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A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

artículo científico publicado en 2017

Biased modulators of NMDA receptors control channel opening and ion selectivity

scientific article published on 20 January 2020

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects

artículo científico publicado en 2015

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor

artículo científico publicado en 2019

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

artículo científico publicado en 2016

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors

artículo científico publicado en 2020

Negative allosteric modulation of GluN1/GluN3 NMDA receptors

scientific article published on 07 May 2020

Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer

artículo científico publicado en 2011

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

artículo científico publicado en 2003

Sphingolipid analogues inhibit development of malaria parasites

artículo científico publicado en 2011

The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor

artículo científico publicado en 2020

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

artículo científico publicado en 2017

The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor.

artículo científico publicado en 2017