Lista de obras -

A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome ⬇️

artículo científico publicado el 1 de febrero de 2012

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model

artículo científico publicado en 2024

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

artículo científico publicado en 2013

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth

artículo científico publicado en 2016

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

artículo científico publicado en 2017

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants

artículo científico publicado en 2008

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

artículo científico publicado en 2012

Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons

artículo científico publicado en 2006

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

scientific article published on 15 April 2019

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.

artículo científico publicado en 2018

Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth

artículo científico publicado en 2005

LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways

artículo científico publicado en 2006

Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth ⬇️

artículo científico publicado el 15 de abril de 2003

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

artículo científico publicado en 2019

Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury

artículo científico publicado en 2020

P3‐212: A SMALL MOLECULE TRKB/TRKC NEUROTROPHIN RECEPTOR CO‐ACTIVATOR PREVENTS SYNAPTIC IMPAIRMENT IN AN AD MOUSE MODEL ⬇️

scholarly article

Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury

artículo científico publicado en 2020

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

artículo científico publicado en 2018

Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function

artículo científico publicado en 2006

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

scientific article published on 27 November 2020

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

artículo científico publicado en 2010

Small molecule approaches for promoting neurogenesis

artículo científico publicado en 2006

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

artículo científico publicado en 2020

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

artículo científico publicado en 2007

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

artículo científico publicado en 2013

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice

artículo científico publicado en 2014

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

artículo científico publicado en 2008

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

artículo científico publicado en 2006

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

artículo científico publicado en 2020

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

artículo científico publicado en 2009

Lista de obras de

A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome ⬇️

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.

Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth

LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways

Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth ⬇️

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury

P3‐212: A SMALL MOLECULE TRKB/TRKC NEUROTROPHIN RECEPTOR CO‐ACTIVATOR PREVENTS SYNAPTIC IMPAIRMENT IN AN AD MOUSE MODEL ⬇️

Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Small molecule approaches for promoting neurogenesis

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo