Lista de obras -

A rapid pro-hemostatic approach to overcome direct oral anticoagulants

artículo científico publicado en 2016

Active site-independent recognition of substrates and product by bovine prothrombinase: a fluorescence resonance energy transfer study

artículo científico publicado en 2004

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

artículo científico publicado en 2011

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

artículo científico publicado en 2018

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

artículo científico publicado en 2009

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT ⬇️

artículo científico publicado el 19 de julio de 2011

Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin

artículo científico publicado en 2004

Clotting in whole blood: analysis of a biochemical reaction network

scientific article published on 01 July 2002

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

artículo científico publicado en 1988

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

artículo científico publicado en 2018

Computational Investigations on the Effects of Gurney Flap on Airfoil Aerodynamics

artículo científico publicado en 2015

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis

artículo científico publicado en 2013

Effect of Reynolds Number on Aerodynamics of Airfoil with Gurney Flap

scholarly article by Shubham Jain et al published 2015 in International Journal of Rotating Machinery

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex

artículo científico publicado en 2020

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

artículo científico publicado en 2002

FVIII-VWF dos-à-dos

artículo científico publicado en 2015

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

artículo científico publicado en 2008

Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase

artículo científico publicado en 2008

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

artículo científico publicado en 2020

Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.

artículo científico publicado en 2004

Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

artículo científico publicado en 2022

Imaging coagulation reactions in vivo ⬇️

artículo científico publicado el 8 de marzo de 2012

Killing 2 proteinases with 1 (dual-acting) stone ⬇️

artículo científico publicado el 8 de marzo de 2012

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states

artículo científico publicado en 2010

Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin ⬇️

artículo científico publicado el 19 de julio de 2012

Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage ⬇️

artículo científico publicado el 12 de agosto de 2013

Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation

artículo científico publicado en 2013

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

artículo científico publicado en 2005

Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase

artículo científico publicado en 2002

New insights into the spatiotemporal localization of prothrombinase in vivo

artículo científico publicado en 2014

Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V

scientific article published on 21 December 2018

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

artículo científico publicado en 2017

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

artículo científico publicado en 2005

Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate

artículo científico publicado en 2009

Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides

artículo científico publicado en 2013

Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

artículo científico publicado en 2007

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex

artículo científico publicado en 2017

Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium ⬇️

artículo científico publicado el 20 de febrero de 2013

Supercharged blood coagulation

artículo científico publicado en 2009

The Contribution of Factor Xa to Exosite-dependent Substrate Recognition by Prothrombinase ⬇️

artículo científico publicado el 8 de enero de 2002

The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase

artículo científico publicado en 2016

The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions

artículo científico publicado en 2005

Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator

artículo científico publicado en 2002

Lista de obras de

A rapid pro-hemostatic approach to overcome direct oral anticoagulants

Active site-independent recognition of substrates and product by bovine prothrombinase: a fluorescence resonance energy transfer study

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT ⬇️

Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin

Clotting in whole blood: analysis of a biochemical reaction network

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Computational Investigations on the Effects of Gurney Flap on Airfoil Aerodynamics

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis

Effect of Reynolds Number on Aerodynamics of Airfoil with Gurney Flap

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

FVIII-VWF dos-à-dos

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.

Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Imaging coagulation reactions in vivo ⬇️

Killing 2 proteinases with 1 (dual-acting) stone ⬇️

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states

Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin ⬇️

Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage ⬇️

Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase

New insights into the spatiotemporal localization of prothrombinase in vivo

Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate

Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides

Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex

Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium ⬇️

Supercharged blood coagulation

The Contribution of Factor Xa to Exosite-dependent Substrate Recognition by Prothrombinase ⬇️

The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase

The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions

Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator