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6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor

artículo científico publicado en 1996

A Cohort Study of the Temporal Stability of ImPACT Scores Among NCAA Division I Collegiate Athletes: Clinical Implications of Test-Retest Reliability for Enhancing Student Athlete Safety

artículo científico publicado en 2020

A Non-invasive System for Delivering Neural Growth Factors across the Blood-Brain Barrier: A Review ⬇️

artículo científico publicado el 1 de enero de 1998

A dual-hit animal model for age-related parkinsonism

artículo científico publicado en 2009

A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation.

artículo científico publicado en 2011

A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients

scientific article published on 02 February 2021

A non-invasive transport system for GDNF across the blood–brain barrier ⬇️

artículo científico publicado el 7 de julio de 1997

A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats

artículo científico publicado en 2017

A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model ⬇️

artículo científico publicado el 1 de enero de 2011

A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra

artículo científico publicado en 2006

Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.

artículo científico publicado en 2002

Age-Related Neurodegeneration and Memory Loss in Down Syndrome ⬇️

artículo científico publicado el 20 de marzo de 2012

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

artículo científico publicado en 2006

Age-induced changes in single locus coeruleus brain transplants grown in oculo: An in vivo electrochemical study ⬇️

artículo científico publicado el 1 de septiembre de 1991

Age-related alterations in noradrenergic input to the hippocampal formation: structural and functional studies in intraocular transplants

artículo científico publicado en 1989

Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo

artículo científico publicado en 1987

Age-related deficits as working memory load increases: relationships with growth factors

artículo científico publicado en 2003

Altered NGF response but not release in the aged septo-hippocampal cholinergic system

artículo científico publicado en 2005

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

artículo científico publicado en 2002

Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers

artículo científico publicado en 2020

At the interface of sensory and motor dysfunctions and Alzheimer's disease

artículo científico publicado en 2014

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function

artículo científico publicado en 2016

BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.

artículo científico publicado en 2015

Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease

artículo científico publicado en 2006

Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen

artículo científico publicado en 2004

Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory

artículo científico publicado en 2003

Blood-brain barrier penetration and in vivo activity of an NGF conjugate

artículo científico publicado en 1993

Blueberry extract enhances survival of intraocular hippocampal transplants.

artículo científico publicado en 2005

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

artículo científico publicado en 2010

Carrier mediated delivery of NGF: Alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors ⬇️

artículo científico publicado el 13 de octubre de 1997

Catecholamine-containing grafts in parkinsonism: past and present.

artículo científico publicado en 1988

Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance

scientific article published on 27 July 2020

Cerebellar noradrenergic systems in aging: studies in situ and in in oculo grafts

artículo científico publicado en 1988

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

artículo científico publicado en 1999

Characterization of histaminergic H3 receptors in intraocular tuberomammillary transplants containing histaminergic neurons

artículo científico publicado en 1995

Chemical signaling in the nervous system in health and disease: Nils-Ake Hillarp's legacy

artículo científico publicado en 2009

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

artículo científico publicado en 2004

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.

artículo científico publicado en 2011

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

artículo científico publicado en 2008

Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats

artículo científico publicado en 2006

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

artículo científico publicado en 2016

Collateral Sprouting of Central Noradrenergic Neurons during Aging: Histochemical and Neurochemical Studies in Intraocular Triple Transplants ⬇️

artículo científico publicado el 1 de junio de 1997

Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli.

artículo científico publicado en 2005

Comparison of fetal rabbit brain xenografts to three different strains of athymic nude rats: electrophysiological and immunohistochemical studies of intraocular grafts

artículo científico publicado el 1 de enero de 1992

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms

artículo científico publicado en 2014

Defects in enteric innervation and kidney development in mice lacking GDNF

artículo científico publicado en 1996

Delayed development of GFA immunoreactivity in intraocular cortex cerebri grafts during thyroid hormone deficiency

artículo científico publicado en 1985

Delayed development of GFA immunoreactivity in the parietal cortex during thyroid hormone deficiency

artículo científico publicado en 1985

Delivery of trophic factors to the primate brain

artículo científico publicado en 1993

Designer receptors enhance memory in a mouse model of Down syndrome

artículo científico publicado en 2015

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats

artículo científico publicado en 2016

Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus ⬇️

artículo científico publicado el 1 de enero de 2011

Dietary blueberry supplementation affects growth but not vascularization of neural transplants.

artículo científico publicado en 2008

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study

scientific article published on 01 January 2019

Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene

artículo científico publicado en 2008

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer’s disease

artículo científico publicado en 2021

Distribution of Thy-1-like immunoreactivity in normal, sympathetically denervated and grafted mouse irides

artículo científico publicado en 1985

Down Syndrome Biobank Consortium: A perspective

scholarly article

Down syndrome and Alzheimer's disease: Common pathways, common goals

artículo científico publicado en 2014

ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age.

artículo científico publicado en 2006

Effects of GDNF on fetal septal forebrain transplants in oculo

artículo científico publicado en 1996

Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat.

artículo científico publicado en 2007

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

article by Ann-Charlotte Granholm et al published 4 June 2008 in Journal of Alzheimer's Disease

Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat

artículo científico publicado en 2008

Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts

artículo científico publicado en 2001

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging

artículo científico publicado en 2010

Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures

artículo científico publicado en 2006

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

artículo científico publicado en 2010

Effects of osteogenic protein-1 (OP-1) treatment on fetal spinal cord transplants to the anterior chamber of the eye.

artículo científico publicado en 1999

Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513.

artículo científico publicado en 1990

Electrophysiological studies of human cerebral and cerebellar cortical tissue grafted to the anterior eye chamber of athymic rodents

artículo científico publicado en 1988

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

artículo científico publicado en 2008

Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice ⬇️

artículo científico publicado el 8 de diciembre de 2010

Environmental influences on brain neurotrophins in rats

artículo científico publicado en 2002

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

artículo científico publicado en 2003

Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.

artículo científico publicado en 2014

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

artículo científico publicado en 2002

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study

artículo científico publicado en 2014

Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat.

artículo científico publicado en 2003

Exosomal biomarkers in Down syndrome and Alzheimer's disease

artículo científico publicado en 2017

Exosome release and cargo in Down syndrome

artículo científico publicado en 2019

Fifth Annual Meeting of the American Society for Neural Transplantation and Repair

artículo científico publicado en 1999

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

artículo científico publicado en 2003

Further understanding the connection between Alzheimer's disease and Down syndrome

artículo científico publicado en 2020

GDNF is required for kidney development and enteric innervation

artículo científico publicado el 1 de enero de 1996

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo.

artículo científico publicado en 1995

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum.

artículo científico publicado en 1997

Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway

artículo científico publicado en 2004

Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

artículo científico publicado en 2000

Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons.

artículo científico publicado en 1995

Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF

artículo científico publicado en 2013

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue.

artículo científico publicado en 2015

Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies

artículo científico publicado en 1987

Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies

artículo científico publicado en 1989

Human fetal tissues grafted to rodent hosts: structural and functional observations of brain, adrenal and heart tissues in oculo

artículo científico publicado en 1987

Human fetal xenografts of brainstem tissue containing locus coeruleus neurons: functional and structural studies of intraocular grafts in athymic nude rats

artículo científico publicado en 1992

Human ventral mesencephalic xenografts to the catecholamine-depleted striata of athymic rats: ultrastructure and immunocytochemistry

artículo científico publicado en 1989

Hypothalamic tissue stimulates hippocampal pyramidal neuron survival during development: evidence from intraocular double transplants

scientific article published on 01 January 1995

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

artículo científico publicado en 2017

Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

artículo científico publicado en 2019

Intracerebral xenografts of human mesencephalic tissue into athymic rats: immunochemical and in vivo electrochemical studies

artículo científico publicado en 1988

Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology

artículo científico publicado en 2014

Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats

artículo científico publicado en 2001

Intraocular development and adrenergic innervation of cortical and subcortical brain areas: influence of thyroid hormone deficiency

artículo científico publicado en 1982

Intraocular fibre growth of grafted locus coeruleus neurons: sensory denervation counteracts alterations induced by thyroid hormone deficiency

artículo científico publicado en 1982

Intraocular hypothalamic transplants containing histaminergic neurons: innervation of host iris and hippocampal cografts

artículo científico publicado en 1990

Kidney Cografts Enhance Fiber Outgrowth from Ventral Mesencephalic Grafts to the 6-Ohda–Lesioned Striatum, and Improve Behavioral Recovery ⬇️

artículo científico publicado el 1 de marzo de 1998

Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice.

artículo científico publicado en 2007

Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain

artículo científico publicado en 2000

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

artículo científico publicado en 2000

Memory and hippocampal architecture following short-term midazolam in western diet-treated rats

artículo científico publicado en 2016

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

artículo científico publicado en 2004

Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning

artículo científico publicado en 2004

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice

scientific article published on 09 December 2008

Mood, memory and movement: an age-related neurodegenerative complex?

artículo científico publicado en 2008

Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies

artículo científico publicado en 1997

Morphological and electrophysiological studies of human hippocampal transplants in the anterior eye chamber of athymic nude rats

scientific article published on 01 May 1989

Motion capture and associated novel measurement devices for movement function in humans and animal models

scientific article published on 01 July 2014

Multiple changes in noradrenergic mechanisms in the coeruleo-hippocampal pathway during aging. Structural and functional correlates in intraocular double grafts

artículo científico publicado en 1989

Myocardium and cortex cerebri xenografts transplanted into the anterior chamber of the eye of athymic rats: a morphologic and electrophysiologic profile

scientific article published on 01 March 1987

NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants.

artículo científico publicado en 1994

Nerve growth factor in treatment and pathogenesis of Alzheimer's disease.

artículo científico publicado en 2006

Nerve growth factor metabolic dysfunction in Down's syndrome brains.

artículo científico publicado en 2014

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy

article published in 2019

Neuronal development in embryonic brain tissue derived from schizophrenic women and grafted to animal hosts

artículo científico publicado en 1994

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

artículo científico publicado en 2016

Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail

artículo científico publicado en 2001

On the localization of Thy-1-like immunoreactivity in the rodent and human nervous system

artículo científico publicado en 1986

Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance

artículo científico publicado en 2003

Ovarian hormones and cognition in the aged female rat: II. progesterone supplementation reverses the cognitive enhancing effects of ovariectomy

artículo científico publicado en 2004

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

artículo científico publicado en 2012

Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations

artículo científico publicado en 2005

Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"?

artículo científico publicado en 2008

Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder

artículo científico publicado en 2014

Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice

artículo científico publicado en 2010

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

artículo científico publicado en 2015

Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain

artículo científico publicado en 2004

Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats

artículo científico publicado en 2006

Receptors for pro-resolving mediators are increased in Alzheimer's disease brain

scientific article published on 07 January 2020

Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome

artículo científico publicado en 2003

Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue

artículo científico publicado en 2020

Resolution of inflammation is altered in Alzheimer's disease

artículo científico publicado en 2014

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

scientific article published on 16 January 2020

Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease

scientific article published on 22 November 2019

Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

artículo científico publicado en 2002

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

artículo científico publicado en 2010

Structural and functional impairment of adrenergic input to intraocular cerebellar grafts during thyroid hormone deficiency

artículo científico publicado en 1984

Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy

artículo científico publicado en 1996

Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats

artículo científico publicado en 2003

The Noradrenergic System of Aged GDNF Heterozygous Mice

artículo científico publicado en 2003

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease

scientific article published on 07 November 2019

The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior

scientific journal article

The noradrenergic system of aged GDNF heterozygous mice.

artículo científico publicado en 2003

Three-dimensional rodent motion analysis and neurodegenerative disorders

artículo científico publicado en 2013

Thy-1-like immunoreactivity in human brain during development

artículo científico publicado en 1986

Thyroid hormone dependency in immature but not mature grafted locus coeruleus neurons. Evidence from intraocular innervation of iris transplants

artículo científico publicado el 1 de febrero de 1981

Thyroid hormone dependency of the developing dorsal raphe nucleus but not the superior cervical ganglion. Evidence from intraocular grafting experiments

artículo científico publicado en 1984

Thyroxin dependency of the developing locus coeruleus. Evidence from intraocular grafting experiments

scientific article published on 01 January 1981

Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion

scientific article published on 01 November 2000

Toluene exposure during maturation of intraocular brain tissue transplants: Alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine

artículo científico publicado en 1988

Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins

scientific article published on 08 January 2020

Use of seniors as mentors to medical students: a collaboration between the University of South Carolina School of Medicine and the Medical University of South Carolina

artículo científico publicado el 1 de febrero de 2011

Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet

artículo científico publicado en 2011

Why do we need to use animal models to study cognition and aging?

artículo científico publicado en 2010

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