Lista de obras -

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

artículo científico publicado en 2018

Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase

artículo científico publicado en 2002

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

artículo científico publicado en 2007

Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design

artículo científico publicado en 2010

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.

artículo científico publicado en 2016

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

artículo científico publicado en 2013

Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase ⬇️

artículo científico publicado el 22 de diciembre de 2011

Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation

artículo científico publicado en 2007

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

artículo científico publicado en 2012

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

scientific journal article

Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases

artículo científico publicado en 2006

Crystal structure of the PdxY Protein from Escherichia coli.

artículo científico publicado en 2004

Crystal structures of influenza A virus matrix protein M1: variations on a theme

artículo científico publicado en 2014

Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons

artículo científico publicado en 2005

Crystallization and preliminary X-ray diffraction analysis of KsgA, a universally conserved RNA adenine dimethyltransferase in Escherichia coli

artículo científico publicado en 2003

Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin ⬇️

artículo científico publicado el 6 de septiembre de 2011

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

artículo científico publicado en 2011

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

artículo científico publicado en 2011

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

artículo científico publicado en 2017

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

artículo científico publicado en 2020

Identification of novel allosteric regulators of human-erythrocyte pyruvate kinase

artículo científico publicado en 2007

Inactive mutants of human pyridoxine 5'-phosphate oxidase: a possible role for a noncatalytic pyridoxal 5'-phosphate tight binding site

artículo científico publicado en 2016

Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase

artículo científico publicado en 2009

Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel ⬇️

artículo científico publicado el 25 de octubre de 2012

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.

artículo científico publicado en 2017

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

artículo científico publicado en 2009

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

artículo científico publicado en 2015

Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR

artículo científico publicado en 2019

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

artículo científico publicado en 2008

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

artículo científico publicado en 2018

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

artículo científico publicado en 2018

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

artículo científico publicado en 2008

Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism

artículo científico publicado en 2004

Structural Insights into the Assembly of the Adeno-associated Virus Type 2 Rep68 Protein on the Integration Site AAVS1

artículo científico publicado en 2015

Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation

artículo científico publicado en 2015

Structural and Functional Divergence within the Dim1/KsgA Family of rRNA Methyltransferases

artículo científico publicado en 2009

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

artículo científico publicado en 2004

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae)

scientific article published on 09 March 2020

Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase

artículo científico publicado en 2003

Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase

artículo científico publicado en 2003

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme

artículo científico publicado en 2005

Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition

artículo científico publicado en 2002

Structure of relaxed-state human hemoglobin: insight into ligand uptake, transport and release

artículo científico publicado en 2008

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.

artículo científico publicado en 2006

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

artículo científico publicado en 2020

X-Ray Crystal Structure of a 2-Amino-3,4-dihydroquinazoline 5-HT3 Serotonin Receptor Antagonist and Related Analogs

artículo científico publicado en 2019

Lista de obras de

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase ⬇️

Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases

Crystal structure of the PdxY Protein from Escherichia coli.

Crystal structures of influenza A virus matrix protein M1: variations on a theme

Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons

Crystallization and preliminary X-ray diffraction analysis of KsgA, a universally conserved RNA adenine dimethyltransferase in Escherichia coli

Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin ⬇️

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Identification of novel allosteric regulators of human-erythrocyte pyruvate kinase

Inactive mutants of human pyridoxine 5'-phosphate oxidase: a possible role for a noncatalytic pyridoxal 5'-phosphate tight binding site

Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase

Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel ⬇️

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism

Structural Insights into the Assembly of the Adeno-associated Virus Type 2 Rep68 Protein on the Integration Site AAVS1

Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation

Structural and Functional Divergence within the Dim1/KsgA Family of rRNA Methyltransferases

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae)

Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase

Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme

Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition

Structure of relaxed-state human hemoglobin: insight into ligand uptake, transport and release

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

X-Ray Crystal Structure of a 2-Amino-3,4-dihydroquinazoline 5-HT3 Serotonin Receptor Antagonist and Related Analogs