Lista de obras - Emil R. Unanue - Dominio Público Uruguay

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity ⬇️

artículo científico publicado el 27 de noviembre de 2012

APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.

artículo científico publicado en 2003

Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes

scientific article published on 01 December 2004

Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells

artículo científico publicado en 2005

Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides

scientific article published on 01 January 2007

Altered peptide ligands make their entry

scientific article published on 01 January 2011

Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex

artículo científico publicado en 2006

Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse

artículo científico publicado en 2016

Antigen presentation events in autoimmune diabetes.

artículo científico publicado en 2011

Antigen presentation in the autoimmune diabetes of the NOD mouse

artículo científico

Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?

artículo científico publicado en 2005

Antigen processing

artículo científico publicado en 2013

Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice

artículo científico publicado en 2003

Autoimmune diabetes mellitus--much progress, but many challenges

artículo científico publicado en 2008

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells ⬇️

artículo científico publicado el 12 de diciembre de 2011

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

artículo científico publicado en 2008

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization

artículo científico publicado en 2011

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

artículo científico publicado en 2015

Binding of immunogenic peptides to Ia histocompatibility molecules. 1985.

artículo científico publicado en 2005

Brigitte Askonas 1923–2013

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

artículo científico publicado en 2003

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes ⬇️

artículo científico publicado el 26 de agosto de 2011

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

artículo científico publicado en 2009

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans ⬇️

artículo científico publicado el 10 de enero de 2011

Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules

artículo científico publicado en 2002

Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

artículo científico publicado en 2021

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

artículo científico publicado en 2016

Conformational isomers of a peptide-class II major histocompatibility complex

artículo científico publicado en 2005

Correction: Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse.

artículo científico publicado en 2014

Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

artículo científico publicado en 2003

Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen

scientific article published on 01 July 2002

Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways

artículo científico publicado en 2002

Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization

artículo científico publicado en 2006

Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse

artículo científico publicado en 2013

Dendritic Cells Process and Present Antigens Across A Range of Maturation States

artículo científico publicado en 2003

Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules

artículo científico publicado en 2008

Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

artículo científico publicado en 2002

Diabetes is predicted by the beta cell level of autoantigen

artículo científico publicado en 2005

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

artículo científico publicado en 2002

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

artículo científico publicado en 2007

Dressing for the occasion: APCs make antigens presentable

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

artículo científico publicado en 2014

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

scientific article published on January 2014

Endoplasmic reticulum: an interface between the immune system and metabolism

artículo científico publicado en 2014

Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response

artículo científico publicado en 2011

First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules

artículo científico publicado en 2008

Following immunization antigen becomes concentrated in a limited number of APCs including B cells

artículo científico publicado en 2004

From antigen processing to peptide-MHC binding

artículo científico publicado en 2006

Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins

artículo científico publicado en 2010

Granzymes drive a rapid listeriolysin O-induced T cell apoptosis

artículo científico publicado en 2008

Herman Eisen (1918-2014).

artículo científico publicado en 2014

Herman N. Eisen, M.D. (1918-2014): Scholar, Gentleman, and AAI President (1968-1969).

artículo científico publicado en 2015

IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes

artículo científico publicado en 2008

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 1981. 127: 1869-1875.

artículo científico publicado en 2007

Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells

artículo científico publicado en 2006

Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

artículo científico publicado en 2013

Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.

artículo científico publicado en 2006

Impact of lymphocyte apoptosis on the innate immune stages of infection

scientific article published on 01 January 2007

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

artículo científico publicado en 2002

In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.

artículo científico publicado en 2006

Influence of saccharide size on the cellular immune response to glycopeptides

artículo científico publicado en 2003

Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells

artículo científico publicado en 2003

Intracellular pathogens and antigen presentation-new challenges with Legionella pneumophila

scientific article published on 01 June 2003

Ita Askonas and her influence in the field of antigen presentation

artículo científico publicado en 2013

Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation

artículo científico publicado en 2007

Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice

artículo científico publicado en 2017

Listeriolysin O Is Strongly Immunogenic Independently of Its Cytotoxic Activity ⬇️

artículo científico publicado el 5 de marzo de 2012

Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule

artículo científico publicado en 2004

Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens

artículo científico publicado en 2006

Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.

artículo científico publicado en 2006

Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ

artículo científico publicado en 2016

Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets

artículo científico publicado en 2016

Mechanisms and Immunological Effects of Apoptosis Caused by Listeria Monocytogenes

artículo científico publicado el 1 de enero de 2012

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

artículo científico publicado en 2002

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

artículo científico publicado en 2005

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants ⬇️

artículo científico publicado el 2 de agosto de 2010

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process ⬇️

artículo científico publicado el 21 de enero de 2013

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

artículo científico publicado en 2018

Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.

artículo científico publicado en 2013

Perspective on antigen processing and presentation.

artículo científico publicado en 2002

Perspectives on anti-CD47 antibody treatment for experimental cancer ⬇️

artículo científico publicado el 19 de junio de 2013

Podocytes use FcRn to clear IgG from the glomerular basement membrane

artículo científico publicado en 2008

Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm

artículo científico publicado en 2007

Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells

artículo científico publicado en 2009

Presentation of Type B Peptide–MHC Complexes from Hen Egg White Lysozyme by TLR Ligands and Type I IFNs Independent of H2-DM Regulation ⬇️

artículo científico publicado el 25 de julio de 2011

Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system ⬇️

artículo científico publicado el 24 de febrero de 2012

Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

scientific article published on 01 April 2020

RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice

artículo científico publicado en 2011

Recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is weakly virulent but immunogenic

artículo científico publicado en 2009

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion ⬇️

artículo científico publicado el 7 de noviembre de 2011

Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor

artículo científico publicado en 2004

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.

artículo científico publicado en 2017

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition

artículo científico publicado en 2003

Starting in Immunology by Way of Immunopathology ⬇️

artículo científico publicado el 1 de enero de 2011

Studies with Listeria Monocytogenes Lead the Way

artículo científico publicado el 1 de enero de 2012

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

artículo científico publicado en 2004

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

artículo científico publicado en 2017

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

artículo científico publicado en 2009

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity

scientific article published on 01 August 2019

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

artículo científico publicado en 2020

The Secrets of the Class II MHC Peptidome Start To Be Revealed

artículo científico publicado en 2016

The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen

scientific article published on February 2009

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

artículo científico publicado en 2013

The ever surprising field of antigen presentation ⬇️

artículo científico publicado el 6 de enero de 2013

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

artículo científico publicado en 2007

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.

artículo científico publicado en 2017

The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection

artículo científico publicado en 2005

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles

artículo científico publicado en 2018

The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse

scientific article published on July 2016

The wide diversity and complexity of peptides bound to class II MHC molecules

artículo científico publicado en 2005

Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

artículo científico publicado en 2009

Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice

scientific article published on 03 July 2018

Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.

artículo científico publicado en 2004

Unconventional recognition of peptides by T cells and the implications for autoimmunity ⬇️

artículo científico publicado el 7 de septiembre de 2012

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

artículo científico publicado en 2010

Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update

artículo científico publicado en 2017

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

artículo científico publicado en 2016

Viral infections and nonspecific protection--good or bad?

artículo científico publicado en 2007

Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice

artículo científico publicado en 2008

ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditions

artículo científico publicado en 2014

Lista de obras de Emil R. Unanue

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity ⬇️

APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.

Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes

Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells

Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides

Altered peptide ligands make their entry

Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex

Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse

Antigen presentation events in autoimmune diabetes.

Antigen presentation in the autoimmune diabetes of the NOD mouse

Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?

Antigen processing

Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice

Autoimmune diabetes mellitus--much progress, but many challenges

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells ⬇️

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Binding of immunogenic peptides to Ia histocompatibility molecules. 1985.

Brigitte Askonas 1923–2013

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes ⬇️

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans ⬇️

Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules

Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

Conformational isomers of a peptide-class II major histocompatibility complex

Correction: Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse.

Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen

Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways

Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization

Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse

Dendritic Cells Process and Present Antigens Across A Range of Maturation States

Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules

Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

Diabetes is predicted by the beta cell level of autoantigen

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

Dressing for the occasion: APCs make antigens presentable

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

Endoplasmic reticulum: an interface between the immune system and metabolism

Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response

First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules

Following immunization antigen becomes concentrated in a limited number of APCs including B cells

From antigen processing to peptide-MHC binding

Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins

Granzymes drive a rapid listeriolysin O-induced T cell apoptosis

Herman Eisen (1918-2014).

Herman N. Eisen, M.D. (1918-2014): Scholar, Gentleman, and AAI President (1968-1969).

IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 1981. 127: 1869-1875.

Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells

Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.

Impact of lymphocyte apoptosis on the innate immune stages of infection

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.

Influence of saccharide size on the cellular immune response to glycopeptides

Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells

Intracellular pathogens and antigen presentation-new challenges with Legionella pneumophila

Ita Askonas and her influence in the field of antigen presentation

Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation

Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice

Listeriolysin O Is Strongly Immunogenic Independently of Its Cytotoxic Activity ⬇️

Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule

Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens

Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.

Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ

Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets

Mechanisms and Immunological Effects of Apoptosis Caused by Listeria Monocytogenes

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants ⬇️

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process ⬇️

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.