Lista de obras -

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

artículo científico publicado en 2013

Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

artículo científico publicado en 2017

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

artículo científico publicado en 2010

Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi

artículo científico publicado en 2006

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

artículo científico publicado en 2002

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

artículo científico publicado en 2005

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

artículo científico publicado en 2003

Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation ⬇️

artículo científico publicado el 1 de enero de 2011

Cyclic nucleotide analogs as probes of signaling pathways.

artículo científico publicado en 2008

Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation

artículo científico publicado en 2002

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

artículo científico publicado en 2006

Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.

artículo científico publicado en 2007

Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX ouse model of Duchenne muscular dystrophy.

artículo científico publicado en 2013

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

artículo científico publicado en 2007

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

artículo científico publicado en 2004

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

artículo científico publicado en 2009

Enzyme Assays for cGMP Hydrolyzing Phosphodiesterases ⬇️

artículo científico publicado el 1 de enero de 2013

Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy ⬇️

artículo científico publicado el 1 de enero de 2011

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

artículo científico publicado en 2002

Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.

artículo científico publicado en 2006

Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm

artículo científico publicado en 2005

Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.

artículo científico publicado en 2003

Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors ⬇️

artículo científico publicado el 30 de agosto de 2011

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

artículo científico publicado en 2020

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

artículo científico publicado en 2016

Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.

artículo científico publicado en 2006

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

artículo científico publicado en 2004

Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?

artículo científico publicado en 2011

PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte

artículo científico publicado en 2006

PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue ⬇️

artículo científico publicado el 14 de marzo de 2013

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

scientific journal article

Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

artículo científico publicado en 2010

Phosphodiesterase type 5: expanding roles in cardiovascular regulation

artículo científico publicado en 2007

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

scientific journal article

Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals

artículo científico publicado en 1998

Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases ⬇️

artículo científico publicado el 1 de enero de 2011

Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

artículo científico publicado en 2001

Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes

artículo científico publicado en 2010

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

artículo científico publicado en 2009

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.

artículo científico publicado en 2014

Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.

artículo científico publicado en 2007

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.

artículo científico publicado en 2016

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

artículo científico publicado en 2005

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

artículo científico publicado en 2010

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

artículo científico publicado en 2008

Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

artículo científico publicado en 2004

Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

artículo científico publicado en 2015

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland ⬇️

artículo científico publicado el 27 de diciembre de 2010

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

artículo científico publicado en 2008

The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites

artículo científico publicado en 2005

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis ⬇️

artículo científico publicado el 29 de septiembre de 2011

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

artículo científico publicado en 2002

Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain

artículo científico publicado en 2004

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.

artículo científico publicado en 2014

cAMP-Specific Phosphodiesterases 8A and 8B, Essential Regulators of Leydig Cell Steroidogenesis ⬇️

artículo científico publicado el 9 de enero de 2012

Lista de obras de

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation ⬇️

Cyclic nucleotide analogs as probes of signaling pathways.

Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.

Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX ouse model of Duchenne muscular dystrophy.

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

Enzyme Assays for cGMP Hydrolyzing Phosphodiesterases ⬇️

Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy ⬇️

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.

Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm

Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.

Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors ⬇️

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?

PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte

PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue ⬇️

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

Phosphodiesterase type 5: expanding roles in cardiovascular regulation

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals

Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases ⬇️

Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.

Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland ⬇️

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis ⬇️

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.

cAMP-Specific Phosphodiesterases 8A and 8B, Essential Regulators of Leydig Cell Steroidogenesis ⬇️