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902. A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of a Single Immunization of Ad26.RSV.preF against RSV Infection in a Viral Challenge Model in Healthy Adults

Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

artículo científico publicado en 2016

Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin

artículo científico publicado en 2005

Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent

scientific article published on 01 January 2008

Correction: Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

artículo científico publicado en 2016

Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome

artículo científico publicado en 2005

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

artículo científico publicado en 2007

Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge

scientific article (publication date: 2014)

LB6. EDP-938, a Novel RSV N-Inhibitor, Administered Once or Twice Daily Was Safe and Demonstrated Robust Antiviral and Clinical Efficacy in a Healthy Volunteer Challenge Study

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways

artículo científico publicado en 2006

Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study

scientific article published on 05 January 2021

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

artículo científico publicado en 2009

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

artículo científico publicado en 2022

T cell-derived TNF down-regulates acute airway response to endotoxin

artículo científico publicado en 2007

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

artículo científico publicado en 2018

The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process

article published in 2018

Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury

scientific journal article

Use of qualitative integrative cycler PCR (qicPCR) to identify optimal therapeutic dosing time-points in a Respiratory Syncytial Virus Human Viral Challenge Model (hVCM).

artículo científico publicado en 2015