Lista de obras -

A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct

artículo científico publicado en 2011

Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

artículo científico publicado en 2010

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery ⬇️

artículo científico publicado el 21 de marzo de 2013

Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis

artículo científico publicado en 2010

Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model

artículo científico publicado en 2015

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

artículo científico publicado en 2017

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

artículo científico publicado en 2016

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

artículo científico publicado en 2013

Discovery of novel isoxazolines as anti-tuberculosis agents

artículo científico publicado en 2007

Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis

artículo científico publicado en 2012

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

artículo científico publicado en 2009

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer ⬇️

artículo científico publicado el 18 de junio de 2012

Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis

artículo científico publicado en 2012

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis

artículo científico publicado en 2010

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species

artículo científico publicado en 2012

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

artículo científico publicado en 2011

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

artículo científico publicado en 2015

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

artículo científico publicado en 2015

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

artículo científico publicado en 2015

Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis ⬇️

artículo científico publicado el 5 de diciembre de 2011

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

artículo científico publicado en 2015

In vivo adaptation of the Wayne model of latent tuberculosis

artículo científico publicado en 2007

In vivo efficacy of apramycin in murine infection models

artículo científico publicado en 2014

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

scientific journal article

Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas

artículo científico publicado en 2014

Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis.

artículo científico publicado en 2011

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment ⬇️

artículo científico publicado el 21 de marzo de 2011

Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

artículo científico publicado en 2007

Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery

artículo científico publicado en 2012

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach

artículo científico publicado en 2010

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

artículo científico publicado en 2011

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis

artículo científico publicado en 2005

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

artículo científico publicado en 2014

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models

artículo científico publicado en 2005

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

artículo científico publicado en 2015

Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice

artículo científico publicado en 2003

Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis

artículo científico publicado en 2006

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

artículo científico publicado en 2012

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

artículo científico publicado en 2016

Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models

artículo científico publicado en 2015

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

artículo científico publicado en 2004

Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors

artículo científico publicado en 2007

Torticollis in mice intravenously infected with Mycobacterium tuberculosis ⬇️

artículo científico publicado el 1 de marzo de 2011

Lista de obras de

A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct

Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery ⬇️

Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis

Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

Discovery of novel isoxazolines as anti-tuberculosis agents

Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer ⬇️

Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis ⬇️

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

In vivo adaptation of the Wayne model of latent tuberculosis

In vivo efficacy of apramycin in murine infection models

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas

Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis.

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment ⬇️

Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice

Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors

Torticollis in mice intravenously infected with Mycobacterium tuberculosis ⬇️