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A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

scientific article published on 01 July 2019

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

artículo científico publicado en 2016

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

artículo científico publicado en 2011

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

artículo científico publicado en 2009

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

artículo científico publicado en 2009

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

artículo científico publicado en 2010

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

artículo científico publicado en 2009

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

scientific article published on 26 August 2016

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

artículo científico publicado en 2011

Global chromatin compaction limits the strength of the DNA damage response

artículo científico publicado en 2007

INK4a/ARF limits the expansion of cells suffering from replication stress

artículo científico publicado en 2013

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

artículo científico publicado en 2015

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

artículo científico publicado en 2009

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

artículo científico publicado en 2015

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

scientific article published on 02 November 2004

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

artículo científico publicado en 2011

POLD3 Is Haploinsufficient for DNA Replication in Mice.

artículo científico publicado en 2016

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs

artículo científico publicado en 2011

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

artículo científico publicado en 2016

USP7 is a SUMO deubiquitinase essential for DNA replication

artículo científico publicado en 2016

Why cells respond differently to DNA damage: a chromatin perspective

scientific article published on 18 January 2008

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