutica: drug research
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES
scholarly article by Arpit Katiyar et al published July 2016 in Acta Poloniae Pharmaceutica: drug research
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs
scientific article published on 30 March 2020
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
artículo científico publicado en 1998
Selection of L Cell Sublines Resistant to (E)-5-(2-Bromovinyl)-2′-Deoxyuridine
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artículo científico publicado el 1 de enero de 1991
Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro
artículo científico publicado en 1989
Selective activity of various antiviral compounds against HHV-7 infection
artículo científico publicado en 1999
Selective anti-herpesvirus agents
artículo científico publicado en 2013
Selective antiherpes agents
article published in 1982
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2′-deoxyuridines: Dependence on specific phosphorylation by viral thymidine kinase
artículo científico publicado en 1985
Selective inhibition of hepatitis B virus replication by RNA interference
artículo científico publicado en 2003
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).
artículo científico publicado en 1990
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates
artículo científico publicado en 2007
Selective inhibitors of picornavirus replication
artículo científico publicado en 2008
Selective inhibitors of the replication of poxviruses
Selective inhibitors of the replication of poxviruses
Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication
artículo científico publicado en 1991
Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro
artículo científico publicado en 1987
Selective virus inhibitors
artículo científico publicado el 1 de abril de 1990
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anticytomegalovirus agents
artículo científico publicado en 1991
Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120
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artículo científico publicado el 1 de diciembre de 1997
Sepharose-bound poly (I)-poly (C): interaction with cells and interferon production
artículo científico publicado el 17 de marzo de 1975
Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds
artículo científico publicado en 2000
Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4
artículo científico publicado en 1999
Short Communication: Lamivudine Resistance of HIV Type 1 Does Not Delay Development of Resistance to Nonnucleoside HIV Type 1-Specific Reverse Transcriptase Inhibitors as Compared with Wild-Type HIV Type 1
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artículo científico publicado el 10 de febrero de 1998
Side-chain derivatives of biologically active nucleosides. 1. Side-chain analogs of 3'-azido-3'-deoxythymidine (AZT)
artículo científico publicado en 1992
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
artículo científico publicado en 1999
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo
artículo científico publicado en 1991
Sister chromatid exchange induced by anti-herpes drugs.
artículo científico publicado en 1981
Sodium and potassium benzeneazophosphonate complexes with crown ethers: Solid-state microwave synthesis, characterization and biological activity
Sodium dodecyl sulphate interactions with mouse interferon [proceedings]
artículo científico publicado en 1979
Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation
artículo científico publicado en 2010
Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.
artículo científico publicado en 2012
Species-dependent and site-specific intestinal metabolism of ester prodrugs
article
Specific HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 1992
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase
artículo científico publicado en 2002
Specific therapies for human papilloma virus infections
artículo científico publicado en 1998
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties
artículo científico publicado en 2003
Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.
artículo científico publicado en 2004
Stabilisation of interferons by defensive reversible denaturation.
artículo científico publicado en 1974
Stability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug design
artículo científico publicado en 2000
Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects
artículo científico publicado en 2004
Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives
artículo científico publicado en 1999
Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.
artículo científico publicado en 2001
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: prediction, synthesis, and in vitro assay of new purine carbanucleosides
artículo científico publicado en 2005
Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms
article
Strategies for the Treatment of Dengue Virus Infections: A Narrative Account
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artículo científico publicado el 1 de abril de 2010
Strategies for the treatment and prevention of cytomegalovirus infections.
artículo científico publicado en 1993
Strategies in the Design of Antiviral Drugs
Strategies in the Design of Antiviral Drugs
Strategies in the design of antiviral drugs
artículo científico publicado en 2002
Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile.
artículo científico publicado en 2016
Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors
Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Structural modifications of DAPY analogues with potent anti-HIV-1 activity
artículo científico publicado en 2009
Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket
artículo científico publicado en 2016
Structure modifications of 6-aminoquinolones with potent anti-HIV activity
artículo científico publicado en 2004
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
scientific article published on 15 April 2020
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants
artículo científico publicado en 2017
Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates
artículo científico publicado en 2009
Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin
artículo científico publicado en 2005
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.
artículo científico publicado en 2003
Structure-activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action
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artículo científico publicado el 1 de diciembre de 1983
Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design
artículo científico publicado en 2008
Structure-activity relationships for interferon induction and inhibition of protein synthesis by polynucleotides
artículo científico publicado el 1 de enero de 1981
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity
artículo científico publicado en 1992
Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.
artículo científico publicado en 2016
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base
artículo científico publicado en 1999
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
artículo científico publicado en 2012
Studies on the mechanism of the priming effect of interferon on interferon production by cell cultures exposed to poly(rI)-poly(rC).
artículo científico publicado en 1973
Study of different substituted cyclic and acyclic benzylpronucleotides of d4T relative to their hydrolytic stability and antiviral activity.
artículo científico publicado en 2003
Substituted 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A New Class of Pestivirus Inhibitors
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors
artículo científico publicado en 2006
Substituted imidazopyridines as potent inhibitors of HCV replication
artículo científico publicado en 2009
Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis
artículo científico publicado en 2013
Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).
artículo científico publicado en 1994
Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis
artículo científico publicado en 2005
Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs
article
Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects
artículo científico publicado en 2002
Sulfanyltriazole/tetrazoles: a promising class of HIV-1 NNRTIs
artículo científico publicado en 2009
Sulfated Polysaccharides Extracted from Sea Algae as Potential Antiviral Drugs
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artículo científico publicado el 1 de octubre de 1997
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate
article
Sulfated polysaccharides as potent inhibitors of HIV-induced syncytium formation: a new strategy towards AIDS chemotherapy
artículo científico publicado en 1990
Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors
artículo científico publicado en 1992
Sulphated and sulphonated polymers inhibit the initial interaction of hepatitis B virus with hepatocytes
artículo científico publicado en 2002
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells
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artículo científico publicado el 1 de marzo de 1998
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine
artículo científico publicado en 1990
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)
artículo científico publicado en 1995
Suramin: A potent inhibitor of the reverse transcriptase of RNA tumor viruses
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artículo científico publicado el 1 de noviembre de 1979
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides
artículo científico publicado en 2005
Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds
artículo científico publicado en 1995
Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors
artículo científico publicado en 2004
Synergism in the antitumor effects of type 1 and type II interferon in mice inoculated with leukemia L1210 cells
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artículo científico publicado el 1 de marzo de 1982
Synergistic antiviral effects of antiherpes compounds and human leukocyte interferon on varicella-zoster virus in vitro
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artículo científico publicado el 1 de abril de 1984
Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro
artículo científico publicado en 1991
Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir
artículo científico publicado en 2007
Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines
Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End
Synthesis and Anti-HIV Activity of Dideoxycytidine Analogues Containing a Pyranose Carbohydrate Moiety
article
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
article
Synthesis and Anti-HIV Properties of 1,2,4,6-Thiatriazin-3-one 1,1-Dioxtoe Nucleosides
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artículo científico publicado el 1 de mayo de 1998
Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives
article
Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine
Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides
Synthesis and Antiviral Activity of 1.4-Dioxane, 1.4-Oxathiane and 1,4-Morpholine Nucleoside Analogues
Synthesis and Antiviral Activity of 2 and 3-Substituted Imidazo[1,2-a]pyrimidine
article published in 1995
Synthesis and Antiviral Activity of 6-Benzyl Analogs of 1-[(2-Hydroxyethoxy)methyl]-5-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents
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artículo científico publicado el 21 de julio de 1995
Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines
Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides
artículo científico publicado en 2004
Synthesis and Antiviral Activity of Some C2-, C4-, and C6-Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG
article
Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine
artículo científico publicado en 2008
Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides).
artículo científico publicado en 1997
Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine
Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety
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artículo científico publicado el 1 de mayo de 2003
Synthesis and Antiviral Properties of Aza-Analogues ofAcyclovir
artículo científico publicado en 2007
Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
artículo científico publicado en 1999
Synthesis and Antiviral/Antiproliferative Activity of Some N-Sulfonylbenzimidazoles
Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers
Synthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides
Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine
Synthesis and Biological Evaluation of 1,2-Disubstituted Carbonucleosides of 6-Substituted Purine and 8-Azapurine
artículo científico publicado en 1999
Synthesis and Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Possess Increased Hydrolytic Stability
article
Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors
artículo científico publicado en 2015
Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides
Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines
article
Synthesis and Evaluation of Antiviral Activity of 3'-C-Cyano-3'-Deoxynucleosides
Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections
artículo científico publicado en 2015
Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
artículo científico publicado en 2010
Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
artículo científico publicado en 2008
Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates.
artículo científico publicado en 2011
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents
artículo científico publicado en 2006
Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.
artículo científico publicado en 2004
Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds
artículo científico publicado en 1991
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2006
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2009
Synthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines
artículo científico publicado en 2008
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 1999
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues
artículo científico publicado en 1999
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives
artículo científico publicado en 2002
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
artículo científico publicado en 2003
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
artículo científico publicado en 1991
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2010
Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives
artículo científico publicado en 2014
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2011
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.
artículo científico publicado en 2001
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings
artículo científico publicado en 2006
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems
artículo científico publicado en 2007
Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives
artículo científico publicado el 1 de diciembre de 2011
Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine
artículo científico publicado en 2006
Synthesis and anti-HIV activity of some new aminoadamantane heterocycles
scientific article published in 1997
Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency
artículo científico publicado en 1998
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides
artículo científico publicado en 1990
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).
artículo científico publicado en 2007
Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines
artículo científico publicado en 2006
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2007
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2
artículo científico publicado en 1991
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives
artículo científico publicado en 2006
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds
artículo científico publicado en 2008
Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues
artículo científico publicado en 2009
Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles
artículo científico publicado en 2002
Synthesis and anti-herpes activity of 5-trifluorovinyl-2′-deoxyuridine
artículo científico publicado en 1992
Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility
artículo científico publicado en 2000
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
artículo científico publicado en 1993
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
artículo científico publicado en 2004
Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine
artículo científico publicado en 1999
Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells
artículo científico publicado en 2016
Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine
artículo científico publicado en 1991
Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation
artículo científico publicado en 2005
Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives
artículo científico publicado en 2003
Synthesis and antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective antiherpes activity of 1-(beta-D-arabinofuranosyl)-5-ethyluracil
artículo científico publicado en 1979
Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues
artículo científico publicado en 2006
Synthesis and antiviral activity assay of novel (E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine.
artículo científico publicado en 2003
Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.
artículo científico publicado en 1989
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
artículo científico publicado en 2009
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles
artículo científico publicado en 2002
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
artículo científico publicado en 2003
Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.
artículo científico publicado en 2004
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds
artículo científico publicado en 2004
Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety
artículo científico publicado en 1996
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines
artículo científico publicado en 1990
Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogs of acyclovir and ganciclovir
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artículo científico publicado el 1 de agosto de 1991
Synthesis and antiviral activity of 3-substituted imidazo[1,2-a]pyridines
article
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine
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artículo científico publicado el 1 de abril de 1981
Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines
artículo científico publicado en 1991
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
artículo científico publicado en 1993
Synthesis and antiviral activity of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives
artículo científico publicado en 1999
Synthesis and antiviral activity of 6-chloropurine arabinoside and its 2'-deoxy-2'-fluoro derivative
artículo científico publicado en 1996
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines
artículo científico publicado en 2011
Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides
artículo científico publicado en 2003
Synthesis and antiviral activity of acyclic analogues of 1,5-anhydrohexitol nucleosides using Mitsunobu reaction
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain
artículo científico publicado en 1992
Synthesis and antiviral activity of benzyl-substituted imidazo[1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives
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artículo científico publicado el 1 de septiembre de 1995
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
artículo científico publicado en 1992
Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides
artículo científico publicado en 2003
Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.
