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A 100-year Nordic perspective on the dose-time problem in radiobiology

artículo científico publicado en 1995

A New Method for Computer Generation of Dose Distributions from External X- and Gamma-Ray Sources ⬇️

artículo científico publicado el 1 de enero de 1973

A Parametric Method for Estimation of Dose-Modifying Factors: Low-Dose Extrapolation Limit

artículo científico publicado el 1 de enero de 1977

A Test for Dose-Modifying Factors

artículo científico publicado el 1 de noviembre de 1978

A biochemical definition of cure after brachytherapy for prostate cancer

scientific article published on 27 April 2020

A dose-surviving fraction curve for mouse colonic mucosa

artículo científico publicado en 1983

A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer

artículo científico publicado en 2014

A morphometric analysis of glomerular and tubular alterations following fast-neutron irradiation of the pig and monkey kidney ⬇️

artículo científico publicado el 15 de julio de 1998

A new isoeffect curve for change in dose per fraction

scientific article published on 01 November 1983

Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis

artículo científico publicado en 2015

Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategies

artículo científico publicado en 1988

Accelerated fractionation vs hyperfractionation: rationales for several treatments per day.

artículo científico publicado en 1983

Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma: downregulation of apoptosis as a possible mechanism

scientific article published on 01 July 1996

An improved computer model for 60cobalt dose distributions

artículo científico publicado el 1 de septiembre de 1977

Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysis

artículo científico publicado en 2006

Biological bases for high RBE values for late effects of neutron irradiation

scientific article published on 01 December 1982

Breast conservation after neoadjuvant chemotherapy

scientific article published on 01 February 2005

Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience

artículo científico publicado en 2004

Cancer stem cells and radiotherapy.

artículo científico publicado en 2009

Changes in TCD50 as a measure of clonogen doubling time in irradiated and unirradiated tumors

artículo científico publicado en 1991

Changes in clonogen number and radiation sensitivity in mouse jejunal crypts after treatment with dimethylsulfoxide and retinoic acid

artículo científico publicado en 1996

Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships

scientific article published on 01 February 1982

Changes in the radiation sensitivity of mouse skin during fractionated and prolonged treatments

artículo científico publicado en 1994

Chemoresistance is not a cause of the apparent failure of adjuvant chemotherapy in postmenopausal women.

artículo científico publicado en 1988

Clinical evidence for tumor clonogen regeneration: interpretations of the data.

artículo científico publicado en 1991

Clinical radiobiology of malignant melanoma

article

Clinical radiobiology of squamous cell carcinoma of the oropharynx

artículo científico publicado en 1991

Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients

artículo científico publicado en 2004

Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study

artículo científico publicado en 2006

Cluster models of dose–volume effects

artículo científico publicado en 2004

Combined modality in advanced Hodgkin's disease

artículo científico publicado en 1998

Comparing cell survival estimated from in vivo and in vitro data: beware in vivo heterogeneity

scientific article published on 01 July 1994

Comparison of alternative biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external beam radiotherapy between 1986 and 1995.

artículo científico publicado en 2003

Comparison of continuous and pulsed low dose rate brachytherapy: biological equivalence in vivo

artículo científico publicado en 1994

Comparison of mathematical models for radiation fractionation.

artículo científico publicado en 1976

Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy

artículo científico publicado en 2004

Computational Modeling of Micrometastatic Breast Cancer Radiation Dose Response

artículo científico publicado en 2016

Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.

artículo científico publicado en 2009

Corrigendum to “HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Rad

article

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

artículo científico publicado en 2005

Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference

artículo científico publicado en 2006

Defining recurrence after radiation for prostate cancer

artículo científico publicado en 2005

Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: a multi-institutional pooled analysis

artículo científico publicado en 2005

Definitive radiotherapy for squamous cell carcinoma of the tonsillar fossa

scientific article published on 01 March 1989

Dependence of stability on inter-enzyme distance in cooperative systems ⬇️

artículo científico publicado el 21 de septiembre de 1973

Direct Estimation of Latent Time for Radiation Injury in Late-responding Normal Tissues: Gut, Lung, and Spinal Cord

artículo científico publicado en 1989

Direct analysis of quantal radiation response data

artículo científico publicado en 1986

Direct evidence that prostate tumors show high sensitivity to fractionation (low α/β ratio), similar to late-responding normal tissue ⬇️

artículo científico publicado el 1 de enero de 2002

Diurnal Variations in the Expression of Radiation-Induced Apoptosis

artículo científico publicado el 1 de abril de 1998

Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

artículo científico publicado en 2011

Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy?

