Lista de obras -

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine

artículo científico publicado en 2017

A gateway to study protein lysine methylation

artículo científico publicado en 2008

A novel arginine methyltransferase inhibitor with cellular activity

artículo científico publicado en 2007

A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus

artículo científico publicado en 2009

A quantitative atlas of histone modification signatures from human cancer cells

artículo científico publicado en 2013

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

artículo científico publicado en 2016

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

artículo científico publicado en 2016

Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure

artículo científico publicado en 2008

Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi

artículo científico publicado en 2002

De novo peptide design and experimental validation of histone methyltransferase inhibitors

artículo científico publicado en 2014

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

artículo científico publicado en 2007

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors

artículo científico publicado en 2016

Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2

artículo científico publicado en 2014

Discovery, design, and synthesis of indole-based EZH2 inhibitors

artículo científico publicado en 2015

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

artículo científico publicado en 2009

EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.

artículo científico publicado en 2014

Epigenetics: Disrupting histone lysine methylation

artículo científico publicado en 2015

Facultative heterochromatin: is there a distinctive molecular signature?

artículo científico publicado en 2007

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

artículo científico publicado en 2017

HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress.

artículo científico publicado en 2005

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

artículo científico publicado en 2006

Histone deacetylases in fungi: novel members, new facts

artículo científico publicado en 2003

Histone lysine demethylases and their impact on epigenetics

artículo científico publicado en 2006

Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity.

artículo científico publicado en 2004

Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

artículo científico publicado en 2009

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, S

artículo científico publicado en 2016

Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth

artículo científico publicado en 2013

Identification of potent, selective KDM5 inhibitors

artículo científico publicado en 2016

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

artículo científico publicado en 2013

L3MBTL1, a histone-methylation-dependent chromatin lock

artículo científico publicado en 2007

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

artículo científico publicado en 2011

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.

artículo científico publicado en 2016

Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.

artículo científico publicado en 2010

Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method

artículo científico publicado en 2015

Methods to identify and functionally analyze factors that specifically recognize histone lysine methylation

artículo científico publicado en 2006

Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy

article published in 2018

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

artículo científico publicado en 2016

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

artículo científico publicado en 2007

Target-based approach to inhibitors of histone arginine methyltransferases

artículo científico publicado en 2007

Targeting histone lysine methylation in cancer

artículo científico publicado en 2015

The key to development: interpreting the histone code?

artículo científico publicado en 2005

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

artículo científico publicado en 2009

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors

artículo científico publicado en 2009

Lista de obras de

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine

A gateway to study protein lysine methylation

A novel arginine methyltransferase inhibitor with cellular activity

A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus

A quantitative atlas of histone modification signatures from human cancer cells

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure

Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi

De novo peptide design and experimental validation of histone methyltransferase inhibitors

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors

Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2

Discovery, design, and synthesis of indole-based EZH2 inhibitors

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.

Epigenetics: Disrupting histone lysine methylation

Facultative heterochromatin: is there a distinctive molecular signature?

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress.

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

Histone deacetylases in fungi: novel members, new facts

Histone lysine demethylases and their impact on epigenetics

Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity.

Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, S

Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth

Identification of potent, selective KDM5 inhibitors

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

L3MBTL1, a histone-methylation-dependent chromatin lock

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.

Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.

Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method

Methods to identify and functionally analyze factors that specifically recognize histone lysine methylation

Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

Target-based approach to inhibitors of histone arginine methyltransferases

Targeting histone lysine methylation in cancer

The key to development: interpreting the histone code?

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors