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Lista de obras de Theo Wallimann

A molecular approach to the concerted action of kinases involved in energy homoeostasis

artículo científico publicado en 2003

A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance

artículo científico publicado en 2000

A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy

artículo científico publicado en 2011

A versatile multidimensional protein purification system with full internet remote control based on a standard HPLC system

artículo científico publicado en 2009

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

artículo científico publicado en 2006

Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans.

artículo científico publicado en 2003

Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply

artículo científico publicado en 2005

Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase

artículo científico publicado el 1 de abril de 1991

Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin

artículo científico publicado en 2006

Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency.

artículo científico publicado en 2008

An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli

artículo científico publicado en 2008

An increase in the myocardial PCr/ATP ratio in GLUT4 null mice

artículo científico publicado en 2002

Autophosphorylation of creatine kinase: characterization and identification of a specifically phosphorylated peptide

artículo científico publicado el 6 de septiembre de 1995

Bioenergetics: Dissecting the role of creatine kinase

artículo científico publicado en 1994

Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid.

artículo científico publicado en 1998

Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase

artículo científico publicado en 2006

C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase

artículo científico publicado en 2004

Calcium and energy transfer

artículo científico publicado en 2005

Cardiac system bioenergetics: metabolic basis of the Frank-Starling law.

artículo científico publicado en 2006

Cardiolipin Clusters and Membrane Domain Formation Induced by Mitochondrial Proteins

scientific article published on 13 October 2006

Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

artículo científico publicado en 2007

Comment on “toxic hepatitis in a group of 20 male body-builders taking dietary supplements” by Timcheh-Hariri et al. (2012)

article

Coupling of creatine kinase to glycolytic enzymes at the sarcomeric I-band of skeletal muscle: a biochemical study in situ

artículo científico publicado en 2000

Creatine and creatine kinase in health and disease--a bright future ahead?

artículo científico publicado en 2007

Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures.

artículo científico publicado en 2005

Creatine kinase and creatine transporter in normal, wounded, and diseased skin

artículo científico publicado en 2002

Creatine kinases: a cornerstone for structural research in the phosphagen kinase family.

artículo científico publicado en 2010

Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures.

artículo científico publicado en 2006

Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system

artículo científico publicado en 2005

Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

artículo científico publicado en 1998

Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle.

artículo científico publicado en 1998

Creatine supplementation reduces skeletal muscle degeneration and enhances mitochondrial function in mdx mice

artículo científico publicado en 2002

Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.

artículo científico publicado en 2005

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine

artículo científico publicado en 2003

Creatine transporters: a reappraisal.

artículo científico publicado en 2004

Creatine treatment promotes differentiation of GABA-ergic neuronal precursors in cultured fetal rat spinal cord.

artículo científico publicado en 2007

Creatine: a miserable life without it.

artículo científico publicado en 2016

Crystallization of Mitochondrial Creatine Kinase on Negatively Charged Lipid Layers

scientific article published on 01 March 1994

Crystallization of the Human, Mitochondrial Voltage-Dependent Anion-Selective Channel in the Presence of Phospholipids

artículo científico publicado en 1999

Development and performance of an enzyme immunoassay to detect creatine kinase isoenzyme MB activity using anti-mitochondrial creatine kinase monoclonal antibodies

artículo científico publicado en 2009

Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse

artículo científico publicado en 2009

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

artículo científico publicado en 2008

Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues

artículo científico publicado en 2003

Differentiation in cultures derived from embryonic chicken muscle. II. Phosphorylase histochemistry and fluorescent antibody staining for creatin kinase and aldolase

artículo científico publicado el 1 de febrero de 1976

Dimer-dimer interactions in octameric mitochondrial creatine kinase

artículo científico publicado en 1995

Direct Evidence for the Control of Mitochondrial Respiration by Mitochondrial Creatine Kinase in Oxidative Muscle Cellsin Situ

artículo científico publicado en 2000

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

artículo científico publicado en 2006

Divergent Enzyme Kinetics and Structural Properties of the Two Human Mitochondrial Creatine Kinase Isoenzymes

artículo científico publicado en 2000

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

artículo científico publicado en 2005

Effects of N-linked glycosylation on the creatine transporter.

artículo científico publicado en 2006

Effects of creatine supplementation in cystic fibrosis: results of a pilot study.

artículo científico publicado en 2003

Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue.

artículo científico publicado en 2005

Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells

artículo científico publicado en 2008

European research needs a dash of anarchy

scientific article published in Nature

Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plants

artículo científico publicado en 2002

Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation

scientific journal article

Functional aspects of creatine kinase in brain.

artículo científico publicado en 1993

Functional aspects of creatine kinase isoenzymes in endothelial cells.

artículo científico publicado en 2001

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

scientific article published on 01 July 1998

Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli.

artículo científico publicado en 2003

Functional expression of phosphagen kinase systems confers resistance to transient stresses in Saccharomyces cerevisiae by buffering the ATP pool.

artículo científico publicado en 2002

Functions and effects of creatine in the central nervous system.

artículo científico publicado en 2008

Hair bundles are specialized for ATP delivery via creatine kinase.

artículo científico publicado en 2007

Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants.

artículo científico publicado en 2004

Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.

artículo científico publicado en 2001

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

artículo científico publicado en 2009

Human, rat and chicken small intestinal Na+ - Cl- -creatine transporter: functional, molecular characterization and localization.

artículo científico publicado en 2002

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

artículo científico publicado en 2003

Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke

Improved reperfusion and neuroprotection by creatine in a mouse model of stroke

artículo científico publicado en 2006

In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog.

artículo científico publicado en 1997

Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

artículo científico publicado en 2007

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

artículo científico publicado en 2003

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

artículo científico publicado en 2005

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

artículo científico publicado en 1992

Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients

artículo científico publicado en 2016

Introduction--creatine: cheap ergogenic supplement with great potential for health and disease.

artículo científico publicado en 2007

Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library.

artículo científico publicado en 2002

Isoenzyme-specific localization of M-line bound creatine kinase in myogenic cells

artículo científico publicado el 1 de agosto de 1983

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

scientific journal article

Light-chain movement and regulation in scallop myosin

artículo científico publicado el 10 de febrero de 1983

Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle

artículo científico publicado el 1 de noviembre de 1977

Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle

artículo científico publicado el 1 de noviembre de 1977

Localization of reactive cysteine residues by maleidoyl undecagold in the mitochondrial creatine kinase octamer

artículo científico publicado en 1995

Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK

scientific article published on 01 January 2006

Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli

artículo científico publicado en 2003

Membrane-Binding and Lipid Vesicle Cross-Linking Kinetics of the Mitochondrial Creatine Kinase Octamer†

artículo científico publicado en 1996

Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells.

artículo científico publicado en 2008

Metabolite Channeling: Creatine Kinase Microcompartments

article published in 2004

Metabolite channelling in aerobic energy metabolism

artículo científico publicado el 7 de septiembre de 1992

Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium

artículo científico publicado en 2001

Mitochondrial creatine kinase in human health and disease

artículo científico publicado en 2005

Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation.

artículo científico publicado en 1998

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

artículo científico publicado el 25 de septiembre de 1992

Mitochondrial intermembrane inclusion bodies: the common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics

artículo científico publicado en 1997

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation.

artículo científico publicado en 2014

Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands

artículo científico publicado en 2006

Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling

artículo científico publicado en 2011

Monovalent antibodies against MM-creatine kinase remove the M line from myofibrils

artículo científico publicado el 1 de septiembre de 1978

Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity

artículo científico publicado en 2002

Multiple-state equilibrium unfolding of guanidino kinases

artículo científico publicado el 22 de agosto de 1995

Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein

artículo científico publicado en 2003

Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability

scientific article published on 01 July 1998

Mutation of conserved active-site threonine residues in creatine kinase affects autophosphorylation and enzyme kinetics

artículo científico publicado en 2002

Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia.

artículo científico publicado en 2002

New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases.

artículo científico publicado en 2007

New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle

artículo científico publicado en 2002

New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.

artículo científico publicado en 2006

Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes

artículo científico publicado en 2006

Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics.

artículo científico publicado en 2002

Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase

artículo científico publicado el 1 de junio de 1983

Nucleotide binding to creatine kinase: an isothermal titration microcalorimetry study

artículo científico publicado en 1999

Octamer-dimer Transitions of Mitochondrial Creatine Kinase in Heart Disease

artículo científico publicado en 1999

Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane

artículo científico publicado en 2005

Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: implications for cellular function and mitochondrial structure.

artículo científico publicado en 1998

Origin of Leg Musculature during Drosophila Metamorphosis

artículo científico publicado el 1 de octubre de 1972

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

artículo científico publicado en 2009

Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects

artículo científico publicado en 2012

Phosphorylation of chicken brain-type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo

artículo científico publicado en 1990

Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma.

artículo científico publicado en 2008

Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β-Amyloid in Rat Hippocampal Neurons

article

Protective effects of oral creatine supplementation on spinal cord injury in rats.

artículo científico publicado en 2002

Rapid suppression of mitochondrial permeability transition by methylglyoxal. Role of reversible arginine modification.

artículo científico publicado en 2003

Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice

artículo científico publicado en 2002

Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heart

artículo científico publicado en 2007

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells

artículo científico publicado en 2010

Science and security: a European view

artículo científico publicado en 2003

Signaling by AMP-activated Protein Kinase

article

Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology.

artículo científico publicado en 1998

Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.

artículo científico publicado en 2005

Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts

scientific article published on 01 December 1999

Structural Properties of AMP-activated Protein Kinase

artículo científico publicado en 2008

Structural changes of creatine kinase upon substrate binding.

artículo científico publicado en 1998

Structure of the mitochondrial creatine kinase octamer: high-resolution shadowing and image averaging of single molecules and formation of linear filaments under specific staining conditions

artículo científico publicado el 1 de enero de 1991

The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

article

The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches.

scientific article published on January 2007

The creatine kinase system and pleiotropic effects of creatine

artículo científico publicado el 30 de marzo de 2011

The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo

artículo científico publicado en 2005

The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits

artículo científico publicado en 2006

The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage

artículo científico publicado en 2016

The extended, dynamic mitochondrial reticulum in skeletal muscle and the creatine kinase (CK)/phosphocreatine (PCr) shuttle are working hand in hand for optimal energy provision.

artículo científico publicado en 2015

The in vitro kinetics of mitochondrial and cytosolic creatine kinase determined by saturation transfer 31P-NMR.

artículo científico publicado en 1996

The interaction of skeletal myosin subfragment 1 with the polyanion, heparin

artículo científico publicado el 3 de septiembre de 1984

The role of creatine kinase in inhibition of mitochondrial permeability transition

artículo científico publicado el 8 de septiembre de 1997

Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry

artículo científico publicado en 2009

Two different B-type creatine kinase subunits dimerize in a tissue-specific manner

artículo científico publicado en 1990

Unity in diversity

Where Have the Fluxes Gone?

artículo científico publicado el 24 de diciembre de 2010

Why is creatine kinase a dimer? Evidence for cooperativity between the two subunits

artículo científico publicado en 2000