artículo científico publicado en 2008
Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides
scientific article published in 1995
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues
artículo científico publicado en 2003
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives
artículo científico publicado en 1992
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
artículo científico publicado en 1985
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 1989
Synthesis and antiviral activity of three pyrazole analogues of distamycin A.
artículo científico publicado en 1994
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine)
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artículo científico publicado el 1 de abril de 1983
Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring
artículo científico publicado en 1999
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives
artículo científico publicado en 2007
Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases
artículo científico publicado en 1991
Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.
artículo científico publicado en 2009
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives
artículo científico publicado en 2003
Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core
artículo científico publicado en 2007
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
artículo científico publicado en 2008
Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid.
artículo científico publicado en 2004
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.
artículo científico publicado en 2005
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives
artículo científico publicado en 2006
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 2001
Synthesis and antiviral evaluation of pyridine fused heterocyclic and nucleosidic derivatives
article published in 1997
Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues
artículo científico publicado en 2004
Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides
artículo científico publicado en 2000
Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design
artículo científico publicado en 1992
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine
scientific article published on 01 June 1981
Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs
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artículo científico publicado el 1 de enero de 1984
Synthesis and antiviral properties of arabino and ribonucleosides of 1,3-dideazaadenine, 4-nitro-1,3-dideazapurine and diketopiperazine.
artículo científico publicado en 2004
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles
artículo científico publicado en 2002
Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide
artículo científico publicado en 2006
Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators
artículo científico publicado en 2006
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
artículo científico publicado en 1999
Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines
artículo científico publicado en 2002
Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir
artículo científico publicado en 2002
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine
artículo científico publicado en 2006
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents
artículo científico publicado en 2007
Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives
artículo científico publicado en 2009
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.
artículo científico publicado en 2010
Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives
article
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine
artículo científico publicado en 2003
Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives
artículo científico publicado en 2006
Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
artículo científico publicado en 2011
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
artículo científico publicado en 2014
Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus.
artículo científico publicado en 2005
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate
artículo científico publicado en 1999
Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides
artículo científico publicado en 2003
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides
artículo científico publicado en 2005
Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base
Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains
scientific article published on 10 May 2019
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine
artículo científico publicado en 1990
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
artículo científico publicado en 2009
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues
artículo científico publicado en 2003
Synthesis and biological evaluation of isomeric dinucleoside monophosphates and monomethylphosphonates of 9-beta-D-arabinofuranosyladenine and related analogues
artículo científico publicado en 1988
Synthesis and biological evaluation of isonucleosides derived from methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranosides
artículo científico publicado en 2002
Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
article
Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues.
artículo científico publicado en 2004
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
artículo científico publicado en 2009
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2011
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2008
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2012
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs
artículo científico publicado en 2013
Synthesis and biological evaluation of some alpha-[6-(1'-carbamoylalkylthio)-1 H-pyrazolo[3,4-D]pyrimidin-4-yl]thioalkylcarboxamide acyclonucleosides
artículo científico publicado en 2007
Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives
artículo científico publicado en 1990
Synthesis and chemotherapeutic activity of a carbocyclic analogue of tegafur
artículo científico publicado el 1 de septiembre de 1998
Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates
artículo científico publicado en 1989
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine
scientific article published on 01 January 1995
Synthesis and cytotoxic evaluation of some styryl ketones and related compounds
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents
artículo científico publicado en 2007
Synthesis and evaluation of in vitro antiviral activity of 2-[3-(substituted phenyl)-4,5-dihydro-1H-5-pyrazolyl]benzofuran-3-yl chloride derivatives
artículo científico publicado en 2009
Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives
artículo científico publicado en 2009
Synthesis and evaluation of novel 4-substituted styryl quinazolines as potential antimicrobial agents.
artículo científico publicado en 2012
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
artículo científico publicado en 2001
Synthesis and fluorescent properties of 6-(4-biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine analogues of acyclovir and ganciclovir
artículo científico publicado en 2003
Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen hetbrocyclic units
artículo científico publicado en 2005
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2008
Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives
artículo científico publicado en 2002
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
artículo científico publicado en 2009
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
artículo científico publicado en 2008
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
artículo científico publicado en 2005
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs
artículo científico publicado en 2011
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication
artículo científico publicado en 2010
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4
artículo científico publicado en 1999
Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents
artículo científico publicado en 2009
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1
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artículo científico publicado el 1 de marzo de 1984
Synthesis of (Z) and (E) α-alkenyl phosphonic acid derivatives of purines and pyrimidines
Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T and DDC
Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase
article
Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach
artículo científico publicado en 2002
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents
artículo científico publicado en 2003
Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties
article
Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents
article published in 1998
Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
artículo científico publicado en 2007
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition
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artículo científico publicado el 1 de marzo de 1980
Synthesis of 5′-N-(α-Amino-β-mercaptoacyl)amino-5′-deoxynucleosides as potential antiviral compounds
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artículo científico publicado el 1 de agosto de 1991
Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication
artículo científico publicado en 2006
Synthesis of Pyranose Nucleosides
Synthesis of Thymidine Analogues with a Cyanoimido Substituent
Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase
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scholarly article
Synthesis of acyclic nucleotide analogues derived from 2-(aminomethyl)purine bases
scholarly article
Synthesis of adamantane spiro sultones as potential antiviral agents
artículo científico publicado en 1992
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article published on 19 September 2008
Synthesis of aza-analogues of Ganciclovir
article
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents
artículo científico publicado en 2010
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
artículo científico publicado en 2004
Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents
artículo científico publicado en 2007
Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities
artículo científico publicado en 2002
Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.
artículo científico publicado en 2012
Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity
artículo científico publicado en 1999
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs
artículo científico publicado en 2007
Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.
artículo científico publicado en 2007
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents
artículo científico publicado en 2007
Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).
artículo científico publicado en 2003
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues
artículo científico publicado en 2004
Synthesis, Anti-HIV and Cytotoxic Activity of Some Novel Isatine-Sulfisomidine Derivatives
article
Synthesis, Antiviral and Cytotoxicity Studies of Novel N-substituted Indophenazine Derivatives
artículo científico publicado en 2012
Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin
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artículo científico publicado el 1 de junio de 1995
Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides
article
Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir
artículo científico publicado en 2001
Synthesis, Cytostatic Activity and Inhibition of Ribonucleotide Reductase by 5′-Phosphoramidates and 5′-Diphosphates, of 2′-O-Allyl-arabinofuranosyl Nucleosides
scientific article published on 01 April 1999
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin
artículo científico publicado en 1989
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues
artículo científico publicado en 2006
Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.
artículo científico publicado en 2005
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2005
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
artículo científico publicado en 2008
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
artículo científico publicado en 1998
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid
artículo científico publicado en 2010
Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin mannich bases
artículo científico publicado en 2000
Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one
artículo científico publicado en 1999
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives
artículo científico publicado en 2007
Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines
artículo científico publicado en 2009
Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds
artículo científico publicado en 2007
Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles
artículo científico publicado en 2009
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives
artículo científico publicado en 2008
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives
artículo científico publicado en 2013
Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes
artículo científico publicado en 2010
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine
artículo científico publicado en 1990
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones
artículo científico publicado en 2010
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide
artículo científico publicado en 2009
Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues.
artículo científico publicado en 1998
Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues
artículo científico publicado en 2002
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2001
Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides.
artículo científico publicado en 2002
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles
artículo científico publicado en 2006
Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates
artículo científico publicado en 2012
Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3'-azido-3'-deoxythymidine (AZT, Zidovudine).
artículo científico publicado en 2010
Synthesis, protonation behavior, conformational analysis, and regioselective enzymatic acylation of the novel diamino analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
artículo científico publicado en 2003
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues
artículo científico publicado en 2003
Synthesis, structural studies, and biological evaluation of some purine substituted 1-aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes.
artículo científico publicado en 2003
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles
artículo científico publicado en 1998
Synthesis, structure-activity relationship and antiviral activity of 3'-N,N-dimethylamino-2',3'-dideoxythymidine and its prodrugs
artículo científico publicado en 2010
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues
artículo científico publicado en 1986
Systemic cidofovir in papillomatosis
artículo científico publicado en 2001
T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use
artículo científico publicado en 1998
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication
artículo científico publicado el 1 de mayo de 1992
TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication
article
TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.
artículo científico publicado en 1993
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides
artículo científico publicado en 1992
TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity
artículo científico publicado en 2000
TSG101: a novel anti-HIV-1 drug target
artículo científico publicado en 2010
Tanovea® for the treatment of lymphoma in dogs
scholarly article by Erik De Clercq published August 2018 in Biochemical Pharmacology
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.
artículo científico publicado en 2018
Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus
artículo científico publicado en 2019
Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues
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artículo científico publicado el 1 de abril de 2012
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF).
artículo científico publicado en 2016
Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?
artículo científico
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later
artículo científico publicado en 2008
Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds
artículo científico publicado en 1989
The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication
artículo científico publicado en 1987
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro
artículo científico publicado en 1987
The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus
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artículo científico publicado el 15 de octubre de 1980
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase
artículo científico publicado en 2002
The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil).
artículo científico publicado en 2008
The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor
artículo científico publicado en 2003
The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis
artículo científico publicado en 2000
The HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (Part V ☆ ): Capravirine and Its Analogues
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artículo científico publicado el 1 de enero de 2012
The HIV-1 reverse transcription (RT) process as target for RT inhibitors
scientific journal article
The Holý Trinity: the acyclic nucleoside phosphonates
artículo científico publicado en 2013
The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication
artículo científico publicado en 2007
The Importance of the 4′-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5′-Noraristeromycin and Two 7-Deaza Analogues
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artículo científico publicado el 1 de junio de 1998
The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages
artículo científico publicado en 2001
The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine
artículo científico publicado en 1999
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication
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artículo científico publicado el 1 de diciembre de 1994
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs
artículo científico publicado en 2005
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
artículo científico publicado en 2003
The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy
artículo científico
The acyclic nucleoside phosphonates from inception to clinical use: historical perspective
artículo científico publicado en 2006
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors
artículo científico publicado en 2005
The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil.
artículo científico publicado en 2001
The anti-yellow fever virus activity of ribavirin is independent of error-prone replication
artículo científico publicado en 2006
The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.
artículo científico publicado en 1998
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
artículo científico publicado en 1989
The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level
artículo científico publicado en 2003
The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice
artículo científico publicado en 1998
The antiviral spectrum of (E)-5-(2-bromovinyl)-2 '-deoxyuridine
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artículo científico publicado el 1 de agosto de 1984
The bicyclam AMD3100 story
artículo científico publicado en 2003
The changing face of Hepatitis C: Recent Advances on HCV Inhibitors Targeting NS5A.
artículo científico publicado en 2015
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates. The magic of the phosphonate bond
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artículo científico publicado el 8 de abril de 2011
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine
artículo científico publicado en 2000
The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure
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artículo científico publicado el 2 de octubre de 1995
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones
artículo científico publicado en 2008
The design of drugs for HIV and HCV
artículo científico publicado en 2007
The discovery of antiviral agents: ten different compounds, ten different stories
artículo científico publicado en 2008
The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2
scholarly article by Xueyi Lu published in May 2018
The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study
artículo científico publicado en 2002
The emerging role of fusion inhibitors in HIV infection.
artículo científico publicado en 1999
The history of antiretrovirals: key discoveries over the past 25 years
artículo científico publicado en 2009
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines
artículo científico publicado en 1995
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling
article
The interaction of polyxanthylic acid with polyadenylic acid
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The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis
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The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.
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The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures
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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
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The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations
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The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.
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The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo
artículo científico publicado en 1998
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
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The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
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The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation
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The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
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The nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors in the treatment of HIV infections (AIDS).
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The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells
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The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
artículo científico publicado en 2004
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
artículo científico publicado en 1995
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
artículo científico publicado en 2005
The race for interferon-free HCV therapies: a snapshot by the spring of 2012.
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The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
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The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity
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artículo científico publicado el 25 de enero de 1983
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.
artículo científico publicado en 2005
The role of tenofovir in the prevention of HIV infections
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The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells
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artículo científico publicado el 1 de septiembre de 1998
The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis
artículo científico publicado el 1 de enero de 1997
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
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The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins
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Therapeutic Approaches to HHV-6 Infection
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections
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Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives
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Therapy for herpesvirus infections
Therapy for herpesvirus infections
Therapy of poxvirus infections
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Therapy of varicella-zoster virus infection--mechanism of action of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
artículo científico publicado en 1985
Thiazolo[4,5-d]pyrimidines. Part II. Synthesis and anti-human cytomegalovirus activity in vitro of certain acyclonucleosides and acyclonucleotides derived from the guanine analogue 5-aminothiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione
artículo científico publicado en 1998
Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity
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Thiosugars. X. Novel nucleoside analogues derived from 4-thio-L-lyxofuranose
artículo científico publicado en 2003
Thiosugars. XII. Synthesis of new 3'-O-substituted 2',5'-anhydro-2'-thio-alpha-D-pentofuranosyl nucleoside analogues.
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Thymidine analogs as potential antiviral agents
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Thymidylate synthetase as target enzyme for the inhibitory activity of 5-substituted 2'-deoxyuridines on mouse leukemia L1210 cell growth
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artículo científico publicado el 1 de marzo de 1981
Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata
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Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches
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Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies
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Translation of mouse interferon mRNA in Xenopus laevis oocytes and in rabbit reticulocyte lysates
artículo científico publicado el 30 de mayo de 1978
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice
artículo científico publicado en 1991
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome
artículo científico publicado en 2001
Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue
artículo científico publicado en 1995
Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: report of a case
scientific article published on 01 July 1998
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].
artículo científico publicado en 1998
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
artículo científico publicado en 1998
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
artículo científico publicado en 1994
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity
artículo científico publicado en 2006
Triple-helical polynucleotides. Mixed triplexes of the poly(uridylic acid)-poly(adenylic acid)-poly(uridylic acid) class
artículo científico publicado el 24 de febrero de 1976
Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells
artículo científico publicado en 1994
Tumor necrosis factor antagonizes inhibitory effect of azidothymidine on human immunodeficiency virus (HIV) replication in vitro
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artículo científico publicado el 14 de febrero de 1990
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones
artículo científico publicado en 2016
Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?
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Unexpected Results in the Reaction of 5′-Tosyl TSAO-m3T With Amines
Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives
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Update on human herpesvirus 6 biology, clinical features, and therapy
artículo científico publicado en 2005
Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides
Use of cotton rats to evaluate the efficacy of antivirals in treatment of measles virus infections
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Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation
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Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.
artículo científico publicado en 1996
Utilisation des antiviraux pour les orthopoxviroses
artículo científico publicado en 2004
Varicella-zoster virus in the human corneal endothelium: a case report
artículo científico publicado el 1 de enero de 1980
Viral DNA Polymerase Inhibitors
Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease
artículo científico publicado en 2000
Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections
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Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era
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artículo científico publicado el 5 de abril de 2012
Xylotubercidin against herpes simplex virus type 2 in mice
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Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions
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Zidovudine‐Resistant Human Immunodeficiency Virus Type 1 Strains Subcultured in the Presence of Both Lamivudine and Quinoxaline HBY 097 Retain Marked Sensitivity to HBY 097 but Not to Lamivudine
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Zinc(II) complexes of constrained antiviral macrocycles.
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[18] Procedures for the measurement of interferon mRNA distribution in induced mouse cells
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[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1
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cycloSal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System
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artículo científico publicado el 23 de abril de 1998
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system
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cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade
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d4TMP Delivery from 7-SubstitutedcycloSal-d4TMPs
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env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors
artículo científico publicado en 2002
synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors
artículo científico publicado en 2012