artículo científico publicado en 2016

Does Variation in thein VitroCellular Radiosensitivity Explain the Shallow Clinical Dose—control Curve for Malignant Melanoma?

artículo científico publicado en 1990

Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?

artículo científico publicado en 2005

Does incomplete repair explain the apparent failure of the basic LQ model to predict spinal cord and kidney responses to low doses per fraction?

artículo científico publicado en 1988

Dose response of squamous cell carcinomas of the upper respiratory and digestive tracts

artículo científico publicado en 1980

Dose-response relationship for supraglottic laryngeal carcinoma

scientific article published on 01 March 1983

Dose-response relationships for late radiation effects in the head and neck: Regarding the analysis of the RTOG 8313 trial, fu et al IJROBP 32:577–588; 1995

article

Dose-survival characteristics of mouse jejunal crypt cells ⬇️

artículo científico publicado el 1 de noviembre de 1981

Dose-volume conundrum for response of prostate cancer to brachytherapy: summary dosimetric measures and their relationship to tumor control probability

artículo científico publicado en 2004

Dose-volume response analyses of late rectal bleeding after radiotherapy for prostate cancer

artículo científico publicado en 2004

Dr. H. Rodney Withers (1932 - 2015).

artículo científico publicado en 2015

Early and Late Normal-tissue Injury after Postmastectomy Radiotherapy Alone or Combined with Chemotherapy

artículo científico publicado en 1989

Early and late injuries in mouse rectum after fractionated X-ray and neutron irradiation

scientific article published on 01 March 1993

Early fractionation methods and the origins of the NSD concept

artículo científico publicado en 1988

Effect of [(18)F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice

artículo científico publicado en 2014

Effect of continuous infusion of bleomycin on the time for completion of repair of sublethal radiation damage in mouse lip mucosa during fractionated irradiation

artículo científico publicado en 1988

Effect of dose per fraction on the division potential of lethally irradiated plateau-phase CHO cells exposed to isoeffective fractionation regimens

artículo científico publicado en 1986

Effect of dose-rate on total body irradiation: lethality and pathologic findings

artículo científico publicado en 1985

Effect of latency on calculated complication rates

scientific article published on 01 October 1986

Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

artículo científico publicado en 2005

Estimation of α/β for Late Rectal Toxicity Based on RTOG 94-06 ⬇️

artículo científico publicado el 4 de marzo de 2011

Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity.

artículo científico publicado en 2017

Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts.

artículo científico publicado en 2011

Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fields

artículo científico publicado en 2004

Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all?

artículo científico publicado en 2005

Final Report of Radiation Therapy Oncology Group Protocol 9003: Provocative, but Limited Conclusions From Exploratory Analyses.

artículo científico publicado en 2015

First scatter to off-axis points and the Clarkson method

artículo científico publicado en 1973

Flexure dose: the low-dose limit of effective fractionation

artículo científico publicado en 1983

Fractionation effect on radiation-induced growth retardation of tibia in rabbits and rats

artículo científico publicado en 1998

Fractionation parameters for human tissues and tumors

artículo científico publicado en 1989

Fractionation sensitivity and latency of telangiectasia after postmastectomy radiotherapy: a graded-response analysis

artículo científico publicado en 1990

Fractionation sensitivity of a functional endpoint: impaired shoulder movement after post-mastectomy radiotherapy

article

GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: subgroup analysis of the prospective randomized CHARTWEL trial

artículo científico publicado en 2013

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Rad

artículo científico publicado en 2016

HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology G

artículo científico publicado en 2014

Heterogeneity in hyperthermic sensitivities of rat 13762NF mammary adenocarcinoma cell clones of differing metastatic potentials

scientific article published on 01 September 1982

How well is the probability of tumor cure after fractionated irradiation described by Poisson statistics?

artículo científico publicado en 1990

Hyperfractionation

scientific article published on 01 October 1982

Immunohistochemically detected p53 mutations in epithelial tumors and results of treatment with chemotherapy and radiotherapy. A treatment-specific overview of the clinical data.

artículo científico publicado en 2002

Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice

artículo científico publicado en 2005

Impact of increased cell loss on the repopulation rate during fractionated irradiation in human FaDu squamous cell carcinoma growing in nude mice

artículo científico publicado en 2003

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours.

artículo científico publicado en 2016

Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995

scientific article published on 01 February 2005

In memoriam: H. Rodney Withers (21 September 1932-25 February 2015).

artículo científico publicado en 2015

In regard to Solomon et al.: EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. IJROBP 2003;55:713-723

artículo científico publicado en 2003

Incidence and latency of radiation reactions

artículo científico publicado en 1989

Increasing external beam dose for T1-T2 prostate cancer: effect on risk groups

artículo científico publicado en 2006

Induction of transforming growth factor alpha in irradiated mouse jejunum

artículo científico publicado en 1998

Influence of technologic advances on outcomes in patients with unresectable, locally advanced non-small-cell lung cancer receiving concomitant chemoradiotherapy

artículo científico publicado en 2009

Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer

artículo científico publicado en 2007

Is the rate of repair of radiation-induced sublethal damage in rat spinal cord dependent on the size of dose per fraction?

artículo científico publicado en 1987

Late radiation response of kidney assayed by tubule-cell survival

artículo científico publicado en 1986

Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model

artículo científico publicado en 2010

Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single-follow-up clinical study

artículo científico publicado en 1989

Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era.

artículo científico publicado en 2003

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

artículo científico publicado en 2016

Machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer brachytherapy

artículo científico publicado en 2020

Metaanalyse klinischer Studien zur alleinigen Chemotherapie im Vergleich zur Kombination aus Chemotherapie plus Strahlentherapie bei der Behandlung des Morbus Hodgkin

Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib ⬇️

artículo científico publicado el 5 de junio de 2012

Multifraction radiation response of mouse lung

artículo científico publicado en 1985

New anticancer agents: in vitro and in vivo evaluation.

artículo científico publicado en 2005

New options in direct analysis of dose-response data

artículo científico publicado en 1990

Optimal design of multifraction assays of colony survival in vivo.

artículo científico publicado en 1983

Overall treatment time and tumor control dose for head and neck tumors: The dog leg revisited

artículo científico publicado en 1992

PSA after radiation for prostate cancer

artículo científico publicado en 2004

PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis

artículo científico publicado en 2005

Pathologic tumor size and lymph node status predict for different rates of locoregional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapy

artículo científico publicado en 2002

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

artículo científico publicado en 2006

Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

scientific article published on 22 May 2007

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy.

artículo científico publicado en 2006

Predicting radiosensitivity using DNA end-binding complex analysis

artículo científico publicado en 2004

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining

artículo científico publicado en 2009

Prognostic value of HIF-1α expression during fractionated irradiation.

artículo científico publicado en 2012

Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control

artículo científico publicado en 2011

Proliferation kinetics of a murine fibrosarcoma during fractionated irradiation

scientific article published on 01 November 1988

Protection of acute and late radiation damage of the gastrointestinal tract by WR-2721

artículo científico publicado en 1986

Protection of mouse jejunal crypt cells by WR-2721 after small doses of radiation

artículo científico publicado en 1986

Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice ⬇️

artículo científico publicado el 1 de mayo de 1982

Radiation dose-fractionation and dose-rate relationships for long-term repopulating hemopoietic stem cells in a murine bone marrow transplant model

artículo científico publicado en 1993

Radiation for prostate cancer: use of biochemical failure as an endpoint following radiotherapy

artículo científico publicado en 2003

Radiation nephropathy in the rhesus monkey: morphometric analysis of glomerular and tubular alterations

artículo científico publicado en 1995

Radiation response of the monkey kidney following contralateral nephrectomy

artículo científico publicado en 1994

Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.

artículo científico publicado en 2010

Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II-III non-small cell lung cancer: preliminary results

artículo científico publicado en 2002

Recovery from radiation damage in mouse lung: interpretation in terms of two rates of repair

artículo científico publicado en 1993

Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

artículo científico publicado en 2005

Repair capacity and kinetics for human mucosa and epithelial tumors in the head and neck: clinical data on the effect of changing the time interval between multiple fractions per day in radiotherapy.

artículo científico publicado en 1996

Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up

scientific article published on 01 June 1989

Repair factors for multifraction irradiations

artículo científico publicado en 1984

Repair in mouse lung between multiple small doses of X rays

scientific article published on 01 May 1983

Repair rate in mouse lung after clinically relevant radiation doses per fraction

scientific article published on 01 January 1995

Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation.

artículo científico publicado en 2001

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

artículo científico publicado en 2011

Residual γH2AX foci predict local tumour control after radiotherapy.

artículo científico publicado en 2013

Response of fibrosarcoma cell subpopulations to small doses of radiation delivered in situ

artículo científico publicado en 1983

Response of plateau-phase C3H 10T1/2 cells to radiation and concurrent administration of bleomycin

artículo científico publicado en 1989

Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma

artículo científico publicado en 2003

Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy

artículo científico publicado en 2018

Rod Withers' Data are Available Online

scientific article published on 01 February 2017

Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment

scientific article published on 01 January 1997

State vector models of the cell cycle II: The first three moments of the transit time distribution ⬇️

artículo científico publicado el 7 de marzo de 1979

State vector models of the cell cycle III: Continuous time cell cycle models ⬇️

artículo científico publicado el 21 de noviembre de 1979

State-vector models of the cell cycle. 1. Parametrization and fits to labeled mitoses data

artículo científico publicado el 22 de agosto de 1977

Survival of mouse testicular stem cells after gamma of neutron irradiation

artículo científico publicado en 1980

Syngeneic and allogeneic bone marrow engraftment after total body irradiation: dependence on dose, dose rate, and fractionation

artículo científico publicado en 1991

Test of equal effect per fraction and estimation of initial clonogen number in microcolony assays of survival after fractionated irradiation

artículo científico publicado en 1980

The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems. ⬇️

artículo científico publicado en 2016

The Withers Archive: Online Availability of H. Rodney Withers' Data

artículo científico publicado en 2016

The Withers archive: Online availability of rod Wither's data

artículo científico publicado en 2016

The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer

artículo científico publicado en 2003

The effect of patient-to-patient variability on the accuracy of predictive assays of tumor response to radiotherapy: a theoretical evaluation

artículo científico publicado en 1989

The effect of proliferative status and clonogen content on the response of mouse jejunal crypts to split-dose irradiation

scientific article published on 01 February 1997

The high steepness of dose-response curves for late-responding normal tissues

artículo científico publicado en 1989

The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is "young"?

artículo científico publicado en 2006

The kinetics of repair in mouse lung after fractionated irradiation

artículo científico publicado en 1987

The origins of translational radiation oncology - In memoriam H. Rodney Withers (21 September 1932-25 February 2015).

artículo científico publicado en 2015

The proliferative response of mouse jejunal crypt cells to radiation-induced cell depletion is not mediated exclusively by transforming growth factor alpha

scientific article published on 01 June 2001

The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: an analysis of prospective data from British

artículo científico publicado en 2007

The response of Chinese hamster ovary cells to fast neutron radiotherapy beams. III. Variation in biological effectiveness with position in the cell cycle

artículo científico publicado el 1 de noviembre de 1978

The role of overall treatment time in the outcome of radiotherapy of prostate cancer: an analysis of biochemical failure in 4839 men treated between 1987 and 1995.

artículo científico publicado en 2010

The translational research chain: is it delivering the goods?

artículo científico publicado en 2001

Time factor for tonsillar carcinoma

scientific article published on 01 October 1995

Time-dose considerations for normal-tissue tolerance

artículo científico publicado en 1989

Time-dose factors in radiotherapy: a review of the human data.

artículo científico publicado en 1990

Tissue repair capacity and repair kinetics deduced from multifractionated or continuous irradiation regimens with incomplete repair.

artículo científico publicado en 1984

Tumor radioresistance in clinical radiotherapy

artículo científico publicado en 1982

Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range

artículo científico publicado en 1984

Tumor volume and local control probability: clinical data and radiobiological interpretations

artículo científico publicado en 1996

Twice-daily fractionation schemes for advanced head and neck cancer

artículo científico publicado en 1984

Use of the LQ model with large fraction sizes results in underestimation of isoeffect doses

scientific article published on 20 September 2013

Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation

artículo científico publicado en 1995

Will identifying or targeting altered marker expression in response to cytotoxic therapy be of prognostic or therapeutic value?

artículo científico publicado en 2003

Year of treatment as independent predictor of relapse-free survival in patients with localized prostate cancer treated with definitive radiotherapy in the PSA era

artículo científico publicado en 2005

γH2AX assay in ex vivo irradiated tumour specimens: A novel method to determine tumour radiation sensitivity in patient-derived material.

artículo científico publicado en 2015

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