Lista de obras -

A biologic role of HIF-1 in the renal medulla

artículo científico publicado en 2005

A disposable, ultra-fine endoscope for non-invasive, close examination of the intraluminal surface of the peritoneal dialysis catheter and peritoneal cavity

artículo científico publicado en 2020

A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

artículo científico publicado en 2008

A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models

artículo científico publicado en 2007

A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis

scientific article published on 14 June 2010

A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia

artículo científico publicado en 2007

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

artículo científico publicado en 2010

A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia

artículo científico publicado en 2013

A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies).

artículo científico publicado en 2006

A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage.

artículo científico publicado en 2009

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice

artículo científico publicado en 2006

A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

artículo científico publicado en 2013

Accelerated glomerular injury in hemi-nephrectomized transgenic mice of mesangial cell-predominant serpin, megsin

artículo científico publicado en 2004

Advanced glycation and advanced oxidation protein products: the effect of peritoneal dialysis

artículo científico publicado en 2006

Affinity adsorption of glucose degradation products improves the biocompatibility of conventional peritoneal dialysis fluid

artículo científico publicado en 2003

Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway

artículo científico publicado en 2007

Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

artículo científico publicado en 2002

Angiotensin II type 1A receptor deficiency and longevity

scientific article published on 07 August 2009

Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation.

artículo científico publicado en 2007

Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model ⬇️

artículo científico publicado el 1 de mayo de 2003

Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats.

artículo científico publicado en 2009

Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells

artículo científico publicado en 2004

Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning

scientific article published on 20 June 2019

Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model

artículo científico publicado en 2010

Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration ⬇️

artículo científico publicado en 2019

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

artículo científico publicado en 2013

Carbonyl stress inhibitor towards new therapeutic interventions in diabetic nephropathy

artículo científico publicado en 2004

Carbonyl stress reduction in peritoneal dialysis fluid: development of a novel high-affinity adsorption bead

artículo científico publicado en 2007

Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model

artículo científico publicado en 2007

Current issues and future perspectives of chronic renal failure.

artículo científico publicado en 2002

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.

artículo científico publicado en 2012

Diabetic nephropathy: a disorder of oxygen metabolism?

scientific article published on 15 December 2009

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

artículo científico

Drug discovery in renal disease--towards a more efficient framework

artículo científico

ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

artículo científico publicado en 2002

Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease

artículo científico publicado en 2010

Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid

artículo científico publicado en 2002

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

artículo científico publicado en 2015

Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress.

artículo científico publicado en 2007

Establishment of a sandwich ELISA for human megsin, a kidney-specific serine protease inhibitor

scientific article published on 25 June 2007

Evidence of tubular hypoxia in the early phase in the remnant kidney model

artículo científico publicado en 2004

From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: a detective story

artículo científico publicado en 2005

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1.

artículo científico publicado en 2018

Glucose dialysate induces mitochondrial DNA damage in peritoneal mesothelial cells.

artículo científico publicado en 2002

Glyoxalase I Retards Renal Senescence ⬇️

artículo científico publicado el 12 de octubre de 2011

Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats

artículo científico publicado en 2009

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

artículo científico publicado en 2014

High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway

artículo científico publicado en 2006

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis

artículo científico publicado en 2004

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.

artículo científico publicado en 2015

Hypoxia and hypoxia-inducible factor in renal disease

scientific article published on 30 July 2008

Hypoxia in renal disease with proteinuria and/or glomerular hypertension

artículo científico publicado en 2004

Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways.

artículo científico publicado en 2003

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

artículo científico publicado en 2005

Hypoxia-sensitive reporter system for high-throughput screening.

artículo científico publicado en 2015

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets ⬇️

artículo científico publicado el 27 de octubre de 2010

Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives

artículo científico publicado en 2018

Idiopathic carbonyl stress in a drug‐naive case of at‐risk mental state ⬇️

artículo científico publicado el 1 de octubre de 2011

Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury

artículo científico publicado en 2003

In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy

artículo científico publicado en 2005

Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis

artículo científico publicado en 2005

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice ⬇️

artículo científico publicado el 9 de mayo de 2012

Inhibition of advanced glycation end products: an implicit goal in clinical medicine for the treatment of diabetic nephropathy?

artículo científico publicado en 2008

Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration

artículo científico publicado en 2014

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

scientific article published on 17 February 2020

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.

artículo científico publicado en 2015

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

scientific journal article

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression

artículo científico publicado en 2009

Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation

artículo científico publicado en 2005

Keap1 inhibition attenuates glomerulosclerosis.

artículo científico publicado en 2014

Mesangial cell-predominant functional gene, megsin ⬇️

artículo científico publicado el 1 de junio de 2003

Mesangial cell-predominant gene, megsin

artículo científico publicado en 2002

Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor ⬇️

artículo científico publicado el 9 de agosto de 2012

Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney

artículo científico publicado en 2008

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

artículo científico publicado en 2009

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

artículo científico publicado en 2010

Molecular pathophysiology of schizophrenia and preventive strategy in pubertal period

artículo científico publicado el 1 de enero de 2011

New era for drug discovery and development in renal disease ⬇️

artículo científico publicado el 5 de julio de 2011

New perspective for drug discovery and clinical development in kidney disease

artículo científico publicado el 1 de enero de 2012

Nitric oxide prevents alveolar senescence and emphysema in a mouse model

artículo científico publicado en 2015

Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin

artículo científico publicado en 2005

Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion

artículo científico publicado en 2002

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

artículo científico publicado en 2015

Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications

artículo científico publicado en 2014

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence

artículo científico publicado en 2013

Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

artículo científico publicado en 2017

Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis

artículo científico publicado en 2015

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population

artículo científico publicado en 2018

Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis

artículo científico publicado en 2008

Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy

artículo científico publicado en 2005

Proteomics and mesangial cell: serpin, megsin and plasmin

artículo científico publicado en 2004

Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in uremic peritoneal dialysis rats

artículo científico publicado en 2005

Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker.

artículo científico publicado en 2007

Reduction of albuminuria by angiotensin receptor blocker beyond blood pressure lowering: evaluation in megsin/receptor for advanced glycation end products/inducible nitric oxide synthase triple transgenic diabetic nephropathy mouse model

artículo científico publicado en 2008

Relationship of Skin Autofluorescence to Severity of Retinopathy in Type 2 Diabetes

scientific article published on 28 May 2014

Relationship of skin autofluorescence to cardiovascular disease in Japanese hemodialysis patients

artículo científico publicado en 2010

Renal proximal tubular metabolism of protein-linked pentosidine, an advanced glycation end product

scientific article published on 01 August 2002

Renoprotection of angiotensin receptor blockers: beyond blood pressure lowering.

artículo científico publicado en 2006

Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering

artículo científico publicado en 2005

Role of chronic hypoxia and hypoxia inducible factor in kidney disease

artículo científico publicado en 2008

Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation.

artículo científico publicado en 2012

Serpinopathy and endoplasmic reticulum stress

artículo científico publicado en 2005

Skin autofluorescence is associated with renal function and cardiovascular diseases in pre-dialysis chronic kidney disease patients.

artículo científico publicado en 2010

Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study

artículo científico publicado en 2013

Skin autofluorescence predicts cardiovascular mortality in patients on chronic hemodialysis

artículo científico publicado en 2014

Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

artículo científico publicado en 2015

Structure-activity relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as plasminogen activator inhibitor-1 inhibitors

artículo científico publicado en 2010

Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors

artículo científico publicado en 2011

Synergistic contributions of carbonyl stress and megsin in diabetic nephropathy

artículo científico publicado en 2005

TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

artículo científico publicado en 2017

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

artículo científico publicado en 2020

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

artículo científico publicado en 2016

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.

artículo científico publicado en 2008

Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes

artículo científico publicado en 2002

Transcriptional regulation of a mesangium-predominant gene, megsin

artículo científico publicado en 2002

Transdifferentiation of cultured tubular cells induced by hypoxia

artículo científico publicado en 2004

Translation of basic science into clinical medicine: novel targets for diabetic nephropathy

artículo científico publicado en 2009

Ultrapure dialysate decreases plasma pentosidine, a marker of "carbonyl stress".

artículo científico publicado en 2004

Very high doses of valsartan provide renoprotection independently of blood pressure in a type 2 diabetic nephropathy rat model

artículo científico publicado en 2009

[Mechanisms in remodeling of the kidney].

artículo científico publicado en 2008

[Post-genome research on megsin, a kidney-specific serpin gene]

scientific article published on 01 February 2006

[Post-genomic studies on kidney diseases and genomic drug design]

artículo científico publicado en 2006

Lista de obras de

A biologic role of HIF-1 in the renal medulla

A disposable, ultra-fine endoscope for non-invasive, close examination of the intraluminal surface of the peritoneal dialysis catheter and peritoneal cavity

A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models

A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis

A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia

A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies).

A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage.

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice

A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

Accelerated glomerular injury in hemi-nephrectomized transgenic mice of mesangial cell-predominant serpin, megsin

Advanced glycation and advanced oxidation protein products: the effect of peritoneal dialysis

Affinity adsorption of glucose degradation products improves the biocompatibility of conventional peritoneal dialysis fluid

Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway

Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

Angiotensin II type 1A receptor deficiency and longevity

Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation.

Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model ⬇️

Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats.

Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells

Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning

Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model

Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration ⬇️

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

Carbonyl stress inhibitor towards new therapeutic interventions in diabetic nephropathy

Carbonyl stress reduction in peritoneal dialysis fluid: development of a novel high-affinity adsorption bead

Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model

Current issues and future perspectives of chronic renal failure.

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.

Diabetic nephropathy: a disorder of oxygen metabolism?

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

Drug discovery in renal disease--towards a more efficient framework

ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease

Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress.

Establishment of a sandwich ELISA for human megsin, a kidney-specific serine protease inhibitor

Evidence of tubular hypoxia in the early phase in the remnant kidney model

From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: a detective story

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1.

Glucose dialysate induces mitochondrial DNA damage in peritoneal mesothelial cells.

Glyoxalase I Retards Renal Senescence ⬇️

Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.

Hypoxia and hypoxia-inducible factor in renal disease

Hypoxia in renal disease with proteinuria and/or glomerular hypertension

Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways.

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

Hypoxia-sensitive reporter system for high-throughput screening.

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets ⬇️

Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives

Idiopathic carbonyl stress in a drug‐naive case of at‐risk mental state ⬇️

Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury

In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy

Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice ⬇️

Inhibition of advanced glycation end products: an implicit goal in clinical medicine for the treatment of diabetic nephropathy?

Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression

Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation

Keap1 inhibition attenuates glomerulosclerosis.

Mesangial cell-predominant functional gene, megsin ⬇️

Mesangial cell-predominant gene, megsin

Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor ⬇️

Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

Molecular pathophysiology of schizophrenia and preventive strategy in pubertal period

New era for drug discovery and development in renal disease ⬇️

New perspective for drug discovery and clinical development in kidney disease