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A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

artículo científico publicado en 2009

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling

artículo científico publicado en 2018

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

artículo científico publicado en 2016

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

artículo científico publicado en 2019

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

artículo científico publicado en 2008

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

artículo científico publicado en 2012

In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer

artículo científico publicado en 2020

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

artículo científico publicado en 2017

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

scientific article published in 2022

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

artículo científico publicado en 2011

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

artículo científico publicado en 2016

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

artículo científico publicado en 2016

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice

artículo científico publicado en 2016

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

artículo científico publicado en 2022

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

scientific article published on 23 August 2019

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

artículo científico publicado en 2008

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

artículo científico publicado en 2010

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

artículo científico publicado en 2014

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development

artículo científico publicado en 2019

Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms

artículo científico publicado en 2020

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

artículo científico publicado en 2022