Lista de obras -

A new avenue for lithium: intervention in traumatic brain injury

artículo científico publicado en 2014

Angiotensin II AT1 receptor blockade ameliorates brain inflammation

artículo científico publicado en 2010

Antidepressant mechanism of ketamine: perspective from preclinical studies

artículo científico publicado en 2015

Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience

artículo científico publicado en 2011

Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models ⬇️

artículo científico publicado el 7 de noviembre de 2011

Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke

artículo científico publicado en 2012

Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease ⬇️

artículo científico publicado el 27 de julio de 2011

Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation

artículo científico publicado en 2006

Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model

artículo científico publicado en 2015

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

artículo científico publicado en 2006

Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain

artículo científico publicado el 1 de octubre de 1992

Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia

artículo científico publicado en 2008

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

artículo científico publicado en 2011

GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder

artículo científico publicado en 2007

GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.

artículo científico publicado en 2018

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder

artículo científico publicado en 2017

Glutamate-modulating drugs as a potential therapeutic strategy in obsessive-compulsive disorder.

artículo científico publicado en 2017

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

artículo científico publicado en 2005

HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation

artículo científico publicado en 2014

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

scientific journal article

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

artículo científico publicado en 2007

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

artículo científico publicado en 2008

In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?

artículo científico publicado en 2007

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

artículo científico publicado en 2010

Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury ⬇️

artículo científico publicado el 20 de enero de 2012

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

artículo científico publicado en 2010

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

artículo científico publicado en 2002

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

artículo científico publicado en 2007

Lithium neuroprotection: molecular mechanisms and clinical implications

artículo científico publicado en 2004

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

artículo científico publicado en 2002

Lithium reduces BACE1 overexpression, β amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury

artículo científico publicado en 2012

Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils

artículo científico publicado en 2007

Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes

artículo científico publicado en 2008

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity

artículo científico publicado en 2003

Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.

artículo científico publicado en 2011

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

artículo científico publicado en 2010

Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions

artículo científico publicado en 2013

Multiple roles of HDAC inhibition in neurodegenerative conditions.

artículo científico publicado en 2009

Neuroprotective action of lithium in disorders of the central nervous system ⬇️

artículo científico publicado el 1 de junio de 2011

Neuroprotective actions of lithium

artículo científico publicado el 1 de enero de 2003

Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases?

artículo científico publicado en 2004

Neuroprotective effects of lithium in cultured cells and animal models of diseases.

artículo científico publicado en 2002

Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction ⬇️

artículo científico publicado el 8 de mayo de 2012

Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum

artículo científico publicado en 2007

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease ⬇️

artículo científico publicado el 1 de marzo de 2003

Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation

scientific article published on 18 June 2020

PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.

artículo científico publicado en 2006

Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

artículo científico publicado en 2014

Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia

artículo científico publicado en 2012

Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model ⬇️

artículo científico publicado el 5 de mayo de 2003

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury

artículo científico publicado en 2013

Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.

artículo científico publicado en 2010

Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

artículo científico publicado en 2013

Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?

artículo científico publicado en 2014

Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

artículo científico publicado en 2016

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.

artículo científico publicado en 2017

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival

artículo científico publicado en 2006

Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

artículo científico publicado en 2003

Safety and efficacy of valproic acid treatment in SCA3/MJD patients

artículo científico publicado en 2016

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

artículo científico publicado en 2005

Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition

artículo científico publicado en 2008

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

artículo científico publicado en 2009

The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials

artículo científico publicado en 2005

The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress

artículo científico publicado en 2014

The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms

scientific journal article

Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder

artículo científico publicado en 2013

Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury

scientific article published on 20 August 2019

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

artículo científico publicado en 2016

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

artículo científico publicado en 2004

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

artículo científico publicado en 2016

Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia

artículo científico publicado en 2013

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

scientific journal article

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

artículo científico publicado en 2004

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition ⬇️

artículo científico publicado el 8 de mayo de 2003

[Research strategy for understanding neuronal plasticity and degeneration]

scientific article published on 01 January 2003

miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3.

artículo científico publicado en 2014

Lista de obras de

A new avenue for lithium: intervention in traumatic brain injury

Angiotensin II AT1 receptor blockade ameliorates brain inflammation

Antidepressant mechanism of ketamine: perspective from preclinical studies

Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience

Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models ⬇️

Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke

Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease ⬇️

Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation

Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain

Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder

GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder

Glutamate-modulating drugs as a potential therapeutic strategy in obsessive-compulsive disorder.

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury ⬇️

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

Lithium neuroprotection: molecular mechanisms and clinical implications

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

Lithium reduces BACE1 overexpression, β amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury

Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils

Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity

Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions

Multiple roles of HDAC inhibition in neurodegenerative conditions.

Neuroprotective action of lithium in disorders of the central nervous system ⬇️

Neuroprotective actions of lithium

Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases?

Neuroprotective effects of lithium in cultured cells and animal models of diseases.

Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction ⬇️

Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease ⬇️

Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation

PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.

Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia

Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model ⬇️

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury

Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.

Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?

Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival

Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

Safety and efficacy of valproic acid treatment in SCA3/MJD patients

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials

The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress

The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms

Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder

Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition ⬇️

[Research strategy for understanding neuronal plasticity and degeneration]

miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3.