Lista de obras -

A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR

artículo científico publicado en 2014

A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N′-[2-(2-thiophene)ethyl]-N′-[2-(5-bromopyridyl)] thiourea]) ⬇️

artículo científico publicado el 1 de febrero de 2012

A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies

artículo científico publicado en 2014

Absence of Genomic Ikaros/IKZF1 Deletions in Pediatric B-Precursor Acute Lymphoblastic Leukemia

artículo científico publicado en 2013

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

artículo científico publicado en 2006

Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog.

artículo científico publicado en 2004

Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

artículo científico publicado en 2007

Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study

artículo científico publicado en 2007

Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity ⬇️

artículo científico publicado el 10 de septiembre de 2010

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

artículo científico publicado en 2014

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia ⬇️

artículo científico publicado el 14 de septiembre de 2010

CD22 Exon 12 deletion is a characteristic genetic defect of therapy‐refractory clones in paediatric acute lymphoblastic leukaemia ⬇️

artículo científico publicado el 21 de octubre de 2011

CD22ΔE12 as a molecular target for RNAi therapy

artículo científico publicado en 2015

CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule

artículo científico publicado en 2015

Clinical activity of folinic acid in patients with chronic fatigue syndrome

artículo científico publicado en 2006

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients

artículo científico publicado en 2013

Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma

scientific article published on 10 December 2018

Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL.

artículo científico publicado en 2015

Evaluating dissolution profiles of an anti-HIV agent using ANOVA and non-linear regression models in JMP software

artículo científico publicado en 2003

Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets

artículo científico publicado en 2010

Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation

artículo científico publicado en 2007

In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates

artículo científico publicado en 2004

In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors

artículo científico publicado en 2011

In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs

artículo científico publicado en 2005

In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats

artículo científico publicado en 2003

In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443)

scientific article published on 01 January 2007

In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice

artículo científico publicado en 2002

Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2013

Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network

artículo científico publicado en 2011

Inhibition of mast cell leukotriene release by thiourea derivatives

artículo científico publicado en 2003

Intronic CD22 Gene Mutations as A Pathogenic Mechanism of Human B-Precursor Leukemia ⬇️

artículo científico publicado en 2010

JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia ⬇️

artículo científico publicado el 11 de noviembre de 2010

KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION.

artículo científico publicado en 2013

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

artículo científico publicado en 2015

Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in Mice

artículo científico publicado en 2015

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia ⬇️

artículo científico publicado el 8 de abril de 2013

Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus

artículo científico publicado en 2004

Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

artículo científico publicado en 2009

Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses

scientific article published on 01 February 2006

Prevention of DMBA-induced mammary gland tumors in mice by a dual-function inhibitor of JAK3 and EGF receptor tyrosine kinases

artículo científico publicado en 2020

Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase

artículo científico publicado en 2010

Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia

artículo científico publicado en 2013

Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2015

Recombinant human CD19‐ligand protein as a potent anti‐leukaemic agent ⬇️

artículo científico publicado el 17 de febrero de 2011

Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase

artículo científico publicado en 2013

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

artículo científico publicado en 2010

SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

artículo científico publicado en 2014

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros ⬇️

artículo científico publicado el 15 de octubre de 2012

Site-specific enzymatic activation of the anti-HIV agent stampidine

scientific article published on 01 February 2006

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas ⬇️

artículo científico publicado el 1 de septiembre de 2010

Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS ⬇️

artículo científico publicado el 24 de febrero de 2012

Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations

artículo científico publicado en 2002

Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.

artículo científico publicado en 2002

Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine).

artículo científico publicado en 2006

Targeting Human B-Precursor Acute Lymphoblastic Leukemia Cells with Recombinant Human CD19 Ligand ⬇️

scholarly article

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

artículo científico publicado en 2010

Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles

artículo científico publicado en 2015

Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells

artículo científico publicado en 2010

Lista de obras de

A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR

A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N′-[2-(2-thiophene)ethyl]-N′-[2-(5-bromopyridyl)] thiourea]) ⬇️

A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies

Absence of Genomic Ikaros/IKZF1 Deletions in Pediatric B-Precursor Acute Lymphoblastic Leukemia

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog.

Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study

Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity ⬇️

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia ⬇️

CD22 Exon 12 deletion is a characteristic genetic defect of therapy‐refractory clones in paediatric acute lymphoblastic leukaemia ⬇️

CD22ΔE12 as a molecular target for RNAi therapy

CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule

Clinical activity of folinic acid in patients with chronic fatigue syndrome

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients

Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma

Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL.

Evaluating dissolution profiles of an anti-HIV agent using ANOVA and non-linear regression models in JMP software

Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets

Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation

In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates

In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors

In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs

In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats

In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443)

In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice

Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia

Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network

Inhibition of mast cell leukotriene release by thiourea derivatives

Intronic CD22 Gene Mutations as A Pathogenic Mechanism of Human B-Precursor Leukemia ⬇️

JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia ⬇️

KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION.

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in Mice

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia ⬇️

Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus

Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses

Prevention of DMBA-induced mammary gland tumors in mice by a dual-function inhibitor of JAK3 and EGF receptor tyrosine kinases

Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase

Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia

Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia

Recombinant human CD19‐ligand protein as a potent anti‐leukaemic agent ⬇️

Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros ⬇️

Site-specific enzymatic activation of the anti-HIV agent stampidine

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas ⬇️

Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS ⬇️

Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations

Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine).

Targeting Human B-Precursor Acute Lymphoblastic Leukemia Cells with Recombinant Human CD19 Ligand ⬇️

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles

Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells