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A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly.

artículo científico publicado en 2015

A self-inhibitory interaction within Nup155 and membrane binding are required for nuclear pore complex formation

artículo científico publicado en 2017

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic

scientific article published on 25 July 2019

Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity

artículo científico publicado en 2003

Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways

scientific article published on 04 May 2007

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

artículo científico publicado en 2006

Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state

artículo científico

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells

artículo científico publicado en 2014

Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic

artículo científico publicado en 2008

IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes

scientific article published on 01 January 2007

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

artículo científico publicado en 2010

Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide

scientific article published on 01 July 2005

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

artículo científico publicado en 2016

Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40.

artículo científico publicado en 2013

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis

artículo científico publicado en 2021

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