Lista de obras -

A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats

artículo científico publicado en 2004

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice

artículo científico publicado en 2015

Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways

artículo científico publicado en 2006

Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity

artículo científico publicado en 2004

Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice

article

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

artículo científico publicado en 2002

Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species

Alcohol and oxidative liver injury

artículo científico publicado en 2006

Alcohol metabolism

artículo científico publicado en 2012

Alcohol, oxidative stress, and free radical damage

artículo científico publicado en 2003

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis

artículo científico publicado en 2017

Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity

artículo científico publicado en 2002

Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations

artículo científico publicado en 2004

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity

artículo científico publicado en 2015

Binge ethanol exposure increases liver injury in obese rats

artículo científico publicado en 2003

CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model

artículo científico publicado en 2018

CYP2E1 and oxidative liver injury by alcohol

artículo científico publicado en 2007

CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells

artículo científico publicado en 2008

CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment

artículo científico publicado en 2012

CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

artículo científico publicado en 2009

CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury.

artículo científico publicado en 2006

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury

artículo científico publicado en 2005

Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1.

artículo científico publicado en 2002

Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53.

artículo científico publicado en 2002

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice ⬇️

artículo científico publicado el 6 de agosto de 2010

Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase

artículo científico publicado en 2009

Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.

artículo científico publicado en 2005

Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels

artículo científico publicado en 2006

Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria

artículo científico publicado en 2002

Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

artículo científico publicado en 2003

Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells

artículo científico publicado en 2006

Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells ⬇️

artículo científico publicado el 8 de enero de 2002

Cytochrome P450s And Alcoholic Liver Disease

artículo científico publicado en 2018

Cytokines in alcoholic liver disease

artículo científico publicado en 2012

Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1.

artículo científico publicado en 2006

Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes

artículo científico publicado en 2007

Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1–JNK1 pathway in HepG2 cells ⬇️

artículo científico publicado el 22 de abril de 2011

Development and properties of HepG2 cells that constitutively express CYP2E1.

artículo científico publicado en 2008

Diallyl sulfide induces heme oxygenase-1 through MAPK pathway

artículo científico publicado en 2004

Editorial: New Insights into Mechanisms of Alcohol-Induced Fatty Liver

artículo científico publicado en 2017

Ethanol induction of CYP2A5: permissive role for CYP2E1

artículo científico publicado en 2010

Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway

artículo científico publicado en 2012

Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway

artículo científico publicado en 2007

Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells

artículo científico publicado en 2006

Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-kappaB DNA binding activity

artículo científico publicado en 2004

Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity.

artículo científico publicado en 2004

HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells

artículo científico publicado en 2014

Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity

artículo científico publicado en 2004

Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

artículo científico publicado en 2010

Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2−/− but not in c-Jun N-terminal kinase 1 −/− mice ⬇️

artículo científico publicado el 1 de noviembre de 2011

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.

artículo científico

Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1

artículo científico publicado en 2003

Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway

artículo científico publicado en 2003

Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice

artículo científico

Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice

artículo científico publicado en 2005

Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine

artículo científico publicado en 2005

Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice

artículo científico publicado en 2008

Iron and CYP2E1-dependent oxidative stress and toxicity

artículo científico publicado en 2003

Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production

artículo científico publicado en 2004

Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole

artículo científico publicado en 2005

Mechanisms of hepatotoxicity

artículo científico publicado en 2002

Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450.

artículo científico publicado en 2006

Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity

artículo científico publicado en 2003

Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction

artículo científico publicado en 2014

Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications

artículo científico publicado en 2014

Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration

artículo científico publicado en 2014

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5

scientific article published on 15 September 2018

Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver ⬇️

artículo científico publicado el 31 de mayo de 2013

Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity

artículo científico publicado en 2006

Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity ⬇️

artículo científico publicado el 1 de enero de 2013

Nrf2 and antioxidant defense against CYP2E1 toxicity

artículo científico publicado en 2009

Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.

artículo científico publicado en 2006

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione

artículo científico publicado en 2005

Oxidative stress and alcoholic liver disease

scientific article published on 22 April 2009

Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.

artículo científico publicado en 2005

Oxidative stress, toxicology, and pharmacology of CYP2E1.

artículo científico publicado en 2004

Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells

artículo científico publicado en 2003

Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.

artículo científico publicado en 2004

Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency

artículo científico publicado en 2008

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability ⬇️

artículo científico publicado el 9 de mayo de 2013

Role of CYP2E1 in Ethanol-Induced Oxidant Stress, Fatty Liver and Hepatotoxicity ⬇️

artículo científico publicado el 1 de enero de 2010

Role of Calcium and Calcium-activated Proteases in CYP2E1-dependent Toxicity in HEPG2 Cells ⬇️

artículo científico publicado el 31 de octubre de 2001

Role of apoptosis in alcoholic liver injury

artículo científico publicado en 2003

Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity

artículo científico publicado en 2005

Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1.

artículo científico publicado en 2006

Role of oxidative stress in alcohol-induced liver injury

artículo científico publicado en 2009

Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity

artículo científico publicado en 2002

Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity

artículo científico publicado en 2006

Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells

artículo científico publicado en 2003

Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells

scientific journal article

S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury

artículo científico

S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice

artículo científico publicado en 2008

S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter

artículo científico publicado en 2005

Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species ⬇️

artículo científico publicado el 1 de enero de 2002

Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells

artículo científico publicado en 2007

The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells

artículo científico publicado en 2005

The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity

artículo científico publicado en 2004

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference

artículo científico publicado en 2015

Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria ⬇️

artículo científico publicado el 1 de enero de 2002

Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity

artículo científico publicado en 2006

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells.

artículo científico publicado en 2017

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

artículo científico publicado en 2005

Lista de obras de

A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice

Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways

Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity

Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species

Alcohol and oxidative liver injury

Alcohol metabolism

Alcohol, oxidative stress, and free radical damage

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis

Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity

Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity

Binge ethanol exposure increases liver injury in obese rats

CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model

CYP2E1 and oxidative liver injury by alcohol

CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells

CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment

CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury.

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury

Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1.

Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53.

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice ⬇️

Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase

Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.

Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels

Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria

Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells

Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells ⬇️

Cytochrome P450s And Alcoholic Liver Disease

Cytokines in alcoholic liver disease

Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1.

Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes

Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1–JNK1 pathway in HepG2 cells ⬇️

Development and properties of HepG2 cells that constitutively express CYP2E1.

Diallyl sulfide induces heme oxygenase-1 through MAPK pathway

Editorial: New Insights into Mechanisms of Alcohol-Induced Fatty Liver

Ethanol induction of CYP2A5: permissive role for CYP2E1

Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway

Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway

Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells

Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-kappaB DNA binding activity

Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity.

HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells

Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity

Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2−/− but not in c-Jun N-terminal kinase 1 −/− mice ⬇️

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.

Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1

Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway

Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice

Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice

Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine

Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice

Iron and CYP2E1-dependent oxidative stress and toxicity

Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production

Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole

Mechanisms of hepatotoxicity

Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450.

Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity

Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction

Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications

Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5

Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver ⬇️

Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity

Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity ⬇️

Nrf2 and antioxidant defense against CYP2E1 toxicity

Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione

Oxidative stress and alcoholic liver disease

Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.

Oxidative stress, toxicology, and pharmacology of CYP2E1.

Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells

Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.

Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency