Lista de obras -

A comprehensive rat transcriptome built from large scale RNA-seq-based annotation

artículo científico publicado en 2020

A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway

scientific article published on 09 December 2020

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

artículo científico publicado en 2014

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.

artículo científico publicado en 2017

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

artículo científico publicado en 2014

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

artículo científico publicado en 2016

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

artículo científico publicado en 2006

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

scientific journal article

Application of microarray-based analysis of gene expression in the field of toxicogenomics

artículo científico publicado en 2010

Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose ⬇️

artículo científico publicado el 23 de julio de 2011

Autophagy in drug-induced liver toxicity

artículo científico publicado en 2014

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

artículo científico publicado en 2019

Calreticulin in cardiac development and pathology

artículo científico publicado en 2002

Calreticulin in the heart

artículo científico publicado en 2004

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

artículo científico publicado en 2005

Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

artículo científico publicado en 2002

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors.

artículo científico publicado en 2019

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

artículo científico publicado en 2007

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

artículo científico publicado en 2020

Corrigendum to: "Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing"

scientific article published on 26 August 2020

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

artículo científico publicado en 2005

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

artículo científico publicado en 2008

DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells.

artículo científico publicado en 2018

Development and application of TK6-derived cells expressing human cytochrome P450s for genotoxicity testing

artículo científico publicado en 2020

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

artículo científico publicado en 2015

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells

artículo científico publicado en 2006

Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine

artículo científico publicado en 2013

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

artículo científico publicado en 2006

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone

scientific article published on 13 December 2018

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

artículo científico publicado en 2016

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

artículo científico publicado en 2015

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells

artículo científico publicado en 2017

Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity

artículo científico

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

scientific article published on 28 March 2020

Evaluation of external RNA controls for the assessment of microarray performance

artículo científico publicado en 2006

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines

artículo científico publicado en 2020

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA

scientific article published on 01 January 2020

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

artículo científico

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

artículo científico publicado en 2007

Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats

artículo científico publicado en 2006

Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements

scientific article published on January 2010

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

artículo científico publicado en 2009

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

artículo científico publicado en 2010

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

artículo científico publicado en 2007

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network

artículo científico publicado en 2010

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

artículo científico publicado en 2015

Identification by mutational analysis of amino acid residues essential in the chaperone function of calreticulin

artículo científico publicado en 2005

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin ⬇️

artículo científico publicado el 12 de diciembre de 2003

Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing

artículo científico publicado en 2020

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

artículo científico publicado en 2016

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

artículo científico publicado en 2020

Mechanism study of goldenseal-associated DNA damage ⬇️

artículo científico publicado el 5 de junio de 2013

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

artículo científico publicado en 2015

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells

artículo científico publicado en 2014

Metabolism, genotoxicity, and carcinogenicity of comfrey

artículo científico publicado en 2010

Methods for Establishing and Using a Stable Cell Line Expressing Both Gaussia Luciferase and Firefly Luciferase to Screen for Endoplasmic Reticulum Stress

scientific article published on 01 January 2020

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

artículo científico publicado en 2011

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

artículo científico publicado en 2017

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation

scientific article published on 22 August 2019

Microarray scanner calibration curves: characteristics and implications

artículo científico publicado en 2005

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent ⬇️

artículo científico publicado el 2 de marzo de 2012

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline

scientific article published on 28 August 2020

Mitochondrial dysfunction induced by leflunomide and its active metabolite

artículo científico publicado en 2018

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells

artículo científico publicado en 2015

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

artículo científico publicado en 2017

Next-generation sequencing in the clinic: Promises and challenges ⬇️

artículo científico publicado el 19 de noviembre de 2012

Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells.

artículo científico publicado en 2013

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

artículo científico publicado en 2003

ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

artículo científico publicado en 2017

Rat toxicogenomic study reveals analytical consistency across microarray platforms

artículo científico publicado en 2006

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells

artículo científico publicado en 2015

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

scientific article published on 15 July 2019

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors

artículo científico publicado en 2008

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.

artículo científico publicado en 2017

Review of usnic acid and Usnea barbata toxicity.

artículo científico publicado en 2008

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

scientific article published on 01 January 2007

Sertraline induces endoplasmic reticulum stress in hepatic cells

artículo científico publicado en 2014

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

artículo científico publicado en 2013

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes ⬇️

artículo científico publicado el 13 de diciembre de 2010

Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes

artículo científico publicado en 2008

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

artículo científico publicado en 2006

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

artículo científico publicado en 2008

The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.

artículo científico publicado en 2017

The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.

artículo científico publicado en 2016

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

artículo científico publicado en 2014

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone.

artículo científico publicado en 2018

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

scientific article published on 05 May 2020

Toxicity of kava kava

artículo científico publicado en 2008

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene

scientific article published on 01 January 2020

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment

artículo científico publicado en 2015

Lista de obras de

A comprehensive rat transcriptome built from large scale RNA-seq-based annotation

A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

Application of microarray-based analysis of gene expression in the field of toxicogenomics

Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose ⬇️

Autophagy in drug-induced liver toxicity

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

Calreticulin in cardiac development and pathology

Calreticulin in the heart

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors.

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

Corrigendum to: "Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing"

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells.

Development and application of TK6-derived cells expressing human cytochrome P450s for genotoxicity testing

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells

Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells

Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

Evaluation of external RNA controls for the assessment of microarray performance

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats

Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

Identification by mutational analysis of amino acid residues essential in the chaperone function of calreticulin

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin ⬇️

Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

Mechanism study of goldenseal-associated DNA damage ⬇️

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells

Metabolism, genotoxicity, and carcinogenicity of comfrey

Methods for Establishing and Using a Stable Cell Line Expressing Both Gaussia Luciferase and Firefly Luciferase to Screen for Endoplasmic Reticulum Stress

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation

Microarray scanner calibration curves: characteristics and implications

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent ⬇️

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline

Mitochondrial dysfunction induced by leflunomide and its active metabolite

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

Next-generation sequencing in the clinic: Promises and challenges ⬇️

Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells.

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

Rat toxicogenomic study reveals analytical consistency across microarray platforms

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.

Review of usnic acid and Usnea barbata toxicity.

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

Sertraline induces endoplasmic reticulum stress in hepatic cells

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes ⬇️