Filtros de búsqueda

Lista de obras de Dennis Selkoe

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

scientific article published on 09 January 2019

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

artículo científico publicado en 2016

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

scientific journal article

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

artículo científico publicado en 2015

A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma

artículo científico publicado en 2002

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain

artículo científico publicado en 2020

A new method for quantitative immunoblotting of endogenous α-synuclein

artículo científico publicado en 2013

A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family

artículo científico publicado en 2019

A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation

artículo científico publicado en 2009

A seed for Alzheimer amyloid in the brain.

artículo científico publicado en 2004

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

artículo científico publicado en 2009

A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice

artículo científico publicado en 2020

A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations

artículo científico publicado en 2017

ADF/cofilin-actin rods and synaptic loss in Alzheimer's disease

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease

scholarly article by Silke Nuber et al published 10 October 2018 in Neuron

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

artículo científico publicado en 2002

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

artículo científico publicado en 2014

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin

artículo científico

Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman

artículo científico publicado el 1 de noviembre de 2003

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

artículo científico publicado en 2009

Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

artículo científico publicado en 2006

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies ⬇️

artículo científico publicado el 23 de septiembre de 2003

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

artículo científico publicado en 2005

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

artículo científico publicado en 2004

Alzheimer disease and aducanumab: adjusting our approach

artículo científico publicado en 2019

Alzheimer disease in 2020.

artículo científico publicado en 2012

Alzheimer disease: mechanistic understanding predicts novel therapies

artículo científico publicado en 2004

Alzheimer's disease

scientific article published on 01 July 2011

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

artículo científico publicado en 2004

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

scientific article published on 01 February 2001

Alzheimer's disease: Conversation with an expert.

artículo científico publicado en 2002

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

artículo científico publicado en 2002

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation ⬇️

artículo científico publicado el 24 de enero de 2011

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

artículo científico publicado en 2008

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

artículo científico publicado en 2005

Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise.

artículo científico publicado en 2006

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation

artículo científico publicado en 2004

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

artículo científico publicado en 2005

Amyloid deposition is associated with impaired default network function in older persons without dementia

artículo científico publicado en 2009

Amyloid β-protein and beyond: the path forward in Alzheimer's disease

scientific article published on 17 March 2020

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

artículo científico publicado en 2008

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

artículo científico publicado en 2002

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease

artículo científico publicado en 2018

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

artículo científico publicado en 2020

Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates

artículo científico publicado en 2010

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

artículo científico publicado en 2003

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease

artículo científico publicado en 2015

Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study

artículo científico publicado en 2011

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

artículo científico publicado en 2012

Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

artículo científico publicado en 2010

Bartels & Selkoe reply

journal article; published in Nature on 2013-06-12

Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development

artículo científico publicado en 2010

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

artículo científico publicado en 2009

Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease

artículo científico publicado en 2008

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

artículo científico publicado en 2012

Biochemistry. Intramembrane proteases--mixing oil and water

artículo científico publicado en 2002

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

artículo científico publicado en 2004

By the way, doctor. Is there a brain scan that can specifically diagnose Alzheimer's disease?

artículo científico publicado en 2005

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

artículo científico publicado en 2015

Caspase-1 clipping causes complications for α-synuclein

scientific article published on 22 August 2016

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

artículo científico publicado en 2004

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

artículo científico publicado en 2019

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

artículo científico publicado en 2017

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

artículo científico publicado en 2005

Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies

artículo científico publicado en 2011

Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations

artículo científico publicado en 2011

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

scientific article published on 31 March 2016

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

artículo científico publicado en 2002

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

artículo científico publicado en 2015

Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory

artículo científico publicado en 2017

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

artículo científico publicado en 2008

Deciphering Alzheimer disease

artículo científico publicado en 2012

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

artículo científico publicado en 2002

Deciphering the genetic basis of Alzheimer's disease

artículo científico publicado en 2002

Deciphering the molecular basis of memory failure in Alzheimer's disease

artículo científico publicado en 2004

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease

artículo científico publicado en 2018

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

artículo científico publicado en 2007

Defining molecular targets to prevent Alzheimer disease

artículo científico publicado en 2005

Defining the native state of α-synuclein

artículo científico publicado en 2013

Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly

artículo científico publicado en 2007

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

artículo científico publicado en 2010

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

artículo científico publicado en 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

artículo científico publicado en 2004

Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease

scientific article published on December 2007

Direct and potent regulation of gamma-secretase by its lipid microenvironment

artículo científico publicado en 2008

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

artículo científico publicado en 2012

Dopamine covalently modifies and functionally inactivates parkin

artículo científico publicado en 2005

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

artículo científico publicado en 2011

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

scientific article published on 19 March 2020

Early network dysfunction in Alzheimer's disease

scientific article published on 01 August 2019

Editorial overview: Neurobiology of disease

artículo científico publicado en 2016

Effects of membrane lipids on the activity and processivity of purified γ-secretase

artículo científico publicado en 2012

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease

artículo científico

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

artículo científico publicado en 2006

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

artículo científico publicado en 2006

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

artículo científico publicado en 2003

Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β

scientific article published on 01 September 2018

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers

artículo científico publicado en 2016

Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways

scientific article published on 24 October 2019

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

artículo científico publicado en 2013

Enzyme target to latch on to

scientific article published in Nature

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

artículo científico publicado en 2003

Evidence that alpha-synuclein does not inhibit phospholipase D

artículo científico publicado en 2009

Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells

artículo científico publicado en 2015

Folding proteins in fatal ways

artículo científico publicado en 2003

Functional alterations in memory networks in early Alzheimer's disease

artículo científico publicado en 2010

Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies

artículo científico publicado en 2014

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

artículo científico publicado en 2003

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

artículo científico publicado en 2004

Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes

scientific journal article

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

artículo científico publicado en 2015

Giving Alzheimer's the old one-two

artículo científico publicado en 2010

HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele

artículo científico publicado en 2009

How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity?

artículo científico publicado en 2010

Identification of beta-secretase (BACE1) substrates using quantitative proteomics

artículo científico publicado en 2009

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain

artículo científico publicado en 2019

Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.

artículo científico publicado en 2013

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

artículo científico publicado en 2013

Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

artículo científico publicado en 2003

Inflammation and therapeutic vaccination in CNS diseases

artículo científico publicado en 2002

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface ⬇️

artículo científico publicado el 2 de octubre de 2003

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

artículo científico publicado en 2003

Intraneuronal Abeta42 accumulation in Down syndrome brain

artículo científico publicado en 2002

Introducing transglutaminase into the study of Alzheimer's disease. A personal look back

artículo científico publicado en 2002

Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain ⬇️

artículo científico publicado el 1 de enero de 2011

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

artículo científico publicado en 2015

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

artículo científico publicado en 2003

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

artículo científico publicado en 2008

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

scientific article published on January 2017

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

artículo científico publicado en 2018

Light at the End of the Amyloid Tunnel

article by Dennis J. Selkoe et al published 1 October 2018 in Biochemistry

Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

artículo científico publicado en 2022

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

scientific article published on 04 December 2018

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype

artículo científico publicado en 2009

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

artículo científico publicado en 2017

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

artículo científico publicado en 2007

Massachusetts Alzheimer's Disease Research Center: progress and challenges

artículo científico publicado en 2015

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

scientific article published on 07 July 2018

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

artículo científico publicado en 2008

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life

artículo científico publicado en 2019

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation

artículo científico publicado en 2014

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

scientific journal article

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

artículo científico publicado en 2002

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

artículo científico

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

artículo científico publicado en 2013

New insights into cellular α-synuclein homeostasis in health and disease.

artículo científico

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain

artículo científico publicado en 2015

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

artículo científico publicado en 2003

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

artículo científico publicado en 2003

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

artículo científico publicado en 2004

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers

artículo científico publicado en 2006

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

artículo científico publicado en 2011

Pancortins interact with amyloid precursor protein and modulate cortical cell migration

scientific journal article

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

artículo científico publicado en 2002

Parkinson's disease: proteinopathy or lipidopathy?

scientific article published on 03 January 2020

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

artículo científico publicado en 2015

Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

artículo científico publicado en 2016

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

artículo científico publicado en 2016

Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

artículo científico publicado en 2016

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

artículo científico publicado en 2004

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis

artículo científico publicado en 2014

Performance characteristics of plasma amyloid-beta 40 and 42 assays

artículo científico publicado en 2009

Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance

artículo científico publicado en 2010

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

artículo científico publicado en 2015

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

artículo científico publicado en 2005

Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

artículo científico publicado en 2007

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

artículo científico publicado en 2009

Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes

artículo científico publicado en 2008

Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis

artículo científico publicado en 2012

Plasma beta-amyloid level, cognitive reserve, and cognitive decline

artículo científico publicado en 2011

Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells

artículo científico publicado en 2007

Potential human transmission of amyloid β pathology: surveillance and risks

scientific article published on 16 September 2020

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

article by Marcia B. Podlisny et al published January 1997 in Neurobiology of Disease

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

artículo científico publicado en 2003

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

artículo científico publicado en 2006

Presenilin: running with scissors in the membrane

artículo científico publicado en 2007

Preventing Alzheimer's disease

artículo científico publicado en 2012

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

artículo científico publicado en 2002

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

artículo científico publicado en 2008

Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures

artículo científico publicado en 2003

Purification and characterization of the human gamma-secretase complex

artículo científico publicado en 2004

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

artículo científico publicado en 2014

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

scientific article published on 22 July 2020

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

artículo científico publicado en 2007

Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview.

artículo científico publicado en 2011

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

artículo científico publicado en 2007

Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study

artículo científico publicado en 2012

Resolving controversies on the path to Alzheimer's therapeutics

artículo científico publicado en 2011

Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554

scientific article published on 01 February 2007

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

artículo científico publicado en 2008

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

artículo científico publicado en 2014

Showing transmitters the door: synucleins accelerate vesicle release

scientific article published on 01 April 2017

Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration

artículo científico publicado en 2005

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening

artículo científico publicado en 2009

SnapShot: pathobiology of Alzheimer's disease

artículo científico publicado en 2013

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

artículo científico publicado en 2007

Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo

artículo científico publicado en 2004

Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region

artículo científico publicado en 2018

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

artículo científico publicado en 2014

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

artículo científico publicado en 2015

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

artículo científico publicado en 2011

Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration ⬇️

artículo científico publicado el 18 de marzo de 2011

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

artículo científico publicado en 2009

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

artículo científico publicado en 2008

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

artículo científico publicado en 2007

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

artículo científico publicado en 2014

Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation

article

Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol

artículo científico publicado en 2015

Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein

scientific article published on 02 May 2013

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

artículo científico publicado en 2019

Ten-year change in plasma amyloid beta levels and late-life cognitive decline

artículo científico publicado en 2009

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

artículo científico publicado en 2003

The amyloid hypothesis of Alzheimer's disease at 25 years

artículo científico publicado en 2016

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

artículo científico publicado en 2002

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

artículo científico publicado en 2016

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

artículo científico publicado en 2014

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

artículo científico publicado en 2003

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

artículo científico publicado en 2011

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

artículo científico publicado en 2010

The therapeutics of Alzheimer's disease: where we stand and where we are heading

artículo científico

The ups and downs of Abeta

artículo científico publicado en 2006

Toward a remembrance of things past: deciphering Alzheimer disease.

artículo científico publicado en 2003

Toward structural elucidation of the gamma-secretase complex

artículo científico publicado en 2009

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study

artículo científico publicado en 2013

Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity

artículo científico publicado en 2020

Verubecestat for Prodromal Alzheimer's Disease

artículo científico publicado en 2019

Vesicle trafficking and lipid metabolism in synucleinopathy

artículo científico publicado en 2020

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

artículo científico publicado en 2010

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

artículo científico publicado en 2003

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

artículo científico publicado en 2005

gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

artículo científico publicado en 2009

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients

scientific article published on 26 November 2019

Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease

artículo científico publicado en 2011

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

artículo científico publicado en 2011

β-secretase inhibitors for Alzheimer's disease: heading in the wrong direction?

scientific article published on 01 July 2019

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

artículo científico publicado en 2017

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 ⬇️

artículo científico publicado el 9 de mayo de 2003

γ-Secretase: a horseshoe structure brings good luck

artículo científico publicado en 2014

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda